21 research outputs found
Regulatory mechanism of high extracellular CaΒ²+ on RANKL expression in mouse osteoblastic cells κ³ λλ μΈν¬μΈ CaΒ²+μ λ§μ°μ€ 쑰골μΈν¬ RANKLλ°ν μ‘°μ κΈ°μ
Thesis (doctoral)--μμΈλνκ΅ λνμ :μΉμνκ³Ό μΉκ³Όμ½λ¦¬νμ 곡,2002.Docto
The meaning and application of Music Education based on Yin-Yang-Wuxing Principle.
νμλ
Όλ¬Έ (λ°μ¬)-- μμΈλνκ΅ λνμ : νλκ³Όμ (μμ
κ΅μ‘μ 곡), 2015. 8. μ μ±μ.λ³Έ μ°κ΅¬λ μ°λ¦¬λλΌ μμ
κ΅μ‘μ² νμμ μμμμ
κ΅μ‘μ² νμ΄ κ±°μ λλΆλΆ μ μ νκ³ μμμ λ¬Έμ λ₯Ό μ κΈ°νλ©° μμλμλ€. μμ
κ΅μ‘μ² νμ νκ΅μμ νκ΅μμ μ μμ
κ΅μ‘μ νλκ°μ λ¬Έμ λ₯Ό νꡬνλ λΆμΌμ΄λ€. μ΄μ λ μ°λ¦¬μ μ ν΅μ¬μμ κΈ°μ΄ν μμ
κ΅μ‘μ² νμ΄ νμνλ€. ννμμ
κ΅μ‘μ² νμΌλ‘λ μμ νμ§ λͺ»ν μ μ λμμ¬μ μ€μμλ μμ¬κ° μ€λλκ³ , μ λΆμ κ΄κ³μμ΄ λͺ¨λ κ³μΈ΅μμ κ°μ₯ λ§μ λΆμΌμ μ μ©, μ¬μ©λ μμμ€νλ‘ μ μ κ·Όλ²μΌλ‘ 보μν μ μλ€.
μ°κ΅¬λͺ©μ μΌλ‘ λμμ μ¬λ¬μ¬μκ³Ό μ² ν μ€μμ μμ
κ΅μ‘κ³μμ κ±°μ μ£Όλͺ©λ°μ§ λͺ»νλ μμμ€νλ‘ μ κ·Όκ±°λ‘ μμ
κ΅μ‘μ μλ―Έλ₯Ό μ‘°λͺ
νκ³ νκ΅μμ
κ΅μ‘μ μ μ©ν μ μλ λ°λ₯Ό λμΆνμ¬ μμμ€νλ‘ μ μμ
κ΅μ‘λ‘ μ μ μνλ κ²μ΄λ€.
μ°κ΅¬λ¬Έμ λ‘λ 첫째, μμμ€νλ‘ μ κ·Όκ±°λ‘ μμ
κ΅μ‘μ² νμ μ΄λ»κ² λΆμν μ μλκ°? λμ§Έ, μμμ€νλ‘ μ κ·Όκ±°λ‘ μμ
κ΅μ‘μ μλ―Έλ₯Ό μ΄λ»κ² μ μν μ μλκ°? μ
μ§Έ, νλ 곡κ΅μ‘μμ μνλκ³ μλ μμ
κ΅μ‘μ μμμ€νλ‘ μ μ΄λ»κ² μ μ©ν μ μλκ°? λ‘ μμΆνμλ€.
μ°κ΅¬λ°©λ²μΌλ‘ λ
Όλ¬Έ, μ μ, μΆνλ¬Ό, μ¬μ , μμμ¬μ΄νΈ, κ΅λ¦½κ΅μ
μ κ³ μμ¬μ΄νΈ, κ΅κ³Όμμ κ°μ λ¬Ένμ°κ΅¬μ κ΅μ, κ΅μ¬, μλνμ, κ΅μ
μΈ, λμμ² νμΈ(ζ±ζ΄ε²εΈδΊΊ), μ κ΅νμ(εζεΈθ
)λ€κ³Όμ μΈν°λ·°μ μμ
λ΄μ© λ±μ μ‘°μ¬, λΆμνλ μ§μ μ°κ΅¬λ₯Ό ν¬ν¨νμ¬ κ΄λ²μν μλ―Έμ μ§μ μ°κ΅¬λ₯Ό νμλ€.
μ°κ΅¬λ΄μ©μΌλ‘ ννμμ
κ΅μ‘μ² νμ μμμ€νλ‘ μ κ·Όκ±°νμ¬ λΉνμ λΆμμ νκ³ μμμ€νλ‘ μ κ·Όκ±°λ‘ κ΅μ‘λ°©λ²μ μ μνμμΌλ©°, 곡κ΅μ‘μ μ μ©ν μ μλ μμ
μμ
μ κ°μ°½, κΈ°μ
, μ°½μ, κ°μ, μ΄λ‘ μ 5κ°μ§λ‘ λΆλ₯νμ¬ μμμ€νλ‘ μ μμ
μμ μ μνμλ€.
μ°κ΅¬κ²°κ³Όλ‘μ μμμ€νλ‘ μ μ μ μ , 물리μ , λ¬Όμ§μ λͺ¨λ κ²λ€μ ν¬ν¨ν΄μ μ(ι°)κ³Ό μ(ι½)(δΈ ν¬ν¨)μΌλ‘ μ΄λ€μ§λ©°, λ λ§λ¬Όμ μ€ν, λͺ©(ζ¨), ν(η«), ν (ε), κΈ(ο€), μ(ζ°΄)λ‘ μ±λΆμ λλ μ μλ€. μμ
μμ μμμ€νμΌλ‘ ꡬλΆνκ³ μμ
κ΅μ‘λ μμμ€νμ λ§κ² μ μ©ν μ μλ€.
μμ
κ΅μ‘μ μΈ‘λ©΄μμλ 첫째, μμ
μ κΈ(ο€), μ(ζ°΄)μ μ²(θ½)κ°κ°μ ν΄λΉνλ€. λμ§Έ, κ΅μ
, μμ
, μΈκ³μμ
λͺ¨λ μμμ€νμΌλ‘ λΆμν μ μλ€. μ
μ§Έ, κ΅μ
μμ
μμ μ₯λ¨μ μ°λ¦¬ μ ν΅μ μΌμ¬(δΈζ)μ¬μ, μΌνκ·Ή(δΈε€ͺζ₯΅) μ¬μμ΄ λ°μλ 3μλ° κ°λ
κ³Ό 3λ°κ³Ό 2λ°μ νΌν©ν μμλ°(ι°ι½ζ)μΌλ‘ λλ μ μλ€. λ·μ§Έ, κ΅κ³Όν΅ν©μμ
λ μμμ μ리μ λ°λΌ μ μ©νλ κ²μ΄ μ’λ€. λ€μ―μ§Έ, κ΅κ³Όλ΄μ© μ¦ κ°μ°½μ ν(η«)μ νλ, μ°μ£Όλ λͺ©(ζ¨)μ νλ, κ°μμ μ(ζ°΄)μ νλ, μ°½μμ κΈ(ο€)μ νλ, μ΄λ‘ μ ν (ε)μ νλμ΄λ―λ‘ λ€μ―κ°μ§κ° κ³¨κ³ λ£¨ μνλμ΄μΌ μμμ€νμ μ΄μΉμ λ§λ€. μ
κΈ°λ μμμ€νμ΄ μμΌλ©°, μ¬λλ μμμ€νμ λ°λΌ 체μ§κ³Ό μ±κ²©μ΄ λλλ―λ‘ κ±°κΈ°μ λ§λ κ΅μ‘κ³Ό νμ΅λ°©λ²μ΄ λ¬λΌμ§λ©°, μμ μκ² λ§λ μ
κΈ°μ νμ΅λ²μ μ ννλ κ²μ΄ μ’λ€.
μμμ€νλ‘ μ μμ
κ΅μ‘μ λμ, νκ΅μ μμ
κ΅μ‘μ² νμ μλ―Έλ₯Ό μ μνκ³ , νμ κ°λ³ νΉμ±μ μ‘΄μ€νλ©°, λ€μν μμ
κ΅κ³Όνλκ³Ό κ΅κ³Όν΅ν©, μ΄μ§κ·Έλ£Ή νΈμ±, μ΅ν©κ΅μ‘μ μλ―Έλ₯Ό λΆμ¬νλ€.
μ£Όμμ΄: μμμ€ν, λͺ
리, 체μ§λ‘ , μμ
κ΅μ‘μ² νI. μλ‘
1. μ°κ΅¬μ νμμ±κ³Ό λͺ©μ 1
2. μ°κ΅¬μ λ¬Έμ μ λ΄μ© 8
3. μ°κ΅¬λ°©λ² 12
4. μ°κ΅¬κΈ°λν¨κ³Ό λ° μ νμ 16
II. μμμ€νλ‘ μ κ°λ
κ³Ό μ΄ν΄ 24
1. μμμ€νλ‘ μ μ μ 24
2. νκ΅ μ ν΅ λ¬Ένμ μ리λ‘μ μμμ€νλ‘ 28
3. μνκ³Ό μμμ€ν 30
4. 체μ§λ‘ κ³Ό μμμ€ν 39
5. μμ
κ³Ό μμμ€ν 52
III. μμμ€νλ‘ μ μμ
κ΅μ‘μ μλ―Έ 71
1. μμ
κ΅μ‘μ λμμ μ κ·ΌμΌλ‘μ μμμ€νλ‘ 71
2. μ²κ°κ°κ³Ό μμμ€ν 81
3. μ
κΈ°μ μμμ€ν 85
4. μ±κ²©κ³Ό μμμ€ν 86
5. 체μ§κ³Ό μμμ€ν 92
IV. μμμ€νλ‘ μ μμ
κ΅μ‘μ μ μ© 119
1. κ°μ°½μμ
119
2. κΈ°μ
μμ
147
3. μ°½μμμ
159
4. κ°μμμ
163
5. μ΄λ‘ μμ
172
V. κ²°λ‘ λ° μ μΈ 175
μ°Έκ³ λ¬Έν 180
λΆλ‘ 197
μλ¬Έμ΄λ‘ 228Docto
Effects of parathyroid hormone, sodium fluoride and estrogen on the calcium uptake in mineralizing bone nodule in vitro λΆκ°μμ νΈλ₯΄λͺ¬, λΆνλνΈλ₯¨ λ° μμ€νΈλ‘μ μ΄ μννμ€μΈ 골결μ μ μΉΌμμ μ μ λ―ΈμΉλ μν₯
Thesis (master`s)--μμΈλνκ΅ λνμ :μΉμνκ³Ό μΉκ³Όμ½λ¦¬νμ 곡,1997.Maste
Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7.
Recent studies have shown that stromal fibroblasts have a more profound influence on the initiation and progression of carcinoma than was previously appreciated. This study aimed at investigating the reciprocal relationship between cancer cells and their associated fibroblasts at both the molecular and cellular level in oral squamous cell carcinoma (OSCC). To identify key molecular regulators expressed by carcinoma-associated fibroblasts (CAF) that promote cancer cell invasion, microarrays were performed by comparing cocultured OSCC cells and CAF with monoculture controls. Microarray and real-time PCR analysis identified marked upregulation of the chemokine (C-C motif) ligand 7 (CCL7) in cocultured CAF. ELISA showed an elevated level of CCL7 secretion from CAF stimulated by coculture with OSCC cells. CCL7 promoted the invasion and migration of OSCC cells, and the invasiveness was inhibited by treatment with CCL7 neutralizing antibody. OSCC cells were shown to express CCR1, CCR2 and CCR3, receptors for CCL7, by RT-PCR. In addition, treatment with anti-CCR1 or anti-CCR3 antibody inhibited CCL7-induced OSCC cell migration, implicating that CCL7 promotes cancer cell migration through CCR1 and CCR3 on OSCC cells. Cytokine antibody array analysis of the supernatant from OSCC cell culture revealed that interleukin-1alpha was an inducer of CCL7 secretion by CAF. This study confirms the reciprocal relationship of the molecular crosstalk regulating the invasion of OSCC and describes new potential targets for future therapy.ope
Immortalized gingival fibroblasts as a cytotoxicity test model for dental materials
In vitro cytotoxicity test is an initial step to identify the harmful effects of new dental materials. Aim of this study was to develop a stable human cell line derived from normal gingival fibroblasts (hNOF) and to assess its feasibility in in vitro cytotoxicity testing. Immortalized human gingival fibroblasts (hTERT-hNOF) were successfully established with human telomerase reverse transcriptase gene transfection, preserving its phenotypical characteristics, replicative potential and biological properties. Utilizing standard cytotoxicity test modeling and dental materials, hTERT-hNOF were evaluated for their feasibility in cytotoxicity testing, compared with hNOF and L929 cells. Similar pattern of cytotoxic response was observed among hNOF, hTERT-hNOF and L929 cells. Cytotoxicity response of hTERT-hNOF was significantly similar to hNOF, moreover hTERT-hNOF and hNOF were found to be more sensitive towards the tested dental materials compared to L929 cells. This study suggested that hTERT-hNOF is an effective cytotoxic test model for dental materials.ope