颅内原发恶性淋巴瘤的MRI诊断(附12例报告)

目的　探讨颅内原发恶性淋巴瘤CT及MR的表现特征 ,以提高诊断准确率。方法　对 12例经手术病理证实的颅内原发恶性淋巴瘤的CT及MR表现进行回顾分析。结果　共检出 3 2个病灶 ,其中单发 9例 ,分别位于额、颞、顶叶深部脑白质 8例 ,位于颞叶表面 1例 ;多发 3例 ,病灶多位于深部脑白质。CT多表现为圆形或类圆形稍高密度灶 ,MRI表现为T1WI低或等信号 ,T2 WI为稍低信号。多数病灶周围有轻 -中度高信号水肿带 ,病灶边界尚清楚。增强扫描见所有病灶均有强化 ,2 3个 ( 72 .0 % )病灶呈均匀强化 ,18个 ( 5 6.2 5 % )病灶强化后出现缺口或凹陷改变。病理结果 :11例为非何杰金氏淋巴瘤 ,1例为浆细胞淋巴瘤。结论　尽管颅内原发恶性淋巴瘤的影像表现与其它颅内肿瘤如脑膜瘤、胶质瘤及转移瘤等有许多相似之处 ,但通过认真分析其影像特征 ,术前的正确诊断是有可能

Progesterone regulating glutathione S-transferase Omega-1 expression in the mouse uterine luminal and glandular epithelium during preimplantation period

目的研究谷胱甘肽S-转移酶Omega-1(Gsto 1)在小鼠胚胎着床过程中的表达和孕酮的调节。方法105只CD1小鼠,分为正常妊娠模型和类固醇激素处理模型。正常妊娠模型中,收集妊娠第1~第5天子宫,采用Real-time PCR、原位杂交和Western blotting 3种方法检测Gsto1的表达变化;类固醇激素处理模型均采用卵巢切除2周后的小鼠,又分为雌孕激素处理组、孕酮处理不同时间组和孕酮受体拮抗剂Ru486处理组,所有组中的对照均用芝麻油处理。雌孕激素处理组中,收集芝麻油、雌激素、孕酮、雌激素加孕酮分别处理12h后的子宫;孕酮处理不同时间组中,收集芝麻油和孕酮分别处理1、3、12、24 h后的子宫;Ru486处理组中,收集芝麻油、Ru486、孕酮、Ru486加孕酮分别处理12 h后的子宫。类固醇激素处理模型使用Real-time PCR和Western blotting两种方法检测Gsto1的表达变化。结果 Gsto1主要在妊娠第1~4天的子宫腔上皮及腺上皮中表达,其中,妊娠第1~3天表达量较高,第4天表达量较低,第5天着床点和非着床点均不表达。孕酮诱导Gsto1的表达,雌激素不能诱导Gsto1的表达,并能抑制孕酮对Gsto1的诱导。Ru486降低孕酮对Gsto1的诱导,孕酮处理1、3、12 h均促进Gsto1的表达,但作用24 h后,抑制Gsto1的表达。结论 Gsto1在小鼠妊娠早期子宫腔上皮及腺上皮中表达,雌激素能够拮抗孕酮对Gsto1的诱导,孕酮可以通过孕酮受体调节Gsto1的表达,并且具有短时调节作用。Objective To investigate the expression and regulation of glutathione S-transferase Omega-1( Gsto1) in the mouse uterus during embryo implantation. Methods A total of 105 CD1 mice were divided into the normal pregnancy model and steriod hormone treatment model. Uterus were collected from days 1 to 5 of pregnancy in normal pregnancy model,and Gsto1 expression was detected by Real-time PCR,in situ hybridization and Western blotting. Ovariectomized mice were used in the steriod hormone model after 2 weeks,and divided into estrogen and progesterone treatment group,progesterone treatment course group,progesterone receptor antagonist Ru486 treatment group. Sesame oil was used for the control of all groups. In the estrogen and progesterone treatment group,uterus was collected after sesame oil,estrogen,progesterone,estrogen plus progesterone treatment 12 hours,respectively. In the progesterone treatment course group,uterus was collected after progesterone treatment 1 hours,3 hours,12 hours and 24 hours,respectively. In Ru486 treatment group,uterus was collected after sesame oil,Ru486,progesterone,Ru486 plus progesterone treatment 12 hours. Gsto1 expression was detected by Real-time PCR,and Western blotting in the steriod hormone model. Results Gsto1 was mainly expressed in the uterine luminal and glandular epithelium on days 1 to 4 of pregnancy. Gsto1 expression was high on day 1 to 3,but became lower onday 4. On day 5,Gsto1 expression was not detected at implantation sites and non-implantation sites. Progesterone induced Gsto1 expression. Estrogen did not induce Gsto1 expression,but inhibited the induction of progesterone on Gsto1. Ru486 reduced the induction of progesterone on Gsto1. Progesterone treatment for 1 hour,3 hours,12 hours promoted Gsto1 expression,but after 24 hours,inhibited Gsto1 expression. Conclusion This study suggests that Gsto1 is mainly expressed in the uterine luminal and glandular epithelium during preimplantation. Estrogen inhibits the induction of progesterone on Gsto1.Progesterone enhances Gsto1 expression by progesterone receptor in short time.国家自然科学基金(31401953);; 安徽省教育厅自然科学重点项目(2014A143

脑动静脉畸形破裂并血肿形成的诊断及急诊手术

目的探讨脑动静脉畸形破裂并血肿形成的诊断及急诊手术。方法回顾性分析我院38例脑动静脉畸形(AVM)合并血肿急诊手术病人的病历资料。病变位于幕上35例,幕下3例。结果血肿清除同时全切除AVM21例,供血动脉夹闭2例,单纯血肿清除或脑室引流加AVMⅡ期手术切除11例,单纯血肿清除4例。手术结果满意,术后死亡2例(5.26%)。结论脑AVM合并血肿出现神经系统症状恶化者需急诊手术清除血肿,同时切除畸形血管;而对于巨大AVM或脑深部AVM应先行血肿清除,然后Ⅱ期手术切除AVM

神经导航系统在颅内病变显微手术中的应用

应用神经导航系统进行颅内病变显微手术50例.本组颅内病变及其周围解剖结构定位准确,平均注册误差 2.4±0.4 mm.术后近期复查颅脑MR证实肿瘤全切率92%,手术并发症10%,手术时间和住院日较常规开颅手术缩短.结果表明:1)神经导航系统术前计划定位精确;2)实时导航下颅内病变显微手术,有助于达到微侵袭效果和提高肿瘤全切除率

神经导航在颅内胶质瘤显微手术的应用

目的　评价神经导航在颅内胶质瘤显微手术的应用价值。方法　应用神经导航系统进行颅内胶质瘤显微手术 30例。结果　用神经导航系统进行胶质瘤及其周围解剖结构定位准确 ,平均注册误差 (2 .5± 0 .4 )mm。术后近期复查CT或MR证实胶质瘤全切率 83.3% ,手术时间和住院日较常规开颅手术缩短。结论　 (1)神经导航定位精确 ,有助于手术计划的精确实施。 (2 )实时导航颅内胶质瘤显微手术 ,有助于达到微侵袭效果和提高胶质瘤全切除率。 (3)摸索一套减少靶点漂移的经验

A Novel Active Contour Model for Object Tracking Based on the Potential Energy of Shape Restriction

将基于轮廓曲率的帧间几何形状约束势能,与目标区域信息和边缘梯度信息相结合,定义新的主动轮廓跟踪模型.该模型可以克服弱边缘及强背景等噪声对轮廓的吸引和干扰,同时保持目标的基本形状,实现和改善对具有尖角、深凹等不规则形状目标的边缘跟踪.采用基于块匹配的边界仿射变换方法对主动轮廓的初始位置进行估计,使其更接近目标的真实边缘.实验结果表明,该算法具有较好的边缘跟踪和抗复杂背景的能力

伴有癫癇发作的脑内病灶的手术治疗

Objective To study the surgical outcome of intracerebral lesion with epilepsy. Methods 24 cases were studied. EEG showed that localized epileptiform waves were found in 13 cases, localized slow waves in 5 cases, and no epileptiform wave in 6 cases. All cases were performed ECoG monitoring during the operations. 11 patients whose epileptogenic foci were in the surface of lesions or adjacent to the edge of lesions received clearance of focal lesion plus epileptogenic foci resection. Among 8 patients whose epileptogenic foci were more than 10 mm distance from the edge of lesion, 6 received clearance of focal lesion plus cortical excision whose epileptogenic foci were in the area of nonfunctional cortexes, 2 plus partial cortex thermocoagulation whose epileptogenic foci were in the area of functional cortexes. 2 cases whose epileptogenic foci in the depth of anterior temporal lobe received anterior temporal lobotomy plus clearance of focal lesion. 3 patients with no epileptiform wave received clearance of focal..

Origin of the high activity of AuFeOx for low-temperature CO oxidation: Direct evidence for a redox mechanism

Origin of the high activity of AuFeOx for low-temperature CO oxidation: Direct evidence for a redox mechanis