BLOOD VISCOSITY CHANGE IN ORAL SQUAMOUS CELL CARCINOMA XENOTRANSPLANTED NUDE MICE

It is well known that malignant tumor have hypoxic cell fraction, which is radio resistant and is one of the most important cause of local recurrence after radiotherapy. One of the causes of hypoxia in tumor is blood flow decrease due to increase in blood flow resistance and one of the causes of increased blood flow resistance could be attributed to the increase in blood viscosity. For the evaluation of the change of blood viscosity in oral cancer, experiments were carried out to test the change of blood viscosity among the normal control and xenografted oral cancer nude mice. Relative viscosity measured against distilled water was for normal control, and for tumor bearing mice at the first time of blood sampling in experimental period ( ). There was no statistically significant difference between the control group and experimental group (p>0.05). However, as the tumor grew, significant difference of blood viscosity was detected at the third time of blood sampling (control group:, and experimental group:2003년도 한국학술진흥재

CHANGE OF BLOOD VISCOSITY AND DEFORMABILITY IN ORAL SQUAMOUS CELL CARCINOMA PATIENTS

Malignant tumor have hypoxic cell fraction, which makes radio-resistant and hypoxia in tumor is a result from the blood flow decrease caused by increase in blood flow resistance. Blood viscosity increase is major factor of increased blood flow resistance and it could be attributed to the decrease in blood deformability index. For the evaluation of the change of blood viscosity and blood deformability in oral squamous cell carcinoma, we perform the test of the change of those factors between the normal control group and oral squamous cell carcinoma cell patient group. Relative viscosity measured against distilled water was for normal control group, and for the SCC patient group and there was statistical significance between the groups. However, there was no significant difference between the groups in blood viscosity between the groups by tumor size (T1+T2 vs T3+T4). Also, there was no significant difference between the normal control group and SCC patient group in blood deformability index and between the groups by tumor size (T1+T2 vs T3+T4). Increase in blood viscosity was confirmed with this study and it can be postulated that modification blood viscosity might contribute to decrease of hypoxia fraction in oral squamous cell carcinoma, thus improve the effect of radiotherapy and it can be assumed that the main factor of blood viscosity increase is not decrease of blood deformability in oral squamous cell carcinoma.2003년도 한국학술진흥재

INTERNAL VS. RIGID EXTERNAL DISTRACTION DEVICE FOR THE MAXILLARY HYPOPLASIA OF CLEFT PATIENTS

Distraction osteogenesis for the advancement of hypoplastic maxilla of cleft patients has shown successful results. In this report, rigid external distraction(RED) system and internal distraction device were used for maxillary advancement. Each system has its advantages and disadvantages. Larger amount of advancement can be achieved with RED system. But complex external device may give patients psychological stress. Internal device is invisible. However its distraction amount have limitation for the advancement (< 20mm) and the vector cannot be changed freely during distraction. The authors treated five cleft patients with maxillary hypoplasia(three with RED system and two with internal distractor). Their results were clinically satisfactory. We present the pros and cons of RED and internal system for maxillary distraction osteogenesis

BLEPHAROPLASTY BY VARIOUS CAUSES

심미적인 이유를 포함한 여러 가지 원인에 의한 안검성형술을 저자등이 사용한 방법, 안검성형술을 받고자 하는 동기, 합병증 등을 보고하며 국내의 턱얼굴외과의사들의 새로운 진료 영역으로의 안면부 연조직미용수술에 관한 관심과 노력을 기대한다

FALSE ANEURYSM IN INTERNAL MAXILLARY ARTERY

구강악안면 영역에서의 외상에 의한 내악 동맥의 가성 동맥류는 극히 드문 병변으로 저자들은 서울 대학교 치과병원 구강악안면외과에서 1례를 치험하였다. 그 원인은 외상에 의한 하악 과두 골절, 관혈적 정복술시의 의원적 외상 또는 둘 다를 고려해 볼 수 있었으며 임상적으로 박동성 잡음,촉진 가능한 맥동이 있었고 술중 과다 출혈의 양상을 보였다. 병소는 혈관 조영술에 의해 확진되었으며, 색전술로 치료하였다. 가성 동맥류는 생명을 위협할 정도의 과다 출혈을 일으킬 수 있으므로 그 진단과 치료는 중요하다. 혈관 조영술은 임상적 증상에 대한 확실한 진단을 가능케 해 주며 이를 이용한 색전술은 관혈적 결찰법에 비해 장점을 가지므로 좋은 치료법이 될 수 있다.보건복지부 보건의료기술진흥사

Total esthetic orthognathic surgery : 1 . New esthetic lines and inter-esthetic line angle

Improvement of orthognathic surgical techniques make it possible to design esthetic surgical correction for total esthetic face. In order to find the esthetic line which guide esthetic surgical correction in patients of orthognathic surgery, cephalometric soft tissue analysis of esthetic faces were performed. In esthetic Korean young adults, 25 males and 25 females who were within 1 S. D. of E-line, ANB, P/A facial height ratio, were analyzed in natural position keeping their face eye level. 1. Sn position is constant in males and females. The Sn-N1-N' Vertical plane angle is 5.3˚ in both sexes. Sn is positioned in front of 5 mm in female 7 mm in male from the N' vertical plane. 2. The Sn-Ls line make constant angle to horizontal plane with 72.5˚ in both sexes, which is called upper esthetic line". The Ls-Pg' line makes constant angle to 72.4˚ (range 72.2˚ in female to 72.6˚ in male), which is called lower esthetic line. 3. When inter-esthetic line angle (the Sn-Ls line to Ls-Pg' line) has 144.9". lower third face has esthetic upper and lower lip. 4. In treatment planning, Sn is fist corrected in proper position, and then upper and lower esthetic line are established with the angle of 144.9. The maxilla is moved to tangent Ls to the upper esthetic line, and mandible is moved to tangent Li and Pgl to the lower esthetic line, according to the "y"-shaped esthetic lines, then lower third face showes esthetics.본 논문은 1992년도 서울대학병원 지정연구비의 보조를 받은것임

Transfacial approaches to the skull base

Development of various crantofacial osteotomies and rigid fixation system allows to approach the skull base with more ease and safety. Transfacial approaches including transzygomatic, transmaxillary and transmandibular approach using osteotmies of the zygoma, Le Fort I, hemimaxillotomy and parasagittal mandibulotomy are descrtbed and discussed. According to the author's experience including 14 cases, trnaszygomatic approach offers the best technique with wide exposure of middle cranial fossa, infratemporal fossa, pterygoid space, and its combined technique with transmaxillary or transmandibular approach exposes clivus and upper cervical spinc. Trnasmandibular approach exposes the cental base of skull better than transmaxillary approach with possibility of neck dissection.본 논문은 1993년도 서울대학병원 임상연구비의 보조를 받은 것임

새로운 얼굴 중앙부 성형술: 구강내 Le Fort Ⅲ, Ⅱ, 및 Ⅰ 복합골절단술의 개발

얼굴 중앙부(Midface)란 위턱, 코뼈, 광대뼈 부위를 말한다. 얼굴 중앙부 함몰은 위턱, 코뼈, 광대뼈 부위의 골절단에 의한 전진술을 시행 함으로서 해결할 수 있다. 즉 1) 위턱만 함몰된 경우 - Le Fort Ⅰ골절단술, 2) 위턱-코뼈 부위 함몰시 - Le Fort Ⅱ, 3) 위턱-코뼈-광대뼈 부위 함몰시 - Le Fort Ⅲ골절단술이 필요하다. 그러나 Le Fort Ⅰ골절단술은 구강내로 시행하지만 Le Fort Ⅱ, Ⅲ골절단술은 구강내 절개만으로는 시행지 못하고 있었다. 즉 Le Fort Ⅱ, Ⅲ골절단술은 구강내 절개뿐 만 아니라 머리속 두피 절개나, 얼굴 일부 즉 코나 눈 주위 절개를 추가 해야만 가능했다. 따라서 저자는 Le Fort Ⅱ, Ⅲ골절단을 구강내 절개만으로 시행할 수 있도록 하는 새로운 악교정 술식을 개발하였기에 이에 보고하고자 한다. 또한 얼굴 중앙부 함몰 치료의 근간은 위턱, 코뼈, 광대뼈 부위의 골절단인데 이들 구성부위가 독립적으로 교정할 수 있어야 정확한 얼굴뼈 성형이 가능하기 때문에 구강내로 시행하는 광대뼈 골절단술을 역시 새로이 개발하여 필요한 부위에 따른 얼굴 중앙부의 총체적 성형수술이 입안으로만 시행하여 가능하도록 하는 복합 악교정 술식을 개발하였기에 이에 보고하고자 한다

A experimental study of undemineralized freeze - dried human bone

In order to develop the allogeneic bone implants instead of autogenous bone grafts for maxillofacial reconstruction, undemineralized freeze-dried human bone was processed. The freeze-dried human bone was implanted into the cranial and mandibular defects of the rabbits. The implants were evaluated clinically, roentgenographically and histomophometrically. And immunohistochemical evaluation of the implants was performed on the rat. The results were as follows : 1. When compared with control defects of 0.8×0.8cm, the implants on the rabbit defects displayed complete osseous bridging clinically and roentgenographically. Histomophometrically a minimal inflammatory cell infiltrate was present but the defects healed well clinically. 2. When compared with control grafts, the freeze-dried implants on the rat muscle displayed decreased antigenicity by immunohistochemical evaluation, due to freeze-drying process. 3. Undemineralized freeze-dried human bone in this study can be preserved as a bank bone in this study and seems to be applicable for clinical allogeneic bone grafts.1992년도 서울대학교병원 일반 연구비(026)의 보조로 이루어짐

MEASUREMENT AND ANALYSIS OF THE RESISTANT MUSCLE FORCE OF MEDIAL PTERYGOID MUSCLE IN THE MANDIBULAR PROGNATHIC PATIENTS

The purpose of this study was to evaluate the resistant force of medial pterygoid muscles against the mandibular advancement and distraction to anterior, and inquire into the relationship between medial pterygoid muscles and cephalometric variables. Sixty six patients with class III malocclusion underwent bilateral sagittal splitting of ramus with intraoralvertico-sagittal ramus osteotomy for mandibular set-back. The spring scale was used to measure the resistance of medial pterygoid muscles after splitting of ramus. Skeletaldental cephalometric analysis was made and statistic package was used for correlation between resistance and cephalometric variables. The resistant force of the right medial pterygoid muscle was greater than the left one in Koreans with class III malocclusion, and the force had a linear regression relationship with facial depth. The results suggested that facial depth has significant correlation with the resistance of medial pterygoid muscle, which can be acquired from patient's cephalometric analysis한국 보건복지부 중점공동연구지원사업(00-PJ1-PG1-CH11-0004