20 research outputs found
Experimental study on the instrinsic healing potential of injuried tendons
μνκ³Ό/μμ¬[νκΈ]μμλ μμ§ κ΅΄κ³‘κ±΄μ μΉλ£λ μμ§λ μ΄λ €μ΄ λ¬Έμ λ‘ λ¨μμκ³ κ΅΄κ³‘μ₯μ λ±μ΄ μ΄λλλ
κ²½μ°λ λΉλ²νλ€. 건 μ‘°μ§μ μ체μ λ΄μ μ¬μλ₯λ ₯μ΄ μμ΄ κ±΄μ μ°½μ μΉμ κ³Όμ μμ, μΈ
λΆλ‘λΆν° μ¬μ μμΈν¬μ νκ΄μ΄ μλΌλ€μ΄μ κ±΄μ΄ λ° κ±΄κ³Ό μ μ°©μ μΌμΌν΄μΌλ‘μ¨ μμ§ κ΅΄κ³‘
건 κΈ°λ₯ ν볡μ μ λμ μΈ μν₯μ μ£Όλ μ€νλ©΄μ ν볡μ μ₯μ λ₯Ό μ£Όλ κ²μΌλ‘ μλ €μ Έ μμΌ
λ μ΅κ·Ό 건 μμ μ, μ΄μμ μΈ μ‘°κ±΄μμλ λ΄μ μ¬μ λ₯λ ₯μ΄ μλ€λ λ³΄κ³ λ€μ΄ μ¦κ°νκ³
μλ€.
λ³Έ μ°κ΅¬μμλ μμ§ κ΅΄κ³‘κ±΄μ λ΄μ μ¬μ κΈ°μ μ κ·λͺ
λ° κ·Έ μμμ μμ©μ κΈ°μ΄μ μ§μ
μ μ»κ³ μ λ€μκ³Ό κ°μ μ€νμ μννμλ€. μ²΄μ€ 2.0-2.5kgμ λ°±μ Leghornλ 14λ§λ¦¬λ₯Ό
μ€νλμμΌλ‘ νμ¬ μ 3μ‘±μ§ μ¬μ§ ꡴곑건μ 8mmκΈΈμ΄λ‘ μ μ ν΄λ΄κ³ μ μ ν΄λΈ 건νΈμ μ€μλΆ
λ₯Ό ν‘μΌλ‘ 1/2μ λ¨ν ν μ΄λ₯Ό λ€μ λ¨μ μ°μ λ΄ν©νμ¬ λμΌν λμ μ¬κ΄μ μΈμΈ‘ νλ§₯μ
μ μμΉμν¨ ν μ¬μ μ± νΌλ§κ³Ό νΌλΆλ₯Ό λ΄ν©νμλ€. μμ ν 1μ£ΌλΆν° 1μ£Ό κ°κ²©μΌλ‘ μ¬κ΄μ
μ κ°λ°©νμ¬ μμ ν 7μ£ΌκΉμ§ νμ‘μ λ΄μ μ΄μν 건νΈμ μ‘μμ μΌλ‘ κ΄μ°°νμκ³ , λμμ
μ‘°μ§νλ³Έμ λ§λ€μ΄ H-EμΌμ λ° Masson's trichrome μΌμνμ κ΄ν νλ―Έκ²½μ μ‘°μ§λ³νλ₯Ό
κ΄μ°°νμ¬ λ€μκ³Ό κ°μ κ²°κ³Όλ₯Ό μ»μλ€.
1. λ°±μ Leghornλμ μ¬μ§ ꡴곑건μ μ λ¨, λ΄ν©ν 건 μ΄μνΈμΌλ‘ λ§λ€μ΄ λμΌν λμ
μ¬κ΄μ λ΄μ λ£μμ λ κ·Έ 건νΈμ 5μ£Ό, 6μ£Ό κ° 1μλ₯Ό μ μΈνκ³ μ€ν ν 6μ£ΌκΉμ§ μ μ°©νμ±
μμ΄ νμ‘ μμ μμ λΆμ μ²΄λ‘ λ μμλ€.
2. μ λ¨ ν λ΄ν©λ 건 μ΄μνΈμ λ΄ν©λΆ νλ©΄μμλ§ μ¬μ μμΈν¬μ μ¦μκ³Ό κ΅μμ§ νμ±μ
κ΄μ°°ν μ μμκ³ λ΄ν© μ¬λΆμλ μΈν¬ μ¦μμ΄ μμλ€.
3. μμ λκ°μ§ μ¬μ€λ‘ λΆν° νμ‘μ λ΄μ μ΄μλ 건 μ νΈμ μ°½μ μΉμ λ μ£Όμ μ‘°μ§μΌλ‘
λΆν° κΈ°μΈνλ νκ΄μ΄λ μΈν¬μ μν κ²μ΄ μλλΌ μ£Όμμ νμ‘μΌλ‘ λΆν° νμ°μ μν΄μ
μμ 곡κΈμ λ°λ 건μΈν¬ μ체μ λ΄μ μ¬μ κΈ°μ μ μν κ²μμ μΆμΈ‘ν μ μλ€.
[μλ¬Έ]
There are still many unresolved problems in the treatment of injured flexor
tendons of the hand and thus with frequent impediment of function. In the past,
tendon surgery was based upon the concept that tendons lack intrinsic potential for
healing. However the primary goal of treatment of flexor tendon injury is the
restoration of gliding surface, applicability of the past concept was greatly
questioned.
Recently there have been many reports insisting on the presence of intrinsic
tendon healing capability in the ideal setting.
In this study, 28 flexor tendons of the 3rd toe in fourteen white Leghorn
chickens, weighing 2.0 to 2.5 kg were resected, and the resected tendon segments,
measuring 8 mm in length were then transversly cut to half of it's width, and was
resutured and then was inserted to the synovial pouch lateral to the femur condyle
of the same chicken. The overlying fibrous tissue and skin were sutured. Change of
the sutured tendon grafts were examined with one week interval from 1 week to 7
week post-operatively. The knee joints were opened and gross and microscopic
observations were made after staining tilth H-E and Masson's trichrome.
We obtained the following results.
1. Among 24 transplanted flexor tendons into synovial pouch, all tendons except
two showed no adhesion up to 6 weeks after transplantation.
2. Newly proliferated fibroblasts and new collagen covered the surface of the
suture gap. But there was no cellular proliferation in the central area of the
suture gap.
3. The free tendon grafts were nourished by diffusional pathways from the
synovial fluid, without influence of cells and vessels from surrounding tissues. It
seems intrinsic healing mechanism of the tenocyte itself.restrictio
Morphometric study on regeneration of vascularized nerve graft
μνκ³Ό/λ°μ¬[νκΈ]
λ§μ΄μ κ²½μ΄μμ λ§μ΄μ κ²½μ κ²°μ μΉλ£λ₯Ό μν΄ μ΄λ―Έ μ μ 립λμ΄ μλ μμ λ°©λ²μ΄κ³ μ±κ³΅μ μΈ μ κ²½μ΄μμ μν΄μλ μ΄μνΈμ μ μ ν ννμ΄ νμμ μ΄λ€.
νμ§λ§ μ΄λ ν μ κ²½μ΄λ μΌλ¨ μμμ λ°κ² λλ©΄ κ·Έ μμλΆμλ Wallerianμ¨ ν΄νμ΄ μΌμ΄λ μ κ²½ μΆμκ³Ό μμ΄λ ν΄ννκ² λκ³ , λ¨μ μλ Schwannμ¨ μΈν¬λ€κ³Ό μ¬μ μΈν¬λ€μ΄ μ¦μνμ¬ μ κ²½λ΄κ°(endoneurial tube)μΌλ‘ μΉ¨μ€λμ΄ λ€μ΄μ€κ² λλ€. κ³ μμ μΈ μ 리μ κ²½μ΄μμ κ²½μ° μ£Όμμ‘°μ§μΌλ‘ λΆν°μ μ¬νννμ μν΄ μ κ²½μ μ¬μμ΄ μΌμ΄λκ² λλ―λ‘ μ무리 μ£Όμλ‘λΆν°μ μ¬νννκ° μ λλ€ νλλΌλ μΆμ¬μ μ¬μμ μ λμ μΌλ‘ μ΄μμ μΈ μ‘°κ±΄μ μ κ³΅ν΄ μ£Όμ§λ λͺ»νλ€. λ°λΌμ μ κ²½μ νμ‘μ 곡κΈνκ³ μλ νκ΄κ²½μ κ·Έλλ‘ μ μ§ν μ± μ κ²½μ΄μνΈμ μ±μ·¨νμ¬ μ΄ νκ΄κ²½μ μνλΆμ νκ΄μ μ΄μ μ¦μ λ¬Έν©νμ¬ μ€μΌλ‘μ¨ μ κ²½μ΄μνΈμ ννμ΄ κ·Έλλ‘ μ μ§λ μ± μ΄μνλ€λ©΄ μ΄μ μ§νλΆν° μ κ²½μ ννμ΄ μ°¨λ¨ μμ΄ κ³μ μ μ§λ¨μΌλ‘μ¨ μ κ²½μ΄μνΈμ λ³΄λ€ μ μν νμμ΄νλ₯Ό μ΄μ§νκ³ κ²°κ³Όμ μΌλ‘ μ¬μμ΄νλ₯Ό μ΄μ§νμ¬ μ μν μΆμμ μ¬μμ μ λν λΏλ§ μλλΌ μ κ²½λ΄κ°μΌλ‘ μ¬μ μμΈν¬κ° μΉ¨μ€λμ΄ λ€μ΄ μ€λ κ²μ λ§κ³ μ κ²½μ¬μ μ μ μν μ¬μμ μ΄μ§μν¬ μ μμ κ²μ΄λ€. νΉν κ΅΅μ μ κ²½κ° μ΄μμ΄ νμν κ²½μ°, μλΉν κΈΈμ΄μ μ κ²½μ΄μμ΄ νμν κ²½μ°, λλ ννμνκ° μ’μ§ μμ μ°½μμ μ κ²½μ΄μμ νκ² λ κ²½μ°μλ μ΄λ¬ν ννν μ κ²½μ΄μμ΄ λμ± μ μ€ν μꡬλλ€.
λ³Έ μ°κ΅¬μμλ κ°ν μμ μ’골 μ κ²½μ΄μ μ€ν λͺ¨λΈμ μλ‘ κ°λ°νκ³ μ΄λ₯Ό μ΄μ©, ννν μ κ²½μ΄μκ³Ό κ³ μμ μΈ μ 리μ κ²½μ΄μμ μνν ν νννμ , μ‘°μ§νμ λ°©λ²μΌλ‘ ννν μ κ²½μ΄μμ μ°μμ± μ¬λΆλ₯Ό κ·λͺ
νμλ€.
κ°ν μ μ’골μ κ²½ 4cmλ₯Ό μ λ¨νμλ€κ° νμͺ½μμλ κ³ μμ μΈ μ 리μ΄μμ, λ°λμͺ½μμλ μλλλΆνκ΄μ΄ μ°κ²°λ νννμ΄μμ μννκ³ 2, 3, 4κ°μ ν μ΄μν μ κ²½μ μ‘°μ§νλ³Έμ μ±μ·¨, toluidine blue μΌμνμ μ μμ κ²½μ¬μ (myelinated nerve fiber)μ Schwannμ¨ μΈ
ν¬μ λΆν¬λ₯Ό λΉκ΅ κ΄μ°°νμ¬ λ€μκ³Ό κ°μ κ²°κ³Όλ₯Ό μ»μλ€.
1. μ κ²½μ΄μ ν 2, 3κ°μμ μ μμ κ²½μ¬μ λ μ κ²½μ¬μ μ μ§κ²½μ κ΄κ³μμ΄ μ 리μ΄μκ΅°μ λΉν΄ νννμ΄μκ΅° κ·ΌμλΆ, μ€κ°λΆ, μμλΆ λͺ¨λμμ λ λ§μλ€.
2. μ 리μ΄μ 2κ°μκ΅° κ·ΌμλΆμ μ€κ°λΆμμλ μ§κ²½μ΄ μμ μ μμ κ²½μ¬μ λ€μ΄ μλ λνλ¬κ³ μμλΆμμλ μ ν κ΄μ°°λμ§ μμμΌλ νννμ΄μ 2κ°μκ΅°μμλ μ§κ²½ 2βΌ8γμ μμ μ κ²½μ¬μ λ€μ΄ κ·ΌμλΆ, μ€κ°λΆ, μμλΆ λͺ¨λμμ λ€μ κ΄μ°°λμλ€.
3. μ 리μ΄μ 3κ°μκ΅°μ κ·ΌμλΆ, μ€κ°λΆ, μμλΆμμλ μ£Όλ‘ μ§κ²½ 2βΌ6γμ μμ μ μμ κ²½μ¬μ λ€μ΄ λνλ¬μΌλ νννμ΄μ 3κ°μκ΅°μμλ 2βΌ10γμ μ κ²½μ¬μ λ€μ΄ κ·ΌμλΆ, μ€κ°λΆ, μμλΆ λͺ¨λμμ λ€μ κ΄μ°°λμλ€.
4. μ κ²½μ΄μ ν 4κ°μ, μ 체 μ μμ κ²½μ¬μ μλ νννμ΄μκ΅°μ κ·ΌμλΆ, μ€κ°λΆ, μμλΆ λͺ¨λμμ μ 리μ΄μκ΅°μ λΉν΄ λ λ§μμΌλ μ§κ²½ 2γ λ―Έλ§μ μμ μ μμ κ²½μ¬μ λ€μ μ€νλ € μ 리μ΄μκ΅°μ λ§μλ€.
5. μ κ²½μ΄μ ν Schwannμ¨ μΈν¬λ 2, 3, 4κ°μμ κ·ΌμλΆ, μ€κ°λΆ, μμλΆ λͺ¨λ νννμ΄μκ΅°μμ λ λ§μ΄ κ΄μ°°λμλ€.
μ΄μμ μ°κ΅¬ κ²°κ³Όλ€μ μ’
ν©ν΄ λ³Ό λ ννν μ κ²½μ΄μμ μ΄μ μ§ν λΆν° μ κ²½μ΄μνΈμ μ μμ μΈ ννμ μ μ§μμΌ μ€μΌλ‘μ¨ λ§μ μ«μμ Schwannμ¨ μΈν¬λ€μ νμ±νμμΌ μ£Όκ³ Wallerianμ¨ ν΄νμ΄ μΌμ΄λ¬λ μ κ²½μΆμκ³Ό μμ΄μ μ μνλ©΄μλ νννμ μΌλ‘ μμ§μ μ¬μμ μ΄μ§μμΌ μ€λ€λ κ²μ μ μ μμλ€.
νμ§λ§ μ κ²½μ¬μ μ΄ν μ κ²½μ¬μ μ μ리νμ κΈ°λ₯ν볡μ μ λ μ°¨μ΄λ₯Ό νμΈνκΈ° μν΄μλ κ°λλ μ€νλͺ¨λΈλ‘μ μ₯κΈ°κ°μ μΆμ κ΄μ°°μ΄ νμν κ²μΌλ‘ μκ°λλ€.
[μλ¬Έ]
Adequate vascularization is pivotally essential for a successful nerve graft. It has been recently confirmed that after conventional nonvascularized nerve graft, the grafts survive by revascularization from the surrounding tissue. Therefore, when a relatively long or thick nerve graft is necessary or when the recipient bed is poorly vascularized, vascularized nerve graft is indicated. Theoretically, the immediate vascularization will inhibit fibroblast infiltration and stimulate nerve cell regeneration.
In this study, a new animal model was developed using the sciatic nerve of New Zealand white rabbits. Conventional nonvascularized as well as vascularized nerve graft were done. To determine if vascularized nerve grafts are superior, histomorphological study was performed.
A 4 cm segment of the sciatic nerve was obtained and placed as a nonvascularized graft on one side, and as a vascularized graft connected to the inferior gluteal vessels on the opposite side. To determine difference in nerve regeneration between the two groups, the distribution of myelinated nerve fibers and Schwann cell were evaluated after toluidine blue staining 2, 3 and 4 months after nerve grafting.
The following results were obtained:
1. Two and three months after grafting, myelinated nerve fibers were more abundant in the vascularized proximal, middle, and distal areas in all nerve fibers of varying diameters.
2. In the post-nonvascularized graft 2 month group, a few myelinated nerve fibers were present in the proximal and middle areas, but none distally. In the Post-vascularized graft 2 month group, myelinated nerve fibers ranging 2βΌ8γ in diameter were abundant in the proximal, middle and distal areas.
3. In the Post-nonvascularized graft 3 month group, a few myelinated nerve fibers ranging in 2βΌ6γ were present in all three areas, but in the post-vascularized graft 3 month group, many myelinated nerve fibers ranging in 2βΌ10γ were present in all three areas.
4. In the post-graft 4 month group, more myelinated nerve fibers were present in all three are-as of the vascularized grafts. However, nerve fibers of less than 2γ in diameter were more abundant in the nonvascularized grafts.
5. Schwann cells were more abundant in the proximal, middle, and distal areas of the post-vascularized 2, 3 and 4 month grafts.
Based on the findings obtained from this study, it can be concluded that the immediate restoration of circulation in vascularazed nerve grafts allows for the increased number of surviving Schwann cells, rapid healing of the axon and myelin
sheath changes which occur during Wallerian degeneration, and thus is able to stimulate a morphologically optimal regeneration.
However, a modified animal model with a prolonged investigative period is most likely warranted to clarify correlation between morphological and functional regeneration of the vascularized nerve graft.restrictio
μ¬λ©΄μ²΄ μμλ₯Ό μ΄μ©ν κ°μμ± μ ν μμ ν΄μ
νμλ
Όλ¬Έ(μμ¬)--μμΈλνκ΅ λνμ :κΈ°κ³μ€κ³νκ³Ό,1998.Maste
AA5182 νμ¬μ AA5182PPAA5182 μλμμΉ νμ¬μ μ±νμ± νκ°
νμλ
Όλ¬Έ(μμ¬)--μμΈλνκ΅ λνμ :μ¬μ κ³ λΆμ곡νκ³Ό,2000.Maste
A Study on the Social Background of Philippine English: Its Implications for Korean Society
λ
Όλ¬Έ μμ½μ΅κ·Ό μ°λ¦¬ μ¬νμμ μμ΄ κ³΅μ©μ΄νλ‘ μ΄ λ€μ νμ μ
κ³ μλ€. μμ΄ κ³΅μ©μ΄λ‘ μμ λ
Όμ§λ μΈκ³ν μλμλ 무ν κ²½μμ΄ λΆκ°νΌνλ©°, μ΄μ λμ²νκΈ° μν΄μλ μΈκ³ μΈμ΄μΈ μμ΄λ₯Ό 곡μ©ννλ κ²μ΄ νμνλ€λ κ²μ΄λ€. μ΄ κΈμμλ μμ΄ κ³΅μ©μ΄ν λ
Όμκ³Ό μμ΄κ΅μ‘μ λν μμ¬μ μ μ»κΈ° μν΄ ν리ν μμ΄μ μ¬νμ λ°°κ²½μ μ΄ν΄λ³΄μλ€. μμ΄λ ν리νμ λͺ¨κ΅μ΄κ° μλμ§λ§ ν리ν μ λΆκ° μΈκ³μμ μμ΄λ₯Ό μ¬μ©νλ μΈ λ²μ§Έ ν° κ΅κ°λΌκ³ μ£Όμ₯νκ³ μλ κ²μμ 보μ΄λ―μ΄ μμ΄λ νλκ² μ¬μ©λκ³ μλ€. ν리νμ΄ μμ΄μμ κ°μΈλ₯Ό 보μ΄λ κ²μ κ΅μ‘μ μΌλ‘λ νκ΅κ΅μ‘μμ μμ΄λ₯Ό κ°μ₯ μ€μνκ³ μμΌλ©°, μ¬νμ μΌλ‘λ μ€λ μΈμ λμ μλ―Ό μ§λ°°λ₯Ό λ°μμ¨ ν리ν μ¬νκ° μλ―Όμ£Όμμλ€μ΄ κ°μνλ μλ―Όμ§ μ’
μ£Όκ΅μ μΈμ΄μ μ±
μμ μμ ν λ²μ΄λμ§ λͺ»νκΈ° λλ¬Έμ΄λ€. ν리νμ νλΆν μμ°μμκ³Ό μ’μ κ΄κ΄μμμ 보μ νκ³ μκ³ , μμ΄κ° λ리 μ¬μ©λκ³ μμμλ λΆκ΅¬νκ³ κ²½μ μ μΌλ‘ λ§€μ° μ΄λ ΅λ€. λͺ¨κ΅μ΄λ³΄λ€ μμ΄λ₯Ό μ€μνκ³ μλ μ°λ¦¬ μ¬νμ ν리ν μμ΄μ λν κ³ μ°°μ λ―Όμ‘± μ μ²΄μ± λ¬Έμ λ λ¬Όλ‘ μ°λ¦¬μ μμ΄κ΅μ‘ μ λ°μ λν μ¬κ²ν λ₯Ό μμ¬νκ³ μλ€.
This paper is to consider the educational and social background of Philippine English in order to cope with the opinion that English must be new official language in Korea. This insistence is almost based on economic reason. Some people take up the position that there is unlimited struggle in the age of globalization and we should speak English as a official language because English is a world language. The Philippines government says the Philippines is the third largest English-speaking country in the world. Even though English is not their native language, many Filipinos can speak English fluently. In addition to the fact that English is the most important subject in schooling, it depends on her social background that many Filipinos still have the colonial mentality until now because the Philippines has not gotten out of the colonial domination completely. Language is not a single instrument of communication but the accumulation of culture and nationality. English is the basic cause that many Filipinos are in utter confusion in the aspect of national identity. We can receive the implications through the Philippines that English is not the driving force of international competitiveness. The Philippines has so many English-speaking people, what is more, she has abundant natural resources and many wonderful tourist attractions. But she is a very poor country and it is difficult to say how her future will turn out. We are currently emphasizing English, then again we are more and more ignoring our Mother tongue. This paper suggests that we should reexamine a subject of national identity in connection with our English language teaching
μ¬μμ μ곑μ΄λμ μ΄μ°κ΅°
Thesis (doctoral)--μμΈλνκ΅ λνμ :μνκ³Ό,2004.Docto
λ ΈλΉμ½νλμ
Thesis (master`s)--μμΈλνκ΅ λνμ :μνκ³Ό μμμνμ 곡,1996.Maste
TaβO5μ μ κ·Ήμ¬λ£λ‘μμ TiNκ° TaN λΉκ΅ μ°κ΅¬
νμλ
Όλ¬Έ(μμ¬)--μμΈλνκ΅ λνμ :κΈμ곡νκ³Ό μ¬λ£κ³΅νμ 곡,1997.Maste
μ μμ λ°©μ¬μ μμ μ μμ 체 λ° κ°μμ μ λμ νκ°
νμλ
Όλ¬Έ(μμ¬)--μμΈλνκ΅ λνμ :μνκ³Ό μΉλ£λ°©μ¬μ κ³Όνμ 곡,1996.Maste
μλμ°¨μ© μλμμΉ νμ¬μ λ§μ°° κ΅λ° μ©μ νμ¬μ μ±νμ±
Thesis(Doctoral)--μμΈλνκ΅ λνμ :μ¬λ£κ³΅νλΆ,2005.Docto