Identification of small-molecule modulators of Cl- transporters using high-throughput screening

의과대학/박사prohibitio

Significance of whole body scan in bone and joint tuberculosis

의학과/석사[한글] 골·관절 결핵은 결핵균이 골과 관절을 침범하여 점진적인 파괴를 일으키는 질환으로 거의 대부분의 경우에서 폐나 임파절등 다른 조직이나 장기의 결핵에 속발되어 발생한다. 골관절 결핵의 진단에 흔히 이용되는 평면 방사선 검사에서 초기에는 독특한 소견이 없고, 병이 상당히 진행된 후에야 발견되므로 평면방사선 검사를 통한 병의 조기 진단은 어려운 실정이다. 이에 저자는 정형외과 영역에서 널리 이용되고 있는 보조적 진단 방법의 하나인 전신골주사의 골관절 결핵에서의 진단적 가치를 알고자 1978년 1월부터 1987년 12월까지 골관절 결핵으로 확진되었던 환자중, 수술전 전신골주사를 시행하였던 35명의 환자 40예를 대상으로 하여 다음과 같은 결과를 얻었다. 1. 결핵성 골관절염에서는 급성 화농성 골관절염 보다는 흡수정도가 감소해서 조기진단적 가치는 낮았으나 만성골수염 보다는 증가된 소견을 보였다. 2. 남자보다 여자에서 흡수정도가 증가되었으며, 10세 미만과 60대의 연령층에서 다른 연령층에 비해 흡수정도가 증가된 소견을 보였다. 3. 병의 경과가 길수록 흡수 정도가 감소되었다. 4. 골결핵이 관절결핵보다 흡수정도가 감소되었으며, 골결핵에서는 척추보다 장관골에서 흡수정도가 감소되었다. 5. 14.3 %로 산재성 골결핵을 감지할 수 있었다. [영문] For confirmative diagnosis of bone and joint tuberculosis, it is made by culture method, inoculation to guinea pig, or histologlc examination of the specimen obtained from a lesion site. But plain reontgenogram is not valuable for early detection of the disease because specific, abnormal finding is not found in early stage and only found in late stage as progressive destruction of bone and joint. Many reports were made that whole body bone scan, as diagnostic tool, was valuable in other orthopedic disease, but report for its diagnostic value in bone and joint tuberculosis is very rare. The study was carried out on 35 patients of bone and joint tuberculosis who whole body bone scan was performed before operation from January, 1978 to December, 1987 in Department of Orthopedic Surgery, Yonsei University college of Medicine. The following results were obtained. 1. Value of early detection of tuberculosis is not much as pyogenic infection. Intensity of uptake was decreased In tuberculosis than acute pyogenic osteomyelitis and arthritis, but increased than chronic osteomyelitis. 2. Intensity of uptake was decreased in tuberculosis than chronic osteomyelitis. 3. The longer duration of the disease, the more decreased intensity of uptake. 4, Intensity of uptake is increased in joint tuberculosis than bone, and also increased in tuberculosis spine than long bone. 5. Multifocal disease was detected in 14.3% by whole body bone scan.restrictio

엑시머 레이저를 위한 회절광학소자의 설계와 제작

학위논문(석사)--서울대학교 대학원 :전기·컴퓨터공학부,2003.Maste

Dissolution behavior of alumina and magnesia particle in CaO-SiO2-Al2O3 mold flux

Maste

Inclusion control for making clean steels

2

Physico-chemical properties of slags

1

CHEMICAL REACTIONS AT PHASE INTERFACES OF SLAG/INCLUSIONS AND STEEL/REFRACTORIES

1

Chemical Interactions at Phase Interfaces in Steel Refining: Steel/Refractories and Slag/Inclusions

1

A Teratogenicity Study on Dimethyl Dimethoxy Biphenylate Derivative (DDB-S) in Rats

A teratogenic study of dimethyl dimethoxy biphenylate derivative (DDB-S) was carriedout on Sprague-Dawley rats. DDB-S dissolved in saline was administered to male and female rats byintravenously injection at daily doses of 50 mg/kg, 75 mg/kg, and 100 mg/kg. A half of dams weresacrificed at 20th day of gestation to scrutinize the pregnant performances and fetal development.And the remaining dams were allowed to deliver. The growth, reflex, behaviour and reproductive func-tion of F1 offsprings were examined. There was no treatment-related diference in body weight, foodconsumption and necropsy findings of dams. No gross, skeletal and visceral abnormalities wasobserved in F1 fetuses from dams treated with DDB-S. F1 offsprings did not show any treatment-related diference in growth, reflex, behaviour and reproductive performance. At caesarean section ofF1 dams, no growth retardation and gross abnormality was observed in F2 fetuses. In conclusion,DDB-S did not show any potential teratogenic effect in rats.N