(A) study of Succinyl trialanine p-nitroanilide hydrolytic activity in workers exposed to organic solvents

보건학과/석사[한글] 유기용제 취급 근로자들의 간기능 장해의 새로운 지표로서 혈청 Succinyl Trialanine p-nitroanilide(STN) 가수분해 효소 활성치에 관한 연구가 신발제조업 제화부서에 근무하는 종사자 114명을 대상으로 시행하여 다음과 같은 결과를 얻었다. 1. 전체 대상자의 간기능 검사치인 혈청 GOT, GPT, rGT의 평균은 22±12.32IU/l, 20± 9.65IU/l, 28±21.35IU/l였고, 혈청 STN 가수분해 효소 활성치는 0.08±0.05였다. 2. 혈청 STN 가수분해 효소 활성치는 남자에서 통계학적으로 유의하게 높았고(p<0.05), 연령군별로는 차이가 없었다. 3. 일일근무시간별 혈청 STN 가수분해 효소 활성치는 차이는 없었으나, 3년이상 근무한 근로자와 100ppm이상의 톨루엔에 노출된 근로자에서는 혈청 STN 가수분해 효소 활성치가 통계학적으로 유의하게 증가하였다.(p<0.05) 4. 톨루엔 노출농도와 혈청 GOT, GPT, rGT 및 혈청 STN 가수분해 효소 활성치 사이에는 통계학적으로 유의한 상관관계를 나타냈다.(p<0.01) 5. 혈청 STN 가수분해 효소 활성치에 영향을 미치는 요소중에서 톨루엔 노출농도가 가장 설명력이 높고, 통계학적으로 유의하였다.(p<0.05) ※ 핵심되는 말 : 유기용제, 간기능검사, 혈청 STN 가수분해 효소 활성 [영문] To Measure the serum Succinyl trialanine p-nitroanilide hydrolytic activity as new index of liver function in workers exposed to organic solvents, this study conducted 114 workers in department of shoe-making of shoes factories. The results obtained from this study were as follows : 1. The mean values of serum GOT, GPT rGT in whole workers were 22±12.32, 20±9.65, 28±21.35IU/l, respectively and the mean value of serum STN hydrolytic activity was 0.08±0.05. 2. The serum STN hydrolytic activity was significantly higher for male(p<0.05) and there was no difference among the groups of age. 3. There was no difference in the groups by working hours but significant difference in persons who worked over 3 years or were exposed to toluene over 100ppm (p<0.05). 4. The correlation of the exposed dose of toluene and serum STN hydrolytic activity were statistically significant (r=0.027-0.518). 5. The exposed dose of toluene was most explainable variable and statistically significant among the factors affecting serum STN hydrolytic activity(p<0.05). ※Key words : organic solvents, liver function text, serum STN hydrolytic activityrestrictio