169 research outputs found

    Effect of Significant Coronary Artery Stenosis on Prognosis in Patients with Vasospastic Angina: A Propensity Score-Matched Analysis

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    Vasospastic angina (VA) is a functional disease of the coronary artery and occurs in an angiographically normal coronary artery. However, it may also occur with coronary artery stenosis. We investigated the effect of coronary artery stenosis on clinical outcomes in VA patients. Study data were obtained from a prospective multicenter registry that included patients who had symptoms of VA. Patients were classified into two groups according to presence of significant coronary artery stenosis. Among 1920 patients with VA, 189 patients were classified in the "significant stenosis" group. The one-year composite clinical events rate was significantly higher in the significant stenosis group than in the "no significant stenosis" group (5.8% vs. 1.4%, respectively; p < 0.001). Additionally, the prevalence of ACS was significantly greater in the "significant stenosis" group (4.8% vs. 0.9%, respectively; p < 0.001). After propensity score matching, the adverse effects of significant stenosis remained. In addition, significant stenosis was independently associated with a 6.67-fold increased risk of ACS in VA patients. In conclusion, significant coronary artery stenosis can increase the adverse clinical outcomes in VA patients at long-term follow-up. Clinicians should manage traditional risk factors associated with atherosclerosis and control vasospasm as well as reduce the burden of atherosclerosis.ope

    Smoking may be more harmful to vasospastic angina patients who take antiplatelet agents due to the interaction: Results of Korean prospective multi-center cohort

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    Background: The interaction between smoking and the use of antiplatelet agents on the prognosis of vasospastic angina (VA) is rarely investigated. Methods: VA-Korea is a nation-wide multi-center registry with prospective design (n = 1812). The primary endpoint was the composite occurrence of acute coronary syndrome (ACS), symptomatic arrhythmia, and cardiac death. Log-rank test and Cox proportional hazard model were for statistical analysis. Also, we conducted interaction analysis in both additive and multiplicative scales between smoking and antiplatelet agents among VA patients. For additive scale interaction, relative excess risk due to interaction (RERI) was calculated and for multiplicative scale interaction, the ratio of hazard ratio (HR) was calculated. All statistical analysis conducted by Stata Ver 16.1. Results: Patients who were smoking and using antiplatelet agents had the highest incidence rate in the primary composite outcome. The incidence rate was 3.49 per 1,000 person-month (95% CI: 2.30-5.30, log-rank test for primary outcome p = 0.017) and HR of smoking and using antiplatelet agents was 1.66 (95%CI: 0.98-2.81). The adjusted RERI of smoking and using antiplatelet agents was 1.10 (p = 0.009), and the adjusted ratio of HR of smoking and using antiplatelet agents was 3.32 (p = 0.019). The current study observed the interaction between smoking and using antiplatelet agents in both additive and multiplicative scales. Conclusions: Smoking was associated with higher rates of unfavorable clinical outcomes among VA patients taking antiplatelet agents. This suggested that VA patients, especially those using antiplatelet agents should quit smoking.ope

    Differential progression of coronary atherosclerosis according to plaque composition: a cluster analysis of PARADIGM registry data

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    Patient-specific phenotyping of coronary atherosclerosis would facilitate personalized risk assessment and preventive treatment. We explored whether unsupervised cluster analysis can categorize patients with coronary atherosclerosis according to their plaque composition, and determined how these differing plaque composition profiles impact plaque progression. Patients with coronary atherosclerotic plaque (n = 947; median age, 62 years; 59% male) were enrolled from a prospective multi-national registry of consecutive patients who underwent serial coronary computed tomography angiography (median inter-scan duration, 3.3 years). K-means clustering applied to the percent volume of each plaque component and identified 4 clusters of patients with distinct plaque composition. Cluster 1 (n = 52), which comprised mainly fibro-fatty plaque with a significant necrotic core (median, 55.7% and 16.0% of the total plaque volume, respectively), showed the least total plaque volume (PV) progression (+ 23.3 mm3), with necrotic core and fibro-fatty PV regression (- 5.7 mm3 and - 5.6 mm3, respectively). Cluster 2 (n = 219), which contained largely fibro-fatty (39.2%) and fibrous plaque (46.8%), showed fibro-fatty PV regression (- 2.4 mm3). Cluster 3 (n = 376), which comprised mostly fibrous (62.7%) and calcified plaque (23.6%), showed increasingly prominent calcified PV progression (+ 21.4 mm3). Cluster 4 (n = 300), which comprised mostly calcified plaque (58.7%), demonstrated the greatest total PV increase (+ 50.7mm3), predominantly increasing in calcified PV (+ 35.9 mm3). Multivariable analysis showed higher risk for plaque progression in Clusters 3 and 4, and higher risk for adverse cardiac events in Clusters 2, 3, and 4 compared to that in Cluster 1. Unsupervised clustering algorithms may uniquely characterize patient phenotypes with varied atherosclerotic plaque profiles, yielding distinct patterns of progressive disease and outcome.ope

    ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ ์‚ฌ๋ก€๋ฅผ ์ค‘์‹ฌ์œผ๋กœ

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    ํ•™์œ„๋…ผ๋ฌธ(์„์‚ฌ) -- ์„œ์šธ๋Œ€ํ•™๊ต๋Œ€ํ•™์› : ์‚ฌํšŒ๊ณผํ•™๋Œ€ํ•™ ์‚ฌํšŒ๋ณต์ง€ํ•™๊ณผ, 2023. 2. ๊น€์ˆ˜์˜.The problem of non-standard workers is a major social problem. The institutions that have been designed around full-time employment relationships are fissured and do not cover non-standard workers, and the labor movement represented by trade unions is also facing a crisis around the world. With the increase in the number of non-standard workers who are not double-inclusive in both institutions and trade unions, the problem of non-standard workers has become one of the social problems that need urgent resolution in modern society. This work focuses on the fact that the worker center, which has recently made significant achievements in representing the interests of non-standard workers, is an example of the institutionalization of labor movements. This study attempts to shed light on both the subversive aspects of the worker center despite institutionalization, and the subsequent limitations that also resulted for the worker center. There are two research questions. First, this study attempts to clarify whether worker centers seek resistance after institutionalization and what their resistance patterns in the event that they resist. Next, this study also tries to clarify whether worker centers pursue organizing after institutionalization, and in what ways. In order to answer the above research question, this study reviewed literature data on the worker center, and collected key data through in-depth interviews with 20 worker center leaders and practitioners. This study analyzed the resistance of the worker center through three aspects: 'captured resistance', 'strategic resistance', and 'infrapolitics'. This study examined the organizing of non-standard workers in the worker center into three processes: 'organizing method', 'organizing process', and local collective bargaining after organizing'. This study recognizes the aim of worker centers, which was to achieve an improvement in non-standard employment and labor conditions, whilst protecting non-regular workers' human rights and expanding social welfare. However, this study revealed the existence of institutional and structural restrictions such as 'public-private partnership, 'formalizing local governments' non-standard workers organizing policy', and 'converting trade unions activities to meet the non-standard labor environment to achieve worker centers aims. This study has the following theoretical implications. First, the resistance and organizing aspects of the worker center identified in this study are significant in that it highlighted that social movement organizations can be subversive even after institutionalization, which previous studies have left as areas of 'possibility'. Second, the invisible resistance and organizing of worker centers tracked by this study are significant in that it revealed worker centers can be effective actors in the collective interest representation of non-standard workers, such as organizing workers or improving institutions. Third, this study is meaningful in that researchers who study social policy changes focusing on equality and democracy can expand their understanding of social policy continuity and adapt by paying more attention to social policy itself as well as actors including social movements. Simultaneously, this study is also an invitation to policymakers, worker center activists, trade union activists. First, it was intended to shed light on the effectiveness of a network approach for policymakers to work together with various actors, including civil society and the market, to define problems and seek solutions beyond the design and execution of the government's one-sided approach. Second, for worker center activists, this study was intended to serve as a starting point in seeking greater change, by connecting experiences from different regions as 'languages', to facilitate a discussion. Third, for trade union activists, the study was intended to highlight one of the ways in which trade unions can expand resources and capabilities of the labor movement. Namely, implementing strategic collaboration within the worker centers.๋น„์ •๊ทœ์ง ๋ฌธ์ œ๋Š” ์ฃผ์š”ํ•œ ์‚ฌํšŒ๋ฌธ์ œ๋‹ค. ์ •๊ทœ์ง ๊ณ ์šฉ๊ด€๊ณ„ ์ค‘์‹ฌ์œผ๋กœ ์„ค๊ณ„๋˜์–ด ์™”๋˜ ์ œ๋„๋“ค์€ ๊ณ ์šฉ๊ด€๊ณ„๊ฐ€ ๋‹ค๋ณ€ํ™”๋˜๋ฉฐ ๋น„์ •๊ทœ์ง ๋…ธ๋™์ž๋“ค์„ ์˜ค๋กฏ์ด ํฌ๊ด„ํ•˜์ง€ ๋ชปํ•˜๋ฉฐ, ๋…ธ๋™์กฐํ•ฉ์œผ๋กœ ๋Œ€ํ‘œ๋˜๋Š” ๋…ธ๋™์šด๋™๋„ ์ „ ์„ธ๊ณ„์ ์œผ๋กœ ์œ„๊ธฐ์— ์ง๋ฉดํ•ด์žˆ๋‹ค. ์ œ๋„์™€ ๋…ธ๋™์กฐํ•ฉ ๋ชจ๋‘์— ์žˆ์–ด ์ด์ค‘์ ์œผ๋กœ ํฌ๊ด„๋˜์ง€ ์•Š๋Š” ๋น„์ •๊ทœ์ง ๋…ธ๋™์ž๋“ค์ด ์ฆ๊ฐ€ํ•จ์— ๋”ฐ๋ผ, ๋น„์ •๊ทœ์ง ๋ฌธ์ œ๋Š” ํ˜„๋Œ€ ์‚ฌํšŒ์—์„œ ์‹œ๊ธ‰ํ•œ ํ•ด๊ฒฐ์ด ํ•„์š”ํ•œ ์‚ฌํšŒ๋ฌธ์ œ ์ค‘ ํ•˜๋‚˜๊ฐ€ ๋˜์—ˆ๋‹ค. ๋ณธ ์ž‘์—…์€ ์ตœ๊ทผ ๋น„์ •๊ทœ์ง ๋…ธ๋™์ž ์ดํ•ด๋Œ€๋ณ€์— ์žˆ์–ด ์œ ์˜๋ฏธํ•œ ์„ฑ๊ณผ๋“ค์„ ๊ฑฐ๋‘๊ณ  ์žˆ๋Š” ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ๊ฐ€ ๋…ธ๋™์šด๋™์ด ์ œ๋„ํ™”๋œ ์‚ฌ๋ก€๋ผ๋Š” ์ ์— ์ฃผ๋ชฉํ•˜๊ณ , ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ๋“ค์ด ์ œ๋„ํ™” ์ดํ›„ ๊ฒช๋Š” ์ œ์•ฝ๊ณผ, ์ œ๋„ํ™”์—๋„ ๋ถˆ๊ตฌํ•˜๊ณ  ์šด๋™์„ฑ์„ ์œ ์ง€ํ•˜๊ณ  ์žˆ๋Š” ์ง€์ ๋“ค์„ ์ž…์ฒด์ ์œผ๋กœ ์กฐ๋ช…ํ•˜๋ ค๋Š” ์‹œ๋„์ด๋‹ค. ์—ฐ๊ตฌ ์งˆ๋ฌธ์€ ๋‘ ๊ฐ€์ง€๋‹ค. ๋จผ์ €, ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ๊ฐ€ ์ œ๋„ํ™” ์ดํ›„ ์ €ํ•ญ์„ ์ถ”๊ตฌํ•˜๋Š”์ง€, ์ถ”๊ตฌํ•œ๋‹ค๋ฉด ์ด๋“ค์˜ ์ €ํ•ญ ์–‘์ƒ์€ ์–ด๋– ํ•œ ๋ชจ์Šต์œผ๋กœ ๋‚˜ํƒ€๋‚˜๋Š”์ง€ ๋ฐํžˆ๊ณ ์ž ํ–ˆ๋‹ค. ๋‹ค์Œ์œผ๋กœ, ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ๊ฐ€ ์ œ๋„ํ™” ์ดํ›„ ์กฐ์งํ™”๋ฅผ ์ถ”๊ตฌํ•˜๋Š”์ง€, ์ถ”๊ตฌํ•œ๋‹ค๋ฉด ์ด๋“ค์˜ ์กฐ์งํ™”๋Š” ์–ด๋– ํ•œ ์–‘ํƒœ๋“ค๋กœ ์ด๋ค„์ง€๊ณ  ์žˆ๋Š”์ง€ ๋ฐํžˆ๊ณ ์ž ํ–ˆ๋‹ค. ์œ„ ์—ฐ๊ตฌ ์งˆ๋ฌธ์— ๋‹ตํ•˜๊ธฐ ์œ„ํ•ด, ๋ณธ ์—ฐ๊ตฌ๋Š” ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ์— ๊ด€ํ•œ ๋ฌธํ—Œ ์ž๋ฃŒ๋“ค์„ ๊ฒ€ํ† ํ•˜๊ณ , ๋…ธ๋™์„ผํ„ฐ ์„ผํ„ฐ์žฅ ๋ฐ ์‹ค๋ฌด์ž 20๋ช…์„ ์‹ฌ์ธต ๋ฉด์ ‘ํ•˜์—ฌ ํ•ต์‹ฌ ์ž๋ฃŒ๋“ค์„ ์ˆ˜์ง‘ํ•˜์˜€๋‹ค. ๋ณธ ์—ฐ๊ตฌ๋Š” ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ์˜ ์ €ํ•ญ ์–‘์ƒ์„ ํฌํš๋œ ์ €ํ•ญ, ์ „๋žต์  ์ €ํ•ญ, ํ•˜๋ถ€์ •์น˜ ์„ธ ๊ฐ€์ง€ ์–‘์ƒ์œผ๋กœ ๋‚˜๋ˆ„์–ด ๋ถ„์„ํ•˜๊ณ , ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ์˜ ๋น„์ •๊ทœ์ง ๋…ธ๋™์ž ์กฐ์งํ™” ์ถ”์ง„ ์–‘์ƒ์„ ์กฐ์งํ™” ๋ฐฉ๋ฒ•, ์กฐ์งํ™” ๊ณผ์ •, ์กฐ์งํ™” ๊ทธ ์ดํ›„, ๊ต์„ญ์˜ ์žฅ ์„ธ ๊ฐ€์ง€ ๊ณผ์ •์œผ๋กœ ๋‚˜๋ˆ„์–ด ์‚ดํŽด๋ณด์•˜๋‹ค. ์—ฐ๊ตฌ๊ฒฐ๊ณผ๋ฅผ ๋ฐ”ํƒ•์œผ๋กœ, ๋ณธ ์—ฐ๊ตฌ๋Š” ๋…ธ๋™์„ผํ„ฐ ์šด๋™์ด ์ œ๋„ํ™”๋ฅผ ํ†ตํ•ด ๋ณธ๋”” ์ด๋ฃจ๋ ค๊ณ  ํ–ˆ๋˜ ๋ชฉํ‘œ์ธ ๋น„์ •๊ทœ์ง ๊ณ ์šฉโ€ง๋…ธ๋™ ์กฐ๊ฑด ๊ฐœ์„ , ๋น„์ •๊ทœ์ง ๋…ธ๋™์ธ๊ถŒ๋ณดํ˜ธ์™€ ์ดํ•ด๋Œ€๋ณ€, ์‚ฌํšŒ๋ณต์ง€ ํ™•์ถฉ ๋“ฑ์„ ๋‹ฌ์„ฑํ•˜๊ธฐ์—๋Š” ๋ฏผ๊ฐ„์œ„ํƒ ํ˜•ํƒœ, ์ง€๋ฐฉ์ •๋ถ€์˜ ๋น„์ •๊ทœ์ง ๋…ธ๋™์ž ์กฐ์งํ™” ์‚ฌ์—… ๊ณต์‹ํ™” ๋„๋ชจ, ๋น„์ •๊ทœ์ง ๋…ธ๋™์ž์˜ ๋…ธ๋™ํ™˜๊ฒฝ์— ๋ถ€ํ•ฉํ•˜๋„๋ก ๊ธฐ์กด ๋…ธ๋™์กฐํ•ฉ์˜ ํ™œ๋™๋ฐฉ์‹ ๋ณ€ํ™˜ ์ถ”๋™, ์กฐ์งํ™” ์ดํ›„ ๋…ธ๋™ํ™˜๊ฒฝ ๊ฐœ์„ ์„ ์ด๋Œ์–ด ๋‚ผ ์ˆ˜ ์žˆ๋Š” ์ง€์—ญ์  ๊ต์„ญ์˜ ์žฅ ๋งˆ๋ จ ๋“ฑ ์—ฌ๋Ÿฌ ์ œ๋„์ โ€ง๊ตฌ์กฐ์  ๋‚œ๊ด€์ด ์—„์กดํ•˜๊ณ  ์žˆ์Œ์„ ๋“œ๋Ÿฌ๋‚ด๊ณ ์ž ํ–ˆ๋‹ค. ๋ณธ ์—ฐ๊ตฌ๋Š” ๋‹ค์Œ๊ณผ ๊ฐ™์€ ์ด๋ก ์  ํ•จ์˜๋ฅผ ๊ฐ–๋Š”๋‹ค. ์ฒซ์งธ, ๋ณธ ์—ฐ๊ตฌ๊ฐ€ ํฌ์ฐฉํ•œ ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ์˜ ์ €ํ•ญ๊ณผ ์กฐ์งํ™” ์–‘์ƒ๋“ค์€ ์„ ํ–‰์—ฐ๊ตฌ๋“ค์ด ๊ฐ€๋Šฅ์„ฑ์˜ ์˜์—ญ์œผ๋กœ ๋‚จ๊ฒจ๋‘์—ˆ๋˜, ์‚ฌํšŒ์šด๋™์กฐ์ง์ด ์ œ๋„์™€์˜ ์ ‘ํ•ฉ ์ดํ›„์—๋„ ์šด๋™์„ฑ์„ ๊ฒฌ์ง€ํ•  ์ˆ˜ ์žˆ๋Š” ์ง€์ ๋“ค์„ ์‹ค์ฆํ•˜๊ณ , ์‚ฌํšŒ์šด๋™์กฐ์ง์˜ ์ œ๋„ํ™”๊ฐ€ ๋‹จ์ˆœํ•œ ํฌ์„ญ์ด๋‚˜ ์˜จ๊ฑดํ™”๋กœ ๊ท€๊ฒฐ๋œ๋‹ค๊ณ  ์ ‘๊ทผํ•˜๋Š” ์ผ๋ จ์˜ ๋น„ํŒ๋“ค์ด ๋‚ก์€ ๋ฌธ์ œ์ œ๊ธฐ์ผ ์ˆ˜ ์žˆ์Œ์„ ์กฐ๋ช…ํ–ˆ๋‹ค๋Š” ์ ์—์„œ ์˜์˜๋ฅผ ๊ฐ€์ง„๋‹ค. ๋‘˜์งธ, ๋ณธ ์—ฐ๊ตฌ๊ฐ€ ์ถ”์ ํ•œ ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ์˜ ๋น„๊ฐ€์‹œ์  ์ €ํ•ญ๊ณผ ์กฐ์งํ™” ์–‘์ƒ์€, ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ๊ฐ€ ์ž„๊ธˆ์ฒด๋ถˆ์ด๋‚˜ ๋ถ€๋‹นํ•ด๊ณ  ์‹œ์ • ๋“ฑ ๊ฐœ์ธ์  ์ดํ•ด๋Œ€๋ณ€๋ฟ๋งŒ ์•„๋‹ˆ๋ผ ๋…ธ๋™์ž ์กฐ์งํ™”๋‚˜ ์ œ๋„ ๊ฐœ์„  ๋“ฑ ๋น„์ •๊ทœ์ง ๋…ธ๋™์ž์˜ ์ง‘๋‹จ์  ์ดํ•ด๋Œ€๋ณ€์— ์žˆ์–ด์„œ๋„ ์œ ํšจํ•œ ํ–‰์œ„์ž๊ฐ€ ๋  ์ˆ˜ ์žˆ์Œ์„ ๋“œ๋Ÿฌ๋ƒˆ๋‹ค๋Š” ์ ์—์„œ ์˜์˜๋ฅผ ์ง€๋‹Œ๋‹ค. ์…‹์งธ, ๋ณธ ์—ฐ๊ตฌ๋Š” ํ‰๋“ฑ ๋ฐ ๋ฏผ์ฃผ์ฃผ์˜์— ์ดˆ์ ์„ ๋‘” ์‚ฌํšŒ์ •์ฑ… ๋ณ€ํ™”๋ฅผ ์—ฐ๊ตฌํ•˜๋Š” ์—ฐ๊ตฌ์ž๋“ค์ด ์‚ฌํšŒ์ •์ฑ… ๊ทธ ์ž์ฒด๋ฟ๋งŒ ์•„๋‹ˆ๋ผ ์‚ฌํšŒ์šด๋™์„ ๋น„๋กฏํ•œ ํ–‰์œ„์ž์— ๋ณด๋‹ค ์ฃผ๋ชฉํ•จ์œผ๋กœ์จ ์‚ฌํšŒ์ •์ฑ…์˜ ์ง€์†๊ณผ ๋ณ€ํ™”์— ๋Œ€ํ•œ ์ดํ•ด์˜ ํญ์„ ํ™•์žฅ์‹œํ‚ฌ ์ˆ˜ ์žˆ์Œ์„ ๋“œ๋Ÿฌ๋ƒˆ๋‹ค๋Š” ์ ์—์„œ ์˜์˜๋ฅผ ์ง€๋‹Œ๋‹ค. ๋ณธ ์—ฐ๊ตฌ๋Š” ์‚ฌํšŒ์ •์ฑ… ์ž…์•ˆ์ž, ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ ์ƒ๊ทผ์ž, ๋…ธ๋™์กฐํ•ฉ ํ™œ๋™๊ฐ€, ์„ธ ์ฒญ์ค‘์—๊ฒŒ ๋ง์„ ๊ฑธ๋ฉฐ ๋ณด๋‚ด๋Š” ์ดˆ๋Œ€์žฅ์ด๊ธฐ๋„ ํ•˜๋‹ค. ์ฒซ์งธ, ์‚ฌํšŒ์ •์ฑ… ์ž…์•ˆ์ž์—๊ฒŒ๋Š” ์ •๋ถ€ ์ผ๋ณ€๋„์˜ ์ œ๋„ ์„ค๊ณ„ ๋ฐ ์ง‘ํ–‰์„ ๋„˜์–ด ์‹œ๋ฏผ์‚ฌํšŒ์™€ ์‹œ์žฅ ๋“ฑ ๋‹ค์–‘ํ•œ ํ–‰์œ„์ž๋“ค๊ณผ ์ƒํ˜ธ ํ˜‘๋ ฅํ•˜๋ฉฐ ๋ฌธ์ œ๋ฅผ ๊ทœ์ •ํ•˜๊ณ  ํ•ด๊ฒฐ์ฑ…์„ ๋ชจ์ƒ‰ํ•˜๋Š” ๋„คํŠธ์›Œํฌ์  ์ ‘๊ทผ์ด ์œ ํšจํ•  ์ˆ˜ ์žˆ์Œ์„ ์กฐ๋ช…ํ•˜๊ณ ์ž ํ–ˆ๋‹ค. ๋‘˜์งธ, ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ ์ƒ๊ทผ์ž์—๊ฒŒ๋Š” ์„œ๋กœ ๋‹ค๋ฅธ ์ง€์—ญ์—์„œ ๊ฒช๋Š” ๊ฒฝํ—˜๋“ค์„ ์–ธ์–ด๋กœ์„œ ์ด์Œ์œผ๋กœ์จ ๋” ๋‚˜์€ ๋ณ€ํ™”๋ฅผ ๋ชจ์ƒ‰ํ•˜๋Š” ๋ฐ ์ถœ๋ฐœ์ ์ด ๋˜๊ณ ์ž ํ–ˆ๋‹ค. ์…‹์งธ, ๋…ธ๋™์กฐํ•ฉ ํ™œ๋™๊ฐ€๋“ค์—๊ฒŒ๋Š” ๋…ธ๋™์šด๋™์˜ ์ž์›๊ณผ ์—ญ๋Ÿ‰์„ ํ™•์ถฉํ•  ์ˆ˜ ์žˆ๋Š” ๋ฐฉ์•ˆ ์ค‘ ํ•˜๋‚˜๊ฐ€ ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ์™€์˜ ์ „๋žต์  ํ˜‘์—…์ด ๋  ์ˆ˜ ์žˆ์Œ์„ ๋“œ๋Ÿฌ๋‚ด๊ณ ์ž ํ–ˆ๋‹ค.์ œ 1 ์žฅ ๋“ค์–ด๊ฐ€๋ฉฐ 1 ์ œ 2 ์žฅ ๋ฐฐ๊ฒฝ: ๋…ธ๋™์„ผํ„ฐ ์šด๋™์˜ ๋“ฑ์žฅ ๋ฐ ํŠน์ง• 6 ์ œ 1 ์ ˆ ํ•œ๊ตญ์˜ ๋น„์ •๊ทœ์ง๊ณผ ๋น„์ •๊ทœ ๋…ธ๋™์šด๋™ 6 1.1. ํ•œ๊ตญ์˜ ๋น„์ •๊ทœ์ง 6 1.2. ํ–‰์œ„์ž๋กœ์„œ ๋น„์ •๊ทœ ๋…ธ๋™์šด๋™ 10 ์ œ 2 ์ ˆ ๋…ธ๋™์„ผํ„ฐ ์šด๋™์˜ ๋ฐœ์ „ ๊ณผ์ • 12 2.1. ๋…ธ๋™์„ผํ„ฐ ์šด๋™์˜ ๋“ฑ์žฅ 12 2.2. ๋…ธ๋™์šด๋™์˜ ์ œ๋„ํ™”: ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ์˜ ์„ฑ์žฅ 15 ์ œ 3 ์ ˆ ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ ํ˜„ํ™ฉ ๋ฐ ํŠน์ง• 20 3.1. ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ ํ˜„ํ™ฉ 20 3.2. ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ ์ฃผ์š” ์‚ฌ์—… 22 3.3. ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ ์ฃผ์š” ํŠน์ง• 26 ์ œ 3 ์žฅ ์ด๋ก ์  ๋ถ„์„ํ‹€ 29 ์ œ 1 ์ ˆ ์‚ฌํšŒ์šด๋™๊ณผ ์‚ฌํšŒ์šด๋™์กฐ์ง์˜ ์ œ๋„ํ™” 29 1.1. ์‚ฌํšŒ์šด๋™์˜ ์ •์ฒด์„ฑ๊ณผ ์—ญํ•  29 1.2. ์‚ฌํšŒ์šด๋™์กฐ์ง์˜ ์ œ๋„ํ™”์˜ ์ •์˜ 32 ์ œ 2 ์ ˆ ์‚ฌํšŒ์šด๋™์กฐ์ง์˜ ์ œ๋„ํ™”๋ฅผ ๋ฐ”๋ผ๋ณด๋Š” ์ƒ์ดํ•œ ์ด๋ก ์  ๊ด€์  34 2.1. ์‚ฌํšŒ์šด๋™์กฐ์ง์˜ ์ œ๋„ํ™”๋ฅผ ๋ฐ”๋ผ๋ณด๋Š” ์ด๋ก ์  ๊ด€์  โ‘  ํฌ์„ญ 34 2.2. ์‚ฌํšŒ์šด๋™์กฐ์ง์˜ ์ œ๋„ํ™”๋ฅผ ๋ฐ”๋ผ๋ณด๋Š” ์ด๋ก ์  ๊ด€์  โ‘ก ์šด๋™์„ฑ ์œ ์ง€ 36 ์ œ 4 ์žฅ ์—ฐ๊ตฌ๋ฐฉ๋ฒ• 40 ์ œ 1 ์ ˆ ์—ฐ๊ตฌ์ž์˜ ์œ„์น˜ 40 ์ œ 2 ์ ˆ ์ž๋ฃŒ์ˆ˜์ง‘ ๋ฐ ๋ถ„์„๋ฐฉ๋ฒ• 41 2.1. ์ž๋ฃŒ์ˆ˜์ง‘๋ฐฉ๋ฒ• 41 2.2. ์ž๋ฃŒ๋ถ„์„๋ฐฉ๋ฒ• 46 ์ œ 3 ์ ˆ ์—ฐ๊ตฌ์˜ ์œค๋ฆฌ์  ๊ณ ๋ ค์‚ฌํ•ญ: ์‚ฌ์ „ ๋™์˜์™€ ๊ธฐ๋ฐ€ ์œ ์ง€ 47 ์ œ 5 ์žฅ ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ์˜ ์ €ํ•ญ ์–‘์ƒ 49 ์ œ 1 ์ ˆ ํฌํš๋œ ์ €ํ•ญ 49 1.1. ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ ์ˆ˜ํƒ ๊ณ„๊ธฐ: ๊ฐ•์š”๋œ ์„ ํƒ๊ณผ ๋Šฅ๋™์  ์„ ํƒ ์‚ฌ์ด 49 1.2. ๋ฏผ๊ด€ํ˜‘๋ ฅ์œผ๋กœ ๋‚˜์•„๊ฐ€์ง€ ๋ชปํ•œ ๋ฏผ๊ฐ„์œ„ํƒ: ๋ฏผ๊ฐ„์œ„ํƒํ˜•ํƒœ์— ๋”ฐ๋ฅธ ์ œ์•ฝ 52 ์ œ 2 ์ ˆ ์ „๋žต์  ์ €ํ•ญ 60 2.1. ๋ฏผ๊ฐ„์œ„ํƒํ˜•ํƒœ๋ฅผ ์—ญ์ด์šฉํ•˜๊ธฐ 60 2.2. ๊ด€(ๅฎ˜)์˜ ๊ด€์Šต์— ๋„์ „ํ•˜๋Š” ์‹ค์ฒœ๋“ค 62 โ‘  ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ์˜ ์ •์ฒด์„ฑ ํˆฌ์Ÿ 62 โ‘ก ์ง€๋ฐฉ์˜ํšŒ๋ฅผ ํ†ตํ•œ ์šฐํšŒ ์ €ํ•ญ 65 โ‘ข ์ง€์—ญ์‚ฌํšŒ ๋„คํŠธ์›Œํฌ๋ฅผ ํ†ตํ•œ ์šฐํšŒ ์ €ํ•ญ 67 ์ œ 3 ์ ˆ ํ•˜๋ถ€์ •์น˜ 69 3.1. ์ €ํ•ญ์˜ ํ† ๋Œ€ ์กฐ์„ฑ 69 โ‘  ์ง€์—ญ๋…ธ๋™๋‹จ์ฒด ๋„คํŠธ์›Œํฌ ๊ตฌ์ถ• 69 โ‘ก ์ง€์—ญ์‹œ๋ฏผ์‚ฌํšŒ๋‹จ์ฒด ๋„คํŠธ์›Œํฌ ๊ตฌ์ถ• 72 โ‘ข ์ฒญ์†Œ๋…„ ๋…ธ๋™์ธ๊ถŒ๊ต์œก ๊ฐ•์‚ฌ๋‹จ ์–‘์„ฑ 75 3.2. ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ์˜ ๋„คํŠธ์›Œํฌ ๊ตฌ์ถ•๊ณผ ์ €ํ•ญ์˜ ์ˆœํ™˜๊ณ ๋ฆฌ 79 ์ œ 6 ์žฅ ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ์˜ ์กฐ์งํ™” ์–‘์ƒ 81 ์ œ 1 ์ ˆ ์กฐ์งํ™” ๋ฐฉ๋ฒ• 81 1.1. ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ ์ฃผ๋„ ์กฐ์งํ™”์˜ ํ•œ๊ณ„ 81 โ‘  ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ ์ธก๋ฉด์˜ ํ•œ๊ณ„ 81 โ‘ก ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ์™€ ๋…ธ๋™์กฐํ•ฉ ๊ฐ„ ํ˜‘์—…์˜ ์–ด๋ ค์›€ 84 1.2. ์ˆ˜๋ฉด ์•„๋ž˜ ์กฐ์งํ™” ๋ฐฉ๋ฒ• 87 โ‘  ์‹คํƒœ์กฐ์‚ฌ๋ฅผ ํ†ตํ•œ ์กฐ์งํ™” ๋ฐฉ๋ฒ• 87 โ‘ก ์ž์กฐ๋ชจ์ž„์„ ํ†ตํ•œ ์กฐ์งํ™” ๋ฐฉ๋ฒ• 90 โ‘ข ์‚ฌ์—…์ฃผ๋ฅผ ํ†ตํ•œ ์กฐ์งํ™” ๋ฐฉ๋ฒ• 93 1.3. ์กฐ์งํ™”๋ฅผ ์ˆ˜๋ฉด ์œ„๋กœ 95 โ‘  ์กฐ์งํ™” ์‚ฌ์—… ๊ณต์‹ํ™” ๋ฐ ์˜ˆ์‚ฐ ๋ฐฐ์ • 95 โ‘ก ์กฐ์งํ™” ์‚ฌ์—…์˜ ๊ณต์‹ํ™”์— ๋”ฐ๋ฅธ ์—ญ์„ค? 98 ์ œ 2 ์ ˆ ์กฐ์งํ™” ๊ณผ์ • 103 2.1. ์•„ํŒŒํŠธ ๊ฒฝ๋น„๋…ธ๋™์ž ์กฐ์งํ™” ๊ณผ์ • 103 2.2. ์–ด๋Š ํ˜•ํƒœ๋กœ ์กฐ์งํ™”ํ•  ๊ฒƒ์ธ๊ฐ€? 106 โ‘  ๋…ธ๋™์กฐํ•ฉ ํ˜•ํƒœ๋กœ ์กฐ์งํ™”ํ•  ๊ฒƒ์ธ๊ฐ€? ํ˜‘ํšŒ ํ˜•ํƒœ๋กœ ์กฐ์งํ™”ํ•  ๊ฒƒ์ธ๊ฐ€? 106 โ‘ก ๋…ธ๋™์กฐํ•ฉ ํ˜•ํƒœ๋กœ ์กฐ์งํ™”ํ•˜๊ธฐ 110 โ‘ข ํ˜‘ํšŒ ๋˜๋Š” ์„ผํ„ฐ ๋‚ด ์ž์กฐ๋ชจ์ž„์œผ๋กœ ์กฐ์งํ™”ํ•˜๊ธฐ 116 2.3. ๊ฒฝ๋น„๋…ธ๋™์ž ์กฐ์งํ™” ๊ณผ์ •์— ๋Œ€ํ•œ ๋‚ด๋ถ€ ์„ฑ์ฐฐ 118 ์ œ 3 ์ ˆ ์กฐ์งํ™” ๊ทธ ์ดํ›„, ๊ต์„ญ์˜ ์žฅ 122 3.1. ์‚ฌ์—…์žฅ ๊ต์„ญ์„ ๋„˜์–ด์„  ์ง€์—ญ๋ณ„ ๊ต์„ญ์˜ ์žฅ: ์‹œ๋„ ๊ทธ๋ฆฌ๊ณ  ๊ต์ฐฉ 122 3.2. ์กฐ์งํ™”์— ๊ธฐ๋ฐ˜ํ•˜์ง€ ๋ชปํ•œ ์ดํ•ด๋Œ€๋ณ€์˜ ํ•œ๊ณ„: ์ „๊ตญ๋‹จ์œ„ ์ƒ์ƒํ˜‘์•ฝ ์ฒด๊ฒฐ๊ณผ์ • 127 3.3. ์‹ค๋งˆ๋ฆฌ?: ์ง€์—ญ๊ธฐ๋ฐ˜ ๋ฏผ๊ด€ํ˜‘๋ ฅ ๋…ธ๋™์„ผํ„ฐ์˜ ์‹คํ—˜๋“ค 134 ์ œ 7 ์žฅ ๋‚˜๊ฐ€๋ฉฐ 137 ์ œ 1 ์ ˆ ์—ฐ๊ตฌ๊ฒฐ๊ณผ ์š”์•ฝ 137 ์ œ 2 ์ ˆ ์—ฐ๊ตฌ์˜ ํ•จ์˜ 142 2.1. ์—ฐ๊ตฌ์˜ ์ด๋ก ์  ํ•จ์˜ 142 2.2. ์—ฐ๊ตฌ์˜ ์ •์ฑ…์ โ€ง์‹ค์ฒœ์  ํ•จ์˜ 145 ์ œ 3 ์ ˆ ์—ฐ๊ตฌ์˜ ํ•œ๊ณ„ 148 ์ฐธ ๊ณ  ๋ฌธ ํ—Œ 149 Abstract 164์„

    Nitrates vs. Other Types of Vasodilators and Clinical Outcomes in Patients with Vasospastic Angina: A Propensity Score-Matched Analysis

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    Although vasodilators are widely used in patients with vasospastic angina (VA), few studies have compared the long-term prognostic effects of different types of vasodilators. We investigated the long-term effects of vasodilators on clinical outcomes in VA patients according to the type of vasodilator used. Study data were obtained from a prospective multicenter registry that included patients who had symptoms suggestive of VA. Patients were classified into two groups according to use of nitrates (n = 239) or other vasodilators (n = 809) at discharge. The composite clinical events rate, including acute coronary syndrome (ACS), cardiac death, new-onset arrhythmia (including ventricular tachycardia and ventricular fibrillation), and atrioventricular block, was significantly higher in the nitrates group (5.3% vs. 2.2%, p = 0.026) during one year of follow-up. Specifically, the prevalence of ACS was significantly more frequent in the nitrates group (4.3% vs. 1.5%, p = 0.024). After propensity score matching, the adverse effects of nitrates remained. In addition, the use of nitrates at discharge was independently associated with a 2.69-fold increased risk of ACS in VA patients. In conclusion, using nitrates as a vasodilator at discharge can increase the adverse clinical outcomes in VA patients at one year of follow-up. Clinicians need to be aware of the prognostic value and consider prescribing other vasodilators.ope

    Association of Early Hysterectomy With Risk of Cardiovascular Disease in Korean Women

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    Importance: Women who undergo surgical hysterectomy before natural menopause may have an earlier increase in hematocrit and storage iron levels than those who continue menstruation, thereby increasing the risk of cardiovascular disease (CVD) at ages younger than usually seen. Examining this issue may provide important implications for women's cardiovascular health to both physicians and patients. Objective: To evaluate the association of hysterectomy with the risk of incident CVD among women before age 50 years. Design, setting, and participants: In this Korean population-based cohort study, 135 575 women aged 40 to 49 years were evaluated from January 1, 2011, to December 31, 2014. After propensity score matching in covariates including age, socioeconomic status, region, Charlson Comorbidity Index, hypertension, diabetes, dyslipidemia, menopause, menopausal hormone therapy, and adnexal surgery before inclusion, 55 539 pairs were included in the hysterectomy and nonhysterectomy groups. Participants were followed up until December 31, 2020. Data analysis was conducted from December 20, 2021, to February 17, 2022. Main outcomes and measures: The primary outcome was an incidental CVD, a composite of myocardial infarction, coronary artery revascularization, and stroke. The individual components of the primary outcome were also evaluated. Results: A total of 55 539 pairs were included; median age in the combined groups was 45 (IQR, 42-47) years. During median follow-up periods in the hysterectomy group of 7.9 (IQR, 6.8-8.9) years and nonhysterectomy group of 7.9 (IQR, 6.8-8.8) years, the incidence of CVD was 115 per 100 000 person-years for the hysterectomy group and 96 per 100 000 person-years for the nonhysterectomy group. After adjusting for confounding factors, the hysterectomy group had an increased risk of CVD compared with the nonhysterectomy group (hazard ratio [HR], 1.25; 95% CI, 1.09-1.44). The incidences of myocardial infarction and coronary artery revascularization were comparable between the groups, whereas the risk of stroke was significantly higher in the hysterectomy group (HR, 1.31; 95% CI, 1.12-1.53). Even after excluding women who underwent oophorectomy, the hysterectomy group had higher risks of CVD (HR, 1.24; 95% CI, 1.06-1.44). Conclusions and relevance: The findings of this cohort study suggest early menopause owing to hysterectomy was associated with increased risks for a composite of CVD, particularly stroke.ope

    Effect of Blood Donation on the Donorโ€™s Hemorheological Properties

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    The circulatory system is closely related to the inter-relationship between the anatomy of the heart and blood vessels, and the fluid dynamic properties of blood. The physical properties of blood, which affect blood flow, are called hemorheologic factors. Hemorheologic factors, such as blood viscosity and erythrocyte aggregation, are influenced mainly by hematocrit. A higher hematocrit level results in an increase in blood viscosity, erythrocyte aggregation, which impedes the circulation itself, and tissue oxygenation. An excess of serum ferritin causes injury to vascular endothelial cells and erythrocytes via oxygen free radicals. In addition, an excess of blood can aggravatee the adverse effects of the hemorheologic parameters and induce atherogenesis, microcirculatory disturbances, and major cardiovascular events. A preventive and therapeutic approach with a phlebotomy or blood donation has been stimulated by the knowledge that blood loss, such as regular donations, is associated with significant decreases in key hemorheologic variables, including blood viscosity, erythrocyte aggregation, hematocrit, and fibrinogen. Major cardiovascular events have been improved in regular blood donors by improving blood flow and microcirculation by decreasing the level of oxidative stress, improving the hemorheologic parameters, and reducing the serum ferritin level. Confirmation of the positive preventive and therapeutic effects of blood donations on cardiovascular disease by a well-designed and well-controlled Cohort study may be good news to patients with cardiovascular disease or at risk of these diseases, as well as patients who require a transfusion.ope

    Computational fluid dynamics in cardiovascular disease

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    Computational fluid dynamics (CFD) is a mechanical engineering field for analyzing fluid flow, heat transfer, and associated phenomena, using computer-based simulation. CFD is a widely adopted methodology for solving complex problems in many modern engineering fields. The merit of CFD is developing new and improved devices and system designs, and optimization is conducted on existing equipment through computational simulations, resulting in enhanced efficiency and lower operating costs. However, in the biomedical field, CFD is still emerging. The main reason why CFD in the biomedical field has lagged behind is the tremendous complexity of human body fluid behavior. Recently, CFD biomedical research is more accessible, because high performance hardware and software are easily available with advances in computer science. All CFD processes contain three main components to provide useful information, such as pre-processing, solving mathematical equations, and post-processing. Initial accurate geometric modeling and boundary conditions are essential to achieve adequate results. Medical imaging, such as ultrasound imaging, computed tomography, and magnetic resonance imaging can be used for modeling, and Doppler ultrasound, pressure wire, and non-invasive pressure measurements are used for flow velocity and pressure as a boundary condition. Many simulations and clinical results have been used to study congenital heart disease, heart failure, ventricle function, aortic disease, and carotid and intra-cranial cerebrovascular diseases. With decreasing hardware costs and rapid computing times, researchers and medical scientists may increasingly use this reliable CFD tool to deliver accurate results. A realistic, multidisciplinary approach is essential to accomplish these tasks. Indefinite collaborations between mechanical engineers and clinical and medical scientists are essential. CFD may be an important methodology to understand the pathophysiology of the development and progression of disease and for establishing and creating treatment modalities in the cardiovascular field.ope

    Prevalence of and Risk Factors for Diseases in Korean Americans and Native Koreans Undergoing Health Checkup

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    BACKGROUND: Korean Americans constitute the fifth largest subgroup in the Asian American population. Despite their increasing population, research and guidelines regarding their health status assessment and disease screening are lacking. This study aimed to compare the prevalence of diseases in Korean Americans and native Koreans to determine the risk factors and guidelines for disease screening. METHODS: Patients who visited the Gangnam Severance Hospital from February 2010 to May 2015 for a health checkup were enrolled in this study. Baseline characteristics, laboratory data, and the organs (stomach, colon, thyroid, brain, prostate, lung, liver, kidney, pancreas, adrenal gland, and heart) of patients were examined. Data regarding patients' dietary patterns were also obtained. Overall, 1,514 Korean Americans (group 1) and 1,514 native Koreans (group 2) were enrolled. RESULTS: The following diseases were more prevalent in group 1 than in group 2: reflux esophagitis (12.9% vs. 10%), gastric ulcer (3.0% vs. 5.5%), colorectal polyp (37.7% vs. 28.7%), hemorrhoids (32.2% vs. 29.9%), and benign prostatic hyperplasia (30.2% vs. 14.3%). Although not statistically significant, coronary artery disease has a high prevalence rate of >20% in both groups. Dietary patterns were not significant between the two groups. CONCLUSION: This study showed that the prevalence of several diseases in Korean Americans differed from that observed in native Koreans. Therefore, a foundation for setting up new guidelines for disease screening among Korean Americans is established.ope

    ์ด๋™๋œ ์ค‘์‹ฌ์ •๋งฅ๋„๊ด€์œผ๋กœ ์ธํ•œ ๊ฐ„ํ—์  ์‹ฌ๊ณ„ํ•ญ์ง„ ํ™˜์ž์˜ ๊ฒฝํ”ผ์  ๋„๊ด€ ์ œ๊ฑฐ

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    The totally implantable venous port device is used in patients undergoing chemotherapy. The complications associated with this device include venous thrombosis, infection, catheter fracture, extravasation, and intravascular dislodgement. The incidence of port catheter dislodgement is low. The treatment of choice for port dislocation involves immediate retrieval of the distal migrated part, and percutaneous transcatheter retrieval is regarded as the standard method. A 40-year-old female presented with intermittent palpitation. She was referred from the Department of General Surgery after detection of a fractured and dislocated implantable venous port system into the main pulmonary artery. We successfully retrieved the dislocated fractured device using a -Fr pigtail catheter and snare catheter. We herein report this case with a literature review.ope
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