139 research outputs found
κΉμΆμ μμ λ©λμ½λ¦¬μ νμμ¬μ± μ°κ΅¬
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Όλ¬Έ (μμ¬)-- μμΈλνκ΅ λνμ : μ¬λ²λν 체μ‘κ΅μ‘κ³Ό, 2018. 2. μ΅μμ°½.λ³Έ μ°κ΅¬μ λͺ©μ μ μ½λ 골νμ νν©μ λΆμνκ³ μ½λ 골νμ μ€ν¬μΈ κ΅μ‘μ νμ© λ°©μμ λͺ¨μνλλ° μλ€. λν μ½λ 골νμ κ΅μ‘μ νμ© λ°©μμΌλ‘ κ²½κΈ°λ ₯μ ν₯μ μν¬ μ μλ λ°©λ², μ§μμ μ΅λ ν μ μλ λ°©λ², μΈμ±μ λ°λ¬μν¬ μ μλ λ°©μμ λͺ¨μνκΈ° μν΄ κ³¨νμμμ κ°λ
κ³Ό ꡬμ±μμλ 무μμΈκ°?, μ½λ 골νμ νν©μ μ΄λ νκ°?, μ½λ 골νμ μ€ν¬μΈ κ΅μ‘μ νμ©λ°©μμ 무μμΈκ°? λΌλ 3κ°μ§μ μ°κ΅¬λ¬Έμ λ₯Ό μ€μ νμλ€. λ³Έ μ°κ΅¬λ₯Ό μν΄ λ¬Ένμ°κ΅¬λ₯Ό ν΅ν μ§μ μ°κ΅¬ λ°©λ²μ μ¬μ©νμλ€. λ€μν λ°©μμΌλ‘ μμ€μ μΆκ°λ 골νμμ 400κΆμ μ μ νμ¬ μ΄μ€ 250κΆμ μ½λ 골νμ κ°λ
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μ΄μμ μ°κ΅¬κ³Όμ μ ν΅ν κ²°κ³Όλ λ€μκ³Ό κ°λ€. 첫째, μ΄λμ μ¬λ°λ₯΄κ², 골νλ₯Ό μ¬λ°λ₯΄κ² λ°μλλ¦¬κ³ λλΌκΈ° μν΄μλ 골νλ₯Ό λ€μν μ κ·ΌμΌλ‘ λ°λΌλ³΄λ κ²μ΄ μ€μνλ©°, μ΄λ₯Ό μν΄μλ 골ν κΈ°μ , μ΄λ‘ , μ§μ, 골νΌμ λ§μμμΈ λ±μ 골νμμμ΄ νμνλ€. 골νμμμ κΈ°μ μ μΈ μΈ‘λ©΄μΈ κ³¨νλ₯(θ½), μ§μμ μΈ μΈ‘λ©΄μΈ κ³¨νμ§(ζΊ), λ§μκ°μ§μ κ΄ν 골νμ¬(εΏ)μΌλ‘ κ΅¬λΆ μ§μ μ μλ€.
λμ§Έ, μ½λ 골νμ νν©μ κ΅λ΄ λνμμ κ³Ό κ΅λ΄μΈ μ¨λΌμΈμ ν΅ν΄ μΆνλμ΄ μλ 골νκ΄λ ¨ μμ 400μ¬κ° μ λλ‘ νμ
νμΌλ©°, μ νλ μμ κ³Ό λ΄μ©μ νκ³κ° μλ μμ μ μ μΈνκ³ 250κΆμ μ μ νμλ€. μ μ λ 250κΆ κ°μ΄λ° λ΄μ©μ νμΈ ν 16κ°μ μ₯λ₯΄λ‘ ꡬλΆνμλ€. μ½λ 골νμ μ₯λ₯΄λ‘λ κ²½μ, 골νμ₯, κ΅μ, κΈ°μ , μμ€, μ¬λ¦¬, μν, μΈλ¬Ό, μκΈ°κ³λ°, μ‘μ§, μ 보, λ§ν, μ λ¨Έ, μν, μ’
κ΅, ν΄λ½μ΄λ€.
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μ§Έ, μ½λ 골νμ κ΅μ‘μ νμ©λ°©λ²μΌλ‘ κ²½κΈ°λ ₯μ ν₯μ μν¬ μ μλ λΆλΆμΈ 골νλ₯μ λνμ¬ κΈ°μ μμ κ³Ό μ¬λ¦¬μμ μ μ½μμΌλ‘μ λ€μν μ΄λ‘ μ μ νκ³ μ¬μμ ν΅ν΄ λ³ΈμΈλ§μ μ΄λ‘ μ΄ μ 립λμ΄ κ²½κΈ°λ ₯μ ν₯μ μν¬ μ μλλ‘ νμμΌλ©°, 골νκ΄λ ¨ μ§μμ ν¨μμΈ κ³¨νμ§μ κ΄ν΄μλ μμ¬, λ¬Έν, μμ€ λ±μ μ½μμΌλ‘μ 골νκ΄λ ¨ μ§μμ μ΅λ ν μ μλλ‘ νμλ€. λ§μ§λ§ 골νΌμ λ§μκ°μ§μ λν 골νμ¬μ 골νμ μ μ μΈ λ£°κ³Ό 맀λλ₯Ό μ μ§ν€λ©°, 골νλ₯Ό ν΅ν΄ λ§μμμ λ° μκΈ°κ³λ°μ΄ λ μ μλλ‘ μν, κ΅μμμ μ μ½μμΌλ‘μ μ¬μ μμμ ν¨μ ν μ μλ€κ³ κ²°λ‘ μ§μλ€.
λ³Έ μ°κ΅¬ κ²°κ³Όλ₯Ό λ°νμΌλ‘ λ€μκ³Ό κ°μ μ μΈμ νκ³ μ νλ€. 첫째, μ½λ 골νλ₯Ό νμ©ν 골νμ½μΉ νλ‘κ·Έλ¨μ΄ κ°λ°λμ΄μΌ νλ€. 골νμ½μΉ νλ‘κ·Έλ¨μ μ½λ 골ν μμμ΄ μΆκ° λμ΄ κ³¨νμμ λμΌ μ μλλ‘ ν΄μΌ ν κ²μ΄λ€. λμ§Έ, νμ₯μ μ½μΉλ€μκ² μ½λ 골νμ λν νμ© κ΅μ‘μ΄ νμνλ€. μ½λ 골νλ₯Ό ν΅νμ¬ νμ₯μ νλ‘, μ½μΉλ€μ κΈ°μ μ μΈ μΈ‘λ©΄μ νΈμ€λ κ΄μ¬μμ λ²μ΄λ λ€λ°©λ©΄μ 골ν μ§λκ° κ°λ₯μΌ νλ μλμ λ°ν ν μ μλλ‘ μ§λμκ΅μ‘μ κ΄ν μ°κ΅¬κ° μ΄λ£¨μ΄ μ ΈμΌ ν κ²μ΄λ€.β
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117
Abstract 118Maste
A Study on the Derivation of Landscape Resources and Characteristics Analysis of Taean Coast National Park in Social Media
νμλ
Όλ¬Έ (μμ¬)-- μμΈλνκ΅ λνμ : νκ²½λνμ νκ²½μ‘°κ²½νκ³Ό, 2018. 2. μμ©ν.2007λ
γκ²½κ΄λ²γμ΄ μ μ λ¨μ λ°λΌ μ°λ¦¬λλΌμ κ²½κ΄μ λ²μ κ·Όκ±°λ₯Ό ν λλ‘ μμ°νκ²½, μμ¬λ¬Έν, μν곡κ°μ μμ°λ₯΄λ κ²½κ΄κ³ν μ립 λ° μ μ©μ΄ κ°λ₯ν΄μ‘λ€. μ΄λλΆν° κ²½κ΄μ λν ꡬ체μ μΈ κ΄λ¦¬κ° μμλμμΌλ γκ²½κ΄λ²γμ λμμ§μμ κ²½κ΄κ΄λ¦¬λ₯Ό μ€μ μ μΌλ‘ λ€λ£¨κ³ μμ΄, μμ°κ²½κ΄μ λν κ²½κ΄νκ° λ° κ΄λ¦¬μ κ΄ν΄μλ νμ¬κΉμ§λ λμμ§μ κ²½κ΄μ λΉν΄ μλμ μΌλ‘ λ―Έν‘ν λΏλ§ μλλΌ κ²½κ΄μμμ κ΄ν μ°κ΅¬λ νν©μ‘°μ¬ μ°¨μμμ μ΄λ£¨μ΄μ§κ±°λ μ λ¬Έκ°μ μ£Όκ΄μ νλ¨μΌλ‘ μ μ λκ³ νκ°λμ΄ μλ€. λν κ²½κ΄μ λ°λΌλ³΄λ λμκ³Ό 주체, 체ννλ λ± λ€μν μΌκ° μ½ν νμ±λλ κ²μμλ λΆκ΅¬νκ³ νμ¬κΉμ§ μ€μλμ΄μ¨ κ²½κ΄μμ μ°κ΅¬λ μκ°μ μμμ κ΅νλμ΄ μ‘°μ¬ λ° κ΄λ¦¬λ°©μμ λ§λ ¨νκ³ μμΌλ©°, μ¬λμ΄ μ²΄ννλ κ²½κ΄μ λν΄μλ μλμ μΌλ‘ λ―ΈλΉνκ² μ°κ΅¬λμ΄ μλ€.
μ΄μ λ³Έ μ°κ΅¬λ κΈ°μ‘΄ μ°κ΅¬μ νκ³λ₯Ό 보μνλ λ°©λ²μΌλ‘μ μμ
λ―Έλμ΄λ₯Ό νμ©ν κ²½κ΄μ°κ΅¬λ₯Ό μ€μνμλ€. μκ°μ μΌλ‘ 보μ΄λ κ²½κ΄μ¬μ§κ³Ό ν¨κ» μ¬μ§μ ν¬ν¨λ ν
μ€νΈ λ° λ°©λ¬Έμμ ννλΆμμ λ³ννμ¬ λ€κ°λμ κ²½κ΄μ°κ΅¬μ νμμ±μ μ κΈ°νλ©°, 체κ³μ μΈ κ²½κ΄κ³ν λ° μ§μκ°λ₯ν κ²½κ΄κ΄λ¦¬λ₯Ό μν΄μλ μμμμ μ
μ₯μμ λ°λΌλ³΄λ κ²½κ΄κ³Ό μ΄μ λν μΈμ λΆμ λν νμνλ€κ³ μΈμνμλ€. μμ
λ―Έλμ΄λ κΈ°λ³Έμ μΌλ‘ μ¬λλ€μ΄ 체νμ νκ±°λ κ²½νμ ν΅ν΄ λλμ μ΄λ μ¬λ¬Ό λλ νμμ λν μ£Όκ΄μ μΈ κ²¬ν΄λ₯Ό νμΈκ³Ό 곡μ νλ νΉμ§μ΄ μ‘΄μ¬νλ€. μ΄λ¬ν νΉμ±μ μ
κ°νμ¬ λ³Έ μ°κ΅¬μμλ μμ
λ―Έλμ΄ λΆμμ ν΅ν΄ μ¬λλ€μ΄ μ΄λ»κ² κ²½κ΄μμ νλνκ³ ν₯μ νλ©° 체ννλμ§ λΆμνκ³ μ νμλ€.
λ³Έ μ°κ΅¬λ νμν΄μκ΅λ¦½κ³΅μμ μ°κ΅¬ λμμ§λ‘ μ μ νμ¬, μΈμ€νκ·Έλ¨μμ λμ€μ΄ μΈμνλ νμν΄μκ΅λ¦½κ³΅μμ λνκ²½κ΄μ λμΆνκ³ , μ¬μ§κ³Ό ν¨κ» μμ±λ ν
μ€νΈ λΆμμ ν΅ν΄ νμν΄μκ΅λ¦½κ³΅μμ κ²½κ΄μ νμ λΆλ₯ν¨μΌλ‘μ¨, μμ
λ―Έλμ΄μ λνλ νμν΄μκ΅λ¦½κ³΅μμ κ²½κ΄μμ λμΆ λ° κ²½κ΄νΉμ± λΆμμ μ€μνμλ€. μ΄λ₯Ό ν λλ‘ λ³Έ μ°κ΅¬μμλ ν¬κ² λ€ λΆλΆμ μμ¬μ μ λμΆνμλ€.
첫째, ν΄μκ²½κ΄ κ΄λ ¨ μ νμ°κ΅¬ κ³ μ°°μ ν΅ν΄ ν΄μκ²½κ΄μ μ ν λ° κ΅¬μ±μμλ₯Ό μ 리νκ³ λ³Έ μ°κ΅¬μμ λ€λ£¨κ³ μ νλ ν΄μκ²½κ΄μ κ°λ
μ κ·μ νμλ€. ν΄μκ²½κ΄μ κ°λ
λ° λ²μλ λ§μ μ°κ΅¬μμ μΈκΈνκ³ μμΌλ, μ°κ΅¬λ§λ€ μ°¨μ΄κ° μ‘΄μ¬νμ¬ λ³Έ μ°κ΅¬μμμ ν΄μκ²½κ΄μ λν κ°λ
μ μ€μ νμλ€.
λμ§Έ, μμ
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λ° μμμ κ²½κ΄ κ΄λ ¨ μ νμ°κ΅¬λ₯Ό κ³ μ°°ν¨μΌλ‘μ¨ κ²½κ΄μ°κ΅¬ λΆμΌμμ μμ
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λ―Έλμ΄λ μλ°μ μ°Έμ¬λ‘ μ΄λ£¨μ΄μ§λ ννμ΄κΈ° λλ¬Έμ μ€κ³λμ§ μμ μ견과 κ²½κ΄μ λν μΈμμ κ°κ° μμ΄ νμ
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λ―Έλμ΄μ λνλ λ°©λ¬Έκ°μ΄ μΈμνλ κ²½κ΄μμ λ° κ²½κ΄νΉμ±μ λΆμνμλ€. μμ
λ―Έλμ΄ μΈμ€νκ·Έλ¨μ λνλ κ΄λ ¨ κ²μλ¬Όμ ν
μ€νΈ λΆμμ ν΅ν΄ νμν΄μκ΅λ¦½κ³΅μμ λν λ°©λ¬Έκ°μ μ λ°μ μΈ μΈμμ μ΄ν΄λ³΄μλ€. μ΄λ₯Ό ν΅ν΄ νμν΄μκ΅λ¦½κ³΅μμ μ£Όμ 곡κ°μ μ μ νμμΌλ©°, λνκ²½κ΄μ λμΆνμλ€. λν λνκ²½κ΄μ ν΄λΉλλ μ¬μ§μ ν¨κ» μμ±λ μ½λ©νΈμ ν΄μνκ·Έλ₯Ό λΆμνμ¬ μ£Όμ ν€μλλ₯Ό λμΆνκ³ μ£Όμ κ²½κ΄ λ° νλκ³Ό μ νΈμμΈμ μ 리ν¨μΌλ‘μ¨, λ°©λ¬Έκ°λ€μ΄ κ·Έ 곡κ°μμ μ΄λ€ 체νμ νλ©° μ΄λ€ μμκ³Ό μμλ₯Ό μ€μνκ² μΈμνκ³ μλμ§ μ΄ν΄λ³΄μλ€. νμν΄μκ΅λ¦½κ³΅μμλ 6κ°μ ꡬμμ΄ λ°©λ¬Έκ°μκ² μ£Όμ 곡κ°μΌλ‘ μΈμλκ³ μμμ μ μ μμμΌλ©°, μ΄μ ν΄λΉλλ λνκ²½κ΄μ 31κ°κ° λμΆλμλ€. λ°λΌμ 31κ°μ λνκ²½κ΄μ λνμ¬ λ°©λ¬Έκ°μ΄ μμ νκ³ μλ μ견μ λΆμνμ¬ νμν΄μκ΅λ¦½κ³΅μμ κ²½κ΄μ λν μΈμμ λμΆνμλ€.
λ·μ§Έ, λ°©λ¬Έκ°μ κ²½κ΄μΈμκ³Ό μ£Όμ νλμ λΆμνμ¬ μ¬λλ€μ νλμ κΈ°λ° ν κ²½κ΄ μ ν λΆλ₯ νμ μ€μ νκ³ , λνκ²½κ΄(CP)μ κ²½κ΄μ νμ λΆλ₯νμλ€. λ°λΌμ μμ λμΆν λνκ²½κ΄ 31κ°μ λνμ¬ κ²½κ΄μ‘°λ§, 곡κ°μ΄λ―Έμ§, λλλ§ν¬, 체ν 4κ°μ§μ κ²½κ΄ μ νμΌλ‘ λΆλ₯νμμΌλ©°, 6κ°μ ꡬμμ΄ λνμ±μ λλ κ²½κ΄μ νμ λΆμνμ¬ μ¬λλ€μ΄ νμν΄μκ΅λ¦½κ³΅μμ κ²½κ΄μ μ΄λ»κ² ν₯μ νκ³ μ΄λ€ νλλ€μ νλμ§ λΆμνμλ€.
μ΄λ₯Ό μ’
ν©νλ©΄ λ³Έ μ°κ΅¬μμλ κΈ°μ‘΄μ μνλμ΄ μ€λ κ²½κ΄μ°κ΅¬μ νκ³λ₯Ό 보μνκ³ μ§μμ νΉμ±μ λ°μν κ²½κ΄μμ μ°κ΅¬ λ°©λ²μ νμμ±μ μΈμνμμΌλ©°, 체κ³μ μΈ κ²½κ΄κ³ν λ° μ§μκ°λ₯ν κ²½κ΄κ΄λ¦¬ λ°©μ μ립μ μν΄μλ λμ€μ΄ μΈμνλ κ²½κ΄μ λν λ€κ°λμ λΆμμ νμνλ€λ μ μ νμ, μλ°μ μ°Έμ¬λ‘ μ΄λ£¨μ΄μ§λ μμ
λ―Έλμ΄μ λνλ νμν΄μκ΅λ¦½κ³΅μμ κ²½κ΄μμ λμΆ λ° κ²½κ΄νΉμ± λΆμμ μ€μνμλ€.
λ³Έ μ°κ΅¬λ κ²½κ΄μ λν λμ€μ μΈμμ νμ
νκΈ° μν΄ μ€μλ¨μΌλ‘μ¨, λμΆλ μ¬μ― κ°μ μ£Όμ 곡κ°μ νμ νμ¬ μ°κ΅¬λ₯Ό μ§ννμλ€. μ΄μ λνμ¬ ν₯ν νμν΄μκ΅λ¦½κ³΅μμμ μ‘°μ±ν νλ°©λ‘μ ꡬκ°λ³ μ°κ΅¬λ₯Ό μΆκ°μ μΌλ‘ μ§νν¨μΌλ‘μ¨ νμν΄μκ΅λ¦½κ³΅μμ μ μμ λνμ¬ μ°κ΅¬λμ΄μΌ ν λΆλΆμ΄λ©°, μ΄λ νμν΄μκ΅λ¦½κ³΅μμ κ²½κ΄κ³ν λ° κ²½κ΄κ΄λ¦¬λ°©μμ κΈ°μ΄μλ£λ‘ νμ©λ μ μλ μλ―Έκ° μλ€. λν λ³Έ μ°κ΅¬μμ μ μ©ν μ°κ΅¬ λ°©λ²μ μ¬λ¬ μ§μμ λμμΌλ‘ μ°κ΅¬λ₯Ό μ§νν¨μΌλ‘μ¨ ν₯ν 체νμ κΈ°λ° ν κ²½κ΄κ΄λ¦¬ λ°©μ μ립μΌλ‘ λ°μ νκΈ° μν κΈ°μ΄μ°κ΅¬λ‘μ κΈ°μ¬ν κ²μΌλ‘ κΈ°λνλ€.Since the legislation of γLandscape Actγin 2007, the world of the landscape in South Korea has been allowed to plan and apply the landscape that incorporates the natural environment, historical culture, and living space based on the legal foundation. From this time on, explicit management on landscape began. Nevertheless, because γLandscape Actγmainly concerns the management of urban area landscape, the assessment and management of natural landscape are still relatively meager compared to that of the urban area landscape. In addition, the research on landscape resources has been conducted on the level of a status survey or selected and evaluated based on the subjective judgment of experts. Moreover, the scope of the previous studies on landscape resources has been limited to surveying and seeking management strategies only pertaining to visible resources although landscape comprises many layers including the viewed object, the viewing entity, and experience activities. Consequently, the experiential landscape perceived by people has rarely been studied in comparison.
In this light, the present study conducted a landscape study using social media as a way of remedying the limitation of previous studies. This study addresses the need for multilateral landscape research by combining the analysis of visual landscape images with analysis of text about the image as well as the users behavior. In addition, this study recognized that systematic landscape planning and sustainable landscape management requires an analysis of the landscape from the consumers perspective and their perception. One characteristic of social media is sharing with others ones emotion from certain experience or ones subjective view of objects or phenomenon. Based on this characteristic, the present study aimed to analyze social media to discover how people behave and what they experience and enjoy around a scenic landscape.
This study selected Taean Coast National Park as the research targetelicited typical landscape points of Taean Coast National Park that the public recognizes on Instagram. Then this study elicited the landscape resources and analyzed the characteristics of Taean Coast National Park manifested in social media by classifying the landscape types in Taean Coast National Park based on the analysis of text description of the uploaded images. Based on this, the present study derived four implications.
First, through the literature review of previous studies on the coastal landscape, this study organized the types and components of the coastal landscape, and defined the concept of the coastal landscape that this study aims to cover. Although the concept and scope of the coastal landscape were mentioned in many studies, this study has re-established the concept of the coastal landscape because of the discrepancy in concepts between the studies.
Second, through examining the previous studies on the landscape in terms of the concept and significance of social media, this study addressed the need for analysis of social media in the field of landscape study. Previous landscape studies have used a questionnaire survey method to understand the visitors perception. However, it is difficult to collect visitors unsolicited opinions because a questionnaire survey is limited in that the response of the survey participant is induced according to the survey items that were designed in advance. By contrast, social media encourage people to participate in them voluntarilythus, it is advantageous because unsolicited opinions and perception on landscape can be examined without adding or subtracting any content.
Third, this study analyzed the landscape resources and characteristic of landscape perceived by visitors in a certain area as shown in social media. Through text analysis of the relevant posts on Instagram, this study examined the overall perception of visitors to Taean Coast National Park. Based on this, primary attractions of Taean Coast National Park are selected, and representative landscape points were extracted. In addition, by analyzing the comment and hashtags posted along with the photos of the representative landscape, this study extracted keywords and organized the main landscape, activities, preferred factors so as to investigate what the visitors experience in the space and what resources and element they value. This study discovered that Taean Coast National Park has six areas that are perceived to be primary attractions by visitors. A total of 31 landscape points that belong to these areas have been extracted. Subsequently, this study analyzed the visitors description and opinions about these 31 landscape points and derived the perception of landscape in Taean Coast National Park.
Fourth, this study analyzed the visitors perception of the landscape and their main activitiesthen established the criteria of landscape type classification based on peoples activities and categorized the CP (Consensus Photograph) landscape. Accordingly, with regard to 31 landscape points previously derived, the landscape types were divided into landscape view, space image, landmark, and experience. By analyzing six representative landscape types, this study investigated how the visitors enjoy the landscape of Taean Coast National Park in terms of activities.
To sum up, the present study remedied the limitation of previous landscape studies and recognized the need for research method of studying landscape resources that reflect the regional characteristics. Under the premise that multilateral analysis on the landscape perceived by the public is essential for establishing a systematic landscape planning and sustainable landscape management strategy, this study extracted the landscape resources of Taean Coast National Park manifested in the social media, which is operated by voluntary participation, and conducted an analysis of landscape features.
The present study was conducted to investigate the publics perception of landscape, targeting the six main spaces. With regard to this, future studies can investigate the entire Taean Coast National Park by performing an additional research by trail section that runs through Taean Coast National Park. This has significance to be used as baseline data for landscape planning and management for Taean Coast National Park. Furthermore, by applying the research method used in the present study to a study targeting many areas, it is expected that this study will contribute to establishing the experience-based landscape management plan as a baseline study.β
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[Abstract] 124Maste
Serotonin transporter gene polymorphism associated with short-term treatment response to venlafaxine
BACKGROUND: Polymorphisms of serotonin transporter, especially serotonin transporter linked promoter region (5- HTTLPR) and serotonin transporter intron 2 variable number tandem repeat (5-HTTVNTR), have been suggested to be associated with treatment response to selective serotonin reuptake inhibitors. However, there have been only few reports of the association between 5-HTTLPR or 5-HTTVNTR and treatment response to venlafaxine.
METHODS: 84 Korean major depressive disorder patients were included in this study. They were administered 75 mg of venlafaxine XR (extended release) for 1 week and then took 150 mg for the next 3 weeks. All patients were evaluated at baseline and week 4 by the Hamilton Depression Rating Scale (HAM-D), Montgomery-Asberg Depression Rating Scale (MADRS), Beck Depression Inventory (BDI), Hamilton Anxiety Rating Scale (HAM-A), and Beck Anxiety Inventory (BAI).
RESULTS: (1) Treatment response of depressive symptoms (BDI, HAM-D, MADRS) to venlafaxine at week 4 was associated with the non-s/s (l/l and l/s) genotype of 5-HTTLPR; (2) in repeated measures ANOVA, the BDI, MADRS and HAM-A scores decreased more significantly in patients with the non-s/s genotype than in those with the s/s genotype, and (3) multiple regression analyses suggested that the 5-HTTLPR polymorphism is a predictive factor for short-term treatment response to venlafaxine. However, 5-HTTVNTR showed no significant association with treatment response to venlafaxine. Both 5-HTTLPR and 5-HTTVNTR were not associated with side effects of venlafaxine.
CONCLUSION: The 5-HTTLPR non-s/s genotype can be associated with venlafaxine treatment responses. However, further large-scale studies are warranted to confirm this finding.ope
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Dept. of Medical Science/λ°μ¬Multidrug resistant protein 1(MRP1/ABCC1), a member of ATP binding cassette(ABC) transporter superfamily, is known as a xenobiotics efflux pump. It is expressed highly in the blood brain barrier(BBB) and choroid plexus of blood cerebrospinal fluid barrier(BCSFB) and has been implicated in altering the treatment response to psychotropic drugs such as antidepressants. This study aimed to identify the association between genetic variations in MRP1/ABCC1 and the therapeutic response to the antidepressant citalopram in the depressive disorder. One hundred and twenty three patients who had been administered citalopram monotherapy to control their major depressive disorder were recruited and genotype data from sixty four patients who had completed their eight-week follow up were evaluated together with those from one hundred controls. Nine MRP1 single nucleotide polymorphisms (SNPs) showing more than 5% allele frequency in the Korean population were analyzed. The c.4002G>A, a synonymous SNP in exon 28, showed a strong association with the remission state at 8 weeks (P=0.005, O.R. 4.7, 95% C.I. 1.5~14.7). The c.4002G>A forms a linkage disequilibrium(LD) block with three other SNPs including c.5462T>A in the 3β untranslated region. Accordingly, the haplotype showed a significant association with the remission state (P=0.014). Subsequent molecular studies were conducted to support the association between these MRP1 polymorphisms and the citalopram response. Thus kinetic studies using MRP1-enriched membrane vesicles revealed that citalopram is a substrate of MRP1 (Km=1.99 ΞΌM, Vmax=137 pmol/min/mg protein). In addition, individuals with A allele of c.4002G>A or c.5462T>A polymorphisms showed higher MRP1 mRNA levels in peripheral blood cells. The cause of the difference in mRNA expressions was assumed from the RNA structural changes according to the c.5462T>A which forms a LD block with c.4002G>A. These results suggest that MRP1 polymorphisms may be a predictive marker of citalopram treatment in major depression.ope
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Thesis (master`s)--μμΈλνκ΅ λνμ :κΈ°κ³ν곡곡νλΆ,2000.Maste
(A)Study on the additive model
Thesis(master`s)--μμΈλνκ΅ λνμ :ν΅κ³νκ³Ό,2006.Maste
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