Differentiation of Pneumocystis carinii from various animals by karyotyping and DNA amplification

학위논문(박사)--서울대학교 대학원 :의학과 기생충학전공,1996.Docto

Aseptic meningitis in 1993

From May to July 1993, we observed an epidemic of aseptic meningitis. We performed clinical and virological studies on 174 children with aseptic meningitis who had been admitted to the Department of Pediatrics, Asan Medical Center, from May to July, 1993 The results were as follows; 1) This epidemic of aseptic meningitis was most prevalent in June 1993. The most of the patients were 3 to 6 years old and male to female ratio was 1.6 : 1. 2) The most patients suffered from fever, vomiting, headache, and abdominal pain was noticed in 36% of patients, characteristically. 3) In 7 cases among 10 randomly sampled cases, enterovirus was cultured. Among them, we performed serotyping in 3 cases and Echovirus 9 was isolated.From May to July 1993, we observed an epidemic of aseptic meningitis. We performed clinical and virological studies on 174 children with aseptic meningitis who had been admitted to the Department of Pediatrics, Asan Medical Center, from May to July, 1993 The results were as follows; 1) This epidemic of aseptic meningitis was most prevalent in June 1993. The most of the patients were 3 to 6 years old and male to female ratio was 1.6 : 1. 2) The most patients suffered from fever, vomiting, headache, and abdominal pain was noticed in 36% of patients, characteristically. 3) In 7 cases among 10 randomly sampled cases, enterovirus was cultured. Among them, we performed serotyping in 3 cases and Echovirus 9 was isolated

Amino Acid and Enzyme Assay in Ornithine Transcarbamylase Deficiency

Ornithine transcarbamylase(OTC) deficiency is the most comon genetic enzyme deficiency in the cycle enzymopathy and is inherited as a sex-linked dominant mode. All of the urea cycle enzymopathies may results in the accumulation of ammonia in serum. This produces clinical symtoms such as episodes of vomiting, lethargy, seizure and coma. If hyperammonemia is not controlled, patient will die ultimately. We experienced a case of hyperammoneic coma in a day old male infant. He was confirmed to have OTC deficiency by the enzyme assay of liver tissue.Ornithine transcarbamylase(OTC) deficiency is the most comon genetic enzyme deficiency in the cycle enzymopathy and is inherited as a sex-linked dominant mode. All of the urea cycle enzymopathies may results in the accumulation of ammonia in serum. This produces clinical symtoms such as episodes of vomiting, lethargy, seizure and coma. If hyperammonemia is not controlled, patient will die ultimately. We experienced a case of hyperammoneic coma in a day old male infant. He was confirmed to have OTC deficiency by the enzyme assay of liver tissue

Transient Methemoglobinemia with Diarrhea in Newborn and Infant

Metoemoglobinemia is an uncommon clinical problem generally caused by inherited disorders of hemoglobin or environmental toxicities from oxidizing agents. We experienced 4 neonate and a infant who exhibit transient methemoglobinemia with diarrhea. So we report our experience with 5 unrelated newborns, ranging from 7 to 40 days, who presented with diarrhea, dehydration, acidosis, and transient methemoglobinemia. No history of toxin exposure and family could be elicited. All were moderately to severely dehydrated, methemoglobin levels ranged from 7.2 to 18.9%. 2 patient showed acidosis and no patient showed decreased arterial oxygen saturation. All patients recovered. One patient was treated by methylene blue and the others were treated by supportive care. The clinician should be aware of methemoglobinemia with diarrhea to avoid unnecessary work up and management.Metoemoglobinemia is an uncommon clinical problem generally caused by inherited disorders of hemoglobin or environmental toxicities from oxidizing agents. We experienced 4 neonate and a infant who exhibit transient methemoglobinemia with diarrhea. So we report our experience with 5 unrelated newborns, ranging from 7 to 40 days, who presented with diarrhea, dehydration, acidosis, and transient methemoglobinemia. No history of toxin exposure and family could be elicited. All were moderately to severely dehydrated, methemoglobin levels ranged from 7.2 to 18.9%. 2 patient showed acidosis and no patient showed decreased arterial oxygen saturation. All patients recovered. One patient was treated by methylene blue and the others were treated by supportive care. The clinician should be aware of methemoglobinemia with diarrhea to avoid unnecessary work up and management

A Case of Idiopathic Pulmonary Hemosiderosis

Idiopathic pulmonary hemosiderosis(IPH) is a relatively rare disease of unknown etiology characterized pathologically by recurrences of intraalveolar pulmonary hemorrhage. Clinical features include hemoptysis, iron deficiency anemia and pulmonary parenchymal infiltrations on chest radiograph. Hemosiderin-laden macrophages are demonstrated by examination of sputum or lung biopsy specimens. We diagnosed IPH by lung biopsy in 9 year-old girl who had had recurrent hemoptysis, iron deficiency anemia and diffuse pulmonary infiltrates on chest radiograph and report this case with brief literature review.Idiopathic pulmonary hemosiderosis(IPH) is a relatively rare disease of unknown etiology characterized pathologically by recurrences of intraalveolar pulmonary hemorrhage. Clinical features include hemoptysis, iron deficiency anemia and pulmonary parenchymal infiltrations on chest radiograph. Hemosiderin-laden macrophages are demonstrated by examination of sputum or lung biopsy specimens. We diagnosed IPH by lung biopsy in 9 year-old girl who had had recurrent hemoptysis, iron deficiency anemia and diffuse pulmonary infiltrates on chest radiograph and report this case with brief literature review