THE EFFECT OF TOPICAL APPLICATION WITH STEROID AND CYCLOSPORINE ON ORAL LICHEN PLANUS PATIENTS

The purpose of this study was comparing the effectiveness in the topical applications of cyclosporine with that of steroid, the conventional and standard drug in the treatment of oral lichen planus. 21 patients with oral lichen planus were treated with cyclosporine (n=11) or steroid (n=10) by random allocations. They were recalled 2 weeks, 4 weeks, and 8 weeks after initial treatments. In each recall, the lesion size, clinical symptoms like pain or burning sensation, and side effects were evaluated. The differences of these measurements were compared and the effects of each drug were checked. In reticulation types, steroid showed higher effectivity than cyclosporine and this difference was significant statistically. But in erythema type lesions, either drug showed no significant recovery, statistically. However, the effect of cyclosporine was thought to be more effective. The pain of the lesions was significantly decreased by cyclosporine but not by steroid. The decrease of burning sensation was more dependant upon steroid than cyclosporine, but no statistical relationship could be found. There were no clinical side effects. There was limitation to draw in conclusion due to small pool of this study group. But with the results, this suggestion could be proposed that either drug might be superior to another in effectivity in a specific lesion type or patient symptom, so selection and usage of one drug in a specific case could be better than universal application of one drug in all cases.서울대학교병원 일반연구과

Patent litigation in LED industry

학위논문 (석사)-- 서울대학교 대학원 : 경제학부, 2011.8. 이근.Maste

Adhesion of Oral Pathogens to Human Submandibular-Sublingual Salivary Proteins

The present study was performed to investigate the binding between salivary proteins(low-molecular-weight mucin;MG2, amylase, proline-rich protenis;PRPs) and oral pathogens(Streptococcus gorconii,Actinomyces viscosus, Staphylococcus) by using solid-phase assay. In the case of transferring proteins to Immobilon-P,S. gordonii binds to MG2. A. viscosus binds to MG2, amylase, and PRPs, and S. aureus binds to MG2 and amylase. On nitrocellulose membrane, S. gordonii and A. viscosus bind to MG2, amylase, and PRPs. S. aureus binds to MG2 and PRPs. However, rabbit anti-A. viscosus antisera and rabbit anti-S. aureus antisera showed cross reactivity to PRPs adsorbed to only nitrocellulose membrane in negative control experiments, which were done without bacterial overlay. The results were different according to the membrane used as solid-phase, which reflected the assat-sensitive nature of binding experiment. PRPs and amylase are known to be comonents of tooth enamel pellicle. In addition, there was experimental evidence that PRPs and MG2 may covalently bind to oral mucosal epithelium. Considering above facts, the results of the present study can provide information on the interactions between salivary proteins and oral bacteria on tooth and oral mucoasl surfaces.서울대학교 일반연구비(04-1998-052-0

The Study on the Diagnostic Value of Salivary Gland Scintigraphy in Patients with Xerostomia

'98년도 서울대학교병원 임상연구비 (01-1998-064-0

Oral Candida Carriage and Counts and the Secretion Status of ABH Blood Group Antigens in Saliva

The aims of the present study were to determine the oral Candida carriage rate using whole saliva culture(WSC) and concentrated oral rinse culture(CRC) in healthy subjects, to compare the sensitivities of these sampling techniques, and to investigate the relationship between the oral Candida carriage and counts and ABO blood groups or the secretion status of ABH blood group antigens. Unstimulated whole saliva and concentrated oral rinse samples were obtained from 90 healthy subjects. These samples were plated on Sabourauds dextrose agar media for determination of the oral Candida carriage and counts. Fresh whole saliva samples were subjected to SDS-PAGE and immunoblotting to determine the secretion status of the blood group antigens. The oral Candida carriage rate was 45.6%. The sensitivity of the CRC was 85.4% and that of WSC was 78.0%. There was no significant relationship between the Candida carriage and counts and the blood group or secretion status of ASH blood group antigens in saliva. However, the oral Candida carriage rate was higher in the subjects with blood type O and ABH antigen non-secretors. There was no significance correlation between the flow rate of unstimulated whole saliva and oral Candida counts. Further studies including larger number of subjects and considering other blood group antigens and local factors are needed to investigate what determines oral Candida carriage in healthy subjects.서울대학교 일반연구