A Case of Pulmonary Sarcoidosis Combined with Neurosarcoidosis

Sarcoidosis is a multi-systemic syndrome of an unknown etiology, and it is characterized by the formation of multiple noncaseating granulomas that disrupt the architecture and function of the tissues in which they reside. The most commonly affected organs are lung, skin and lymph nodes. Overt clinical involvement of the nervous system is uncommon and this occurs in about 5% of all patients during the course of their disease. The most common manifestations are granulomatous leptomeningitis, cranial nerve palsy, electrolyte or other endocrinologic abnormalities, but isolated memory impairment is a rare manifestation. This is a case of 59 years-old male with recent memory impairment, and he was previously diagnosed with pulmonary sarcoidosis by transbronchial lung biopsy. The brain MRI imaging revealed the leptomeningeal and parenchymal involvement of sarcoidosis. He was treated with high dose corticosteroid and his memory function was improved to nearly a normal level. We report here on a case of successful treatment of pulmonary sarcoidosis combined with neurosarcoidosis with using high dose corticosteroid, and the patient presented with recent memory impairment.ope

A Case of Pneumothorax Caused by Cystic Lung Metastasis of Angiosarcoma

Angiosarcoma is a rare but highly malignant tumorthat usually arises in the scalp or face of elderly males. Distant metastases favor the lung, liver, lymph nodes and skin. Metastatic pulmonary angiosarcoma commonly takes the form of a nodule but can sometimes appear as a thin-walled cyst. We report a case of 65 years-old male with a spontaneous pneumothorax, who underwent excision and radiotherapy for an angiosarcoma of the scalp 2 years ago. A chest CT scan revealed multiple cysts in the lung. The video-assisted thoracoscopic lung biopsy demonstrated subpleural cysts without tumor cells. A skin biopsy of the scalp showed an angiosarcoma. This case was diagnosed as a recurrence of an angiosarcoma with a supposed lung metastasis. This case suggests that a spontaneous pneumothorax in elderly people may be secondary to a pulmonary metastasis from an angiosarcoma of the scalp.ope

전사체 분석에 기반한 질소 공급 조건 변화에 따른 벼 유전자 및 Non-coding RNA의 변화 관찰

학위논문 (석사)-- 서울대학교 대학원 : 농생명공학부, 2014. 8. 신찬석.Nitrogen is a key nutrient in plant growth and development, and usage of nitrogen fertilizer is directly involved in crop yields. To increase crop yield, the enormous amount of chemical nitrogen fertilizer has been used. However, limitation on nitrogen-use-efficiency of crop plant make amounts of fertilizer to be remained in soil, and leaching of those remaining nitrogen sources to river and ocean occur environmental problems, such as eutrophication. Non-coding RNAs, including miRNAs and long non-coding RNAs, are a class of RNAs that are not be translated into protein. In recent studies, it is known that some of those miRNAs and long non-coding RNAs function as key regulator and regulate expression level of its target gene through various molecular mechanisms. Moreover, most of those non-coding RNAs also respond to various stimuli and stresses, and they could control the changes of plant physiology in response to those stimuli and stresses. However, roles of non-coding RNAs on nitrogen supply status in rice have not been deeply studied yet. To comprehensively investigate and understand transcriptome-wide responses of rice to nitrogen starvation, multimodal RNA-Seq methods were applied: strand-specific RNA-Seq, small RNA-Seq, and 2P-Seq. Using strand-specific RNA-Seq, expression profiling and analysis of annotated genes including nitrogen metabolism-related genes were performed. Also, nitrogen-responsive miRNAs were identified in nitrogen-starved rice roots, and the relationship between representative nitrogen supply status-responsive miRNA, miR169, and its target genes, NF-YAs, were analyzed by expression pattern analysis and 5 RLM-RACE. Using strand-specific RNA-Seq dataset, identification of putative lncRNA-deriving loci and analysis of their expression patterns were performed. Moreover, identifying 3 end of transcripts was tried by analyzing 2P-Seq data and those sites detected by 2P-Seq were confirmed by 3 RACE against putative lncRNA candidate. Dataset analyzed in this study will be used as a fundamental dataset for further studies about roles of genes and non-coding RNAs in response of rice to change of nitrogen supply status.ABSTRACT..........................................................................................................1 CONTENTS..........................................................................................................4 LIST OF TABLES AND FIGURES.....................................................................5 LIST OF ABBREVIATIONS...............................................................................7 INTRODUCTION................................................................................................9 MATERIALS AND METHODS.......................................................................16 RESULTS AND DISCUSSION.........................................................................22 SUMMARY.........................................................................................................41 FIGURES AND LEGENDS...............................................................................43 TABLES..............................................................................................................68 REFERENCE.....................................................................................................76 SUPPLEMENTARY FIGURES AND LEGENDS...........................................88 ABSTRACT IN KOREAN.................................................................................93Maste