8 research outputs found
νμ κ²½μμμ μν κ·ΌμμΆμμ μ κΈ°μκ·Ήμ μ μ©μκΈ°μ λ°λ₯Έ ν¨κ³Ό
νμλ
Όλ¬Έ (λ°μ¬)-- μμΈλνκ΅ λνμ : μνκ³Ό μ곡ν μ 곡, 2013. 8. κΉν¬μ°¬.μλ‘ : νμ κ²½ μμμ μν κ·ΌμμΆμ μΉλ£λ‘ μ κΈ°μκ·Ήμ κ·Όμ‘μ μ μ©νλ κ²μ μμμ μΌλ‘ λ리 μ΄μ©λμ΄ μλ€. κ·Έλ¬λ, κ·Όμ‘λ΄μ κΈ°μκ·Ήμ νμ κ²½ μμμ μν κ·ΌμμΆμ λν ν¨κ³Όλ, μ μ ν μμ μκΈ°μ λν΄μλ λ
Όλμ΄ κ³μλκ³ μλ€.
λͺ©ν: λ³Έ μ°κ΅¬μ λͺ©μ μ κ·Όμ‘λ΄μ κΈ°μκ·Ήμ΄ λ§μ΄μ€μ μ€μ(myosin heavy chain)μ κ΄λ ¨νμ¬ νμ κ²½λ κ·Όμ‘μ λ―ΈμΉλ ν¨κ³Όλ₯Ό μμλ³΄κ³ , νμ κ²½ μμ μ§νμ μμ 2μ£Όνμ κ°κ° κ·Όμ‘λ΄μ κΈ°μκ·Ήμ μμνλ κ²μ λΉκ΅νμ¬ μ μ ν μμμκΈ°λ₯Ό κ²°μ νκ³ μ νλ€.
λ°©λ²: 8μ£Όλ Ήμ Sprague-Dawley ν°μ₯ 18λ§λ¦¬ μ€ 14λ§λ¦¬λ₯Ό λμμΌλ‘ μ°μΈ‘ μ’골 μ κ²½μ μκΆ€μμμ κ°νμ¬ λΆλΆ νμ κ²½ λͺ¨λΈμ λ§λ€μλ€. λΆλΆ νμ κ²½λ 14λ§λ¦¬ μ€ 5λ§λ¦¬μ©μ μ¦μ μκ·Ήκ΅°κ³Ό μ§μ° μκ·Ήκ΅°μΌλ‘ λλμ΄ κ°κ° μμ 1μΌ νλΆν° 14μΌκΉμ§, μμ 15μΌ νλΆν° 28μΌκΉμ§ κ·Όμ‘λ΄μ κΈ°μκ·Ήμ 2 μ£Όκ° μννμλ€. λ¨μ 4λ§λ¦¬λ κ·Όμ‘λ΄μ κΈ°μκ·Ήμ κ°νμ§ μλ νμ κ²½ λμ‘°κ΅°μΌλ‘ μ¬μ©νμλ€. νμ κ²½ μμμ μ£Όμ§ μμ 4λ§λ¦¬λ μ μ λμ‘°κ΅°μΌλ‘ νμλ€. νμ κ²½ μμ 4μ£Ό ν, μ κΈ°μ리νμ νκ°μ νλ νκ°λ₯Ό μννκ³ , λͺ¨λ ν¬μνμ¬ λΉλ³΅κ·Όκ³Ό κ°μλ―Έκ·Όμ μ μΆν ν, κ·Όμ‘ μ΅μ€λ λ° κ·Όμ¬μ λ¨λ©΄μ μ μΈ‘μ νκ³ , λ¨λ°±μ§ κ· μ§μ‘κ³Ό λ¨μΌκ·Όμ¬μ μμ λ§μ΄μ€μ μ€μ μ΄μν λΆμμ μννμλ€.
κ²°κ³Ό: μ¦μ μκ·Ήκ΅°μμ, νμ κ²½λ λΉλ³΅κ·Όμ κ·Όμ¬μ λ¨λ©΄μ μ΄ μ μνκ² μ¦κ°νμκ³ , νμ κ²½μ μν λ§μ΄μ€μ μ€μ μ΄μν λΉμ¨μ λ³νκ° κ°μνμμΌλ©°, νμ΄λΈλ¦¬λ λ¨μΌκ·Όμ¬μ μ λΉμ¨ μ¦κ°κ° μνλμλ€. κ·Έλ¬λ, μ§μ° μκ·Ήκ΅°μμλ μ μν ν¨κ³Όκ° λνλμ§ μμλ€.
κ²°λ‘ : λ³Έ μ°κ΅¬μ κ²°κ³Όλ νμ κ²½ μμ μ§νμ κ·Όμ‘λ΄μ κΈ°μκ·Ήμ μννλ κ²μ΄ μμ 2μ£Ό νλΆν° μννλ κ²λ³΄λ€ νμ κ²½ μμμ μν λ§μ΄μ€μ μ€μμ λ³νλ₯Ό ν볡μν€λ λ° μ’λ ν¨κ³Όμ μμ λνλΈλ€.Introduction: Electromyostimulation (EMS) has been widely utilized to reduce muscle atrophy in clinical setting. Nevertheless, the effects of EMS on denervation atrophy and the optimal timing for the initiation of EMS remain unclear.
Objectives: This study was performed to evaluate the effects of EMS on denervated muscles in relation to the changes in myosin heavy chain (MHC) isoform, and to determine the optimal timing for EMS application.
Methods: A total of 18 Sprague-Dawley rats were divided into four groups. Two treatment groups underwent a sciatic nerve crush and received EMS for 30 minutes a day, 5 days a week, for 2 weeks. EMS was initiated on post-injury day 1 for immediate EMS (IES, n=5) group and on post-injury day 15 for delayed EMS (DES, n=5) group. The denervation control (Dcon, n=4) group received identical operation without EMS. Rats in the normal control (Ncon, n=4) group did not receive either surgery or EMS. Foot print analysis using the CatWalk method, extensor postural thrust test and nerve conduction studies were also performed to assess the denervation and reinnervation process after injury. Four weeks after injury, muscle wet weight and cross- sectional area of muscle fiber were measured. MHC isoform types was analyzed in both protein homogenates and single muscle fibers.
Results: Significantly lower IIx isoform and higher proportion of MHC IIb isoform in gastrocnemius muscle were observed in IES group than in Dcon group, which was not found in DES group. IES group also showed larger cross-sectional area of denervated gastrocnemius muscle fiber and lower hybrid single fiber proportion compared with DES group.
Conclusions: These results indicate that immediate EMS is more effective in recovery of denervation induced MHC changes compared to the delayed EMS.Introduction 1
Material and Methods 6
Results 22
Discussion 35
Conclusion 40
References 41
Abstract in Korean 47Docto
ν΅μ¦μ± 견λΆκ°μ§ νμμ λν λ°λ³΅μ κ΄μ κ°λ΄ μμν½μ°½μ μ μμνμ λ° μμμ μΉλ£ ν¨κ³Ό
Thesis(masters) --μμΈλνκ΅ λνμ :μνκ³Ό(μ곡νμ 곡),2010.2.Maste
Determinants of labour market success in Denmark and the Netherlands
Thesis (master`s)--μμΈλνκ΅ κ΅μ λνμ :κ΅μ νλ ₯μ 곡,2003.Maste