18 research outputs found
์ ์ฉ์นด๋ ์ฌ์ฉ์์ ์นด๋ ์ฌ์ฉ ํํ์ ์ฐ์ฒด์ ๊ดํ ์ฐ๊ตฌ
ํ์๋
ผ๋ฌธ (์์ฌ)-- ์์ธ๋ํ๊ต ๋ํ์ : ๊ฒฝ์ ํ๋ถ, 2012. 2. ์กฐ์ฑ์ง.๋ณธ ์ฐ๊ตฌ์์๋ ์ ์ฉ์นด๋ ์ฌ์ฉ์์ ์ ์ฉ์นด๋ ์ฌ์ฉ๋ด์ญ์ ํตํ์ฌ ์ ์ฉ์นด๋ ๊ฒฐ์ ๋ฐฉ์๊ณผ ์๋น์ ํ์ด ์ ์ฉ์นด๋ ์ฌ์ฉ์์ ์นด๋๋๊ธ ์ฐ์ฒด ์ฌ๋ถ์ ๋ฏธ์น๋ ์ํฅ์ ๊ณ ์ ํจ๊ณผ ๋ก์ง๋ชจํ์ ํตํด์ ๋ถ์ํ์๋ค. ์ ์ฉ์นด๋ ๊ฒฐ์ ๋ฐฉ์์ ์ผ์๋ถ, ํ ๋ถ, ํ๊ธ์๋น์ค๋ก ๊ตฌ๋ถํ์์ ๋, ํ๊ธ์๋น์ค์ ์ฌ์ฉ์ด ํ ๊ฑด์ด ์ฆ๊ฐํ ๋ ์ฐ์ฒดํ ํ๋ฅ ์ ํ๊ท ์ ์ผ๋ก 2.3%์ ๋ ์ฆ๊ฐํ์๋ค. ๊ทธ๋ฆฌ๊ณ ์ ์ฉ์นด๋ ์ฌ์ฉ์๊ฐ ํ์ ๊ฐ์ ๋ฑ ๊ต์ก ํญ๋ชฉ์ ๋ํ ์ผ์๋ถ ์๋น๋ฅผ ์ฆ๊ฐ ์ํฌ ๊ฒฝ์ฐ ์ ์ฉ์นด๋ ์ฌ์ฉ์๊ฐ ์ฐ์ฒดํ ํ๋ฅ ์ ๊ฐ์ํ์๊ณ , ์ ํฅ, ์ฌํ, ์๋น์ค, ๊ธฐํ ํญ๋ชฉ์ ์๋น๋ฅผ ํ ๋ถ๋ก ๊ฒฐ์ ํ ๊ฒฝ์ฐ ์ ์ฉ์นด๋ ์ฌ์ฉ์์ ์ฐ์ฒดํ ํ๋ฅ ์ด ์ฆ๊ฐํ๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ๋ค.
๊ฐ๊ณ๋ถ์ฑ์ ๊ธฐ์ธํ ์ต๊ทผ์ ๊ธ๋ก๋ฒ ๊ธ์ต์๊ธฐ ์ดํ ๊ฐ๊ณ์ ์ฑ๋ฌด๋ถ์ดํ์ ๊ดํ ์ฐ๊ตฌ์ ์ค์์ฑ์ ๋์์ง๊ณ ์์ง๋ง, ๊ฐ๊ณ์ ์นด๋ ์๋น ์ ํ์ด ์ฑ๋ฌด๋ถ์ดํ์ ๋ฏธ์น๋ ์ํฅ์ ๋ณด๊ณ ํ ์ฐ๊ตฌ๋ ๊ฑฐ์ ์๋ ์ํฉ์ด๋ค. ๋ณธ ์ฐ๊ตฌ๋ ๊ฐ๊ณ์ฑ๋ฌด์ ์ํ์ ๋ํ ์ฐ๋ ค๊ฐ ๊ธ์ฆํ๊ณ ์๋ ์ํฉ์์ ์ ์ฉ์นด๋ ์๋น ์ ํ์ด ์ฑ๋ฌด๋ถ์ดํ์ ๋ฏธ์น๋ ์ํฅ์ ๋ถ์ํ ์ฐ๊ตฌ๋ผ๋ ์ ์์ ์์๊ฐ ์๋ค. ํนํ ์ ์ฉ์ด ๋ฎ์ ๊ฐ๊ณ์ ์ฃผ์ ์๊ธ ์กฐ๋ฌ์์ธ ํ๊ธ์๋น์ค๊ฐ ์ฑ๋ฌด๋ถ์ดํ์ ๋ฏธ์น๋ ์ํฅ์ ์ค์ ์ ์ผ๋ก ๋ด์ผ๋ก์จ ์นด๋์ฌ์ ์ ์ฌ์ ์ธ ์ฑ๋ฌด๋ถ์ดํ ์ํ์ ์ธก์ ํ๋๋ฐ ์ค์ํ ์ ๋ณด๋ฅผ ์ ๊ณตํ๋ค.Maste
Sarcopenia's Prognostic Impact on Patients Treated with Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis
Background: Although sarcopenia has been reported to predict survival in cancer patients, its impact on patients who received immune checkpoint inhibitors (ICIs) has not been thoroughly investigated. This systematic review aimed to assess the long-term oncologic impact of sarcopenia on patients who received ICIs.
Methods: A systematic review of studies indexed in the PubMed, Embase, and Cochrane databases, up to April 1, 2021, was conducted. Studies that reported hazard ratios (HRs) for overall survival (OS) and progression-free survival (PFS) based on sarcopenia in patients treated with ICIs were included. The inverse variance method was used with a random-effects model for data analysis.
Results: A total of 1284 patients from 14 studies were included. Among the patients who received ICIs, patients with sarcopenia had a significant increase in overall mortality compared to patients without sarcopenia in univariate analyses (HR = 1.66, 95% CI = 1.20-2.29, p = 0.002) and in adjusted HRs (HR = 1.55, 95% CI = 1.15-2.10, p = 0.004). The same results were obtained for PFS by both univariate analysis (HR = 1.75, 95% CI = 1.37-2.23, p < 0.001) and adjusted HRs (HR = 1.63, 95% CI 1.28-2.09, p < 0.001).
Conclusions: Sarcopenia appears to be an effective biomarker for predicting long-term oncologic outcomes in patients receiving ICI therapy and hence plays an important role when making treatment decisions. However, the fundamental role of this association with survival should be further investigated in large cohorts and clinical trials.ope