Modeling and Simulation for hemodynamics of coronary artery stenosis

冠状动脉性心脏病（coronaryheartdisease，CHD），简称冠心病，是由冠状动脉各种病变导致心肌供血不足或中断所引起的心脏疾病。据世界卫生组织2010年报告统计，在2008年估计有1730万人死于心血管疾病，占全球死亡总数的30％，其中约730万人死于冠心病，已经严重危害人类的健康。研究CHD病理状态下冠状动脉循环系统并分析其血液动力学特性，对于进一步明确CHD发病机理和促进临床治疗手段的提高具有重要的意义。由于有创介入性临床实验存在一些禁忌症和并发症的问题，同时也由于生理系统自身的错综复杂机制以及无扰动在体实验手段的缺乏，通常采用建模与仿真方法研究生理系统的不同特征。 本文以...Coronary heart disease (CHD for short) is one kind of heart disease caused by deficiencies in blood flow in the heart muscle. This heart disease has bad effects on human health with high incidence and mortality. The study of coronary artery circulation system and analysis of hemodynamics is important for further understand mechanisms of CHD and promote the improvement of clinical treatment. Due to...学位：工程硕士院系专业：信息科学与技术学院_计算机技术学号：2302010115300

Application and Improvement of Finite-difference Time-domain Algorithm in the Analyses of Optical Waveguide

对时域有限差分算法在弱导光纤中应用时吸收边界条件的设置和计算结果的误差进行了讨论 ,并提出改善计算精度的方法。文中给出用这种方法计算普通光纤传输特性的结果In this paper,we discuss the application of CFDTD (Cylindrical Finite Difference Time Domain)algorithm in the analyses of weak guide optical fiber.Especially,the setting of the absorbing boundary condition and the error of the result are discussed.We present a way to improve the accuracy of the algorithm.Finally,the propagation characters of optical fiber are given in the paper

An Improved Region Growing Algorithm and Its Application in Coronary Artery Angiographic

冠状动脉造影过程中,由于人体骨骼、肌肉、器官等组织对X射线吸收程度不同,得到的冠状动脉造影图像亮度不均匀,传统的区域生长算法无法准确分割不均匀亮度的图像,而且种子点的选取需要人工交互,效率低下.针对这些问题,提出了一种改进区域生长算法,该算法自动生成一组种子点,种子点生长时,使用生长区域的局部平均值作为生长准则中的参数,最后使用医学影像计算与计算机辅助介入(MEdICAl IMAgE COMPuTIng And COMPuTEr ASSISTEd InTErVEnTIOn,MICCAI)准则对分割后的图像进行评价.实验表明,使用该算法对冠状动脉造影图像进行分割,能得到较好的结果,且不需要人工交互,提高了图像分割的效率和准确性.The intensity of coronary artery angiograms is non-uniform since different organizations,such as the bones,muscles,and organs,have different absorption of X-ray during angiography.The classical region growing algorithm has poor effect on these non-uniform intensity images,and it is also inefficient since the seeds must select manually.An improved region growing algorithm is presented by this paper,which not only produce seeds automatically,but also use a local parameter in growing criteria.Then we used Miccai criteria to evaluate the result of our algorithm.The efficacy of the approach is demonstrated with experiments.国家自然科学基金项目(61102137;60971085); 福建省自然科学基金项目(2011J01366;2010J01350

Modeling and Simulation for the Coronary Circulation of Ischemic Heart Disease

冠状动脉粥样硬化性心脏病发病率和死亡率都很高,对其进行建模与仿真有重要的医学意义.在左心循环系统的血流动力学仿真建模的基础上,结合冠状动脉粥样硬化的病理学特点及临床数据,建立描述心血管冠状循环与系统循环之间血液动力学关系的模拟电路模型,并运用MATlAb/SIMulInk对模型进行仿真,模拟冠状动脉粥样硬化性心脏病病理状态下的冠脉循环血流情况.模型通过修改参数,能模拟不同个体生理情况特征,仿真不同程度的冠状动脉狭窄的血流情况.仿真波形与动物实验结果相吻合,通过对血流储备分数(ffrMyO)的计算,也进一步验证仿真结果的正确性.It is acknowledged that the coronary atherosclerotic heart disease is the most widespread kind of heart disease.The researches on the field of modeling and simulation for the coronary circulation of CHD have great medicinal significance.Based on previous work on some simulation experiments of arterial system on left heart-arterial interaction coincide with the pathological characteristics and clinical parameters of CHD,a dynamic simulation model was built for the system of coronary circulation on CHD by using Matlab/Simulink,characterized the hemodynamic relations between the coronary circulation and systemic circulation.This model has been digitally simulated for coronary flow of different physiology and different degree of coronary artery stenosis of CHD by changing the parameter,the results were consistent with clinical observations of animal experimentation.The correctness of the results are further verified from the calculation of the conclusion of FFRmyo.国家自然科学基金项目(61102137;61071151;60971085);福建省自然科学基金项目(2011J01366;2010J01350

Application and Improvement of Finite-Difference Time-Domain Algorithm in the Analysis of Optical Waveguides

对时域有限差分算法在圆柱坐标下弱导光纤中应用时吸收边界条件的设置及其对计算精度的影响进行了讨论 ,提出了改善的方法。并且将这种方法应用于一般光纤和光电子晶体光纤传输特性的计算 ,得到了有用结果。The application of CFDTD (cylindrical finite-difference time-domain) algorithm in the analysis of weak-guiding optical fiber and other types of fibers is discussed. Especially, the setting of the absorbing boundary condition and the calculation error are presented, improvement way is proposed. Further more, this method is applied to the calculation of propagation characters of optical fiber and the photonic crystal fiber, some useful results are given.国家自然科学基金 ( 6 97770 12,6 91770 2 6 );; 福建省自然科学基金 (A0 0 10 0 0 4)资助课题