New targeted therapies for non-small cell lung cancer

Background: Lung cancer is representative of a high frequency and high mortality disease and ranks at the top in incidence and mortality in Korea, when excluding thyroid cancer. In this manuscript, we focused on current targeted therapies for lung cancer used widely in the medical field. Current Concepts: The majority of patients with lung cancer cannot be treated with surgery only and require chemotherapeutics or radiation therapy. Currently, classical chemotherapeutic agents, targeted agents, and immune checkpoint inhibitors are the most widely used. Recently, the Research and Development of antibody drug conjugates is gaining attention, and this may become a more widely prescribed treatment in the future. Among the available treatment options, targeted therapy is becoming increasingly feasible and widespread for treating inoperable lung cancers, where driver mutations have been identified, and for adjuvant or neoadjuvant therapies. Next-generation sequencing (NGS) improves the ability to identify driver mutations that were previously difficult to detect and can also be performed on blood samples where no cancer tissue is available for testing. This makes it possible to identify therapeutic targets for targeted therapy more rapidly. Discussion and Conclusion: The most common type of lung cancer in Korea is adenocarcinoma, for which a driver mutation has been identified. Newly developed drugs target previously problematic mutations or cancer cell lines that have acquired resistance induced during the treatment process. The survival rate of patients with lung cancer is expected to improve with the development of tailored treatments for targets identified from the NGS data of the patient. This paper will help clinicians understand the current state of targeted therapies for lung cancer treatment.ope

초등학생이 지각한 부모-자녀간 의사소통과 또래관계와의 관계에서 갈등해결의 매개효과

학위논문(석사)----아주대학교 교육대학원 :상담심리,2013. 8목 차 Ⅰ. 서론 1. 연구의 필요성 및 목적 2. 연구문제 Ⅱ. 이론적 배경 1. 부모-자녀간 의사소통 2. 갈등해결 전략 3. 또래 관계 4. 세 변인간의 관계 Ⅲ. 연구방법 1. 연구대상 2. 측정도구 3. 연구절차 4. 자료처리 및 분석 Ⅳ. 연구결과 1. 연구대상의 일반적 특성에 따른 부모-자녀간 의사소통, 아동의 친구간 갈등해결전략, 또래관계의 차이 2. 아동이 지각한 부모-자녀간 의사소통, 아동의 친구간 갈등해결전략, 또래관계의 상관관계 3. 아동이 지각한 부모-자녀간 의사소통이 아동의 친구간 갈등해결전략, 또래관계에 미치는 영향 4. 아동이 지각한 부-자녀간 의사소통과 또래관계와의 관계에 친구간 갈등해결전략의 매개효과 5. 아동이 지각한 모-자녀간 의사소통과 또래관계와의 관계에 친구간 갈등해결전략의 매개효과 Ⅴ. 논의 및 결론 1. 요약 및 논의 2. 결론 및 제언 참고문헌 부록(설문지)Maste