BLOOD VISCOSITY CHANGE IN ORAL SQUAMOUS CELL CARCINOMA XENOTRANSPLANTED NUDE MICE

It is well known that malignant tumor have hypoxic cell fraction, which is radio resistant and is one of the most important cause of local recurrence after radiotherapy. One of the causes of hypoxia in tumor is blood flow decrease due to increase in blood flow resistance and one of the causes of increased blood flow resistance could be attributed to the increase in blood viscosity. For the evaluation of the change of blood viscosity in oral cancer, experiments were carried out to test the change of blood viscosity among the normal control and xenografted oral cancer nude mice. Relative viscosity measured against distilled water was for normal control, and for tumor bearing mice at the first time of blood sampling in experimental period ( ). There was no statistically significant difference between the control group and experimental group (p>0.05). However, as the tumor grew, significant difference of blood viscosity was detected at the third time of blood sampling (control group:, and experimental group:2003년도 한국학술진흥재

CHANGE OF BLOOD VISCOSITY AND DEFORMABILITY IN ORAL SQUAMOUS CELL CARCINOMA PATIENTS

Malignant tumor have hypoxic cell fraction, which makes radio-resistant and hypoxia in tumor is a result from the blood flow decrease caused by increase in blood flow resistance. Blood viscosity increase is major factor of increased blood flow resistance and it could be attributed to the decrease in blood deformability index. For the evaluation of the change of blood viscosity and blood deformability in oral squamous cell carcinoma, we perform the test of the change of those factors between the normal control group and oral squamous cell carcinoma cell patient group. Relative viscosity measured against distilled water was for normal control group, and for the SCC patient group and there was statistical significance between the groups. However, there was no significant difference between the groups in blood viscosity between the groups by tumor size (T1+T2 vs T3+T4). Also, there was no significant difference between the normal control group and SCC patient group in blood deformability index and between the groups by tumor size (T1+T2 vs T3+T4). Increase in blood viscosity was confirmed with this study and it can be postulated that modification blood viscosity might contribute to decrease of hypoxia fraction in oral squamous cell carcinoma, thus improve the effect of radiotherapy and it can be assumed that the main factor of blood viscosity increase is not decrease of blood deformability in oral squamous cell carcinoma.2003년도 한국학술진흥재

초극소 저체중 출생아에서의 저알부민혈증

목적: 본 연구에서는 초극소 저체중 출생아에서 저알부민혈증의 발생 및 임상 양상을 조사하여 사망률을 비롯한 예후와의 관련성을 확인하고 알부민 투여의 효과를 평가하고자 한다. 방법: 2008년 1월부터 2012년 12월까지 본원 신생아 중환자실에 입원한 1.000 g 미만의 초극소 저체중 출생아 83명을 대상으로 의무기록을 후향적으로 조사하였다. 혈중 알부민 2.5 g/dL 이상(정상 알부민혈증, n=42)과 2.5 g/dL 미만(저알부민혈증, n=41)인 두 군으로 나누어 임상적 특징을 조사하였고, 저알부민혈증군을 알부민을 투여한 군(n=36)과 투여하지 않은 군(n=5)으로 나누어 임상적 특징과 알부민 투여 후 예후를 조사하였다. 결과: 총 83명의 초극소 저체중 출생아 중에서 41명이 저알부민혈증군으로 분류되었다. 저알부민혈증과 관련된 임상적 상태로 동맥관개존증은 19.5%, 뇌실 내 출혈(≥grade III)은 4.9%, 괴사성 장염(≥stage IIa)은 46.3%, 폐렴은 4.9%, 패혈증은 24.4% 였다. 단변수 분석에서 저알부민혈증군과 정상 알부민혈증군에서 재태연령(26+6±2+1 vs. 26+0±1+5,P=0.045)과 출생체중(868±117 vs. 783±121, P=0.002)의 유의한 차이가 있었으나, 동맥관개존증, 뇌실 내 출혈, 괴사성장염, 기관지폐 이형성증 등의 주요 합병증 및 사망률의 차이는 유의한 차이가 없었다. 다변수 로지스틱 회귀분석에서는 어린 출생체중이 유일하게 저알부민혈증과 연관된 인자로 밝혀졌다(OR .995, 95% CI .990-.999, P=.019). 저알부민혈증군에서 알부민 투여 여부가 사망률(47.2% vs. 0%, P=0.065)을 비롯한 예후에 영향을 미 치치는 않았다. 결론: 초극소 저체중 출생아에서 저알부민혈증군과 정상 알부민혈증군 사이에 합병증 및 사망률은 차이가 없었다. 다만, 저알부민혈증과 관련한 유일한 인자는 작은 출생체중이 있었다. 또한 저알부민혈증에서 알부민 투여의 여부에 따른 합병증 및 사망율에 차이는 없었다.Purpose: We investigated the incidence and clinical course of hypoalbuminemia and identified relevance of prognosis including mortality in extremely low birth weight infants (ELBWIs). Also, we assessed the efficacy of intravenous albumin infusion. Methods: A retrospective study including 83 preterm infants <1,000 g of birth weight who were admitted to Ajou university hospital`s neonatal intensive care unit from January 2008 to December 2012 was performed. Patients were divided into the normoalbuminemia (≥2.5 g/dL serum albumin, n=42) group and the hypoalbuminemia (<2.5 g/dL serum albumin, n=41) group, and also the hypoalbuminemia group were subdividedinto the intravenousalbumin infusion group (n=36) and the control group (n=5). Results: Of those 83 ELBWIs, 41 infants (49.4%) were classified as the hypoalbuminemia group. Associated conditions with hypoalbuminemia were patent ductus arteriosus (PDA, 19.5%), intraventricular hemorrhage(IVH, ≥grade III, 4.9%), necrotizing enterocolitis (NEC, ≥stage IIa, 46.3%), pneumonia (4.9%), sepsis (24.4%). Inunivariate analysis, there were no statistically significant differences in major morbidities such as PDA, IVH, NEC, bronchopulmonary dysplasia and mortality between the normoalbuminemia and the hypoalbuminemia groups except gestational age (26+6±2+1 vs. 26+0±1+5, P =0.045) and birth weight (868±117 vs. 783±121,P =0.002). In multivariate logistic regression, birth weight is the only meaningful factor associated with hypoalbuminemia(OR .995, 95% CI .990-.999, P =0.019). The mortality (47.2% vs. 0%, P =0.065) and morbidities did not differ between the intravenous albumin infusion and the control group. Conclusion: In ELBWIs, there were no significant differences in major morbidities and mortality between thehypoalbuminemia and the normoalbuminemia groups. The lower birth weight is the only factor associated with hypoalbuminemia. In addition, major morbidities and mortality rate were not affected by the albumin infusion

FALSE ANEURYSM IN INTERNAL MAXILLARY ARTERY

구강악안면 영역에서의 외상에 의한 내악 동맥의 가성 동맥류는 극히 드문 병변으로 저자들은 서울 대학교 치과병원 구강악안면외과에서 1례를 치험하였다. 그 원인은 외상에 의한 하악 과두 골절, 관혈적 정복술시의 의원적 외상 또는 둘 다를 고려해 볼 수 있었으며 임상적으로 박동성 잡음,촉진 가능한 맥동이 있었고 술중 과다 출혈의 양상을 보였다. 병소는 혈관 조영술에 의해 확진되었으며, 색전술로 치료하였다. 가성 동맥류는 생명을 위협할 정도의 과다 출혈을 일으킬 수 있으므로 그 진단과 치료는 중요하다. 혈관 조영술은 임상적 증상에 대한 확실한 진단을 가능케 해 주며 이를 이용한 색전술은 관혈적 결찰법에 비해 장점을 가지므로 좋은 치료법이 될 수 있다.보건복지부 보건의료기술진흥사

BLEPHAROPLASTY BY VARIOUS CAUSES

심미적인 이유를 포함한 여러 가지 원인에 의한 안검성형술을 저자등이 사용한 방법, 안검성형술을 받고자 하는 동기, 합병증 등을 보고하며 국내의 턱얼굴외과의사들의 새로운 진료 영역으로의 안면부 연조직미용수술에 관한 관심과 노력을 기대한다

THE EFFECT OF TOPICAL APPLICATION WITH STEROID AND CYCLOSPORINE ON ORAL LICHEN PLANUS PATIENTS

The purpose of this study was comparing the effectiveness in the topical applications of cyclosporine with that of steroid, the conventional and standard drug in the treatment of oral lichen planus. 21 patients with oral lichen planus were treated with cyclosporine (n=11) or steroid (n=10) by random allocations. They were recalled 2 weeks, 4 weeks, and 8 weeks after initial treatments. In each recall, the lesion size, clinical symptoms like pain or burning sensation, and side effects were evaluated. The differences of these measurements were compared and the effects of each drug were checked. In reticulation types, steroid showed higher effectivity than cyclosporine and this difference was significant statistically. But in erythema type lesions, either drug showed no significant recovery, statistically. However, the effect of cyclosporine was thought to be more effective. The pain of the lesions was significantly decreased by cyclosporine but not by steroid. The decrease of burning sensation was more dependant upon steroid than cyclosporine, but no statistical relationship could be found. There were no clinical side effects. There was limitation to draw in conclusion due to small pool of this study group. But with the results, this suggestion could be proposed that either drug might be superior to another in effectivity in a specific lesion type or patient symptom, so selection and usage of one drug in a specific case could be better than universal application of one drug in all cases.서울대학교병원 일반연구과

INTERNAL VS. RIGID EXTERNAL DISTRACTION DEVICE FOR THE MAXILLARY HYPOPLASIA OF CLEFT PATIENTS

Distraction osteogenesis for the advancement of hypoplastic maxilla of cleft patients has shown successful results. In this report, rigid external distraction(RED) system and internal distraction device were used for maxillary advancement. Each system has its advantages and disadvantages. Larger amount of advancement can be achieved with RED system. But complex external device may give patients psychological stress. Internal device is invisible. However its distraction amount have limitation for the advancement (< 20mm) and the vector cannot be changed freely during distraction. The authors treated five cleft patients with maxillary hypoplasia(three with RED system and two with internal distractor). Their results were clinically satisfactory. We present the pros and cons of RED and internal system for maxillary distraction osteogenesis

구강편평세포암종에서의 제1막형 금속함유 단백분해효소의 발현

Thesis (doctoral)--서울대학교 대학원 :치의학과 구강병리과 전공,2001.Docto

고관절 골절 환자에서 골밀도와 전산화 단층촬영으로 측정한 대퇴 근육의 지방화 변성

Muscle size and fatty degeneration in the thigh muscles were most positively correlated with the body weight. Bone mineral density was positively correlation with Cross sectional area and Cross sectional muscle area of all thigh muscles, and muscle attenuation coefficient of 2 gluteal muscles and fatty degeneration of 2 mid-thigh muscles. There was no statistically significant difference in the size of the femoral muscle and the degree of fatty degeneration between the two fracture groups.대퇴 주변의 근육의 크기와 지방화 정도는 몸무게와 가장 통계적으로 유의하게 양의 상관관계를 보였으며 비만도가 높을수록 대퇴 주변 근육의 단면적, 근육내 근 단면적이 컸지만 지방화 정도도 같이 커지는 양상을 보였다. 골밀도가 높을수록 둔부 부위의 근쇠약 지수가 크고 허벅지 주변 근육의 지방화 변성이 많은 것으로 나타났다.Ⅰ. INTRODUCAITON 1 Ⅱ. MATERAL AND METHOD 1 A. SUBJECTS 1 B. MEASUREMENT 2 1. PHYSICAL CHARACTERISTICS 2 2. BONE MINERAL DENSITY 2 3. MUSCLE MEASUREMENTS OF THE FEMORAL REGION 3 C. STATISTICAL ANALYSIS 3 Ⅲ. RESULTS 4 A. PHYSICAL CHARACTERISTICS AND MUSCLE MEASUREMENTS 4 B. CORRELATION BETWEEN THE MEASUREMENTS 4 C. THE DIFFERNCE BETWEEN INTERTROCHANTERIC FRACTURE GROUP AND FEMORAL NECK FRACTURE GROUP 7 Ⅳ. DISCUSSION 8 Ⅴ. CONCLUSION 10 REFERENCES 11 국문 요약 14Docto