463 research outputs found

    결정둠적 μŠ€μΌ€μ₯΄λ§μ„ μ΄μš©ν•˜μ—¬ λ™μ‹œμ„± 버그λ₯Ό μž¬ν˜„ν•˜λŠ” 컀널 퍼져 μ œμž‘

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    ν•™μœ„λ…Όλ¬Έ(석사) -- μ„œμšΈλŒ€ν•™κ΅λŒ€ν•™μ› : κ³΅κ³ΌλŒ€ν•™ 전기·정보곡학뢀, 2022. 8. μ΄λ³‘μ˜.컀널 퍼져듀이 졜근 λͺ‡ λ…„κ°„ λ°œμ „ν•΄μ˜€λ©΄μ„œ 퍼져에 μ˜ν•΄ λ³΄κ³ λ˜λŠ” λ²„κ·Έλ“€μ˜ μˆ˜κ°€ λŠ˜μ–΄λ‚¬λ‹€. 컀널 κ°œλ°œμžλ“€μ΄ 이런 버그듀을 λͺ¨λ‘ 뢄석할 수 μ—†κΈ° λ•Œλ¬Έμ— 이런 상황은 디버깅 정보λ₯Ό μ œκ³΅ν•΄μ€„ 수 μžˆλŠ” 버그 μž¬ν˜„μ˜ μ€‘μš”μ„±μ„ λ”μš± μ€‘μš”ν•˜κ²Œ λ§Œλ“ λ‹€. λΆˆν–‰ νžˆλ„, νΌμ ΈλŠ” μ’…μ’… 버그 μž¬ν˜„μ— μ‹€νŒ¨ν•˜λŠ”λ° μž¬ν˜„μ΄ νž˜λ“  버그 쀑 ν•˜λ‚˜κ°€ λ°”λ‘œ λ™μ‹œμ„± 버그닀. λ™μ‹œμ„± λ²„κ·ΈλŠ” μ—¬λŸ¬ μŠ€λ ˆλ“œ μ‚¬μ΄μ˜ νŠΉμ •ν•œ 쑰건을 λ§Œμ‘±ν• λ•Œ λ°œμƒν•˜λŠ”λ° 컀 널 μŠ€μΌ€μ₯΄λ§μ˜ 비결정적인 μŠ€λ ˆλ“œ 간섭은 λ™μ‹œμ„± λ²„κ·Έμ˜ μž¬ν˜„μ„ λ§‰λŠ”λ‹€. κ·Έ κ²°κ³Ό, 일뢀 λ™μ‹œμ„± 버그듀은 λ²„κ·Έμ˜ μž¬ν˜„μ— μ‹€νŒ¨ν•œ λ’€ 고쳐지지 μ•Šμ€μ±„ 버렀진닀. 이 λ…Όλ¬Έμ—μ„œλŠ”, 퍼져에 μ˜ν•΄ 발견된 버그λ₯Ό κ²°μ •μ μœΌλ‘œ μž¬ν˜„ν•  수 μžˆλ„λ‘ 도와주 λŠ” REPFUZZER λ₯Ό μ†Œκ°œν•œλ‹€. μ΄λŠ” 선택적 μŠ€λ ˆλ“œ 좔적과 결정적 μŠ€μΌ€μ₯΄λŸ¬λ₯Ό 톡해 λ¬Έ 제λ₯Ό ν•΄κ²°ν•œλ‹€. 선택적 μŠ€λ ˆλ“œ 좔적을 톡해 REPFUZZER λŠ” 퍼져에 μžˆμ–΄μ„œ ν₯미둜운 μŠ€λ ˆλ“œμ—λ§Œ 집쀑할 수 μžˆλ„λ‘ ν•œλ‹€. 그리고 REPFUZZER λŠ” 결정적 μŠ€μΌ€μ₯΄λŸ¬λ₯Ό 톡해 μ„ νƒλœ μŠ€λ ˆλ“œλ₯Ό μŠ€μΌ€μ₯΄ ν•΄μ£Όλ©° 결정적인 μŠ€λ ˆλ“œ 간섭을 λ§Œλ“€μ–΄ λ‚Έλ‹€. 퍼징 단계와 μž¬ν˜„ 단계 λͺ¨λ‘μ—μ„œ REPFUZZER λ₯Ό μ‚¬μš©ν•¨μœΌλ‘œμ¨ νΌμ ΈλŠ” μ°Ύμ•„λ‚Έ 버그λ₯Ό μž¬ν˜„ν•΄λ‚Ό 수 있게 λœλ‹€. 결과적으둜 REPFUZZER λŠ” 15개의 μ‹€μ œ λ™μ‹œμ„± 버그λ₯Ό μž¬ν˜„ν•˜λ©΄μ„œ νš¨μœ¨μ„±μ„ λ³΄μ—¬μ€¬μœΌλ©°, 버그 쀑 μΌλΆ€λŠ” 비결정적인 컀널 μŠ€μΌ€μ₯΄λ§μœΌλ‘œ μž¬ν˜„ν•΄λ‚΄κΈ° μœ„ν•΄ μ—„μ²­λ‚œ μ‹œκ°„μ„ ν•„μš”λ‘œ ν–ˆλ‹€.As kernel fuzzer has been studied and becomes better for years, the number of reported bugs from the fuzzer increased. Since kernel developers could not analyze all of the bugs, the situation emphasizes the importance of bug reproduce which can provide debug information. Unfortunately, the fuzzer often fails to reproduce bug, and one of the most difficult bug type is concurrency bug. The concurrency bug requires certain conditions between several threads, and non-deterministic thread interleavings from kernel scheduling prevent reproducing. As a result, some concurrency bugs are left unpatched after failures of reproduce. In this thesis, we presents REPFUZZER which enables deterministic reproduce for bugs found by fuzzer. It solves the problem with selective thread tracing and deterministic scheduler. With selective thread tracing, REPFUZZER can focus on only interesting thread in fuzzing context. Then REPFUZZER schedules the selected threads with deterministic scheduler and produces deterministic thread interleavings. Using REPFUZZER’s scheduling at both fuzzing and reproduce phase, the fuzzer can reproduce bugs found at fuzzing phase. As a result, REPFUZZER shows its effectiveness for reproducing concurrency bugs with 15 real-world bugs, and some of the bugs require enormous times to be reproduced with non-deterministic kernel scheduling.Abstract i Contents ii List of Tables iv List of Figures v 1 INTRODUCTION 1 2 BACKGROUND 5 2.1 Fuzzing 5 2.2 Concurrency Bug 6 3 DESIGN 7 3.1 Design 7 3.1.1 Selective Thread Tracing 9 3.1.2 Deterministic Scheduler 12 3.2 Implementation 18 4 EVALUATION 20 4.1 Effectiveness of Deterministic Scheduler 20 4.2 Statistics of Deterministic Scheduler 23 4.3 Overhead of Deterministic Scheduler 25 5 DISCUSSION 27 6 RELATED WORKS 29 6.1 Kernel Concurrency Bugs 29 6.2 Reproducing Bugs 30 7 CONCLUSION 32 Abstract (In Korean) 37석

    Evaluation of Interfacial Properties of Thin film considering Constraint Effect between Film and Substrate using Flat-end Vickers Indenter

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    ν•™μœ„λ…Όλ¬Έ (박사) -- μ„œμšΈλŒ€ν•™κ΅ λŒ€ν•™μ› : κ³΅κ³ΌλŒ€ν•™ μž¬λ£Œκ³΅ν•™λΆ€, 2020. 8. κΆŒλ™μΌ.Delamination of thin-coating films on substrates has become a critical issue for the reliability of micro- and nanoelectronic devices. Since failures of the interface may eventually lead to total system failure, evaluation of the interface between its film and substrate becomes an important problem and several testing methods such as a scratch test, pull-off test and peel test have been proposed. However, these conventional tests have limitations as a universal test methods because of limitations of the film characteristics and requirements such as specially designed specimen. In this thesis, nanoindentation test was developed to overcome the limitations of conventional test methods. In general, nanoindentation testing has been widely applied to evaluate the mechanical properties of thin films such as hardness and elastic modulus at small scale. It was initially used only to evaluate hardness and elastic modulus from the loading/unloading curve of the indentation testing, but has now been extended to evaluate residual stress, tensile, fracture properties and so on. The nanoindentation test has the advantage that local and thin-film properties can be evaluated through only a single indentation, and no specially designed specimen is needed. When an indentation is made in nanoindentation testing, the amount of elastic-plastic deformation beneath the indent increases as the indentation load increases. In addition, in the case of a thin film, which is a bond-type heterogeneous material, the total amount of work involved in indentation testing can be expressed as the sum of the work in the film, work in the substrate, and work at the interface. The work at the interface generated by indentation testing can be defined as the resistance to interaction between the film and the substrate, which can be expressed as adhesion at the interface. As a result, in order to evaluate the adhesive force at the interface, the work at the interface is evaluated by a quantitative evaluation of the work in the composite film-substrate structure and the work occurring in the film and the substrate in an independent situation. If a film of differing hardness and elastic modulus is placed on the substrate and the composite structure is indented, the plastic deformation in the film is expected to differ from the plastic deformation of the substrate. The stress-strain field of the film and substrate can be determined based on elastic-plastic theory, and the expanding spherical cavity model for indentation gives the individual radial strain components. If there is no adhesion between film and substrate, the radial strain profile exhibits strain discontinuity, but if there is strong adhesion between them, the strain continuity will act strongly. Eventually, the strain continuity across the film and the substrate causes the shape of the strain to bend and the deformation geometry will be distorted. In addition, the relatively soft material will be constrained to the hard material side. As a result, the constraint on film and substrate will depend on the degree of adhesion at the interface between the film and the substrate, and the extent of the constraint can be explained by the change in constraint according to indentation testing. It is thus possible to quantitatively evaluate the amount of constraint change through indentation testing on the film and substrate structure system, and to evaluate the adhesion at the interface using this quantitative evaluation.μ‚°μ—…ν™”κ°€ 닀양해지고 고도화가 될수둝 κ΅­κ°€κΈ°κ°„ μ‚°μ—…μ—μ„œλŠ” λ‹€μ–‘ν•œ μ—­ν•  및 νŠΉμ„±μ„ 가지고 μžˆλŠ” μ†Œμž¬λ₯Ό μš”κ΅¬ν•˜κ³  μžˆλ‹€. 특히 μ „μž, λ””μŠ€ν”Œλ ˆμ΄ λ“± 첨단 μ‚°μ—…μ—μ„œλŠ” μ΄μ’…μ†Œμž¬λ₯Ό μ ‘ν•©μ‹œν‚¨ λ‹€κΈ°λŠ₯μ„± μ†Œμž¬μ˜ ν™œμš©μ΄ μ¦κ°€ν•˜κ³  μžˆλ‹€. ν•˜μ§€λ§Œ μ΄λŸ¬ν•œ μ΄μ’…μ†Œμž¬μ˜ 접합은 물리, 화학적인 μΈμœ„μ  μ ‘ν•©μœΌλ‘œμ„œ λ°œμƒλ˜λŠ” 계면은 박막과 λͺ¨μž¬μ— λΉ„ν•΄ 기계적인 νŠΉμ„±μ΄ μƒλŒ€μ μœΌλ‘œ μ·¨μ•½ν•œ λΆ€λΆ„μœΌλ‘œ λ‚˜νƒ€λ‚˜λ©°, μ™ΈλΆ€μ—μ„œ 응λ ₯이 κ°€ν•΄μ§€λŠ” 상황 λ˜λŠ” ν™˜κ²½μ  μš”μΈμ— μ˜ν•΄ 박리와 νŒŒμ†μ΄ μš°μ„ μ μœΌλ‘œ λ°œμƒν•œλ‹€. κ·Έλ ‡κΈ° λ•Œλ¬Έμ— μ΄λŸ¬ν•œ κ³„λ©΄μ˜ νŠΉμ„±μ€ λ°•λ§‰μ‹œμŠ€ν…œμ˜ 신뒰성을 ν‰κ°€ν•˜λŠ” μ΅œμš°μ„  μš”μ†Œλ‘œμ„œ μ •λŸ‰μ μœΌλ‘œ ν‰κ°€ν•˜κΈ° μœ„ν•œ 연ꡬ와 λ‹€μ–‘ν•œ μ‹œν—˜λ²•λ“€μ΄ κ°œλ°œλ˜μ—ˆλ‹€. κ·ΈλŸ¬λ‚˜ 기쑴의 μ‹œν—˜λ²•μ€ μ •λŸ‰μ μœΌλ‘œ μ ‘μ°©λ ₯을 ν‰κ°€ν•˜κΈ°μ— λͺ‡κ°€μ§€ ν•œκ³„μ μ„ 가지고 μžˆλ‹€. 첫 번째둜, 박막과 λͺ¨μž¬μ˜ 영ν–₯이닀. 기쑴에 μ‚¬μš©λ˜μ–΄μ™”λ˜ μ ‘μ°©λ ₯ 평가 μ‹œν—˜λ²•μ˜ 경우 μ‹œν—˜λ²•μƒ νŠΉμˆ˜μ„±μœΌλ‘œ 인해 ν•„μˆ˜λΆˆκ°€κ²°ν•˜κ²Œ 박막과 λͺ¨μž¬μ˜ νŠΉμ„±μ΄ 결과값에 μ£Όλ„μ μœΌλ‘œ μž‘μš©ν•˜κ²Œ λœλ‹€. ν•˜μ§€λ§Œ μ•„μ§κΉŒμ§€ 박막과 λͺ¨μž¬μ˜ 영ν–₯을 μ •λŸ‰μ μœΌλ‘œ ν•΄μ„ν•˜λŠ” 연ꡬ가 λ―ΈλΉ„ν•˜μ—¬ μ •ν™•ν•œ μ ‘μ°©λ ₯을 ν‰κ°€ν•˜λŠ”λ° λ¬Έμ œμ μ„ 가지고 μžˆλ‹€. 두 λ²ˆμ§Έλ‘œλŠ”, 기쑴의 μ‹œν—˜λ²•μ΄ ν•΄λ‹Ή μ†Œμž¬μ˜ 파괴λ₯Ό κ°€μ Έμ˜¨λ‹€λŠ” 점이닀. 파괴 μ‹œν—˜λ²•μœΌλ‘œμ„œ κ°€μ§€λŠ” ν•œκ³„μ μœΌλ‘œ 수 λ‚˜λ…Έλ―Έν„° μˆ˜μ€€μœΌλ‘œ κ²½λ°•ν™” 되고 μžˆλŠ” λ°•λ§‰μ‹œμŠ€ν…œμ—μ„œ μ •ν™•ν•œ 계면 박리 μ‹œμ  및 κ΄‘ν•™ μž₯λΉ„λ₯Ό ν†΅ν•œ νŒŒμ† μ˜μ—­μ˜ 관찰이 ν•„μˆ˜μ μ΄λΌλŠ” 점이닀. κ²°κ΅­ μ •ν™•ν•œ 박리 μ‹œμ μ˜ μ„ νƒμ˜ 어렀움과 맀우 쒁은 μ˜μ—­μ˜ μ •ν™•ν•œ 관찰이 λ™λ°˜λ˜μ–΄μ•Ό λͺ©μ μœΌλ‘œ ν•˜λŠ” μ ‘μ°©λ ₯의 μ •ν™•ν•œ 평가가 κ°€λŠ₯ν•˜λ‹€λŠ” λ¬Έμ œμ μ„ 가지고 μžˆλ‹€. μ„Έ 번째둜, μ‹œν—˜λ²•μ— 따라 μ μš©ν•  수 μžˆλŠ” μ†Œμž¬κ°€ μ œν•œλ˜μ–΄ μžˆμ–΄ μ μš©μƒμ˜ ν•œκ³„κ°€ μžˆλ‹€. μ‚°μ—…μ—μ„œ ν•„μš”λ‘œ ν•˜λŠ” μ†Œμž¬λŠ” μ‹œκ°„μ΄ μ§€λ‚ μˆ˜λ‘ 닀양해지고 μžˆλ‹€. ν•˜μ§€λ§Œ 기쑴의 μ‹œν—˜λ²•μ΄ 적용 κ°€λŠ₯ν•œ μ†Œμž¬μ— ν•œκ³„λ₯Ό 가지고 있으며, κ²°κ΅­ ν•˜λ‚˜μ˜ μ‹œν—˜λ²•μ„ ν†΅ν•˜μ—¬ λ‹€μ–‘ν•œ μ†Œμž¬μ— λŒ€ν•œ μ ‘μ°©λ ₯ 평가 및 κ²°κ³Ό 비ꡐ에 λ¬Έμ œμ μ„ 가지고 μžˆλ‹€κ³  ν•  수 μžˆλ‹€. λ³Έ ν•™μœ„ λ…Όλ¬Έμ—μ„œλŠ” 기쑴의 μ‹œν—˜λ²•λ“€μ΄ κ°€μ§€λŠ” ν•œκ³„μ μ„ κ·Ήλ³΅ν•˜κ³ μž λΉ„νŒŒκ΄΄ μ‹œν—˜μ΄ κ°€λŠ₯ν•˜κ³  박막과 기판의 영ν–₯을 μ •λŸ‰ν™” μ‹œν‚€κΈ° μœ„ν•΄ μ••μž…μ‹œν—˜μ„ μ΄μš©ν•˜μ—¬ μ ‘μ°©λ ₯을 ν‰κ°€ν•˜λŠ” λͺ¨λΈμ„ μ—°κ΅¬ν•˜μ˜€λ‹€. μ••μž…μ‹œν—˜μ€ κ°„λ‹¨ν•œ μ‹œν—˜μ„ 톡해 μ••μž…μž ν•˜λΆ€μ˜ 응λ ₯ 뢄포 및 μƒνƒœλ₯Ό ν•΄μ„ν•¨μœΌλ‘œμ¨ λ‹€μ–‘ν•œ μ—­ν•™νŠΉμ„±μ„ ν‰κ°€ν•˜λŠ” μ΅œμ‹ μ˜ 기계적 μ‹œν—˜λ²•μ΄λ‹€. λ˜ν•œ 높은 ν•˜μ€‘ λΆ„ν•΄λŠ₯κ³Ό λ³€μœ„ λΆ„ν•΄λŠ₯을 κ°€μ§€λŠ” μž₯λΉ„ κ°œλ°œμ„ 톡해 맀크둜, 마이크둜 μŠ€μΌ€μΌ 뿐만 μ•„λ‹ˆλΌ λ‚˜λ…Έ μŠ€μΌ€μΌ λ°•λ§‰κΉŒμ§€μ˜ 기계적 물성을 ν‰κ°€ν•˜λŠ”λ° ν™œμš©μ„±μ΄ μ¦κ°€ν•˜κ³  μžˆλ‹€. λ°•λ§‰μ‹œμŠ€ν…œμ— μ••μž…μ‹œν—˜μ„ μˆ˜ν–‰ν•˜λ©΄ 박막과 λͺ¨μž¬μ˜ κ°œλ³„μ μΈ ν•˜μ€‘λ³€μœ„ 곑선을 얻을 수 있으며 이와 ν•¨κ»˜ κ³„λ©΄μ˜ 영ν–₯이 λ³΅ν•©μ μœΌλ‘œ 반영이 된 μ••μž… ν•˜μ€‘λ³€μœ„ 곑선을 νšλ“ν•  수 μžˆλ‹€. ν•˜μ§€λ§Œ λ‹¨μˆœνžˆ μ΄λ ‡κ²Œ 얻은 κ³‘μ„ μ—μ„œ 박막과 λͺ¨μž¬μ˜ 영ν–₯을 μ‹€ν—˜μ μœΌλ‘œ κ΅¬λΆ„ν•˜μ—¬ 뢄리해 λ‚Ό 수 μ—†μ—ˆκΈ° λ•Œλ¬Έμ— 이둠적 λͺ¨λΈλ§μ„ ν†΅ν•΄μ„œ 각각의 영ν–₯을 κ΅¬λΆ„ν•˜μ˜€λ‹€. λ³Έ μ—°κ΅¬μ—μ„œλŠ” μ••μž…μ‹œν—˜ μ‹œ λ°œμƒλ˜λŠ” μ—λ„ˆμ§€μ˜ 총합을 박막/계면/λͺ¨μž¬μ˜ ν•©μœΌλ‘œ μ •μ˜ν•˜κ³ , 가해진 ν•˜μ€‘κ³Ό 면적의 λΉ„λ‘œ μ •μ˜λ˜λŠ” 경도λ₯Ό μ••μž…μ‹œν—˜ μ‹œ λ°œμƒλœ μ—λ„ˆμ§€μ™€ μ••μž…μž ν•˜λΆ€μ˜ μ†Œμ„±λ³€ν˜•μ— λ™λ°˜λ˜λŠ” λΆ€ν”Όμ˜ λΉ„λ‘œ ν™•μž₯μ‹œν‚¨ κ°œλ…μ„ μΈμš©ν•˜μ˜€λ‹€. ν™•μž₯된 경도λ₯Ό λ°”νƒ•μœΌλ‘œ 박막과 λͺ¨μž¬μ˜ λ³€ν˜•μ— μ˜ν•΄ λ°œμƒλœ 일을 각각 ν•΄μ„ν•˜μ˜€λ‹€. λ˜ν•œ 계면에 μ˜ν•΄μ„œ μ••μž…μž ν•˜λΆ€μ— ν™•μž₯λ˜λŠ” μ†Œμ„±μ—­μ΄ κ΅¬μ†λ˜λŠ” 상황을 ν•΄μ„ν•˜μ˜€λ‹€. 박막과 λͺ¨μž¬ 쀑 μƒλŒ€μ μœΌλ‘œ μ—°μ§ˆμ˜ μž¬λ£Œκ°€ 경질의 μž¬λ£Œμ— μ˜ν•΄ μ†Œμ„±μ—­μ΄ ꡬ속됨을 κ°€μ •ν•˜μ˜€κ³ , μˆ˜μΉ˜ν™”λ₯Ό μœ„ν•΄ 곡극확μž₯λͺ¨λΈμ„ μ‚¬μš©ν•˜μ—¬ μˆ˜μ‹μ„ μ „κ°œν•˜μ˜€λ‹€. 이λ₯Ό 톡해 계면에 μ˜ν•΄ μƒλŒ€μ μœΌλ‘œ μ—°μ§ˆ 재료의 κ΅¬μ†λ˜λŠ” λΆ€ν”Όμ˜ 양을 ν‘œν˜„ν•˜λŠ” κ³„λ©΄μΈμžλ₯Ό μ •μ˜ν•˜μ˜€κ³ , κ³„λ©΄μΈμžλ₯Ό 재료 인자λ₯Ό μ΄μš©ν•˜μ—¬ μˆ˜ν•™μ μœΌλ‘œ λ„μΆœν•˜μ˜€λ‹€. μ••μž…μ‹œν—˜μ—μ„œ 계면에 μ˜ν•œ κ΅¬μ†νš¨κ³Όλ₯Ό ν•΄μ„ν•˜μ—¬ κ³„λ©΄μ˜ 일의 양을 μ •λŸ‰μ μœΌλ‘œ ν‰κ°€ν•˜λŠ” μˆ˜μ‹μ„ μ œμ•ˆν•˜μ˜€μœΌλ©°, μ••μž…κΉŠμ΄μ— 따라 λ‹¬λΌμ§€λŠ” 일의 양을 κ΅¬μ†λ˜λŠ” λΆ€ν”Όλ‘œ μ •κ·œν™” ν•˜μ—¬ μ΅œμ’…μ μœΌλ‘œ 접착강도λ₯Ό ν‰κ°€ν•˜λŠ” μˆ˜μ‹μ„ μ œμ•ˆν•˜μ˜€λ‹€. μ œμ•ˆν•œ μ ‘μ°©λ ₯ 평가 λͺ¨λΈμ˜ 타당성을 κ²€μ¦ν•˜κΈ° μœ„ν•΄ 기쑴의 λ°•λ¦¬μ‹œν—˜μ„ 톡해 얻어진 결과와 μ••μž…μ‹œν—˜μ„ μ΄μš©ν•˜μ—¬ λ„μΆœλœ 접착강도λ₯Ό λΉ„κ΅ν•˜μ—¬ μœ μ‚¬ν•œ κ²½ν–₯성을 ν™•μΈν•˜μ˜€λ‹€.Chapter 1. Introduction 1 1.1. Objective of the Thesis 2 1.2. Organization of the Thesis 7 Chapter 2. Research Background 11 2.1. Adhesion evaluation method 12 2.1.1. True work of adhesion 12 2.1.2. Practical Work of Adhesion 14 2.2. Instrumented indentation tests 17 2.2.1. Elastic Contact mechanics 19 2.2.2. Elastic-Plastic Contact mechanics 23 2.3. Nanoindentation 29 2.3.1. Development 29 2.3.2. Application 31 Chapter 3. Theoretical Modeling 68 3.1. Thin-film indentation 69 3.2. Interfacial Constraint Effect 71 3.3. Interface parameter 76 3.4. Factor analysis 79 3.5. Modeling 81 3.5.1 Film constraint 82 3.5.2 Substrate constraint 83 3.6 Physical meaning of equation 85 Chapter 4. Verification of models 98 4.1. Experimental Details 99 4.1.1. Sample preparation 101 4.1.2. Experiment conditions 103 4.2. Results & Discussion 103 4.2.1. Comparison with scratch and pull-off 103 4.2.2. Indentation parameter 104 4.2.3. Indentation adhesion strength 105 4.2.4. Experimental results 107 Chapter 5. Conclusion 127 Reference 133 Abstract in Korean 141 List of publications 147Docto

    Distal Chevron Osteotomy with One BOLD ScrewⓇ Fixation in Hallux Valgus

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    Purpose: To present our experience of distal chevron osteotomy utilizing one BOLD screwⓇ as an alternative fixation method which has advantages over the Kirschner (K)-wire fixation. Materials and Methods: Between January 2001 and June 2003, 19 patients with a symptomatic hallux valgus deformity underwent 20 distal metatarsal chevron osteotomies with one BOLD screwⓇ fixation. The mean age was 55.6 years with a minimum follow up period 12 months. For radiographical evaluation, hallux valgus angle (HVA) and intermetatarsal angle (IMA) were used. For clinical evaluation, we used AOFAS hallux metatarsophalangeal interphalangeal scale and overall satisfaction of the patients. Results: The AOFAS scores improved from mean 47.5 points to mean 68.1 points at postoperative 3 months and mean 86.0 points at last follow-up. The average HVA corrected from 25.3 degrees to 12.7 degrees. The IMA was corrected from 11.6 degrees to 7.6 degrees. The overall satisfaction of the patients was 85%. There was no major complication. Conclusion: We demonstrated that distal chevron osteotomy with one BOLD screwⓇ fixation has advantages such as no additional procedure, no loss of correction, early rehabilitation, no prominent hardware and skin irritation. This method also showed excellent bone union, correction and patient satisfaction.ope

    Peroxisome Proliferator-Activated Receptor Ξ³ Activation Promotes Adipogenesis in Human Mesenchymal Stem Cells

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    Purpose: In this study, we determined that the troglitazones could induce uniform adipogenesis of human mesenchymal stem cells (MSCs) within a short time in a dose- and a time-dependent manners. Materials and Methods: Human MSCs were isolated from bone marrow and cultured in basal or adipogenic medium in the presence of 0 50 ΞΌM troglitazone for 5 days. Then we performed flow cytometry, RT-PCR and western blot analysis. Results: In FACS assay, troglitazone induced adipocyte differentiation in a dose-dependent manner. At concentration of 25 ΞΌM troglitazone in adipogenic medium, over 50% of the cells differentiated into adipocytes at day 5. This was accompanied by increased mRNA levels for the adipocyte gene markers (LPL, aP2 and PPARΞ³) in RT-PCR. In western blot analysis, we found that ERK phosphorylation was inhibited in the early stage of adipogenesis. Conclusion: Through the addition of troglitazone as a PPAR Ξ³ agonist, we could get the uniform adipogenic differentiation within a short time. Thus, troglitazone directly regulates differentiation of human MSCs into adipocytes; induced PPAR Ξ³ expression may play a key regulatory role in this process. And we suggest a role for ERK as a regulatory switch for these differentiation pathwaysope

    Spectral ratio methodλ₯Ό μ΄μš©ν•œ νƒ„μ„±νŒŒ 감쇠 νŠΉμ„± 연ꡬ

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    νƒ„μ„±νŒŒ κ°μ‡ λŠ” νƒ„μ„±νŒŒ 자료의 ν•΄μƒλ„μ˜ ν–₯상과 직접적인 νƒ„ν™”μˆ˜μ†Œ μ§€μ‹œμžλ‘œμ¨ μœ μš©ν•˜κ²Œ μ‚¬μš©λœλ‹€. 이둠적으둜 νƒ„ν™”μˆ˜μ†Œκ°€ 맀μž₯된 μ €λ₯˜μΈ΅μ€ 물둜 ν¬ν™”λœ λ‹€κ³΅μ§ˆ 암석보닀 감쇠가 잘 μΌμ–΄λ‚˜λ©°, μ΄λŠ” λ§€μ§ˆμ„ ν†΅κ³Όν•˜λŠ” νƒ„μ„±νŒŒμ˜ 속도와 μ§„ν­μ˜ 감쇠가 지각을 κ΅¬μ„±ν•˜λŠ” 맀질과 곡극 λ‚΄λΆ€μ˜ 곡극수 및 κ·Έ μƒν˜Έκ°„μ˜ μž‘μš©μ— μ˜ν•˜μ—¬ 영ν–₯을 λ°›λŠ” 것이 원인이닀. λ³Έ μ—°κ΅¬μ—μ„œλŠ” νƒ„μ„±νŒŒ 감쇠와 λ°˜λΉ„λ‘€ 관계λ₯Ό κ°€μ§€λŠ” Quality factor λ₯Ό Spectral ratio methodλ₯Ό μ΄μš©ν•˜μ—¬ μΆ•μ†Œλͺ¨ν˜•μ‹€ν—˜, 수치λͺ¨ν˜•μ‹€ν—˜ 그리고 ν˜„μž₯μžλ£Œμ— μ μš©ν•˜μ—¬ λΆ„μ„ν•˜μ˜€λ‹€. μΆ•μ†Œλͺ¨ν˜•μ‹€ν—˜μ—μ„œλŠ” 일반적으둜 μ‹€λ‚΄λΆ„μ„λ°©λ²•μ—μ„œ κΈ°μ€€ μ‹œλ£Œλ‘œ μ‚¬μš©ν•˜λŠ” μ•Œλ£¨λ―ΈλŠ„μ— λŒ€ν•˜μ—¬ μ•„ν¬λ¦΄μ˜ λ₯Ό μ‚°μΆœν•˜μ˜€κ³ , 수치λͺ¨ν˜•μ‹€ν—˜μ—μ„œλŠ” νƒ„μ„±νŒŒ λ°˜μ‚¬λ²•κ³Ό μˆ˜μ§μž…μ‚¬ 탐사법을 μ΄μš©ν•˜μ—¬ μ§€μΈ΅μ˜ λ¬Όμ„± 변화와 κ·Έ κ²½κ³„μ—μ„œ λ°œμƒν•˜λŠ” νƒ„μ„±νŒŒ κ°μ‡ μ˜ν–₯을 λΆ„μ„ν•˜μ—¬ λ₯Ό λ„μΆœν•˜μ˜€λ‹€. λ§ˆμ§€λ§‰μœΌλ‘œ ν˜„μž₯자료의 μ μš©μ€ λ‚¨ν•΄μ•ˆ κ±°μ œλ„μ—μ„œ μ·¨λ“ν•œ νƒ„μ„±νŒŒ λ°˜μ‚¬λ²• μžλ£Œμ— λŒ€ν•˜μ—¬ 각 측의 λ°˜μ‚¬λ©΄μ— λ”°λ₯Έ 감쇠 정도λ₯Ό νŒŒμ•…ν•˜μ˜€λ‹€. Quality factor의 뢄석은 μ €λ₯˜μΈ΅ νŠΉμ„±κ³Ό νƒ„ν™”μˆ˜μ†Œ 탐지λ₯Ό μœ„ν•œ 예츑 μˆ˜λ‹¨μ΄λ©°, AVO의 효과적인 해석, νƒ„μ„±νŒŒ μ˜μƒμ˜ 해상도 ν–₯상과 맀질의 νŠΉμ„± 연ꡬλ₯Ό μœ„ν•΄ 맀우 μ€‘μš”ν•˜λ‹€.1. μ„œ λ‘  1 1.1 κ°œμš” 1 2. νƒ„μ„±νŒŒ 감쇠 이둠 3 2.1 νƒ„μ„±νŒŒ κ°μ‡ μ˜ μ •μ˜ 3 2.2 νƒ„μ„±νŒŒ Quality factor, 와 Spectral ratio method 6 3. νƒ„μ„±νŒŒ 감쇠 λͺ¨ν˜•μ‹€ν—˜ 및 적용 15 3.1 νƒ„μ„±νŒŒ 감쇠 μΆ•μ†Œλͺ¨ν˜•μ‹€ν—˜ 15 3.1.1 νƒ„μ„±νŒŒ 감쇠 μΆ•μ†Œλͺ¨ν˜•μ‹€ν—˜ ꡬ성 15 3.1.2 νƒ„μ„±νŒŒ 감쇠 μΆ•μ†Œλͺ¨ν˜•μ‹€ν—˜ 방법 19 3.1.3 νƒ„μ„±νŒŒ 감쇠 μΆ•μ†Œλͺ¨ν˜•μ‹€ν—˜ κ²°κ³Ό 22 3.2 νƒ„μ„±νŒŒ 감쇠 수치λͺ¨ν˜•μ‹€ν—˜ 27 3.2.1 νƒ„μ„±νŒŒ 감쇠 수치λͺ¨ν˜•μ‹€ν—˜ ꡬ성 27 3.2.2 νƒ„μ„±νŒŒ 감쇠 수치λͺ¨ν˜•μ‹€ν—˜ 방법 29 3.2.3 νƒ„μ„±νŒŒ 감쇠 수치λͺ¨ν˜•μ‹€ν—˜ κ²°κ³Ό 31 3.2.3.1 1번 λͺ¨λΈ 31 3.2.3.2 2번 λͺ¨λΈ 37 3.2.3.3 3번 λͺ¨λΈ 39 3.2.3.4 4번 λͺ¨λΈ 42 3.3 ν˜„μž₯ 자료 적용 47 3.3.1 ν˜„μž₯ 자료 취득 및 처리 47 3.3.2 ν˜„μž₯ 자료 적용 및 뢄석 49 4. κ²°λ‘  52 κ°μ‚¬μ˜ κΈ€ 54 References 56 Bibliography 6

    Superior pedal function recovery of newly designed three spike insole over total contact insole in refractory plantar fasciitis: A randomized, double-blinded, non-inferiority study

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    Introduction: Plantar fasciitis is one of the common foot complaints that is chronic and can induce dysfunction. Total contact insole (TCI) is simple but effective in treating plantar fasciitis. Despite its effect, the cost and long duration for production have been the major flaws. Therefore, we developed a newly designed three-spike insole (TSI) that can be commercially productive and compared its clinical outcomes to TCI. Methods: Patients with plantar fasciitis refractory to conservative treatment for more than 6 weeks were candidates. We produced insoles with hardness of 58 Β± 5 Shore-A. Twenty-eight patients were randomized with equal allocation to either TSI or TCI. The following assessment tools were used: visual analog scale (VAS), American Orthopaedic Foot and Ankle score, Foot and Ankle Outcome Score, Karlsson-Peterson (KP) score, Short Form-36 for quality of life, and Foot Function Index. Non-inferiority was declared if VAS was within the statistical variability of minimal important difference. A blinded assessor evaluated the groups at baseline and after 6, 12, and 24 weeks. Results: The groups were homogenous for majority of variables at baseline. Overall patient-reported satisfaction showed improvement from mean 5.2 (range, 1-12) weeks of wearing and all clinical outcome scores showed significant improvements in both groups over time on Friedman test (p ≀.032). TSI showed non-inferiority to TCI at each time point. Post hoc analysis revealed that many scales showed significant superiority of TSI at 3 month (p ≀.008) and KP score at 6 month (p < .001). Conclusion: We reaffirmed that semi-rigid insole is effective in refractory plantar fasciitis and showed TSI restores pedal function more rapidly than TCI. TSI can be not only effective in deriving better clinical outcomes but also be manufactured for popularization to lower the price and producing time of orthosis.ope

    Tendon transfer with a microvascular free flap for injured feet in children

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    We reviewed 11 patients who had been treated between January 1986 and June 1994 for severe foot injuries by tendon transfer with microvascular free flaps. Their mean age was 5.6 years (3 to 8). Five had simultaneous tendon transfer and a microvascular free flap and six had separate operations. The mean interval between the tendon transfer and the microvascular free flap was 5.8 months (2 to 15) and the mean time between the initial injury and the tendon transfer was 9.6 months (2 to 21). The anterior tibial tendon was split in five of six cases. The posterior tibial tendon was used three times and the extensor digitorum longus tendon twice. The mean follow-up was 39.7 months (24 to 126). There were nine excellent and two good results. Postoperative complications included loosening of the transferred tendon (2), plantar flexion contracture (1) mild flat foot deformity (1) and hypertrophic scars (2). We recommend tendon transfer with a microvascular free flap in children with foot injuries combined with nerve injury and extensive loss of skin, soft tissue and tendon.ope

    Terminology for osteochondral lesions of the ankle: proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle

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    Background: The evidence supporting best practice guidelines in the field of cartilage repair of the ankle is based on both low quality and low levels of evidence. Therefore, an international consensus group of experts was convened to collaboratively advance toward consensus opinions based on the best available evidence on key topics within cartilage repair of the ankle. The purpose of this article is to report the consensus statements on "terminology for osteochondral lesions of the ankle" developed at the 2019 International Consensus Meeting on Cartilage Repair of the Ankle. Methods: Forty-three international experts in cartilage repair of the ankle representing 20 countries were convened and participated in a process based on the Delphi method of achieving consensus. Questions and statements were drafted within four working groups focusing on specific topics within cartilage repair of the ankle, after which a comprehensive literature review was performed, and the available evidence for each statement was graded. Discussion and debate occurred in cases where statements were not agreed on in unanimous fashion within the working groups. A final vote was then held, and the strength of consensus was characterised as follows: consensus, 51%-74%; strong consensus, 75%-99%; unanimous, 100%. Results: A total of 11 statements on terminology and classification reached consensus during the 2019 International Consensus Meeting on Cartilage Repair of the Ankle. Definitions are provided for osseous, chondral and osteochondral lesions, as well as bone marrow stimulation and injury chronicity, among others. An osteochondral lesion of the talus can be abbreviated as OLT. Conclusions: This international consensus derived from leaders in the field will assist clinicians with the appropriate terminology for osteochondral lesions of the ankle.ope

    Arthroscopic Debridement for the Osteoarthritic Ankle: Clinical Results and Prognostic Factors

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    Purpose: To evaluate the clinical results of arthroscopic debridement in osteoarthritic ankle and prognostic factors. Materials and Methods: Between Feb. 2001 and Mar. 2004, twenty-seven patients who had an osteoarthritic ankle disease were managed by arthroscopic debridement. The mean age of the patients was 50.0 years (20-71) and the mean follow-up after operation was 16.2 months (12-36). There were 18 men (66.7%) and 9 women (33.3%). The preoperative radiographic findings were divided into 4 groups according to the classification system by Takakura et al. Preoperative AOFAS ankle-hindfoot scale and subjective satisfaction were checked at the last follow-up visit, and the results were compared. Results: In radiological evaluation, stage β…  was 6 cases (22.2%), stage β…‘ was 14 cases (51.9%), stage β…’ was 4 cases (14.8%), and stage β…£ was 3 cases (11.1%). The mean preoperative AOFAS ankle-hindfoot scale was 59.1Β±16.7 and improved to 66.5Β±24.3 at last follow-up. Especially, in stage β… , preoperative AOFAS score was 69.3Β±18.7 and improved to 74.3Β±29.7, and in stage β…‘, preoperative AOFAS socre was 63.0Β±9.6 and improved to 77.1Β±12.9. But in the stage β…’ and β…£, preoperative scores were not improved. The preoperative radiographic findings correlated with the outcome at the last follow-up time (p<0.05). The group with loose body and the group without anterior osteophyte showed better AOFAS score compared to the control group, but there was no statistically significant difference between the two-groups. In subjective satisfaction, excellent or good results were achieved in 14 cases (51%). Conclusion: We suggest that arthroscopic debridement is an effective treatment in which preservation of alignment and reasonable articular cartilage can be achieved.ope

    Clinical comparison of the osteochondral autograft transfer system and subchondral drilling in osteochondral defects of the first metatarsal head

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    BACKGROUND: Osteochondral defects of the first metatarsal head can deteriorate to osteoarthritis of the first metatarsophalangeal joint if left untreated. Treatment options for osteochondral defects of the first metatarsal head vary widely. PURPOSE: To compare the clinical outcomes of the osteochondral autograft transfer system with those of subchondral drilling for the treatment of osteochondral defects of the first metatarsal head. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: The authors retrospectively evaluated 24 cases of osteochondral defects of the first metatarsal head treated operatively; 14 patients underwent subchondral drilling (group A), while 10 were treated with the osteochondral autograft transfer system (group B). The association of variables of osteochondral defects with clinical outcomes was assessed in each group. Clinical outcomes were evaluated according to a visual analog scale (VAS) for pain, the American Orthopaedic Foot and Ankle Society (AOFAS) hallux metatarsophalangeal-interphalangeal scale, and the Roles and Maudsley score. The Tegner activity scale and an activity rating scale were used to determine the activity levels. RESULTS: The mean VAS score in both groups was significantly improved (from 6.9 Β± 0.9 to 3.9 Β± 1.3 in group A and from 7.4 Β± 0.8 to 3.4 Β± 1.2 in group B; P .05). No association was found between location of the defect area and clinical outcome in either group. CONCLUSION: For osteochondral defects larger than 50 mm(2) or when a subchondral cyst exists, the osteochondral autograft transfer system could potentially be used as a treatment of choice for osteochondral defects of the first metatarsal head to restore functionality of the metatarsophalangeal joint.ope
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