Discovery of FAAH inhibitors by rational drug design

脂肪酰胺水解酶(FAAH)是调控内源性脂肪酰胺信使脂质分子代谢的主要酶。FAAH活性抑制即可以使体内内源性脂肪酰胺水平升高，达到镇痛、抗炎、协调运动机能的目的，过去十年间，具有FAAH抑制活性的大量化合物也得到报道，但是到目前为止，还没有成功上市的FAAH抑制剂，关键的原因就在于其选择性与抑制效率无法兼顾。本文在此基础上，展开了如下工作： 一、利用药效团构建软件DiscoveryStudio2.1构建定性的CommonFeature药效团和定量的3DQSAR药效团模型。得到的最优CommonFeature药效团模型Hiphop-1包含一个氢键受体特征(hba)、一个芳香环特征(ra)、一个芳...Fatty acid amide hydrolase (FAAH) is the primary enzyme responsible for the catabolism of fatty acid amide (FAA) family of endogenous signaling lipids. FAAH inactivation can modulate pain, inflammation, appetite, motility, sleep, cognitive and emotional states etc. But so far, there has no FAAH inhibitors were used to treat any disease, lies in the difficult to take into consideration both effecti...学位：理学硕士院系专业：医学院药学系_药物化学学号：2452008115349

貌合神离：中英文同款广告的符号和眼动分析

通过一系列中英文同款广告，该研究结合符号和眼动技术，指出相似的表象之下，微妙的细节调整如何折射出中西方读者对媒介内容叙述方式的不同偏好，以及处理群己关系的不同价值取向，从而呈现出“貌合神离”的警民、亲子、师生、夫妻、男女等社会关系。本文系国家自然科学基金项目“东西方不同文化思维方式对广告说服的影响：一个自下而上的脉络建构与验证”（项目编号：71372076）的阶段性研究成果

The effects of ocean acidification on marine organisms and ecosystem

海洋酸化是CO2排放引起的另一重大环境问题.工业革命以来,海洋吸收了人类排放CO2总量的三分之一.目前,海洋每年吸收的量约为人类排放量的四分之一(即约每小时吸收100万吨以上的CO2),对缓解全球变暖起着重要的作用.然而,随着海洋吸收CO2量的增加,表层海水的碱性下降,引起海洋酸化.海洋酸化会引起海洋系统内一系列化学变化,从而影响到大多数海洋生物的生理、生长、繁殖、代谢与生存,可能最终导致海洋生态系统发生不可逆转的变化,影响海洋生态系统的平衡及对人类的服务功能.地球历史上曾多次发生过海洋酸化事件,伴随着生物种类的灭绝,其内在联系虽然不甚明确,却也可能暗示未来海洋酸化可能对海洋生态系统产生重大的影响.Ocean acidification is known as another global change problem caused by increasing atmospheric CO2.Since the industrial revolution, the oceans have absorbed more than one third of the anthropogenic CO2 released to the atmosphere, currently, at a rate of over 1 million tons per hour, totaling to about one quarter of all anthropogenic CO2 emissions annually.Uptake of CO2 by the ocean has played an important role in stabilizing climate by mitigating global warming.However, rising ocean carbon levels caused by the uptake of anthropogenic CO2 (acidic gas) leads to increased ocean acidity (reduced pH) and related changes in ocean carbonate chemistry, or "ocean acidification".Recent research has shown that ocean acidification affects the physiology, growth, survival, and reproduction of many, if not most marine organisms.Ultimately, future ocean acidification may lead to significant changes in many marine ecosystems, with consequential impact on ecosystem services to societies.Several ocean acidification events are known to have occurred during Earth’s history, each coinciding with high rates of species’ extinctions.Although the mechanisms involved in past massive species extinction associated with ocean acidification events, they certainly hint potential disastrous impacts on ecosystem functions in short future.中国科学院“百人计划”(2006-067); 国家自然科学基金(40872168)资