만성 신장 질환이 있는 개에서 발생한 각막 궤양의 양상 및 예후

학위논문 (석사)-- 서울대학교 대학원 : 수의학과, 2017. 2. 서강문.Delayed corneal healing could lead to complications such as corneal vascularization and uveitis in corneal ulcer. Insufficient stromal regeneration affected by complicated healing process could result in a weak corneal structure to maintain the globe. Healing of the cornea could be affected by the presence of systemic disease. In practice, chronic kidney disease (CKD) is known that one of the most common systemic diseases seen in corneal ulcer patients. This study was perforned to investigate the characteristics of corneal ulcers in dogs with chronic kidney disease (CKD). Medical records of 34 dogs (38 eyes) that had been diagnosed with corneal ulcers and chronic kidney disease at Haemaru Referral Animal Hospital from April, 2011 to March, 2016 were investigated. A control group was randomly selected during the same time period (31 dogs, 37 eyes) which was included patients with corneal ulcers but no evidence of systemic disease. The mean healing time of superficial corneal ulcers in the CKD group was 21.0 ± 15.0 days, which was significantly longer than that was observed in the control group (11.0 ± 6.6 days, p < 0.05). The incidence rates of uveitis and keratoconjunctivitis sicca in the CKD group were significantly higher than in the control group (p < 0.01 and p < 0.05, respectively). The healing process of the corneal ulcers with CKD patients could be complicated by KCS and uveitis, therefore, prompt and aggressive treatment would be recommended when corneal ulcer was diagnosed in CKD patients.INTRODUCTION 1 MATERIALS AND METHODS 2 1. Patient selection 2 2. Data selection 4 3. Statistical analyses 6 RESULTS 7 1. Concurrent ophthalmic diseases 8 2. Clinical features of corneal healing 9 3. Correlations with BUN, creatinine and WBC 11 4. Correlations with surgical intervention 14 DISCUSSION 15 CONCLUSIONS 19 REFERENCES 20 ABSTRACT IN KOREAN 22Maste

불안증상과 자살사고의 연관성

Object In South Korea, the number of deaths from suicide has increased in the last two decades, and suicide has become both a social and political problem. In this study, after controlling the variables influencing suicidal ideation, it was expected that it would be determined if anxiety is independently related to suicidal ideation. Methods Data were obtained from 327 psychiatric outpatients accomplished a self-reported questionnaire that included sociodemographic characteristics and clinical variables as well as self-rating scales for measuring the severity of one’s anxiety, depression, and suicidal ideation. Logistic-regression analyses were used to determine the correlation between anxiety and significant suicidal ideation, adjusting for covariates. Results The patients with significant suicidal ideation were shown to be less educated, unemployed, never married, divorced, or separated by death, or living alone, and were shown to have a lower income, a drinking habit, a higher number of past suicide attempts, and more family members who committed suicide, than the patients without significant suicidal ideation. After adjusting the covariates influencing significant suicidal ideation, anxiety was associated with significant suicidal ideation. However, after adjusting for depressive symptoms, only the trait of anxiety was associated with significant suicidal ideation. Conclusion These findings suggest that anxiety symptoms are an independent risk factor for suicidal ideation. Clinicians may thus use anxiety for the screening examination when evaluating suicidal ideation and risk, and will have to actively evaluate and treat the anxiety of patients with suicidal tendencies.;연구 배경 및 목적: 지난 20년 간 한국에서 자살로 인한 사망자는 점차 증가하여 자살은 의학적인 문제 뿐 아니라 사회적 문제로 대두되었다. 본 연구에서는 자살 사고에 영향을 줄 수 있는 변인을 통제한 후, 불안이 자살 사고에 독립적으로 영향을 줄 수 있는지를 평가하였다. 방법: 일 대학병원 정신과 외래를 내원한 327명의 환자를 대상으로 자가 보고식 설문지로 사회인구학적 특성, 병력 및 가족력을 조사하였고, 불안 증상, 우울 증상, 자살 사고를 평가하였다. 로지스틱 회귀분석을 이용하여 자살사고에 영향을 줄 수 있는 변인을 통제하여 불안과 자살사고의 상관 관계를 분석하였다. 결과: 나이가 어리고, 교육 수준이 낮고, 무직이고, 미혼이거나, 이혼, 사별인 경우, 독거인 경우에 의미 있는 자살 사고를 보였다. 또한 자살 사고가 높은 군에서는 소득이 적고, 음주가 더 많이 동반되어 있었고, 과거 자살 시도력이 많았고, 가족 중 자살로 사망한 사람도 더 많았다. 자살 사고가 증가할수록 우울 증상, 불안증상의 정도도 증가했다. 자살 사고 증가에 영향을 줄 수 있는 사회인구학적 요인을 보정한 후에도 불안 증상은 자살 사고와 연관성이 있었으나, 우울증상을 같이 보정했을 경우에는 불안 중에서 특성 불안만 자살 사고와 의미 있는 연관성을 보였다. 결론: 불안 증상은 자살 사고에 독립적인 위험 요인이다. 불안 증상은 흔히 나타나는 증상이고 비교적 쉽게 측정될 수 있기 때문에 자살 위험성에 대한 평가 시에 불안 증상을 중요한 선별 검사로 사용할 수 있겠으며, 자살의 위험성이 있는 환자에서는 불안 증상을 적극적으로 평가하고 치료해야 한다.I. Introduction 1 II. Methods 4 A. Subjects 4 B. Measures 6 C. Statistical analysis 6 III. Results 8 IV. Discussion 11 Reference 21 국문초록 3

A Comparative Study on the Differences of the Melodies of Haekeum and Peeree in JungAck

학위논문 (박사)-- 서울대학교 대학원 : 음악과, 2011.2. 황준연.Docto

奚琴 連音 旋律 硏究

학위논문(석사)--서울大學校 大學院 :音樂科 國樂器樂專攻,1996.Maste

Social Behavioral Problems and the Health-Related Quality of Life in Children and Adolescents with Epilepsy

Objective The purpose of this study was to investigate the impact of specific behavioral problems on the health-related quality of life (HRQOL) in children and adolescents with epilepsy. Methods Children and adolescents with epilepsy (n=92; age range=6-17 years) and their mothers completed questionnaires about behavioral problems, HRQOL, socio-demographics, and epilepsy-related variables. To determine significant predictor variables of the HRQOL, the stepwise regression analyses and partial correlations were performed to adjust for other behavioral problems and covariates. Results The analyses revealed that an increase in social behavioral problems and delinquent behavior was associated with a decrease in the HRQOL. Lower levels of maternal education and the number of antiepileptic drugs were also associated with a decline in the HRQOL; the HRQOL and social behavioral problems remained significantly correlated after adjusting for maternal education level, number of antiepileptic drugs, and non-social behavioral problems. Conclusion Parents and practitioners should provide intervention if behavioral problems, particularly social behavioral problems, are observed in children or adolescents with epilepsy

Psychological and genetic risk factors associated with suicidal behavior in Korean patients with mood disorders

Introduction: To prevent suicide, a nationwide important issue in Korea, understanding its etiology is essential. This study aimed to delineate the risk factors for suicidal behavior in mood disorder patients in Korea. Methods: 216 patients with mood disorders were recruited. We measured suicidal ideation (SI) and suicide attempt (SA) history and the association of six gene polymorphisms with SB: COMT (rs4680), HTR1A (rs6295), TPH1 (rs1800532), BDNF (rs6265), SLC1A3 (rs2269272), and SLC1A2 (rs4755404). Results: Patients in the high-SI and SA groups reported more severe depressive, hopelessness, and anxiety symptoms and lower resilience and used less social support-seeking coping than those in the non-significant SI and non-SA groups. Multivariate logistic analysis revealed that depressive disorder, depressive symptoms, poor social support, and less social support-seeking coping were significant independent predictors of suicidal ideation. After adjustment for covariates, age, alcohol consumption, and the rs4680 AA genotype in the COMT gene were associated with suicide attempt. Limitations: The modest sample size and a relatively few candidate genes are limitations of the study. In addition, there is no normal control group and the retrospective evaluation of SA limits the interpretation of the causal relationship with factors affecting SA. Conclusions: Suicidal behavior in Korean patients with mood disorders may be associated with younger age, alcohol consumption, depressive symptoms, poor social support, less social support-seeking coping, and the COMT rs4680 Met/Met genotype. © 2018Ewha Womans Universit

Psychological and genetic risk factors associated with suicidal behavior in Korean patients with mood disorders

Introduction: To prevent suicide, a nationwide important issue in Korea, understanding its etiology is essential. This study aimed to delineate the risk factors for suicidal behavior in mood disorder patients in Korea. Methods: 216 patients with mood disorders were recruited. We measured suicidal ideation (SI) and suicide attempt (SA) history and the association of six gene polymorphisms with SB: COMT (rs4680), HTR1A (rs6295), TPH1 (rs1800532), BDNF (rs6265), SLC1A3 (rs2269272), and SLC1A2 (rs4755404). Results: Patients in the high-SI and SA groups reported more severe depressive, hopelessness, and anxiety symptoms and lower resilience and used less social support-seeking coping than those in the non-significant SI and non-SA groups. Multivariate logistic analysis revealed that depressive disorder, depressive symptoms, poor social support, and less social support-seeking coping were significant independent predictors of suicidal ideation. After adjustment for covariates, age, alcohol consumption, and the rs4680 AA genotype in the COMT gene were associated with suicide attempt. Limitations: The modest sample size and a relatively few candidate genes are limitations of the study. In addition, there is no normal control group and the retrospective evaluation of SA limits the interpretation of the causal relationship with factors affecting SA. Conclusions: Suicidal behavior in Korean patients with mood disorders may be associated with younger age, alcohol consumption, depressive symptoms, poor social support, less social support-seeking coping, and the COMT rs4680 Met/Met genotype. © 201

Effect of Food on the Pharmacokinetics and Pharmacodynamics of a Single Oral Dose of Tegoprazan

Purpose: Tegoprazan is a potassium-competitive acid blocker (P-CAB) that is designed to treat acidrelated diseases through a fundamentally different mechanism than that of proton pump inhibitors (PPIs). Because PPIs inhibit only activated parietal cell H+/K+ adenosine triphosphatase, stimulation of parietal cells by a meal is necessary for optimal results. In contrast, P-CABs can inactivate proton pumps without acid activation and bind to both activated and inactivated adenosine triphosphatase. This study evaluates the effect of food consumption on the pharmacokinetic and pharmacodynamic properties of tegoprazan after a single oral dose in healthy men. Methods: In this open-label, 2-period crossover study, 24 healthy men were randomized to 1 of 2 treatment sequence groups: administration of tegoprazan under the fasting condition and administration of tegoprazan under the fed condition. The dosing periods of both sequence groups were separated by a washout period of 7 days. At each dosing period, the participants received a single dose of 200 mg of tegoprazan followed by pharmacokinetic and pharmacodynamic analysis. Findings: After the oral administration of 200 mg tegoprazan, the C-max was decreased and delayed under the fed condition compared with that of the fasting condition. However, no significant differences were observed in the AUC and the time of gastric acid suppression (inhibition of integrated acidity) during 24 hours. (C) 2021 Elsevier Inc