Features of pulmonary lobes and fissures in Korean adults : a study utilizing HRCT

의학과/석사[한글] 폐엽과 펴틈새 및 그 변이의 숙지는 폐병변의 진단 및 병소의 위치파악에 중요하고, 또한 각종 폐시술 및 수술방법의 선택에 영향을 준다. 최근 고해상 CT의 등장으로 폐틈새 및 폐엽의 관찰이 더욱 용이해졌으므로 서양인들의 폐엽과 틈새에 대한 많은 보고가 있으 나 아직 우리나라에서는 이에 대한 연구가 미흡하며 또한 폐부피에 관한 정보가 부족하다. 그러므로 이 연구는 우리나라 성인의 폐엽과 틈새의 형태를 고해상 CT상에서 관찰하여 발표되어 있는 서양에서의 결과와 비교하고 아울러 CT에서 폐부피를 측정하고자 하였다. 정상성인 남녀 94명을 대상으로 고해상 CT를 폐꼭대기에서 바닥까지 1.5 ㎝ 또는 2.O ㎝ 간격으로 시행하여 경사틈새, 수평틈새, 덧틈새 및 기타 변이틈새 등을 관찰하였고 남녀 각 10명의 CT스캔을 그라프 용지에 제도하여 면적을 구한후 폐부피를 측정하여 다음과 같은 결과를 얻었다. 1. 불완전 경사틈새는 아래부분보다 위에 많았고 대부분 내측에 위치하였다. 오른쪽 경사틈새는 48%에서 불완전하여 왼쪽의 39%에 비하여 높았고 양측성은 22%였다. 경사틈새의 불완전성은 총 60%로 서양에서 보고된 70-80%에 비하여 낮았다. 2. 중간엽면 기시부와 접한 수평틈새의 가장 높은 부위는 내측후방에 위치하였고 다음이 외측 후방이었다. 불완전 수평틈새는 대부분 내측에 존재하였다. 수평틈새의 불완전성은 층 51%로 60-75%로 알려져 있는 서양에서의 결과에 비하여 낮았다. 3. 홀정맥틈새, 수직전 수평틈새, 위덧틈새 등은 관찰되지 않았고 위 외측 경사틈새 1%, 아래덧틈새 13%, 왼쪽 수평틈새 7%. 그리고 기타 덧틈새가 8%에서 관찰되어 총 틈새변이의 빈도는 30%로 비교적 낮았다. 4. 정상 한국성인 남자의 폐부피는 5137m1였고 여자는 3494m1로 우리나라와 중국의 폐기능검사 및 기타 전폐응량 측정의 결과와 유사하였고 서양인들보다 적었다. 이상과 같은 결과을 종합해 볼 때 일반적인 정상 및 변이 폐틈새와 엽의 분포형태는 알려져 있는 서양에서의 결과와 유사하였으나 불완전 경사틈새와 수평틈새, 그리고 틈새변이의 총 빈도 등은 낮았고 CT상의 폐부피의 측정은 앞으로 임상진단에 유용하리라 생각된다. Features of pulmonary lobes and fissures in Korean adults : a study utilizing HRCT Kyung ll Chung Department of Medical Science The Graduate School, Yonsei University (Directed by Professor In Hyuk Chung) Familiarity with anatomic detail of lobes and fissures is important in diagnosis and exact localization of lung lesions. With the recent appearance of HRCT, pulmonary fissures and lobes have deceived much attention in West but not in East. In order to evaluate features of pulmonary lobes and fissures in Eastemers arts to determine lung volume in CT, HRCT scans of 82 healthy Korean adults were reviewed. Incidence of incomplete oblique fissure was 48% (upper part 35%, lower part 28%) on the right and 39% (upper 33%, lower 19%) on the left. Upper portion of lower lobe surface faced laterally (right 91%, fen 82%) and lower portion medially(right 6177, left 79%). Right middle lobe was highest posteromedially (49%) followed by posterolateral (35%) location. Horizontal fissure was incomplete in 51%. Superolateral oblique fissure, inferior accessory fissure, left horizontal fissure and other accessory fissures (RML, LUL, LLL) were shown in 1%, 13%, 7%, and 8% of the cases respectively, while azygos fissure, sagittal anterior horizontal fissure, and superior accessory fissures were not detected. Measurement of lung volume with tracing of CT scans in graph resulted in average volume of 5137 ml in male and 3494 ml in female. Overall features of pulmonary lobes and fissures in Koreans were similar to the previous reports in west but the absolute incidences of incomplete and accessory fissures were lower. Lung volume measured in HRCT were similar to previous results of other methods on the measurement of total lung capacity including pulmonary function test. With these results in account, the role of HRCT is further emphasized in observation of pulmonary lobes, fissures and lung volume. [영문] Familiarity with anatomic detail of lobes and fissures is important in diagnosis and exact localization of lung lesions. With the recent appearance of HRCT, pulmonary fissures and lobes have deceived much attention in West but not in East. In order to evaluate features of pulmonary lobes and fissures in Eastemers arts to determine lung volume in CT, HRCT scans of 82 healthy Korean adults were reviewed. Incidence of incomplete oblique fissure was 48% (upper part 35%, lower part 28%) on the right and 39% (upper 33%, lower 19%) on the left. Upper portion of lower lobe surface faced laterally (right 91%, fen 82%) and lower portion medially(right 6177, left 79%). Right middle lobe was highest posteromedially (49%) followed by posterolateral (35%) location. Horizontal fissure was incomplete in 51%. Superolateral oblique fissure, inferior accessory fissure, left horizontal fissure and other accessory fissures (RML, LUL, LLL) were shown in 1%, 13%, 7%, and 8% of the cases respectively, while azygos fissure, sagittal anterior horizontal fissure, and superior accessory fissures were not detected. Measurement of lung volume with tracing of CT scans in graph resulted in average volume of 5137 ml in male and 3494 ml in female. Overall features of pulmonary lobes and fissures in Koreans were similar to the previous reports in west but the absolute incidences of incomplete and accessory fissures were lower. Lung volume measured in HRCT were similar to previous results of other methods on the measurement of total lung capacity including pulmonary function test. With these results in account, the role of HRCT is further emphasized in observation of pulmonary lobes, fissures and lung volume.restrictio

The Frequency of Appearance of the Metaphase Cells from the Primary Tissues of Rat Fetus

The materials generally used in most chromosomal studies except for a particular purp ose are the cultured cells of animal or plant tissues. For the purpose of the studies of the chromosomal aberrations possibly obtainable by the administration of teratogens to the early embryo, the examination of chromosomes from the primary tissues of embryo is the most desirable, since it seems not to be able to rule out completely the possibilities of some disturbing effects by culture conditions (Bloom et aI, 1970) and/or culture media per se. Another reason why the primary tissue should be used is to examine the immediate effects of the teratogens upon the embryonic chromosomes within relatively short period of time, 2 to 5 days after administration of teratogens. However, it was impossible, if any, to find out the reports regarding the chromosomal studies, particularly the frequency of appearance of metaphase cells from the primary tissue of rat fetus. The intention of the present work is to develop a simple procedure of smear preparations from the chemical-free primary tissues of early rat fetus and to standardize the conditions by which an appropriate number of metaphase cells enough to analyze the cromosomal aberrations could be revealed