초상자성 산화철 나노클러스터 중심@방사형 실리카 피막의 나노복합체에 이산화티타늄 나노입자가 부착된 재사용이 가능한 광촉매에 대한연구

학위논문 (석사)-- 서울대학교 대학원 : 융합과학부, 2017. 2. 박원철.A magnetically recoverable photocatalyst was prepared by supporting TiO2 nanoparticles on a superparamagnetic iron oxide nanocluster (SION) core@fibrous silica shell (FSS) nanocomposite. Using the raspberry-shaped magnetic iron oxide nanocluster core as a seed, FSS with uniform thickness was grown directly on the core surface by a sol-gel process. The preparation method was optimized to have a single core for each nanoparticle by adjusting the amount of the silica source. The FSS has a fanning structure of radial pores, which enable large amounts of TiO2 nanoparticles to be supported easily on the pore surface. SION@FSS with amorphous TiO2 loaded on the pores (SION@FSS@Am-TiO2) was crystallized to the anatase phase (SION@FSS@A-TiO2), which shows good photocatalytic effect. When used for water purification, SION@FSS@A-TiO2 shows faster dye degradation kinetics compared to commercial P25 nanoparticles. The as-prepared SION@FSS@A-TiO2 photocatalyst could be magnetically recovered easily from water after decolorization of dye.Chapter 1. Introduction 1 1.1. TiO2 Photocatalyst 1 1.2. Mesoporous silica (MSN) supports 1 1.3. Fibrous silica materials 2 1.3.1. Characteristics and applications 2 1.3.2. Synthesis 3 1.4. Magnetically recoverable photocatalyst 4 1.4.1. Magnetic recollection 4 1.4.2. Superparamagnetic iron oxide nanocluster (SION) core 4 1.4.3. SION Core@Fibrous Silica Shell (FSS) 5 1.4.4. SION@FSS@Anatase TiO2 (A-TiO2) 6 Chapter 2. Experimental 7 2.1. Materials 7 2.2. Preparation of SION 7 2.3. Preparation of SION@FSS 8 2.4. Preparation of SION@FSS@Am-TiO2 and SION@FSS@A-TiO2 9 2.5. FSS thickness control of SION@FSS 11 2.6. Material Characterization 11 2.7. Photodecolorization Test 12 2.8. Recollection and Reusability Test 13 Chapter 3. Result and discussion 14 3.1. Synthetic procedures 14 3.1.1. Overview 14 3.1.2. SION core 15 3.1.3. FSS coating on SION core (SION@FSS) 15 3.1.4. Control of FSS thickness 19 3.1.5. Supporting TiO2 on SION@FSS and crystallization 20 3.1.6. Control of TiO2 amounts 22 3.2. characterization 26 3.2.1. Size and morphology 26 3.2.2. Crystal structure 29 3.2.3. Pore structure analysis 31 3.2.4. Magnetic property 33 3.3. Photodegradation of MetB 35 Chapter 4. Conclusion 42 References 43 요약(국문초록) 48Maste

태국 에이즈 감염인의 의약품 접근권 운동

학위논문(석사) --서울대학교 대학원 :인류학과,2008.2Maste

Discovery and Structure-Activity Relatioship of Novel AIMP2-DX2 Inhibitors as Anti-cancer Agents

학위논문 (석사)-- 서울대학교 대학원 : 약학과, 2017. 2. 박형근.P38로도 알려진 AIMP2(ARS interacting multi-functional protein2)는 Aminoacyl tRNA synthetase의 보조단백질 중 하나로 MSC(Multi-tRNA Synthetase Complex)라는 복합체를 이루며 단백질 합성에 관여한다. 기본적으로 AIMP2는 TGF-beta에 의한 성장 억제 신호를 강화시키고 p53의 유비퀴틴화을 억제하여 세포자멸사를 유도하는 TNF를 매개하는 중요한 역할을 하여 암을 억제한다고 알려져 있다. AIMP2는 엑손 1번부터 4번까지 모두 발현된 full length로 존재하지만 스플라이싱 변이체로 엑손 2번이 결여되어있는 AIMP2-DX2(ARS interacting multi-functional protein2-Exon2 deleted)는 AIMP2-Full length와 상반된 작용을 하여 과 발현 될 경우 발암을 유발하게 되며 특히 폐암세포에서 과 발현 되어있다. 따라서 본연구는 AIMP2-Full length는 저해하지 않고 AIMP2-DX2만을 선택적으로 저해하는 화합물을 합성하였다. 실험실 in-house library를 통해 얻은 선도 물질의 저해 선택성, 활성과 물성을 개선하기 위해 선도 물질의 구조를 세 부분으로 나누어 다양한 작용기 도입하였으며 합성 경로의 key step으로 szuki coupling, aromatic nucleophilic substitution reaction, 그리고 microwave irradiation-mediated aromatic amination reaction을 이용해 합성 과정을 최적화 하였다. 합성된 유도체들의 AIMP2-Full length & AIMP2-DX2 luciferase와 WI-26 & A549 cell line에 대한 cytotoxicity를 평가하여 SAR을 진행하였다. 최종적으로 AIMP2에 비해 AIMP2-DX2에 그리고 정상세포 대비 암세포 저해에 뛰어난 선택성을 가지며 submicromolar 수준의 AIMP2-DX2저해 활성과 in vitro 항암활성을 가지는 신규 저분자 화합물을 수종 개발하였다.I. 서론 1 1. 폐암 치료제 개발의 필요성 1 2. AIMP2-DX2 저해에 따른 암 억제 효과 2 3. AIMP2-DX2 저해 저분자 물질을 통한 항암 작용 4 4. 선행 연구 6 II. 본론 10 1. 유도체 설계 전략 10 2. 합성 12 2.1. A part modification 13 2.2. B part modification 15 2.3. C part modification 16 2.4. Position exchange 19 3. 활성 평가 21 3.1. In vitro DX2 nanoluciferase activity results of A part modified analogues 21 3.2. In vitro DX2 nanoluciferase activity results of B part modified analogues 24 3.3. In vitro DX2 nanoluciferase activity results of C part modified analogues 25 3.4. In vitro DX2 nanoluciferase activity results of position exchanged analogues 28 3.5. 투여량 의존적 반응과 선택성 29 III. 결론 31 IV. Experimental 33 References 80 Abstract 82Maste

다중객체추적을 위한 특징 기반의 파티클 필터

학위논문 (석사)-- 서울대학교 대학원 : 전기·컴퓨터공학부, 2012. 8. 유석인.This paper proposes an advanced particle filter for multi-target tracking with speed-up robust features. In this study, a mixture of the Gaussian Background Model and the SURF algorithm are used for target representation and localization. This approach transforms an image into a large collection of local feature vectors, each of which is invariant to the images translation, scaling, and rotation. Additionally, it is also partially invariant to illumination changes and affine or 3D projection. Lastly, NN algorithm is used for segmenting multiple objects into a single-object state space. Several experimental results show that the proposed algorithm has good performance for object tracking in the presence of object translation, rotation and partial occlusion. Overall, this approach makes the system robust to occlusions and allows false positive detections in the background to be identified and removed.Chapter 1 Introduction Chapter 2 Related Work 2.1 Object Detection 2.1.1 Geometry-based Object Detection 2.1.2 Appearance-based Object Detection 2.1.3 Feature-based Object Detection 2.2 Data Association 2.3 Multi-targets Tracking 2.3.1 Bayesian Filtering Chapter 3 Object Detection and Matching 3.1 Fast Interest Point Detection 3.2 Descriptor of Interest Point 3.3 Object Matching Chapter 4 Particle Filter for Object Tracking Chapter 5 Experimental Result 5.1 Environment 5.2 Result 5.2.1 Single Object Detection 5.2.2 Key Points Extraction 5.2.3 Key Points Matching 5.2.4 Multi-Objects Tracking 5.2.5 Comparing performance Chapter 6 Conclusion Bibliography AbstractMaste

Urban Regeneration and Gentrification

TRU