Expression and defferent mucins (MUC1, MUC2, MUC4, MUC5AC, MUC5B, MUC6) in colon of pigs naturally infected with Salmonella typhimurium

Thesis(masters) --서울대학교 대학원 :수의학과 수의병리학 전공,2008.8.Maste

Association Between Possible Osteoporosis and Shunt-Dependent Hydrocephalus After Subarachnoid Hemorrhage.

Background and Purpose Pathological obstruction in arachnoid granulations after subarachnoid hemorrhage (SAH) can impede cerebrospinal fluid flow outward to the venous sinus and causing hydrocephalus. Because bone and arachnoid granulations share the same collagen type, we evaluated the possible relation between bone mineral density and shunt-dependent hydrocephalus after SAH.Methods We measured Hounsfield units of the frontal skull on admission brain computed tomography in patients with SAH. Receiver operating characteristic curve analysis was performed to determine the optimal cutoff Hounsfield unit in skull to predict osteopenia and osteoporosis in a large sample registry. According to the optimal cutoff skull Hounsfield unit values, study patients were then categorized as hypothetical normal, osteopenia, and osteoporosis. Odds ratios were estimated using logistic regression to determine whether the osteoporotic conditions are independent predictive factors for the development of shunt-dependent hydrocephalus after clipping for SAH.Results A total of 447 patients (alive 14 days) with ruptured aneurysm SAH who underwent surgical clipping were retrospectively enrolled in this study during a 9-year period from 2 hospitals. We found that hypothetical osteoporosis was an independent predictor for shunt-dependent hydrocephalus after aneurysmal clipping for SAH after full adjustment for other predictive factors, including age (odds ratio, 2.08; 95% confidence interval, 1.06-4.08; P=0.032).Conclusions Our study demonstrates a possible relation between possible osteoporosis and hydrocephalus after SAH. Hounsfield unit measurement on admission brain computed tomography may be helpful for predicting hydrocephalus during the clinical course of SAH in patients with osteoporosis or suspected osteoporosis.This work was supported by the research fund of Hanyang University (HY-201600000002777)

발사체 충돌에 의한 철근콘크리트패널에 발생하는 관입깊이예측

학위논문 (석사)-- 서울대학교 대학원 : 공과대학 건설환경공학부, 2018. 8. 조재열.Since impact of large commercial aircraft became a serious issue for safety after 9.11 terror, it has been required that nuclear power plant(NPP) structures should be designed considering aircraft impact because failure of NPP structure lead to severe disaster by radiation leakage. When the object considered as projectile like aircraft collides with structure, the impact load that have large in a very short time is generated in the structure. This impact force generates not only global behavior that means conventional behavior of deflection but also local effects that means premature damage occurring in proximal area of impact. The local effects mainly consist of penetration, spalling, scabbing, perforation. Penetration means tunneling into structure by the projectile, scabbing means ejection of fragments of structural material from distal face of the structure, and perforation means complete passage of the projectile through thickness of the structure. Generally, the local effects dont lead to overall collapse of structure, but design for the local effects is necessary because fragments of the structure by scabbing and projectile entering inside of structure by perforation can damage internal facility like reactor of NPP structure. Penetration of the local effects is the primary behavior occurring immediately after projectile impact, so scabbing and perforation are affected by penetration because scabbing and perforation occur after penetration. Therefore, to evaluate and predict the local effects accurately when NPP structure is designed for the local effects, accurate evaluation and prediction of penetration behavior is required preferentially. In 1997, Forrestal & Tzou suggested penetration mechanism model for concrete target by using dynamic cavity expansion theory. Then, Forrestal et al. (2003) conducted experimental verification of the penetration mechanism model by performing impact test, and suggested semi-analytical prediction formula of penetration depth. However, the semi-analytical formula has limitations to apply to prediction of penetration depth for actual structure size because the previous research performed impact test for not structural member specimen simulating the actual structure but only non-structural specimen of cylinder shape having very large diameter and thick thickness. In addition, the previous research performed the impact test for not several nose shapes of projectile but only ogive nose shape, so there is limitation for lack of experimental evaluation for effect of nose shape on penetration. In this study, impact tests for Reinforced concrete(RC) panels simulating actual containment wall of NPP and several nose shapes of projectile were performed to predict penetration depth accurately for structural RC member. Then, by utilizing the form of semi-analytical prediction formula of penetration depth widely used by several researchers, undetermined coefficients of the semi-analytical formula were modified by experimental verification and evaluation from the test results. Therefore, penetration depth for structural RC member simulating the actual structure is well predicted by using the modified undetermined coefficients. In addition, it is expected that the result of this study can be used as basic research to predict penetration depth of several structures difficult to test and to predict scabbing and perforation affected by penetration behavior.LIST OF TABLES vii LIST OF FIGURES viii NOTATIONS x 1. Introduction 1 1.1. Research Background 1 1.2. Research Objectives 7 1.3. Outline 8 2. Theoretical Background 9 2.1. Semi-Analytical Formula for Penetration Depth 9 2.1.1. Dynamic cavity expansion theory for concrete material 9 2.1.1.1 Plastic region 31 2.1.1.2 Cracked-elastic region 31 2.1.1.3 Inverse calculation procedure 31 2.1.1.4 Results of the previous studies 31 2.1.2. Derivation of impact load 21 2.1.3. Derivation of prediction formula for penetration depth 21 2.2. Global Behavior Effect on Penetration 28 2.3. Previous Studies 28 2.3.1. Experimental studies 9 2.3.1.1 Forrestal et al. (1994) 31 2.3.1.2 Frew et al. (1998) 31 2.3.1.3 Forrestal et al. (2003) 31 2.3.2. Study for nose shape of projectile 9 2.3.2.1 Teland et al. (2004) 31 2.3.2.2 Li et al. (2003) 31 2.3.3. Summary and limitations of previous studies 9 3. Impact Test for Penetration 34 3.1. Specimen of Impact Test 34 3.1.1. RC panels 34 3.1.2. Projectile 36 3.2. Test Apparatus of Gas Gun 37 3.3 Impact Test Results 39 3.3.1. Test variables 34 3.3.2. Measurements of impact test 36 3.3.3. Test results 34 3.3.4. Verification of test results 36 4. Modification of Coefficient for Prediction Formula of Penetration Depth 46 4.1 Evaluation of Global Behavior Effect on Penetration 46 4.2 Evaluation of Semi-Analytical Formula 48 4.2.1 Determination of the coefficient k 48 4.2.2 Determination of the coefficient A 51 4.2.3 Determination of the coefficient B 51 4.3 Discussion of Evaluation Result 46 5. Conclusions 58 Reference 59 국문초록 62Maste

금속과 전이 금속 산화물 표면의 스핀, 궤도, 격자 상호작용

Significant progress in materials science of the past decade is associated with the emerging paradigm of phase complexity and cross-coupling phenomena in functional complex materials, in which various degrees of freedom are intricately coupled and mutually interacting. Such mutual interactions couple the spin-orbital-lattice, and often induce various emerging phenomena such as colossal magnetoresistance, multiferroicity, strain induced ferroelectricity, etc. Fundamental understanding of such phenomena requires detailed microscopic information on each physical degree of freedom for different physical qualities of spin, orbital, and lattice. In this thesis, we discuss how to approach to the physical quantities on spin, orbital and lattice degree of freedom and report theoretical analyses on emerging phenomena in surface of both transition metal oxides and metals. Firstly, thickness and strain dependent magnetism in SrRuO$_3$ ultra thin film shows a dimensional crossover character of surface electronic states. We observed that the magnetism of SrRuO$_3$ films is sensitive to the thickness and the applied strain. Stoner theory of itinerant magnetism is successfully applied to explain this behavior. Secondly, surface play a role as a boundary between normal insulator (vacuum) and non-trivial $Z_2$ topological insulator in possible topological insulator phase of $5d$ transition metal oxides Na$_2$IrO$_3$. Non-trivial topological states which is obtained by increasing the inter-layer distance make the topological surface states which is robust against the perturbation preserving time-reversal symmetry. Topological surface states of transition metal compound is special among other topological insulators since it contains the moderate electron correlation effects to make novel topological states such as topological Mott insulators and Weyl semimetal phases. Finally, chiral orbital angular momentum on the metal surfaces is originated from the inversion symmetry breaking nature of surfaces. We propose that the existence of chiral orbital angular momentum is a general consequence of inversion symmetry breaking potential, regardless of strength of spin-orbit coupling. And this local orbital angular momentum on the surfaces of high-$Z$ materials play a crucial role in the formation of Rashba-type surface band splitting. To detect such orbital angular momentum, circular dichroism experiment using the angle-resolved photoemission could be used.Docto

Relationships between CYP3A5 gene polymorphisms and efficacy of praziquantel therapy in clonorchiasis patients

학위논문(박사) --서울대학교 대학원 :의학과(기생충학 전공),2009.2.Docto

파이테이즈의 수준별 첨가가 육성·비육돈의 성장, 도체특성, 뼈 강도 및 인 이용성에 미치는 영향

학위논문(석사)--서울대학교 대학원 :농생명공학부,2005.Maste

돼지폐렴의 병원체에 대한 뮤신의 발현성 연구

학위논문 (박사)-- 서울대학교 대학원 : 수의학과, 2011.2. 채찬희.Docto

An analysis of Emission Trading Policy making process in South Korea- through the Application of Advocacy Coalition Framework -

학위논문 (석사)-- 서울대학교 행정대학원 : 행정학과(정책학전공), 2012. 8. 권혁주.본 논문은 한국의 온실가스배출권거래제도의 정책형성과정에서 나타난 정책내용변동을 정책옹호연합모형(Advocacy Coalition Framework: 이하 ACF모형이라 한다.)을 통해 분석한다. 분석내용은 이론적 측면과 정책적 측면 두가지로 나눌 수 있다. 첫째, 이론적 측면에서 정책분석을 위해 적용하는 분석틀(수정한 ACF모형)이 온실가스배출권거래제도의 정책형성과정을 설명하는데 적합한지 ACF모형의 기본 가설의 검증을 통해 확인한다. 둘째, 정책적 측면에서 정책형성과정에서 나타나는 온실가스배출권거래제의 내용변화 과정을 옹호연합을 중심으로 분석한다. 분석방법은 질적연구 방법을 활용한다. Sabatier의 정책옹호연합모형에 관련해 학술서적과 학위논문 및 학술지를 중심으로 문헌검토(literature review)를 실시한다. 온실가스배출권거래제도의 정책 형성과정에 관련해서는 제도 관련 논문과 학술지, 녹색성장위원회의 연구자료와 발간자료, 환경부/지식경제부 등의 정부부처와 지방자치단체의 발간자료 및 대통령의 국정연설, 제도관련 언론보도, 포럼이나 토론회의 자료, 국회 녹색성장특별위원회·법제사법위원회의 회의록 등을 기초로 문헌검토(literature review)를 실시한다. 분석 결과 온실가스배출권거래제도의 형성에 있어서 최초 방향설정시의 내용보다 산업계의 요구를 수용하는 방향으로 정책 내용이 변동된 점을 확인할 수 있다. ACF모형을 이용해 내용 변동을 검토한 결과 이러한 정책 내용 변동 과정에 외적 환경과 하위 정치체제의 상호 작용이 있었음을 알 수 있다. 또한, 이론적인 측면에서 ACF모형이 10년 이상의 장기간을 범위로 하지 않는 경우에도 유의미함을 확인할 수 있다. 구체적으로, 옹호연합의 전략과 상호작용면에서 친시장연합 중 산업계는 온실가스배출권거래제도의 논의 초기에는 비교적 소극적인 자세를 보였으나 제도가 법안으로 구체화되는 과정에서 적극적으로 정책핵심 신념을 법안에 반영하기 위한 자세를 보였음을 확인할 수 있다. 특히, 정책변동의 기제와 관련해 사회경제적 조건의 변화와 문제영역의 기본속성이 두드러진다. 온실가스배출권거래제가 갖는 규제적인 성격과 시장거래적 성격은 최초 친환경연합의 입장에 가까운 법안에서 친시장연합의 입장에 가까운 법안으로의 내용변화를 가능하게 하는 기초가 됐다. 여기에 2008년 이후의 국제적 금융위기, 국제기후협약의 정체 같은 외적충격, 이명박 대통령의 입장표명과 리더십발휘와 같은 내적충격은 배출권 거래제의 내용이 최초 도입 시보다 산업계의 입장에 가깝게 변동하는데 기여했다. 한편 정책지향학습의 경우 친시장 연합과 친환경연합의 신념체계 변화는 쉽게 나타나지 않았다. 전문적인 포럼의 부족, 각 연합의 태도변화 노력 부족이 정책지향학습의 부족을 가져온 원인으로 작용했다. 이러한 정책변동의 내용을 기초로 ACF모형의 가설의 유의미성을 검토한 결과 정책연합, 정책변동에 관한 가설 두가지는 유의미함을 확인할 수 있다. 그러나 정책학습과 관련한 가설의 경우 다섯가지 가설중 세가지는 확인할 수 없고, 한가지는 불성립하며, 한가지만 성립한다.제 1 장 서 론 1 제 1 절 연구의 목적과 필요성 1 제 2 절 연구의 대상과 범위 2 제 3 절 연구의 방법 3 제 2 장 이론적 배경과 분석틀 5 제 1 절 온실가스배출권 거래제의 내용과 현황 5 1. 온실가스배출권 거래제의 내용 5 2. 국내외 추진현황 12 제 2 절 정책결정과정 분석을 위한 이론과 선행연구 15 1. 정책옹호연합모형 15 2. 선행연구검토 18 제 3 절 분석틀 설정 23 1. 정책옹호연합모형 적용의 적실성 23 2. 연구 분석틀 구성 23 제 3 장 온실가스배출권 거래제도 결정과정분석 30 제 1 절 외적조건 30 1. 상대적으로 안정적인 외적변수 30 2. 역동적 외적요인 35 제 2 절 정책하위체제의 구조 분석 38 1. 정책옹호연합의 형성과 계층적 신념체계 38 2. 각 옹호연합의 전략 39 3. 정책중개자 46 4. ACF가설검증(옹호연합) 49 제 3 절 정책변동의 기제 51 1. 정책변동의 내용 51 2. 외적충격과 각 옹호연합의 대응전략 53 3. 내적충격과 정책변동 54 4. 정책지향 학습 성립여부 56 5. ACF가설검증(정책변동, 정책지향학습) 57 제 4 장 결론 61 제 1 절 연구결과의 요약 61 제 2 절 시사점 및 한계 62 1. 이론적, 정책적 시사점 63 2. 한계 64Maste

간흡충증의 충란 검사법 비교에 관한 연구

학위논문(석사)--서울대학교 대학원 :의학과 기생충학전공,2004.Maste