Effect of dietary proteins on exocrine pancreas in rats

의학과/박사[한글] Effect of Dietary Proteins on Exocrine Pancreas in rats Joon Ki Ahn Department of Medical Science The Graduate School, Yonsei University (Directed by Prof. Sa Suk Hong) In view of the great metabolic activity of the pancreas in the synthesis as well as secretion of digestive enzymes, deficiencies of dietary protein or amino acids through the detective protein supply can be expected to interfere with pancreatic function and also with structural integrity of the gland. Presnt study was investigated on the dietary regulation of the synthesis, secretion or morphologic pattern of the exocrine pancreas in rats fed a protein free, protein deficiency, low protein, protein sufficiency diets or diets containing gluten, gelatin or zein as a protein source. Measurement of the enzyme content of the pancreas in rats fed with protein free diet showed a depressed synthesis from the first week and a marked depression particularly in amylase and lipase from the third week. A gradual disappearance of zymogen granules and diminution in the size of acinar cells were seen in first week and the changes became more pronounced in the third week when revealed a marked atrophy of the acini. Animals fed protein deficiency diets showed a great depression of the three pancreatic enzymes and a marked atrophic changes of the acini at the fourth week. In the low protein diet (8% casein) the pancreas revealed a slight atrophy of acini, however, no depression of the pancreatic enzyme content was seen even at the fourth week. The animals fed gelatin or zein diet showed a considerable weight loss, but organ weights were not much changed in comparing with casein group. The enzyme secretion was greatly depressed in animals fed gluten, gelatin or mein diet in contrast to the casein, and biliary-pancreatic juice volume was reduced significantly only in the zein diet. Atrophy of acinar cells and dissociation of acini in animals fed zein diet were marked and the less atrophic lotions were observed in gelatin group. By these data the dietary protein levels or dietary defective proteins were intimately reflected on the either the function or morphologic integrity of the pancreas and it is confirmed that on a synthetic diet containing more than 8% protein which consisted of the adequate essential amino acids as casein, in both the exocrine function and the morphologic pattern of the pancreas would he normal. [영문] In view of the great metabolic activity of the pancreas in the synthesis as well as secretion of digestive enzymes, deficiencies of dietary protein or amino acids through the detective protein supply can be expected to interfere with pancreatic function and also with structural integrity of the gland. Presnt study was investigated on the dietary regulation of the synthesis, secretion or morphologic pattern of the exocrine pancreas in rats fed a protein free, protein deficiency, low protein, protein sufficiency diets or diets containing gluten, gelatin or zein as a protein source. Measurement of the enzyme content of the pancreas in rats fed with protein free diet showed a depressed synthesis from the first week and a marked depression particularly in amylase and lipase from the third week. A gradual disappearance of zymogen granules and diminution in the size of acinar cells were seen in first week and the changes became more pronounced in the third week when revealed a marked atrophy of the acini. Animals fed protein deficiency diets showed a great depression of the three pancreatic enzymes and a marked atrophic changes of the acini at the fourth week. In the low protein diet (8% casein) the pancreas revealed a slight atrophy of acini, however, no depression of the pancreatic enzyme content was seen even at the fourth week. The animals fed gelatin or zein diet showed a considerable weight loss, but organ weights were not much changed in comparing with casein group. The enzyme secretion was greatly depressed in animals fed gluten, gelatin or mein diet in contrast to the casein, and biliary-pancreatic juice volume was reduced significantly only in the zein diet. Atrophy of acinar cells and dissociation of acini in animals fed zein diet were marked and the less atrophic lotions were observed in gelatin group. By these data the dietary protein levels or dietary defective proteins were intimately reflected on the either the function or morphologic integrity of the pancreas and it is confirmed that on a synthetic diet containing more than 8% protein which consisted of the adequate essential amino acids as casein, in both the exocrine function and the morphologic pattern of the pancreas would he normal.restrictio

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학위논문(석사) - 한국과학기술원 : 원자력공학과, 1992.2, [ vi, 61 p. ]The response of ex-core detectors depends on the core power level, power distribution, and reactor configuration. To predict the response of ex-core detectors to the core power level and power distribution, it is thus necessary to know the spatial weighting functions for ex-core detectors which are functions of reactor configurations but are independent of the core power distribution. In this study, two-dimensional discrete ordinates adjoint transport method is introduced and the calculational models are presented to calculate the spatial weighting functions. Two kinds of spatial weighting functions, i. e., assemblywise weighting functions and core heightwise weighting functions, are calculated for individual ex-core detectors which are mounted at different core elevations. The relationship of spatial weighting functions to the major reactor operating parameters is also analyzed and it is found that the soluble boron in the reactor coolant does not affect the spatial weighting functions but the reactor core power level affects the relative core heightwise weighting functions. It is concluded that the discrete ordinates adjoint transport method is suitable for calculating the spatial weighting functions for ex-core detectors, because the method provides more detailed information and reduces the computing times. The calculated spatial weighting functions for ex-core detectors at a given reactor configurations can be used to predict the response of each ex-core detector to the core power distribution throughout the fuel cycle, but only at a specified power level. The comparison of calculated spatial weighting functions with the measured plant data on ex-core detector response rates is needed for the validation of the calculation method.한국과학기술원 : 원자력공학과