八神汤治疗腹泻型肠易激综合征的临床观察

目的:观察八神汤治疗腹泻型肠易激综合征的疗效及对生活质量的影响。方法:将105例腹泻型肠易激综合征患者按照随机数字表法分为治疗组(53例)和对照组(52例)。治疗组采用八神汤治疗;对照组口服匹维溴铵片,50Mg TId。两组疗程均为4周。观察两组治疗前后症状积分、生活质量评分、中医症状疗效及安全性评价。结果:治疗组主要症状积分改善程度优于对照组;治疗组中医症状疗效总有效率为86.54%,对照组中医症状疗效总有效率为66.0%,治疗组中医症状疗效优于对照组(P<0.05);治疗组治疗后CldQ各项积分改善程度优于对照组(P<0.01)。结论:八神汤是治疗腹泻型肠易激综合征行之有效的方法,值得进一步推广。福建省卫生厅青年科研课题(No.2012-2-105

A study of the Flame-retardant Modification on fiexible Polyurethace Foam and Its Physico-Chtemical Effect

本文研究了环氧氯丙烷与磷酸的反应条件，合成具有化学活 性的新型阻燃剂——氯羟丙基磷酸酯（简称CHPA）；用这类 阻燃剂对聚醚型聚氨酯（简称PU）软泡进行化学阻燃改性； 通过P、CL两元素单独或并合的物理化学阻燃作用探索，较系 统地研究了CHPA的阻燃效果。用红外光谱、TGA、DT A等技术研究了阻燃剂CHPA对PU软泡的阻燃稳定性及其 阻燃机理；又用相差显微技术观测阻燃PU软泡的泡孔结构， 探讨了阻燃剂对泡沫塑料物性、强度等的影响，进而研讨这类 阻燃剂对PU软炮弹性强度的增强原理；结果表明： ①制备CHPA时，反应条件对反应物转化率和产品性能 影响较大，当反应温度95℃、时...A new type of chemical active flame retardants, chlorohydroxypropyl phosphate (CHPA) foam was synthesized by epichlorohydrin and H3PO4. The flameretardant effect of CHPA on PUF was researched systematically through the study on the physico-chemical flame retardance of phosphorus and/or chlorine; the IR spectrum、TGA＆DTA were used to study the stability and machanism of the flame retardant effect of...学位：理学硕士院系专业：化学化工学院化学系_高分子化学与物理学号：1991350

STUDIES of FLAME-RETARDING MECHANISM of CHPA ON FLEXIBLE PU FOAM

采用含活性氢的氯羟丙基磷酸酯（CHPA）参与Pu发泡配方中的异氰酸酯反应，使生成的软质聚氨酯泡沫（软Puf）分子含阻燃元素Cl、P而实现其阻燃化。研究结果表明，含12PHrCHPA的软质Puf的阻燃性能可达gb10800-89/Ⅰ级。着重研究了CHPA对软质Puf的阻燃机理，提出燃烧初期Puf/CHPA中的C-Cl键断裂，释放出HCl与磷酸酯作用，生成POCl3、PCl3、PCl5等不燃性化合物。此P/Cl化合物一方面因其散发速度比HCl慢，而延长在燃烧区域的停滞时间，更有效地在气相起阻燃作用；另一方面，在高温有氧存在下，与氧作用生成各种形态的磷酸，其强烈的脱水作用使含氧的Puf在层碳化而生成阻隔燃烧的覆盖层，起到固相阻燃的作用。二者的协同是使软质Puf呈较佳阻燃效应的原因。In the Foaming of PU,chlorohydroxypropylphosphate(CHPA) was used to react with the isocyanate to participate the Foaming recipe so that Fire-extinguishing elements such as P,Cl was made to join in the molecular chain of PU to make the Foam Flame-retarding.It was studied to show that the Flame-retarding eFFect of the Flexible PUF containing 12 phr CHPA hit the speciFication of GB-10800-89/I.In this paper,the Flame-retarding mechanism is investigated to show that in the early stage of the combustion,C-Cl bond in PU-CHPA is broken and HCl is given ofF to interact with the phosphate so that incombustible compounds such as POCl_3 PCl_3,PCl_3 are released.On the one hand,they have a smaller volatizing speed than HCl and consequently a longer interval of time to suspend in the material,so they can act more eFFiciently under gas phase;on the other hand,under high temperatures,they react with oxygen in the enviroment to produce varieties of phosphoric acids whose extremelt strong eFFect of dehydration carbonizes the PU Foam to Form an insulation surFace layer to prevent the material From Further combustion,that is,act under solid phase.The cooperation of the two aspects is the major reason to give the PUF a Fairly good Flame-retarding eFFect

Studies of the Flame-retarding EFFect and Mechanism of CHPA on Flexible PU Foam

本文研究了含活性氢的氯羟丙基磷酸酯(CHPA)对聚氨酯(Pu)软泡的化学阻燃作用及其阻燃机理.结果表明,含12PHrCHPA的Pu软泡阻燃性达到gb10800—89/I级.通过对阻燃机理的研究,可以认为,在燃烧初期Pu—CHPA中的C—Cl键断裂释出HCl,HCl可与磷酸酯相互作用生成POCl_3、PCl_3和POCl_5等不燃性物,在气相起阻燃作用;在燃烧过程中,这些含P化合物在高温有氧存在下又形成具有很强脱水作用的各种形态磷酸,它们使含氧的Pu软泡炭化形成阻隔燃烧的覆盖层,这些是使软泡具有较佳阻燃性的原因.The Flame-retarding eFFect and mechanism of chlorohydroxypropylphosphate(CHPA) containing active hydrogen on PU Foam were studied.The results showed the Foam containing 12 PHR CHPA hit the Flame-retarding speciFication of GB10800-89/I.The result of the study of the Flame-retarding mechanism of CHPA showed in the early stage of combustion, the C -Cl bond in PU -CHPA was broken and HC1 was released to interact with the phosphate so that incombustible compounds such as POC13, PCl3 ,POCl5 were given ofF to act as Flame-retardants.In the very stage of combustion, under higher temperaturs the compoundes containing phosphorus reacted with oxygen to lead to the producing of varieties of phosphoric acids, whose extremely strong eFFect of dehydration carbonized the PU Foam to Form an insulation surFace layer to prevent the material From Further comubstion.These two aspects were the major reasons because of which the Foam had a Fairly good Flame-retardant property