基于基因组学的中医“证”本质的研究概况

随着后基因组时代(即功能基因组学)的到来,基因组学使得现代分子生物学从局部观走向整体观,从线性思维走向复杂思维,因此成为生命科学的研究热点,并在中医药领域得到广泛的应用。文章从基因组学在中医证候本质研究中的理论探讨、应用实例、存在问题及展望等方面进行了系统性的文献研究,以探讨基因组学与中医证候本质的相关性及意义

Progress in clinical application of tongue inspection objectivity based on digital image processing technique

舌诊作为中医望诊的重要组成部分,一直是临床辨证及疗效评价的重要依据之一,传统中医舌诊重于形象描述轻于客观量化的特点限制了中医诊断方法与技术的发展,然而随着近10年计算机技术的发展,数字图像处理技术在中医舌诊客观量化的研究中已取得了一定的成果,同时也被大量应用于临床研究。文章对近5年有关数字图像处理技术的舌诊客观化在疾病及相关指标、中医证候、疗效评价、健康与亚健康状态及体质的客观化辨识、中医舌诊检索技术方面的临床应用研究进行了概述,并且指出了其在临床应用研究中存在的问题与展望。As an essential component of inspection in traditional Chinese medicine(TCM), tongue inspection was always one of the important bases for clinical syndrome differentiation and efficacy evaluation.Traditional tongue inspection focused on image description and despised the objective quantitative, which limited the development of TCM diagnosis methods and technologies.With the development of computer technology in recent 10 years, it had achieved certain achievements in applying digital picture processing technique in objective researches of TCM tongue inspection, and the digital picture processing technique was also applied in clinical research widely.This article summarized the clinical application of digital picture processing technique in objective researches of TCM tongue inspection in related indicators of diseases, TCM syndromes, efficacy evaluation, objective identification of health and sub-health status and constitutions and TCM tongue inspection technologies, and pointed out the existing problems and prospects in its clinical application.国家自然科学基金项目(No.81173200;No.81102558;No.81373556); 国家科技支撑计划(No.2012BAI37B06); 上海曙光计划(No.12SG36)~