The Change and Position of Cheonan Festival －Focusing on Korean Traditional Cheerful Songs and the Dance Festival－

This study is to review the change process of Cheonan Festival that is recognized as Koreaʼs only dance festival and analyze the trend of ʻDanceʼ reinforcing the local identity as the icon of the festival. Chuan Festival was started in 1987 as ʻCheonan Samgeoru（3 Way） Culture Festivalʼ and developed to become ʻCheonan Heungtaryeong（Korean Traditional Cheerful Song） Dance Festivalʼ having the dance as its agenda in 2003. After the name changed to ʻCheonan Heungtaryeong Dance Festivalʼ in 2011, globally superb folk dance and performance organizations have been invited to the festival. While accepting professional performance organizations composed of Korean folk dance groups and professional dancers, the festival has been confirmed its position as the only dance festival. Cheonan Festival pursuits the popularity, the creativity as well as the art with performances of citizens, students and professional dancers under the differentiated agenda, `Danceʼ. The street parade is welcomed as a place of participation where performers and audiences together communicate with excitements and dances. Through various additional events, myeons, eups and other various ignored areas could have been extending the opportunity of communication and foreign workersʼ participations in the festival are increased with the grand stage for multicultural families. Especially, Cheonan established the Federation of International Dance Festivals and promotes the internalization of Cheonan Festival by vitalizing festivals and increasing exchanges and cooperation with the Europe, the U.S. and Asian countries.　For the local economy, Cheonan Festival encourages active participations of the local citizens and local universities and proposes new paradigm of festival that connects the local and the world regardless countlessly many number of commercialized festivals. As the festival of long history of 26 years, the study to consider the change and meaning of Cheonan Festival is anticipated to be data to establish the local festivalʼs cultural identity and to explore for the festivalʼs continuous development.論

Nam Soo Han

학위논문(석사)--아주대학교 일반대학원 :의학과,2009. 2TABLE OF CONTENTS ABSTRACT i TABLE OF CONTENTS ii LIST OF FIGURES iii LIST OF TABLES iv Ⅰ. INTRODUCTION 1 Ⅱ. MATERIALS AND METHODS 3 A. Patients 3 B. Immunohistochemistry 3 C. Reverse transcriptase polymerase chain reaction 4 D. Western blotting 5 Ⅲ. RESULTS 6 A. Expression of Ndrg-1 in hypopharyngeal cancer tissue 6 B. RT-PCR and Western blotting in hypopharyngeal cancer tissue 9 Ⅳ. DISCUSSION 11 Ⅴ. CONCLUSION 16 REFERENCES 17 국문요약 21MasterExpression and Clinical Significance of The N-myc downstream regulated gene-1 in Hypopharyngeal Cancer Objective. N-myc downstream regulated gene-1 (Ndrg-1), a potent metastasis suppressor gene, is identified as a gene that is up-regulated by the induction of differentiation in various cancer cell lines. Ndrg-1 has been shown to be involved in tumor progression and metastasis in colon, prostate and breast cancer. However, the clinical significance of Ndrg-1 in hypopharyngeal cancer remains to be investigated, and we therefore examined the role of Ndrg-1 in the survival rate, invasion and metastasis of hypopharyngeal squamous cell carcinoma (SCC). Materials and methods. We performed immunohistochemical staining of 56 specimens each of normal mucosa and SCC of the hypopharynx with Ndrg-1 antibodies. For reverse transcriptase polymerase chain reaction (RT-PCR) and Western blotting, fresh normal and cancer tissue from the hypopharynx obtained from three patients were used. Results. Positive rates of Ndrg-1 expression in hypopharyngeal SCC were 21.4%, respectively. Ndrg-1 staining was significantly inverse correlated with lymph node metastasis. (p=0.048) Decreased expression of Ndrg-1 protein (Western blotting) was detected in hypopharyngeal cancer tissue. Conclusion. Our results suggest that N-myc downstream regulated gene-1 (Ndrg-1) may play an important role in the progression and metastasis of hypopharyngeal cancer

류코노스톡 속 균주 발현용 고복제수 셔틀벡터

본 발명은 류코노스톡 속 균주 발현용 고복제수 셔틀벡터 및 상기 고복제수를 나타내는 벡터로 형질전환된 미생물을 이용하여 목적 단백질을 제조하는 방법에 관한 것으로, 본 발명에 따른 고복제수 플라스미드를 사용하면, 기존의 류코노스톡 속 균주에서 재조합 유전자 발현에 이용되던 저복제수 플라스미드에 비하여 유전자가 현저히 높은 비율료 발현되어, 류코노스톡 속에서 생산되는 재조합 단백질을 보다 높은 수율로 생산할 수 있다