Serum Reactivity Against Herpes Simplex Virus Type 1 UL48 Protein in Behçet's Disease Patients and a Behçet's Disease-like Mouse Model

Herpes simplex virus (HSV) infection is a possible pathogenic factor in Behçet's disease (BD). Using proteomics analysis, this study detected a target HSV protein. Serum IgA and IgG reactivities against the identified protein were evaluated in patients with BD and in BD-like mice. A total of 4 protein bands generated by immunoprecipitation were analysed by proteomics, and HSV UL48 was commonly found in both IgA- and IgG-reactive protein bands. Compared with controls, patients with BD and BD-like mice exhibited higher titres of IgA reacting with recombinant HSV UL48 protein. Further proteomics analysis revealed that human heat shock cognate 71 kDa protein (Hsc71) is a cross-reacting target antigen against anti-HSV UL48 antibody. In addition, our data demonstrated a very strong association between serum IgG reactivity against recombinant human Hsc71 and recombinant HSV UL48 in patients with BD. We suggest that HSV infection and impaired human Hsc71 activity may be associated with the activation of autoreactive lymphocytes.ope

Detection of tuberculous lymphadenopathy by positron emission tomography/computed tomography in a patient with Behçet's disease

ope

Multiple Scarring Following Removal of Pigmented Nevi by Acupuncture in an Oriental Clinic

The concept of oriental medicine is according to the Yin-Yang Doctrine and the Five Elements theory which is based on oriental philosophy. Traditionally, doctors of oriental medicine have practiced by feeling pulses for diagnosis, acupuncturing, and prescribing herbal medicine for treatment. Nowadays, however, most oriental doctors are having hard time in managing their own clinics by progressive worsening of the medical environment, because the numbers of patients are absolutely decreasing, but the numbers of oriental clinics are relatively increasing. Therefore, they are intending to overcome the difficulties by enlarging their field of medical treatment in various aspects, and introducing treatment remedies including unreasonable or unproved methods, especially into the field of dermatology. Here we present a case of multiple scarring of the face following removal of pigmented nevi by acupuncture in an oriental clinic. We report this case to emphasize the necessity of understanding the current status of dermatologic treatments conducted in oriental clinics, and to inform the dangerousness and correct medical information to the publicope

Restoring the Role of Credit Rating Agencies as Gatekeepers

Credit rating agencies(CRAs) are accused of failing to provide accurate and fair credit ratings and hence being responsible for the crisis. This paper tries to add on to the literature on credit rating reform through examining the CRAs in a model where raⅠ. 서 론 　Ⅱ. 기본모형 　Ⅲ. 모형의 확장 　Ⅳ. 분석의 종합 및 결론 　참 고 문 헌 　부

Interdependence of Corporate Control Mechanisms and Firm Performance in Korea

This paper examines a simultaneous determination of corporate control mechanisms, and its effects on firm performance. The corporate control mechanisms considered include the followinginsider shareholding, institutional shareholding, the board of directⅠ.서론 　Ⅱ. 지배구조 관련 제도의 변천 및 현황 　Ⅲ. 실증분석 　　1. 변수의 구축 및 분석자료 　　2. 기업통제장치의 시간별 변화 및 인과관계 　　3. 실증분석방법 　　4. 추정결과 　Ⅴ. 분석의 종합 및 결

Strategic Cross-fund Subsidization: Evidence from Equity Funds in Korea

This study uses Korea’s equity fund-related data ranging from Jan. 2002 to Apr. 2010 to analyze the existence of cross-subsidization among funds managed by the same management company. The findings are as follows: i) a transfer of performance outcome isⅠ. 서 론 　Ⅱ. 자료 및 방법론 　Ⅲ. 분석 결과 　Ⅳ. 정책적 시사점 　Ⅴ. 분석의 종합 및 결론 　참고문

Product Market Competition and Internal Efficiency of the Firm

This paper analyzes a mechanism through which product market competition affects allocation of the managerial efforts. There are two types of firms, incumbents and entrants. Each incumbent firm delegates its control to a manager and cannot observe the manⅠ. 서론 　Ⅱ. 모형 　Ⅲ. 최적계약 　　1. 신규기업의 문제 　　2. 기존기업의 최적계약(Optimal Contract for the Incumbents) 　　　가. 완전정보(Full Information) 　　　나. 비대칭적 정보 　Ⅳ. 시장경쟁과 경영자의 유인 　　1. 진입을 불허하

New insights in the clinical understanding of Behçet's disease

Behçet's disease is a chronic relapsing multisystemic inflammatory disorder characterized by four major symptoms (oral aphthous ulcers, genital ulcers, skin lesions, and ocular lesions) and occasionally by five minor symptoms (arthritis, gastrointestinal ulcers, epididymitis, vascular lesions, and central nervous system symptoms). Although the etiology of Behçet's disease is still unknown, there have been recent advances in immunopathogenic studies, genome-wide association studies, animal models, diagnostic markers, and new biological agents. These advances have improved the clinical understanding of Behçet's disease and have enabled us to develop new treatment strategies for this intractable disease, which remains one of the leading causes of blindness.ope

Kaposi's Varicelliform-Like Eruption in a Patient Treated with Everolimus for Metastatic Renal Cell Carcinoma: Report of a Rare Case.

Kaposi's varicelliform eruption is a cutaneous eruption caused by the herpes simplex virus and a few other viruses that infect persons with pre-existing dermatosis such as atopic dermatitis. We report the case of a 56-year-old man who was treated with the mammalian target of rapamycin inhibitor, everolimus, for metastatic renal cell carcinoma. He presented with painful, umbilicated vesicles and pustules on his face, genital region, forearms, and legs suggestive of Kaposi's varicelliform eruption. He did not have a history of any visceral viral disease and pre-existing dermatosis. The diagnosis was based on the clinical features. He was treated with acyclovir for 7 days, with improvement of his skin lesions. We discuss the clinical manifestations of the Kaposi varicelliform-like eruption in an immunocompromised patient treated with everolimus.ope

Reactivation of anti-human alpha-enolase antibody-positive Behçet's disease by carbon dioxide laser treatment.

ope