169 research outputs found
Effect of Significant Coronary Artery Stenosis on Prognosis in Patients with Vasospastic Angina: A Propensity Score-Matched Analysis
Vasospastic angina (VA) is a functional disease of the coronary artery and occurs in an angiographically normal coronary artery. However, it may also occur with coronary artery stenosis. We investigated the effect of coronary artery stenosis on clinical outcomes in VA patients. Study data were obtained from a prospective multicenter registry that included patients who had symptoms of VA. Patients were classified into two groups according to presence of significant coronary artery stenosis. Among 1920 patients with VA, 189 patients were classified in the "significant stenosis" group. The one-year composite clinical events rate was significantly higher in the significant stenosis group than in the "no significant stenosis" group (5.8% vs. 1.4%, respectively; p < 0.001). Additionally, the prevalence of ACS was significantly greater in the "significant stenosis" group (4.8% vs. 0.9%, respectively; p < 0.001). After propensity score matching, the adverse effects of significant stenosis remained. In addition, significant stenosis was independently associated with a 6.67-fold increased risk of ACS in VA patients. In conclusion, significant coronary artery stenosis can increase the adverse clinical outcomes in VA patients at long-term follow-up. Clinicians should manage traditional risk factors associated with atherosclerosis and control vasospasm as well as reduce the burden of atherosclerosis.ope
Smoking may be more harmful to vasospastic angina patients who take antiplatelet agents due to the interaction: Results of Korean prospective multi-center cohort
Background: The interaction between smoking and the use of antiplatelet agents on the prognosis of vasospastic angina (VA) is rarely investigated.
Methods: VA-Korea is a nation-wide multi-center registry with prospective design (n = 1812). The primary endpoint was the composite occurrence of acute coronary syndrome (ACS), symptomatic arrhythmia, and cardiac death. Log-rank test and Cox proportional hazard model were for statistical analysis. Also, we conducted interaction analysis in both additive and multiplicative scales between smoking and antiplatelet agents among VA patients. For additive scale interaction, relative excess risk due to interaction (RERI) was calculated and for multiplicative scale interaction, the ratio of hazard ratio (HR) was calculated. All statistical analysis conducted by Stata Ver 16.1.
Results: Patients who were smoking and using antiplatelet agents had the highest incidence rate in the primary composite outcome. The incidence rate was 3.49 per 1,000 person-month (95% CI: 2.30-5.30, log-rank test for primary outcome p = 0.017) and HR of smoking and using antiplatelet agents was 1.66 (95%CI: 0.98-2.81). The adjusted RERI of smoking and using antiplatelet agents was 1.10 (p = 0.009), and the adjusted ratio of HR of smoking and using antiplatelet agents was 3.32 (p = 0.019). The current study observed the interaction between smoking and using antiplatelet agents in both additive and multiplicative scales.
Conclusions: Smoking was associated with higher rates of unfavorable clinical outcomes among VA patients taking antiplatelet agents. This suggested that VA patients, especially those using antiplatelet agents should quit smoking.ope
Differential progression of coronary atherosclerosis according to plaque composition: a cluster analysis of PARADIGM registry data
Patient-specific phenotyping of coronary atherosclerosis would facilitate personalized risk assessment and preventive treatment. We explored whether unsupervised cluster analysis can categorize patients with coronary atherosclerosis according to their plaque composition, and determined how these differing plaque composition profiles impact plaque progression. Patients with coronary atherosclerotic plaque (n = 947; median age, 62 years; 59% male) were enrolled from a prospective multi-national registry of consecutive patients who underwent serial coronary computed tomography angiography (median inter-scan duration, 3.3 years). K-means clustering applied to the percent volume of each plaque component and identified 4 clusters of patients with distinct plaque composition. Cluster 1 (n = 52), which comprised mainly fibro-fatty plaque with a significant necrotic core (median, 55.7% and 16.0% of the total plaque volume, respectively), showed the least total plaque volume (PV) progression (+ 23.3 mm3), with necrotic core and fibro-fatty PV regression (- 5.7 mm3 and - 5.6 mm3, respectively). Cluster 2 (n = 219), which contained largely fibro-fatty (39.2%) and fibrous plaque (46.8%), showed fibro-fatty PV regression (- 2.4 mm3). Cluster 3 (n = 376), which comprised mostly fibrous (62.7%) and calcified plaque (23.6%), showed increasingly prominent calcified PV progression (+ 21.4 mm3). Cluster 4 (n = 300), which comprised mostly calcified plaque (58.7%), demonstrated the greatest total PV increase (+ 50.7mm3), predominantly increasing in calcified PV (+ 35.9 mm3). Multivariable analysis showed higher risk for plaque progression in Clusters 3 and 4, and higher risk for adverse cardiac events in Clusters 2, 3, and 4 compared to that in Cluster 1. Unsupervised clustering algorithms may uniquely characterize patient phenotypes with varied atherosclerotic plaque profiles, yielding distinct patterns of progressive disease and outcome.ope
๋ฏผ๊ดํ๋ ฅ ๋ ธ๋์ผํฐ ์ฌ๋ก๋ฅผ ์ค์ฌ์ผ๋ก
ํ์๋
ผ๋ฌธ(์์ฌ) -- ์์ธ๋ํ๊ต๋ํ์ : ์ฌํ๊ณผํ๋ํ ์ฌํ๋ณต์งํ๊ณผ, 2023. 2. ๊น์์.The problem of non-standard workers is a major social problem. The institutions that have been designed around full-time employment relationships are fissured and do not cover non-standard workers, and the labor movement represented by trade unions is also facing a crisis around the world. With the increase in the number of non-standard workers who are not double-inclusive in both institutions and trade unions, the problem of non-standard workers has become one of the social problems that need urgent resolution in modern society.
This work focuses on the fact that the worker center, which has recently made significant achievements in representing the interests of non-standard workers, is an example of the institutionalization of labor movements. This study attempts to shed light on both the subversive aspects of the worker center despite institutionalization, and the subsequent limitations that also resulted for the worker center. There are two research questions. First, this study attempts to clarify whether worker centers seek resistance after institutionalization and what their resistance patterns in the event that they resist. Next, this study also tries to clarify whether worker centers pursue organizing after institutionalization, and in what ways. In order to answer the above research question, this study reviewed literature data on the worker center, and collected key data through in-depth interviews with 20 worker center leaders and practitioners.
This study analyzed the resistance of the worker center through three aspects: 'captured resistance', 'strategic resistance', and 'infrapolitics'. This study examined the organizing of non-standard workers in the worker center into three processes: 'organizing method', 'organizing process', and local collective bargaining after organizing'. This study recognizes the aim of worker centers, which was to achieve an improvement in non-standard employment and labor conditions, whilst protecting non-regular workers' human rights and expanding social welfare. However, this study revealed the existence of institutional and structural restrictions such as 'public-private partnership, 'formalizing local governments' non-standard workers organizing policy', and 'converting trade unions activities to meet the non-standard labor environment to achieve worker centers aims.
This study has the following theoretical implications. First, the resistance and organizing aspects of the worker center identified in this study are significant in that it highlighted that social movement organizations can be subversive even after institutionalization, which previous studies have left as areas of 'possibility'. Second, the invisible resistance and organizing of worker centers tracked by this study are significant in that it revealed worker centers can be effective actors in the collective interest representation of non-standard workers, such as organizing workers or improving institutions. Third, this study is meaningful in that researchers who study social policy changes focusing on equality and democracy can expand their understanding of social policy continuity and adapt by paying more attention to social policy itself as well as actors including social movements.
Simultaneously, this study is also an invitation to policymakers, worker center activists, trade union activists. First, it was intended to shed light on the effectiveness of a network approach for policymakers to work together with various actors, including civil society and the market, to define problems and seek solutions beyond the design and execution of the government's one-sided approach. Second, for worker center activists, this study was intended to serve as a starting point in seeking greater change, by connecting experiences from different regions as 'languages', to facilitate a discussion. Third, for trade union activists, the study was intended to highlight one of the ways in which trade unions can expand resources and capabilities of the labor movement. Namely, implementing strategic collaboration within the worker centers.๋น์ ๊ท์ง ๋ฌธ์ ๋ ์ฃผ์ํ ์ฌํ๋ฌธ์ ๋ค. ์ ๊ท์ง ๊ณ ์ฉ๊ด๊ณ ์ค์ฌ์ผ๋ก ์ค๊ณ๋์ด ์๋ ์ ๋๋ค์ ๊ณ ์ฉ๊ด๊ณ๊ฐ ๋ค๋ณํ๋๋ฉฐ ๋น์ ๊ท์ง ๋
ธ๋์๋ค์ ์ค๋กฏ์ด ํฌ๊ดํ์ง ๋ชปํ๋ฉฐ, ๋
ธ๋์กฐํฉ์ผ๋ก ๋ํ๋๋ ๋
ธ๋์ด๋๋ ์ ์ธ๊ณ์ ์ผ๋ก ์๊ธฐ์ ์ง๋ฉดํด์๋ค. ์ ๋์ ๋
ธ๋์กฐํฉ ๋ชจ๋์ ์์ด ์ด์ค์ ์ผ๋ก ํฌ๊ด๋์ง ์๋ ๋น์ ๊ท์ง ๋
ธ๋์๋ค์ด ์ฆ๊ฐํจ์ ๋ฐ๋ผ, ๋น์ ๊ท์ง ๋ฌธ์ ๋ ํ๋ ์ฌํ์์ ์๊ธํ ํด๊ฒฐ์ด ํ์ํ ์ฌํ๋ฌธ์ ์ค ํ๋๊ฐ ๋์๋ค.
๋ณธ ์์
์ ์ต๊ทผ ๋น์ ๊ท์ง ๋
ธ๋์ ์ดํด๋๋ณ์ ์์ด ์ ์๋ฏธํ ์ฑ๊ณผ๋ค์ ๊ฑฐ๋๊ณ ์๋ ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ๊ฐ ๋
ธ๋์ด๋์ด ์ ๋ํ๋ ์ฌ๋ก๋ผ๋ ์ ์ ์ฃผ๋ชฉํ๊ณ , ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ๋ค์ด ์ ๋ํ ์ดํ ๊ฒช๋ ์ ์ฝ๊ณผ, ์ ๋ํ์๋ ๋ถ๊ตฌํ๊ณ ์ด๋์ฑ์ ์ ์งํ๊ณ ์๋ ์ง์ ๋ค์ ์
์ฒด์ ์ผ๋ก ์กฐ๋ช
ํ๋ ค๋ ์๋์ด๋ค. ์ฐ๊ตฌ ์ง๋ฌธ์ ๋ ๊ฐ์ง๋ค. ๋จผ์ , ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ๊ฐ ์ ๋ํ ์ดํ ์ ํญ์ ์ถ๊ตฌํ๋์ง, ์ถ๊ตฌํ๋ค๋ฉด ์ด๋ค์ ์ ํญ ์์์ ์ด๋ ํ ๋ชจ์ต์ผ๋ก ๋ํ๋๋์ง ๋ฐํ๊ณ ์ ํ๋ค. ๋ค์์ผ๋ก, ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ๊ฐ ์ ๋ํ ์ดํ ์กฐ์งํ๋ฅผ ์ถ๊ตฌํ๋์ง, ์ถ๊ตฌํ๋ค๋ฉด ์ด๋ค์ ์กฐ์งํ๋ ์ด๋ ํ ์ํ๋ค๋ก ์ด๋ค์ง๊ณ ์๋์ง ๋ฐํ๊ณ ์ ํ๋ค. ์ ์ฐ๊ตฌ ์ง๋ฌธ์ ๋ตํ๊ธฐ ์ํด, ๋ณธ ์ฐ๊ตฌ๋ ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ์ ๊ดํ ๋ฌธํ ์๋ฃ๋ค์ ๊ฒํ ํ๊ณ , ๋
ธ๋์ผํฐ ์ผํฐ์ฅ ๋ฐ ์ค๋ฌด์ 20๋ช
์ ์ฌ์ธต ๋ฉด์ ํ์ฌ ํต์ฌ ์๋ฃ๋ค์ ์์งํ์๋ค.
๋ณธ ์ฐ๊ตฌ๋ ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ์ ์ ํญ ์์์ ํฌํ๋ ์ ํญ, ์ ๋ต์ ์ ํญ, ํ๋ถ์ ์น ์ธ ๊ฐ์ง ์์์ผ๋ก ๋๋์ด ๋ถ์ํ๊ณ , ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ์ ๋น์ ๊ท์ง ๋
ธ๋์ ์กฐ์งํ ์ถ์ง ์์์ ์กฐ์งํ ๋ฐฉ๋ฒ, ์กฐ์งํ ๊ณผ์ , ์กฐ์งํ ๊ทธ ์ดํ, ๊ต์ญ์ ์ฅ ์ธ ๊ฐ์ง ๊ณผ์ ์ผ๋ก ๋๋์ด ์ดํด๋ณด์๋ค. ์ฐ๊ตฌ๊ฒฐ๊ณผ๋ฅผ ๋ฐํ์ผ๋ก, ๋ณธ ์ฐ๊ตฌ๋ ๋
ธ๋์ผํฐ ์ด๋์ด ์ ๋ํ๋ฅผ ํตํด ๋ณธ๋ ์ด๋ฃจ๋ ค๊ณ ํ๋ ๋ชฉํ์ธ ๋น์ ๊ท์ง ๊ณ ์ฉโง๋
ธ๋ ์กฐ๊ฑด ๊ฐ์ , ๋น์ ๊ท์ง ๋
ธ๋์ธ๊ถ๋ณดํธ์ ์ดํด๋๋ณ, ์ฌํ๋ณต์ง ํ์ถฉ ๋ฑ์ ๋ฌ์ฑํ๊ธฐ์๋ ๋ฏผ๊ฐ์ํ ํํ, ์ง๋ฐฉ์ ๋ถ์ ๋น์ ๊ท์ง ๋
ธ๋์ ์กฐ์งํ ์ฌ์
๊ณต์ํ ๋๋ชจ, ๋น์ ๊ท์ง ๋
ธ๋์์ ๋
ธ๋ํ๊ฒฝ์ ๋ถํฉํ๋๋ก ๊ธฐ์กด ๋
ธ๋์กฐํฉ์ ํ๋๋ฐฉ์ ๋ณํ ์ถ๋, ์กฐ์งํ ์ดํ ๋
ธ๋ํ๊ฒฝ ๊ฐ์ ์ ์ด๋์ด ๋ผ ์ ์๋ ์ง์ญ์ ๊ต์ญ์ ์ฅ ๋ง๋ จ ๋ฑ ์ฌ๋ฌ ์ ๋์ โง๊ตฌ์กฐ์ ๋๊ด์ด ์์กดํ๊ณ ์์์ ๋๋ฌ๋ด๊ณ ์ ํ๋ค.
๋ณธ ์ฐ๊ตฌ๋ ๋ค์๊ณผ ๊ฐ์ ์ด๋ก ์ ํจ์๋ฅผ ๊ฐ๋๋ค. ์ฒซ์งธ, ๋ณธ ์ฐ๊ตฌ๊ฐ ํฌ์ฐฉํ ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ์ ์ ํญ๊ณผ ์กฐ์งํ ์์๋ค์ ์ ํ์ฐ๊ตฌ๋ค์ด ๊ฐ๋ฅ์ฑ์ ์์ญ์ผ๋ก ๋จ๊ฒจ๋์๋, ์ฌํ์ด๋์กฐ์ง์ด ์ ๋์์ ์ ํฉ ์ดํ์๋ ์ด๋์ฑ์ ๊ฒฌ์งํ ์ ์๋ ์ง์ ๋ค์ ์ค์ฆํ๊ณ , ์ฌํ์ด๋์กฐ์ง์ ์ ๋ํ๊ฐ ๋จ์ํ ํฌ์ญ์ด๋ ์จ๊ฑดํ๋ก ๊ท๊ฒฐ๋๋ค๊ณ ์ ๊ทผํ๋ ์ผ๋ จ์ ๋นํ๋ค์ด ๋ก์ ๋ฌธ์ ์ ๊ธฐ์ผ ์ ์์์ ์กฐ๋ช
ํ๋ค๋ ์ ์์ ์์๋ฅผ ๊ฐ์ง๋ค. ๋์งธ, ๋ณธ ์ฐ๊ตฌ๊ฐ ์ถ์ ํ ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ์ ๋น๊ฐ์์ ์ ํญ๊ณผ ์กฐ์งํ ์์์, ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ๊ฐ ์๊ธ์ฒด๋ถ์ด๋ ๋ถ๋นํด๊ณ ์์ ๋ฑ ๊ฐ์ธ์ ์ดํด๋๋ณ๋ฟ๋ง ์๋๋ผ ๋
ธ๋์ ์กฐ์งํ๋ ์ ๋ ๊ฐ์ ๋ฑ ๋น์ ๊ท์ง ๋
ธ๋์์ ์ง๋จ์ ์ดํด๋๋ณ์ ์์ด์๋ ์ ํจํ ํ์์๊ฐ ๋ ์ ์์์ ๋๋ฌ๋๋ค๋ ์ ์์ ์์๋ฅผ ์ง๋๋ค. ์
์งธ, ๋ณธ ์ฐ๊ตฌ๋ ํ๋ฑ ๋ฐ ๋ฏผ์ฃผ์ฃผ์์ ์ด์ ์ ๋ ์ฌํ์ ์ฑ
๋ณํ๋ฅผ ์ฐ๊ตฌํ๋ ์ฐ๊ตฌ์๋ค์ด ์ฌํ์ ์ฑ
๊ทธ ์์ฒด๋ฟ๋ง ์๋๋ผ ์ฌํ์ด๋์ ๋น๋กฏํ ํ์์์ ๋ณด๋ค ์ฃผ๋ชฉํจ์ผ๋ก์จ ์ฌํ์ ์ฑ
์ ์ง์๊ณผ ๋ณํ์ ๋ํ ์ดํด์ ํญ์ ํ์ฅ์ํฌ ์ ์์์ ๋๋ฌ๋๋ค๋ ์ ์์ ์์๋ฅผ ์ง๋๋ค.
๋ณธ ์ฐ๊ตฌ๋ ์ฌํ์ ์ฑ
์
์์, ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ ์๊ทผ์, ๋
ธ๋์กฐํฉ ํ๋๊ฐ, ์ธ ์ฒญ์ค์๊ฒ ๋ง์ ๊ฑธ๋ฉฐ ๋ณด๋ด๋ ์ด๋์ฅ์ด๊ธฐ๋ ํ๋ค. ์ฒซ์งธ, ์ฌํ์ ์ฑ
์
์์์๊ฒ๋ ์ ๋ถ ์ผ๋ณ๋์ ์ ๋ ์ค๊ณ ๋ฐ ์งํ์ ๋์ด ์๋ฏผ์ฌํ์ ์์ฅ ๋ฑ ๋ค์ํ ํ์์๋ค๊ณผ ์ํธ ํ๋ ฅํ๋ฉฐ ๋ฌธ์ ๋ฅผ ๊ท์ ํ๊ณ ํด๊ฒฐ์ฑ
์ ๋ชจ์ํ๋ ๋คํธ์ํฌ์ ์ ๊ทผ์ด ์ ํจํ ์ ์์์ ์กฐ๋ช
ํ๊ณ ์ ํ๋ค. ๋์งธ, ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ ์๊ทผ์์๊ฒ๋ ์๋ก ๋ค๋ฅธ ์ง์ญ์์ ๊ฒช๋ ๊ฒฝํ๋ค์ ์ธ์ด๋ก์ ์ด์์ผ๋ก์จ ๋ ๋์ ๋ณํ๋ฅผ ๋ชจ์ํ๋ ๋ฐ ์ถ๋ฐ์ ์ด ๋๊ณ ์ ํ๋ค. ์
์งธ, ๋
ธ๋์กฐํฉ ํ๋๊ฐ๋ค์๊ฒ๋ ๋
ธ๋์ด๋์ ์์๊ณผ ์ญ๋์ ํ์ถฉํ ์ ์๋ ๋ฐฉ์ ์ค ํ๋๊ฐ ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ์์ ์ ๋ต์ ํ์
์ด ๋ ์ ์์์ ๋๋ฌ๋ด๊ณ ์ ํ๋ค.์ 1 ์ฅ ๋ค์ด๊ฐ๋ฉฐ 1
์ 2 ์ฅ ๋ฐฐ๊ฒฝ: ๋
ธ๋์ผํฐ ์ด๋์ ๋ฑ์ฅ ๋ฐ ํน์ง 6
์ 1 ์ ํ๊ตญ์ ๋น์ ๊ท์ง๊ณผ ๋น์ ๊ท ๋
ธ๋์ด๋ 6
1.1. ํ๊ตญ์ ๋น์ ๊ท์ง 6
1.2. ํ์์๋ก์ ๋น์ ๊ท ๋
ธ๋์ด๋ 10
์ 2 ์ ๋
ธ๋์ผํฐ ์ด๋์ ๋ฐ์ ๊ณผ์ 12
2.1. ๋
ธ๋์ผํฐ ์ด๋์ ๋ฑ์ฅ 12
2.2. ๋
ธ๋์ด๋์ ์ ๋ํ: ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ์ ์ฑ์ฅ 15
์ 3 ์ ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ ํํฉ ๋ฐ ํน์ง 20
3.1. ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ ํํฉ 20
3.2. ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ ์ฃผ์ ์ฌ์
22
3.3. ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ ์ฃผ์ ํน์ง 26
์ 3 ์ฅ ์ด๋ก ์ ๋ถ์ํ 29
์ 1 ์ ์ฌํ์ด๋๊ณผ ์ฌํ์ด๋์กฐ์ง์ ์ ๋ํ 29
1.1. ์ฌํ์ด๋์ ์ ์ฒด์ฑ๊ณผ ์ญํ 29
1.2. ์ฌํ์ด๋์กฐ์ง์ ์ ๋ํ์ ์ ์ 32
์ 2 ์ ์ฌํ์ด๋์กฐ์ง์ ์ ๋ํ๋ฅผ ๋ฐ๋ผ๋ณด๋ ์์ดํ ์ด๋ก ์ ๊ด์ 34
2.1. ์ฌํ์ด๋์กฐ์ง์ ์ ๋ํ๋ฅผ ๋ฐ๋ผ๋ณด๋ ์ด๋ก ์ ๊ด์ โ ํฌ์ญ 34
2.2. ์ฌํ์ด๋์กฐ์ง์ ์ ๋ํ๋ฅผ ๋ฐ๋ผ๋ณด๋ ์ด๋ก ์ ๊ด์ โก ์ด๋์ฑ ์ ์ง 36
์ 4 ์ฅ ์ฐ๊ตฌ๋ฐฉ๋ฒ 40
์ 1 ์ ์ฐ๊ตฌ์์ ์์น 40
์ 2 ์ ์๋ฃ์์ง ๋ฐ ๋ถ์๋ฐฉ๋ฒ 41
2.1. ์๋ฃ์์ง๋ฐฉ๋ฒ 41
2.2. ์๋ฃ๋ถ์๋ฐฉ๋ฒ 46
์ 3 ์ ์ฐ๊ตฌ์ ์ค๋ฆฌ์ ๊ณ ๋ ค์ฌํญ: ์ฌ์ ๋์์ ๊ธฐ๋ฐ ์ ์ง 47
์ 5 ์ฅ ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ์ ์ ํญ ์์ 49
์ 1 ์ ํฌํ๋ ์ ํญ 49
1.1. ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ ์ํ ๊ณ๊ธฐ: ๊ฐ์๋ ์ ํ๊ณผ ๋ฅ๋์ ์ ํ ์ฌ์ด 49
1.2. ๋ฏผ๊ดํ๋ ฅ์ผ๋ก ๋์๊ฐ์ง ๋ชปํ ๋ฏผ๊ฐ์ํ: ๋ฏผ๊ฐ์ํํํ์ ๋ฐ๋ฅธ ์ ์ฝ 52
์ 2 ์ ์ ๋ต์ ์ ํญ 60
2.1. ๋ฏผ๊ฐ์ํํํ๋ฅผ ์ญ์ด์ฉํ๊ธฐ 60
2.2. ๊ด(ๅฎ)์ ๊ด์ต์ ๋์ ํ๋ ์ค์ฒ๋ค 62
โ ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ์ ์ ์ฒด์ฑ ํฌ์ 62
โก ์ง๋ฐฉ์ํ๋ฅผ ํตํ ์ฐํ ์ ํญ 65
โข ์ง์ญ์ฌํ ๋คํธ์ํฌ๋ฅผ ํตํ ์ฐํ ์ ํญ 67
์ 3 ์ ํ๋ถ์ ์น 69
3.1. ์ ํญ์ ํ ๋ ์กฐ์ฑ 69
โ ์ง์ญ๋
ธ๋๋จ์ฒด ๋คํธ์ํฌ ๊ตฌ์ถ 69
โก ์ง์ญ์๋ฏผ์ฌํ๋จ์ฒด ๋คํธ์ํฌ ๊ตฌ์ถ 72
โข ์ฒญ์๋
๋
ธ๋์ธ๊ถ๊ต์ก ๊ฐ์ฌ๋จ ์์ฑ 75
3.2. ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ์ ๋คํธ์ํฌ ๊ตฌ์ถ๊ณผ ์ ํญ์ ์ํ๊ณ ๋ฆฌ 79
์ 6 ์ฅ ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ์ ์กฐ์งํ ์์ 81
์ 1 ์ ์กฐ์งํ ๋ฐฉ๋ฒ 81
1.1. ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ ์ฃผ๋ ์กฐ์งํ์ ํ๊ณ 81
โ ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ ์ธก๋ฉด์ ํ๊ณ 81
โก ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ์ ๋
ธ๋์กฐํฉ ๊ฐ ํ์
์ ์ด๋ ค์ 84
1.2. ์๋ฉด ์๋ ์กฐ์งํ ๋ฐฉ๋ฒ 87
โ ์คํ์กฐ์ฌ๋ฅผ ํตํ ์กฐ์งํ ๋ฐฉ๋ฒ 87
โก ์์กฐ๋ชจ์์ ํตํ ์กฐ์งํ ๋ฐฉ๋ฒ 90
โข ์ฌ์
์ฃผ๋ฅผ ํตํ ์กฐ์งํ ๋ฐฉ๋ฒ 93
1.3. ์กฐ์งํ๋ฅผ ์๋ฉด ์๋ก 95
โ ์กฐ์งํ ์ฌ์
๊ณต์ํ ๋ฐ ์์ฐ ๋ฐฐ์ 95
โก ์กฐ์งํ ์ฌ์
์ ๊ณต์ํ์ ๋ฐ๋ฅธ ์ญ์ค? 98
์ 2 ์ ์กฐ์งํ ๊ณผ์ 103
2.1. ์ํํธ ๊ฒฝ๋น๋
ธ๋์ ์กฐ์งํ ๊ณผ์ 103
2.2. ์ด๋ ํํ๋ก ์กฐ์งํํ ๊ฒ์ธ๊ฐ? 106
โ ๋
ธ๋์กฐํฉ ํํ๋ก ์กฐ์งํํ ๊ฒ์ธ๊ฐ? ํํ ํํ๋ก ์กฐ์งํํ ๊ฒ์ธ๊ฐ? 106
โก ๋
ธ๋์กฐํฉ ํํ๋ก ์กฐ์งํํ๊ธฐ 110
โข ํํ ๋๋ ์ผํฐ ๋ด ์์กฐ๋ชจ์์ผ๋ก ์กฐ์งํํ๊ธฐ 116
2.3. ๊ฒฝ๋น๋
ธ๋์ ์กฐ์งํ ๊ณผ์ ์ ๋ํ ๋ด๋ถ ์ฑ์ฐฐ 118
์ 3 ์ ์กฐ์งํ ๊ทธ ์ดํ, ๊ต์ญ์ ์ฅ 122
3.1. ์ฌ์
์ฅ ๊ต์ญ์ ๋์ด์ ์ง์ญ๋ณ ๊ต์ญ์ ์ฅ: ์๋ ๊ทธ๋ฆฌ๊ณ ๊ต์ฐฉ 122
3.2. ์กฐ์งํ์ ๊ธฐ๋ฐํ์ง ๋ชปํ ์ดํด๋๋ณ์ ํ๊ณ: ์ ๊ตญ๋จ์ ์์ํ์ฝ ์ฒด๊ฒฐ๊ณผ์ 127
3.3. ์ค๋ง๋ฆฌ?: ์ง์ญ๊ธฐ๋ฐ ๋ฏผ๊ดํ๋ ฅ ๋
ธ๋์ผํฐ์ ์คํ๋ค 134
์ 7 ์ฅ ๋๊ฐ๋ฉฐ 137
์ 1 ์ ์ฐ๊ตฌ๊ฒฐ๊ณผ ์์ฝ 137
์ 2 ์ ์ฐ๊ตฌ์ ํจ์ 142
2.1. ์ฐ๊ตฌ์ ์ด๋ก ์ ํจ์ 142
2.2. ์ฐ๊ตฌ์ ์ ์ฑ
์ โง์ค์ฒ์ ํจ์ 145
์ 3 ์ ์ฐ๊ตฌ์ ํ๊ณ 148
์ฐธ ๊ณ ๋ฌธ ํ 149
Abstract 164์
Nitrates vs. Other Types of Vasodilators and Clinical Outcomes in Patients with Vasospastic Angina: A Propensity Score-Matched Analysis
Although vasodilators are widely used in patients with vasospastic angina (VA), few studies have compared the long-term prognostic effects of different types of vasodilators. We investigated the long-term effects of vasodilators on clinical outcomes in VA patients according to the type of vasodilator used. Study data were obtained from a prospective multicenter registry that included patients who had symptoms suggestive of VA. Patients were classified into two groups according to use of nitrates (n = 239) or other vasodilators (n = 809) at discharge. The composite clinical events rate, including acute coronary syndrome (ACS), cardiac death, new-onset arrhythmia (including ventricular tachycardia and ventricular fibrillation), and atrioventricular block, was significantly higher in the nitrates group (5.3% vs. 2.2%, p = 0.026) during one year of follow-up. Specifically, the prevalence of ACS was significantly more frequent in the nitrates group (4.3% vs. 1.5%, p = 0.024). After propensity score matching, the adverse effects of nitrates remained. In addition, the use of nitrates at discharge was independently associated with a 2.69-fold increased risk of ACS in VA patients. In conclusion, using nitrates as a vasodilator at discharge can increase the adverse clinical outcomes in VA patients at one year of follow-up. Clinicians need to be aware of the prognostic value and consider prescribing other vasodilators.ope
Association of Early Hysterectomy With Risk of Cardiovascular Disease in Korean Women
Importance: Women who undergo surgical hysterectomy before natural menopause may have an earlier increase in hematocrit and storage iron levels than those who continue menstruation, thereby increasing the risk of cardiovascular disease (CVD) at ages younger than usually seen. Examining this issue may provide important implications for women's cardiovascular health to both physicians and patients.
Objective: To evaluate the association of hysterectomy with the risk of incident CVD among women before age 50 years.
Design, setting, and participants: In this Korean population-based cohort study, 135 575 women aged 40 to 49 years were evaluated from January 1, 2011, to December 31, 2014. After propensity score matching in covariates including age, socioeconomic status, region, Charlson Comorbidity Index, hypertension, diabetes, dyslipidemia, menopause, menopausal hormone therapy, and adnexal surgery before inclusion, 55 539 pairs were included in the hysterectomy and nonhysterectomy groups. Participants were followed up until December 31, 2020. Data analysis was conducted from December 20, 2021, to February 17, 2022.
Main outcomes and measures: The primary outcome was an incidental CVD, a composite of myocardial infarction, coronary artery revascularization, and stroke. The individual components of the primary outcome were also evaluated.
Results: A total of 55 539 pairs were included; median age in the combined groups was 45 (IQR, 42-47) years. During median follow-up periods in the hysterectomy group of 7.9 (IQR, 6.8-8.9) years and nonhysterectomy group of 7.9 (IQR, 6.8-8.8) years, the incidence of CVD was 115 per 100 000 person-years for the hysterectomy group and 96 per 100 000 person-years for the nonhysterectomy group. After adjusting for confounding factors, the hysterectomy group had an increased risk of CVD compared with the nonhysterectomy group (hazard ratio [HR], 1.25; 95% CI, 1.09-1.44). The incidences of myocardial infarction and coronary artery revascularization were comparable between the groups, whereas the risk of stroke was significantly higher in the hysterectomy group (HR, 1.31; 95% CI, 1.12-1.53). Even after excluding women who underwent oophorectomy, the hysterectomy group had higher risks of CVD (HR, 1.24; 95% CI, 1.06-1.44).
Conclusions and relevance: The findings of this cohort study suggest early menopause owing to hysterectomy was associated with increased risks for a composite of CVD, particularly stroke.ope
Effect of Blood Donation on the Donorโs Hemorheological Properties
The circulatory system is closely related to the inter-relationship between the anatomy of the heart and blood vessels, and the fluid dynamic properties of blood. The physical properties of blood, which affect blood flow, are called hemorheologic factors. Hemorheologic factors, such as blood viscosity and erythrocyte aggregation, are influenced mainly by hematocrit. A higher hematocrit level results in an increase in blood viscosity, erythrocyte aggregation, which impedes the circulation itself, and tissue oxygenation. An excess of serum ferritin causes injury to vascular endothelial cells and erythrocytes via oxygen free radicals. In addition, an excess of blood can aggravatee the adverse effects of the hemorheologic parameters and induce atherogenesis, microcirculatory disturbances, and major cardiovascular events. A preventive and therapeutic approach with a phlebotomy or blood donation has been stimulated by the knowledge that blood loss, such as regular donations, is associated with significant decreases in key hemorheologic variables, including blood viscosity, erythrocyte aggregation, hematocrit, and fibrinogen. Major cardiovascular events have been improved in regular blood donors by improving blood flow and microcirculation by decreasing the level of oxidative stress, improving the hemorheologic parameters, and reducing the serum ferritin level. Confirmation of the positive preventive and therapeutic effects of blood donations on cardiovascular disease by a well-designed and well-controlled Cohort study may be good news to patients with cardiovascular disease or at risk of these diseases, as well as patients who require a transfusion.ope
Computational fluid dynamics in cardiovascular disease
Computational fluid dynamics (CFD) is a mechanical engineering field for analyzing fluid flow, heat transfer, and associated phenomena, using computer-based simulation. CFD is a widely adopted methodology for solving complex problems in many modern engineering fields. The merit of CFD is developing new and improved devices and system designs, and optimization is conducted on existing equipment through computational simulations, resulting in enhanced efficiency and lower operating costs. However, in the biomedical field, CFD is still emerging. The main reason why CFD in the biomedical field has lagged behind is the tremendous complexity of human body fluid behavior. Recently, CFD biomedical research is more accessible, because high performance hardware and software are easily available with advances in computer science. All CFD processes contain three main components to provide useful information, such as pre-processing, solving mathematical equations, and post-processing. Initial accurate geometric modeling and boundary conditions are essential to achieve adequate results. Medical imaging, such as ultrasound imaging, computed tomography, and magnetic resonance imaging can be used for modeling, and Doppler ultrasound, pressure wire, and non-invasive pressure measurements are used for flow velocity and pressure as a boundary condition. Many simulations and clinical results have been used to study congenital heart disease, heart failure, ventricle function, aortic disease, and carotid and intra-cranial cerebrovascular diseases. With decreasing hardware costs and rapid computing times, researchers and medical scientists may increasingly use this reliable CFD tool to deliver accurate results. A realistic, multidisciplinary approach is essential to accomplish these tasks. Indefinite collaborations between mechanical engineers and clinical and medical scientists are essential. CFD may be an important methodology to understand the pathophysiology of the development and progression of disease and for establishing and creating treatment modalities in the cardiovascular field.ope
Prevalence of and Risk Factors for Diseases in Korean Americans and Native Koreans Undergoing Health Checkup
BACKGROUND:
Korean Americans constitute the fifth largest subgroup in the Asian American population. Despite their increasing population, research and guidelines regarding their health status assessment and disease screening are lacking. This study aimed to compare the prevalence of diseases in Korean Americans and native Koreans to determine the risk factors and guidelines for disease screening.
METHODS:
Patients who visited the Gangnam Severance Hospital from February 2010 to May 2015 for a health checkup were enrolled in this study. Baseline characteristics, laboratory data, and the organs (stomach, colon, thyroid, brain, prostate, lung, liver, kidney, pancreas, adrenal gland, and heart) of patients were examined. Data regarding patients' dietary patterns were also obtained. Overall, 1,514 Korean Americans (group 1) and 1,514 native Koreans (group 2) were enrolled.
RESULTS:
The following diseases were more prevalent in group 1 than in group 2: reflux esophagitis (12.9% vs. 10%), gastric ulcer (3.0% vs. 5.5%), colorectal polyp (37.7% vs. 28.7%), hemorrhoids (32.2% vs. 29.9%), and benign prostatic hyperplasia (30.2% vs. 14.3%). Although not statistically significant, coronary artery disease has a high prevalence rate of >20% in both groups. Dietary patterns were not significant between the two groups.
CONCLUSION:
This study showed that the prevalence of several diseases in Korean Americans differed from that observed in native Koreans. Therefore, a foundation for setting up new guidelines for disease screening among Korean Americans is established.ope
์ด๋๋ ์ค์ฌ์ ๋งฅ๋๊ด์ผ๋ก ์ธํ ๊ฐํ์ ์ฌ๊ณํญ์ง ํ์์ ๊ฒฝํผ์ ๋๊ด ์ ๊ฑฐ
The totally implantable venous port device is used in patients undergoing chemotherapy. The complications associated with this device include venous thrombosis, infection, catheter fracture, extravasation, and intravascular dislodgement. The incidence of port catheter dislodgement is low. The treatment of choice for port dislocation involves immediate retrieval of the distal migrated part, and percutaneous transcatheter retrieval is regarded as the standard method. A 40-year-old female presented with intermittent palpitation. She was referred from the Department of General Surgery after detection of a fractured and dislocated implantable venous port system into the main pulmonary artery. We successfully retrieved the dislocated fractured device using a -Fr pigtail catheter and snare catheter. We herein report this case with a literature review.ope
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