9 research outputs found
๊ฒฝ๋๋งฅ ํ๋ฅ๋ชจ๋ธ์์ ๊ณ ํด์ ์ ํธ์ค์ฒฉ๊ธฐ๋ฒ ์ผ์ฐจ์TOF ์๊ธฐ๊ณต๋ช
Department of Medicine/์์ฌ[ํ๊ธ]
In Vitro comparative flow phantom study about the difference of relaxivity between
Gadomer-17 and Gd-DTPA using high resolution 3D-TOF MRA
Byung-June Jo
Department of Medicine, The Graduate School, Yonsei University
(Directed by Associate Professor Tae-Sub Chung)
With the recent development of magnetic resonance imaging, the visualization of
small vasculatures has become possible. Especially, high resolution 3D-TOF MRA
technique has enabled us to obtain higher resolution images and visualization of
tortuous vessel structures running parallel into the slice, such as the cerebral
vessel, compared with two-dimensional MRA because of its lower saturation effect.
Also, to reduce the saturation effect of TOF MRA, MR contrast agents are being
used. Gadomer-17, a new macromolecular blood pool agent, is known to have three to
four times higher relaxivity than that Gd-DTPA.
The purpose of our study was to reveal the difference of relaxivity between
Gadomer-17 and Gd-DTPA applying high resolution 3D-TOF MRA with slice interpolation
technique using a flow phantom model and to support the preliminary data about the
proper dose concentration of Gadomer-17.
In the pulsating flow system, three concentrations of Gadomer-17 and Gd-DTPA were
filled. Using the carotid phantom model composed of normal and 70% stenosis, MRA
was obtained by 3D-TOF MRA with slice interpolation technique. By the visual
analysis of vessel conspicuity, the degree of compensation effects of contrast
agents over the turbulent flow-related artifact was done in MIP reconstructed
images. For quantitative analysis, the signal intensities were measured in the
axial base 3D-TOF images, and relative contrast enhancement was calculated. The
results of our studies were;
1. Maximal signal intensities were obtained at 1mmol/L of Gadomer-17 and at
1mmol/L of Gadomer-17 and 4mmol/L Gd-DTPA.
2. In the flow phantom model study, maximal signal intensities were obtained at
1mmol/L of Gadomer-17 and at 1mmol/L of Gadomer-17 and 4mmol/L Gd-DTPA.
3. Flow-related signal loss was compensated by Gd-DTPA proportional to
concentration, but Gadomer-17 did not show such a dose accumulative effect.
Conclusively, the left-sided shifting of signal intensities-to-concentration of
contrast curve suggest the intrinsic higher relativity of Gadomer-17 over Gd-DTPA.
Improvement of MRA image quality and higher signal intensities of the vessel were
obtained in the lower concentration of Gadomer-17 than that of Gd-DTPA.
With the recent development of magnetic resonance imaging, the visualization of
small vasculatures has become possible. Especially, high resolution 3D-TOF MRA
technique has enabled us to obtain higher resolution images and visualization of
tortuous vessel structures running parallel into the slice, such as the cerebral
vessel, compared with two-dimensional MRA because of its lower saturation effect.
Also, to reduce the saturation effect of TOF MRA, MR contrast agents are being
used. Gadomer-17, a new macromolecular blood pool agent, is known to have three to
four times higher relaxivity than that Gd-DTPA.
The purpose of our study was to reveal the difference of relaxivity between
Gadomer-17 and Gd-DTPA applying high resolution 3D-TOF MRA with slice interpolation
technique using a flow phantom model and to support the preliminary data about the
proper dose concentration of Gadomer-17.
In the pulsating flow system, three concentrations of Gadomer-17 and Gd-DTPA were
filled. Using the carotid phantom model composed of normal and 70% stenosis, MRA
was obtained by 3D-TOF MRA with slice interpolation technique. By the visual
analysis of vessel conspicuity, the degree of compensation effects of contrast
agents over the turbulent flow-related artifact was done in MIP reconstructed
images. For quantitative analysis, the signal intensities were measured in the
axial base 3D-TOF images, and relative contrast enhancement was calculated. The
results of our studies were;
1. Maximal signal intensities were obtained at 1mmol/L of Gadomer-17 and at
1mmol/L of Gadomer-17 and 4mmol/L Gd-DTPA.
2. In the flow phantom model study, maximal signal intensities were obtained at
1mmol/L of Gadomer-17 and at 1mmol/L of Gadomer-17 and 4mmol/L Gd-DTPA.
3. Flow-related signal loss was compensated by Gd-DTPA proportional to
concentration, but Gadomer-17 did not show such a dose accumulative effect.
Conclusively, the left-sided shifting of signal intensities-to-concentration of
contrast curve suggest the intrinsic higher relativity of Gadomer-17 over Gd-DTPA.
Improvement of MRA image quality and higher signal intensities of the vessel were
obtained in the lower concentration of Gadomer-17 than that of Gd-DTPA.
์ต๊ทผ์ ์๊ธฐ๊ณต๋ช
ํ๊ด์กฐ์์ ์ ๋ฐ๋ฌ๋ก ๋ฏธ์ธํ ํ๊ด์กฐ์ง์ ์์ํ๊ฐ ๊ฐ๋ฅํด์ก๋ค. ํนํ ์ต๊ทผ ๊ฐ๋ฐ๋ ๊ณ ํด์ ์ ํธ์ค์ฒฉ๊ธฐ๋ฒ ์ผ์ฐจ์-TOf ์๊ธฐ๊ณต๋ช
ํ๊ด์กฐ์์ ์ ๊ธฐ์กด์ ์ด์ฐจ์-TOF ์๊ธฐ๊ณต๋ช
ํ๊ด์กฐ์์ ์ ๋นํด ๊ณ ํด์๋์ ํ๊ด์์์ ๋ง๋ค ์ ์๊ณ ์ ํธ ๋ด์์ ์ ํธ๊ณผ ํํํ๊ฒ ๋ฌ๋ฆฌ๋ ํ๊ด์ ๋ํ ํฌํํจ๊ณผ(saturation effect)๊ฐ ์ ์ด ๊ตฌ๋ถ๊ตฌ๋ถํ ๋ํ๊ด์ ์์ํ์ ์ ๋ฆฌํ๋ค. ๋ํ TOF ์๊ธฐ๊ณต๋ช
ํ๊ด์กฐ์์ ์ ๋จ์ ์ธ ํฌํํจ๊ณผ๋ฅผ ์ค์ด๊ธฐ ์ํด ์กฐ์์ ๋ฅผ ์ฌ์ฉํ๊ณ ์๋ค. ์ต๊ทผ์ ๊ฐ๋ฐ๋ Gadomer-17์ ๊ธฐ์กด์ ๋๋ฆฌ ์ฌ์ฉ๋๋ Gd-DTPA์ ๋นํด 4๋ฐฐ ์ ๋ ๋์ ์ด์๋ (relativity)๋ฅผ ๋ณด์ธ๋ค๊ณ ๋ณด๊ณ ๋์์ง๋ง ์ด๋ฌํ ๋ฐ์ดํฐ๋ Gadomer-17์ ๊ฐ๋ฐ์์ธ Weinmann์ด ํ ๋ผ๋ฅผ ์ด์ฉํ ๋๋ฌผ์์ฒด์คํ๊ณผ ๊ฐ์์ปดํจํฐ ๋ชจ๋ธ๋ก์จ ๊ณ์ฐํ ์์น๋ง์ด ์๋ ค์ ธ ์์ ๋ฟ์ด๋ค. ๋ฐ๋ผ์ Gadomer-17์ Gd-DTPA์ ๋นํด ์๋์ ์ผ๋ก ๋์ ์ด์๋๊ฐ ์์ฒด๋ด์ ์ฌ๋ฌ ๋ณ์์์ธ์ ์ํ ๊ฒ์ธ์ง ์๋๋ฉด ๊ทธ ๋ฌผ์ง์์ฒด์ ํน์ฑ์ ์ํ ๊ฒ์ธ์ง๋ ์์ง ์๋ ค์ ธ ์์ง ์๋ค. ๋ณธ ์ฐ๊ตฌ๋ ์ด๋ฌํ ์ ํ๋ ์ ๋ณด๋ง์ด ์๋ ค์ง Gadomer-17์ ์ด์ฉํ์ฌ ๊ณ ํด์ ์ ํธ์ค์ฒฉ ๊ธฐ๋ฒ ์ผ์ฐจ์-TOF ์๊ธฐ๊ณต๋ช
ํ๊ด์กฐ์์ ์ ์ดฌ์ํจ์ผ๋ก์จ Gadomer-17์ Gd-DTPA์ ๋นํด ์๋์ ์ผ๋ก ๋์ ์ด์๋๋ฅผ ์์์ ์ผ๋ก ๊ตฌํํ๊ณ ์ ํ๋ฉฐ ๋์๊ฐ ์กฐ์ํจ๊ณผ์ ๊ทน๋ํ๋ฅผ ์ํ ์ ์ ์กฐ์์ ๋๋ ๊ฒฐ์ ์ ๊ดํ ๊ธฐ๋ณธ์ ์ธ ๋ฐ์ดํ๋ฅผ ์ ์ํ๋ ๋ฐ ๊ทธ ๋ชฉ์ ์ด ์๋ค.
๋ณธ ์ฐ๊ตฌ์์๋ ์ฐ์ Gd-DTPA์ Gadomer-17 ์ผ๋ จ์ ๋๋์ฉ์ก์ ๊ฐ์ง๊ณ ์ต์ ์ ๋๋๋ฅผ ๊ตฌํ ํ ์๊ธฐ๊ณต๋ช
ํ๊ด์กฐ์์ ์ ์ํํ์ฌ ๊ฐ๊ฐ์ ์ฉ์ก์์ ์ ํธ๊ฐ๋๋ฅผ ์ธก์ ํ์ฌ ์ต๊ณ ์ ํธ๊ฐ๋๋ฅผ ๋ณด์ด๋ ๋๋๋ฅผ ์ป์๋ค. ์ ์๊ณผ ํ์ฐฉ์ด ์๋ ๊ฒฝ๋๋งฅ ํ๋ฅ๋ชจ๋ธ์ ์ด์ฉํ์ฌ ์ฉ์ก ๋๋์ ๋ฐ๋ฅธ ์ ํธ๊ฐ๋๊ณก์ ์ ์ป์ด Gd-DTPA์ Gadomer-17๊ฐ์ ์ฐจ์ด๊ฐ ์๋ ์ง๋ฅผ ์์๋ณด๊ณ ์กฐ์ ์ , ํ์ ์ ํธ๊ฐ๋๋ฅผ ๊ตฌํ์ฌ ์๊ธฐ๊ณต๋ช
ํ๊ด์กฐ์์ ์ percent enhancement ์ ๋์ ๊ฒฝ๋๋งฅ ํ๋ฅ๋ชจ๋ธ์ ์์์ ์ง์ ์ฐ์์ ์ต์ ์ ์ ํธ๊ฐ๋๋ฅผ ๋ณด์ด๋ ๋๋๋ฅผ ๊ตฌํ์์ผ๋ฉฐ ๋ค์๊ณผ ๊ฐ์ ๊ฒฐ๊ณผ๋ฅผ ์ป์๋ค.
1. Gadomer-17์ 1mmol/L, Gd-DTPA๋ 4mmol/L๋๋์ ์ฉ์ก์์ ๊ฐ์ฅ ๋์ ์ ํธ๊ฐ๋๊ฐ ๋ํ๋ฌ๋ค.
2. ๊ฒฝ๋๋งฅ ํ๋ฅ๋ชจ๋ธ์์๋ Gadomer-17๊ณผ Gd-DTPA๋ ๊ฐ๊ฐ 1mmol/L, 4mmol/L์์ ๊ฐ์ฅ ๊ฐํ ์ ํธ๊ฐ๋๋ฅผ ๋ํ๋ด์๋ค.
3. 70% ํ์ฐฉ ๊ฒฝ๋๋งฅ ํ๋ฅ๋ชจ๋ธ์ ์ด์ฉํ ์คํ์์๋ ์๋ฅ๋ก ์ธํ ํ์ฐฉ๋ถ ์ดํ์ ์ ํธ๊ฐ๋ ๊ฐ์๊ฐ Gadomer-17์ 1mmol/L, Gd-DTPA์์๋ 4mmol/L์์ ๊ฐ์ฅ ์ ๊ฒ ๋ํ๋ฌ๋ค.
์ด์์ ๊ฒฐ๊ณผ์์ Gadomer-17์ Gd-DTPA์ ๋นํด ์๋์ ์ผ๋ก ๋์ ์ด์๋์์ฐจ์ด๊ฐ ๋๋-์ ํธ๊ฐ๋๊ณก์ ์ ์ข์ธก์ด๋์ ์๊ฒฌ์ผ๋ก ๋ํ๋ฌ๊ณ Gadomer-17์ Gd-DTPA์ ๋นํด ์ ์ ๋๋์์ ๊ฐํ ์ ํธ๊ฐ๋์ ์ ์ฒด์ ์ธ ํ๊ด์กฐ์์ ์ ์์์ ์ง์ด ๋์๋ค.
[์๋ฌธ]
With the recent development of magnetic resonance imaging, the visualization of small vasculatures has become possible. Especially, high resolution 3D-TOF MRA technique has enabled us to obtain higher resolution images and visualization of tortuous vessel structures running parallel into the slice, such as the cerebral vessel, compared with two-dimensional MRA because of its lower saturation effect. Also, to reduce the saturation effect of TOF MRA, MR contrast agents are being used. Gadomer-17, a new macromolecular blood pool agent, is known to have three to
four times higher relaxivity than that Gd-DTPA.
The purpose of our study was to reveal the difference of relaxivity between Gadomer-17 and Gd-DTPA applying high resolution 3D-TOF MRA with slice interpolation technique using a flow phantom model and to support the preliminary data about the
proper dose concentration of Gadomer-17.
In the pulsating flow system, three concentrations of Gadomer-17 and Gd-DTPA were filled. Using the carotid phantom model composed of normal and 70% stenosis, MRA was obtained by 3D-TOF MRA with slice interpolation technique. By the visual analysis of vessel conspicuity, the degree of compensation effects of contrast agents over the turbulent flow-related artifact was done in MIP reconstructed images. For quantitative analysis, the signal intensities were measured in the axial base 3D-TOF images, and relative contrast enhancement was calculated. The results of our studies were;
1. Maximal signal intensities were obtained at 1mmol/L of Gadomer-17 and at 1mmol/L of Gadomer-17 and 4mmol/L Gd-DTPA.
2. In the flow phantom model study, maximal signal intensities were obtained at 1mmol/L of Gadomer-17 and at 1mmol/L of Gadomer-17 and 4mmol/L Gd-DTPA.
3. Flow-related signal loss was compensated by Gd-DTPA proportional to concentration, but Gadomer-17 did not show such a dose accumulative effect.
Conclusively, the left-sided shifting of signal intensities-to-concentration of contrast curve suggest the intrinsic higher relativity of Gadomer-17 over Gd-DTPA. Improvement of MRA image quality and higher signal intensities of the vessel were obtained in the lower concentration of Gadomer-17 than that of Gd-DTPA.
With the recent development of magnetic resonance imaging, the visualization of small vasculatures has become possible. Especially, high resolution 3D-TOF MRA technique has enabled us to obtain higher resolution images and visualization of tortuous vessel structures running parallel into the slice, such as the cerebral vessel, compared with two-dimensional MRA because of its lower saturation effect. Also, to reduce the saturation effect of TOF MRA, MR contrast agents are being used. Gadomer-17, a new macromolecular blood pool agent, is known to have three to four times higher relaxivity than that Gd-DTPA.
The purpose of our study was to reveal the difference of relaxivity between Gadomer-17 and Gd-DTPA applying high resolution 3D-TOF MRA with slice interpolation technique using a flow phantom model and to support the preliminary data about the
proper dose concentration of Gadomer-17.
In the pulsating flow system, three concentrations of Gadomer-17 and Gd-DTPA were filled. Using the carotid phantom model composed of normal and 70% stenosis, MRA was obtained by 3D-TOF MRA with slice interpolation technique. By the visual analysis of vessel conspicuity, the degree of compensation effects of contrast agents over the turbulent flow-related artifact was done in MIP reconstructed images. For quantitative analysis, the signal intensities were measured in the axial base 3D-TOF images, and relative contrast enhancement was calculated. The results of our studies were;
1. Maximal signal intensities were obtained at 1mmol/L of Gadomer-17 and at 1mmol/L of Gadomer-17 and 4mmol/L Gd-DTPA.
2. In the flow phantom model study, maximal signal intensities were obtained at 1mmol/L of Gadomer-17 and at 1mmol/L of Gadomer-17 and 4mmol/L Gd-DTPA.
3. Flow-related signal loss was compensated by Gd-DTPA proportional to concentration, but Gadomer-17 did not show such a dose accumulative effect.
Conclusively, the left-sided shifting of signal intensities-to-concentration of contrast curve suggest the intrinsic higher relativity of Gadomer-17 over Gd-DTPA.
Improvement of MRA image quality and higher signal intensities of the vessel were obtained in the lower concentration of Gadomer-17 than that of Gd-DTPA.restrictio