A method to improve the tumor diagnostic efficiency of multivalent ligands by regulating the stoichiometric ratio between inner surface functionalities and ligand moieties for tumor targeting

본 발명은 다가성 리간드(multivalent ligand)의 내부 표면작용기(inner surface functionality)와 암 표적 리간드 단위(moiety)의 비율을 조절하여 암 진단 효율을 향상시키는 방법 및 암 진단용 다가성 리간드에 관한 것으로, 본 발명에 따른 방법은 다가성 리간드(multivalent ligand)의 내부 표면작용기와 암 표적 리간드 단위(moiety)의 비율을 조절함에 따라서, 생체에 투여하여 암 진단시 리간드 단위 하나가 먼저 암 세포 표면에 발현하는 특정 수용체에 결합(binding)하면 결합을 이룬 수용체 주위로 다른 동질의 수용체들이 모여드는 현상이 발생하게 되면서 결합에 참여하지 못한 다른 리간드 단위가 모여든 수용체와 다가(multivalent)로 결합하기에 보다 유리한 기회가 발생하게 되는데, 이때 결합한 리간드 단위로 인해 세포 표면에 보다 근접해진 적절히 선택된 종류의 내부 표면작용기가 암 세포 표면에 인력적인 상호작용을 함으로써 결합에 참여하지 못한 리간드 단위가 모여든 수용체에 추가로 동시에 결합하는 결합활성(avidity)을 현저히 향상시키는 효과가 있다.국

논리퍼즐을 활용한 수학교육에 관한 연구

학위논문(석사) --서울대학교 대학원 :수학교육과,2009.2.Maste

A method to improve the tumor diagnostic efficiency of multivalent ligands by regulating the stoichiometric ratio between inner surface functionalities and ligand moieties for tumor targeting

Disclosed herein is a method of improving tumor diagnostic efficiency of multivalent ligands by regulating the stoichiometric ratio between inner surface functionalities and ligand moieties for tumor targeting, and the multivalent ligands for tumor diagnosis.국

Upward trend in follicular lymphoma among the Korean population: 10-year experience at a large tertiary institution

Background: Follicular lymphoma (FL) is the second most common non-Hodgkin lymphoma (NHL) in Western countries. However, it is relatively rare in Asia. This study examined epidemiologic characteristics of FL in South Korea, with an emphasis on recent trends of increase in cases. Methods: We retrospectively examined 239 cases of newly diagnosed FL at a large tertiary institution in Korea (Asan Medical Center, Seoul, Republic of Korea) between 2008 and 2017. Age-adjusted incidence rates and clinicopathological variables were analyzed, and joinpoint regression analysis was used to identify the changes. Results: The age-adjusted incidence of FL significantly increased during the study period (p = .034), and the ratio of (relative incidence) patients with FL to patients with NHL increased from 4.28% to 9.35% in the same period. Over the 10-year study assessment duration, the proportion of patients with stage III/IV FL (p = .035) and expression of BCL2 (p = .022) or BCL6 (p = .039) significantly increased. From 2013?2017, the proportion of patients with highrisk Follicular Lymphoma International Prognostic Index (FLIPI) score increased (21.5% to 28.7%), whereas that of low-risk FLIPI decreased (55.4% to 38.6%), although those results were not statistically significant (p = .066). Conclusions: We found an increasing incidence of FL, with a disproportionate increase in the incidence of high-stage disease and recent changes in the clinicopathologic features of the Korean patient population

A User-centered Decision Support System for Climate Change Adaptation Planning

The extent to which climate information is used to support decision-making remains unclear for various adaptation planning contexts. Recent research efforts have sought to better understand the needs and requirements of users to better format climate information to relevant parameters. This study examines the development of practice-driven climate change services in South Koreas adaptation planning based on self-reviews and interviews. A review of current research trends confirmed the need for integrated, flexible, collaborative, and decision-driven climate services. Combining the two findings, we outline and describe the resulting climate change adaptation planning decision support system (ADAPT-Ko) made available for South Koreas adaptation planners.N

The limited role of comprehensive staging work-up in ocular adnexal extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type (MALToma) with excellent prognosis

The limited role of comprehensive staging work-up in ocular adnexal extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type (MALToma) with excellent prognosi