내인성과 외인성 아토피피부염 환자 T 세포의 프로테오믹 프로파일링

Dept. of Medicine/석사Background Atopic dermatitis (AD) is a highly pruritic, chronic relapsing inflammatory skin disease. The pathogenesis of AD has been known to be altered skin barrier and immune dysregulation. As new subsets of T cells are recently introduced as contributing factors to the immune dysregulation of AD, variable subsets of T cells play pivotal roles in the pathogenesis of AD. Objective To understand the role of T cells in the pathogenesis of AD between different AD subsets, differentialy expressed proteins (DEPs) of T cells were compared from patients with extrinsic AD, intrinsic AD and healthy controls (HC) Methods For proteomic analysis, normalized spectral index quantification and tandem mass tag (TMT) labeling based quantification were used. For following validation western blotting and fluorescence activated cell sorting was used. Results We identified several DEPs between extrinsic, intrinsic AD and HCs. Among them, the upregulation of galectin-10 and S100A9 were validated by western blotting analysis. In addition, galectin-10 expressing CD3+T cells showed higher expression of IL-22 in AD than in HC. Conclusion Based on proteomic analysis comparing the extrinsic, intrinsic AD and HCs, several DEPs that might be related with pathogenesis were identified. By following validation study, galectin-10 was shown to have a role in the pathogenesis of AD in association with Th22.prohibitio

네트워크 온 칩 상에서의 크레딧 기반 흐름 제어기법 성능 및 복잡도 분석

학위논문(석사) - 한국정보통신대학교 : 공학부, 2008.2, [ ix, 53 p. ]Network-on-Chip is an alternative paradigm to improve communication bandwidth compared to bus-based communication, and its performance degrades if there is no effective flow control method. Heterogeneous networks with very slow processing elements especially need a flow control mechanism at the transport layer to prevent too much packet injection. In this thesis, a credit-based end-to-end flow control (CB-EEFC) is implemented to control the network latency at high traffic loads. Simulation in mesh networks shows improved performance in latency and 0.5%~3% saturated throughput decrease with the CB-EEFC method. RTL gate level simulation shows that a network interface using CB-EEFC brings about a 12.9% increase in complexity compared to a network interface without CB-EEFC.한국정보통신대학교 : 공학부

Elevated Galectin-10 Expression of IL-22-Producing T Cells in Patients with Atopic Dermatitis

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