Imaging anatomy and hemodynamic simulation of the extracranial segment of vertebral artery

研究背景:椎-基底动脉系统是脑组织供血的重要血管之一，主要为脑干、小脑及双侧大脑半球后1/3供血。双侧椎动脉（vertebralartery，VA）主要发自于锁骨下动脉，于C6水平入横突孔，穿行于上6颈椎横突孔内，经枕大孔入颅；在脑桥前下合并为基底动脉，其寰枢段走行弯曲，周围解剖结构复杂。深入研究椎动脉的相关形态及血流动力学，对提高后循环缺血诊断和治疗具有重要的临床意义。 目的：（1）利用多排螺旋CT（multi-slicespiralCTangiography，MSCTA）进行正常椎动脉血管成像及相关解剖测量。（2）构建椎动脉颅外段在中立位、头颈部左右旋转后及寰枢关节脱位后有限元模型，并进...Background: Vertebrobasilar artery (VBA) is one of the important artery of brain,it provides a large proportion of blood to nourish cerebellum, brainstem and the posterior 1/3 parts bilateral cerebral hemisphere. The vertebral artery （VA）is usually the first branch of the subclavian artery. It ascends through the transverse foramina of C6 to C1 vertebrae, curves postermedially to the lateral mass ...学位：医学硕士院系专业：医学院_影像医学与核医学学号：2452013115348

Fractional Elliptic equations and Heat Equations Related Problems

首先，我们在具有Dirichlet零边界条件的光滑有界区域内，研究一类带有分数阶拉普拉斯算子的超线性椭圆问题.我们使用调和扩张方法来研究变号解对于参数的依赖性. 其次，我们考虑一类带有分数阶拉普拉斯算子的热方程（具有低能量初值），研究该方程全局解的存在性和衰减估计以及爆破解。并且考虑任何具有高能量初值的全局解的性态，应用这种思想来准确描述全局解的衰减性.Firstly, we consider a class of superlinear elliptic problems involving fractional Laplacian in a bounded smooth domain with zero Dirichlet boundary condition. We use the method on harmonic extension to study the dependence of the number of sign-changing solutions on the parameter. Secondly, we are concerned with the existence and asymptotic estimates of global solutions and blowup of a clas...学位：博士后院系专业：物理科学与技术学院_理论物理学号：201417005

The Exploration into the Future Orientation of Our state Audit

国家审计的职责是通过法律、行政授权或缔结契约等方式确定的。当客观条件发生变化时，审计的职责也应随之进行调整。只有及时调整审计职责，找准定位，才能有效地发挥审计监督职能，为党政宏观经济决策服务，为社会主义经济建设和社会发展保驾护航。本文首先从政治环境、经济环境、法律环境等三方面的外部环境因素进行了分析，说明对我国国家审计进行重新定位的外在必要性。其次，从现行我国国家审计所存在的审计依据、审计目标定位、审计人员、审计方式、审计风险和审计体制等六个方面的不足进行了分析，说明我国国家审计需要重新定位的内在必要性。再次，对国外国家审计的先进经验和做法进行了具体地介绍，并深入分析了我国国家审计与国外国家审...The duties of state audit are ruled by the law,the administrative authorization or the contract and so on. When objective conditions change,the duties of state audit should also be adjusted when necessary. Only by adjusting the responsibilities of our state audit promptly and finding the accurate orientation,can our state audit effectively exercise its power of supervision,serve for the party’s a...学位：经济学硕士院系专业：经济学院财政金融系_财政学(含税收学)学号：K20034225

Fractional Heat Equation and systems, Hyperbolic Systems and Quasi-geostrophic Equation Related Problems

本文讨论了四个偏微分方程解的存在性，爆破性以及适定性。全文分为四个部分。第一部分为本文的 第三章。本部分主要研究一个广义的分数阶热传导方程\\numberwithin{equation}{section} \begin{displaymath} \left\{ \begin{array}{ll} u_{t}=-(-\Delta)^{\alpha}u+h(t)u^{v}，&\hbox{$(x，t)\in\mathbb{R}^{N}\times(0，T)$;}\u(x，0)=\phi(x)，&\hbox{$\phi(x)\geq0，\phi(x)\not\equiv0$，} \end{...Part 1, which is the third chapter in this paper, studies the the Cauchy problem for the fractional differential heat equation \ \numberwithin{equation}{section} \begin{displaymath} \left\{ \begin{array}{ll} u_{t}=-(-\Delta)^{\alpha}u + h(t)u^{v}, & \hbox{$(x,t)\in \mathbb{R}^{N}\times (0,T)$;} \ u(x,0)=\phi(x), & \hbox{$\phi(x)\geq 0, \phi(x) \not\equiv 0$.} \end{array} \right...学位：理学博士院系专业：数学科学学院数学与应用数学系_应用数学学号：1902009015361

A Study on Centralized Disposal of Accounting Based on BPR: A Case in X Bank

摘要 中国加入WTO以后，各家银行充分地认识到国内会计业务处理水平与国外银行的差距，面对这种情况，我国的商业银行如何在将来的竞争中占据主动、成为竞争的强者，成为我国银行界共同关注的问题。在借鉴和分析西方商业银行改革成功的经验时，风靡西方的业务流程再造成为我国商业银行改革和创新的主要方法。作为服务行业的商业银行由于业务的相似性使业务流程的差别成为商业银行的主要竞争力。 本文将业务流程再造理论引入会计业务处理工作，主要从五个部分阐述银行会计业务处理大集中的问题。首先介绍了国内外相关业务流程再造的状况和特点，与问题有关的理论，对研究方法、论文的内容和结构进行了阐述；其次，结合银行目前会计业务流程...Abstract Chinese commercial banks has realized the distance of the accounting information processing capability between chine and other advance countries. When confronting such circumstances, it is important to consider various means that would allow the Chinese commercial banks to maintain their activeness with regards to future competition, and to succeed in such an environment. With reference,...学位：工商管理硕士院系专业：管理学院工商管理教育中心（MBA中心）_工商管理硕士(MBA)学号：2005130144

桩–筏–土体系的地震软化行为及ABAQUS模拟研究

通过开展离心机动力试验,充分揭示在地震荷载的持续作用下,土体将发生一定程度的软化,表现为周期的持续增大;然而基础(筏板)周期和桩身弯矩包络图几乎不发生改变,说明整个桩–筏结构在地震作用下的行为不会类似于土体发生软化(恶化的现象),而是能持续保持稳定,其动力行为主要取决于自身特性如桩身刚度和上部结构传递给筏板的荷载水平(惯性)等,同时土体的动力软化效应对桩–筏结构的影响很小。为了验证试验结果的正确性和合理性,采用ABAQUS 6.9程序对试验结果进行计算分析,土体模型包括软件内嵌的Hypoelastic非线性模型和所开发的考虑动力降强效应的HyperMas用户子程序模型(UMAT)。计算结果符合试验实测结果,尤其能准确地捕捉桩身最大弯矩值和周期等重要的工程设计参数。且有侧重于基础单元的地震响应分析,非降强模型和降强模型的计算差异很小,再次说明土体软化对既有桩–筏结构影响很小,但采用非降强模型计算更为快捷、高效

基于颗粒阻尼技术的数控机床轻量化研究

随着数控机床向高精度、高速度和绿色化发展,轻量化数控机床的优势越来越明显。以ZN-XK2840数控龙门镗铣床为例,提出一种基于颗粒阻尼技术的数控机床轻量化设计方法。首先通过有限元法对常规数控机床结构的静态性能进行分析,对其壁厚进行优化,对轻量化的机床结构的静态性能进行分析,确保其最大变形量和强度满足使用要求;然后对常规数控机床的动特性如模态特性、谐响应进行分析。颗粒阻尼技术能够在振动传递路径有效降低机床结构振动,通过建立颗粒系统-龙门铣床动力学模型,采用自主开发的离散元动力学软件分析安装颗粒阻尼器后的机床结构动态特性,与常规机床进行动特性对比。对按轻量化的设计方案制造安装颗粒阻尼器的龙门镗铣床,在空运转和铣削加工过程中测量其加速度幅值与位移幅值,发现两者均小于常规机床;经检测,其重量相比同类产品减少53.8%,有效实现了轻量化。福建省重点科技专项(2016H0032);;厦门市科技计划项目(3202Z20173021);;航空科学基金项目(20171668003);;中央高校基本科研业务费专项资金项目(20720180063);;厦门市交通基础设施智能管养工程技术研究中心开放基金(TCIMI201813

pJAK2 polypeptide,an antagonist of suppressors of cytokine signaling-1,can enhance the antitumor effect of dendritic cells

目的:探讨细胞因子信号转导抑制因子-1(SuPPrESSOrS Of CyTOkInE SIgnAlIng1,SOCS1)拮抗物PJAk2多肽(氨基酸序列号为1001-1013)参与树突状细胞(dEndrITIC CEllS,dCS)的体外诱导培养后对dCS抗肿瘤作用的影响。方法:采集健康人外周血,离心获得单个核细胞,用重组人粒细胞巨噬细胞集落刺激因子(rECOMbInAnT HuMAn grAnulOCyTE-MACrOPHAgE COlOny STIMulATIng fACTOr,rHgM-CSf)及重组人白细胞介素-4(rECOMbInAnT HuMAn InTErlEukIn-4,rHIl-4)诱导dCS,第5天分为4组:单纯dCS培养(对照)组、抗原负载(lySATE-dCS)组、多肽修饰(PJAk2-dCS)组和抗原与多肽共培养(lySATE+PJAk2-dCS)组,第6天各组加入肿瘤坏死因子-α(TuMOr nECrOSIS fACTOr-AlPHA,Tnf-α)促成熟。倒置显微镜下观察dCS形态;fCM法检测dCS表型;乳酸脱氢酶(lACTATE dEHydrOgEnASE,ldH)细胞毒实验检测各组细胞毒性T淋巴细胞(CyTOTOXIC T lyMPHOCyTE,CTl)对胃癌细胞bgC-823的靶向杀伤作用;ElISA法检测白细胞介素-12(InTErlEukIn-12,Il-12)和γ干扰素(InTErfErOn-γ,Ifn-γ)的水平。结果:与未加入诱导剂组相比,各组均成功诱导出成熟dCS,均高表达Cd80、Cd83、Cd86和人类白细胞dr抗原(HuMAn lEukOCyTE AnTIgEn dr,HlA-dr),但以lySATE+PJAk2-dCS组的表达水平最高。在10:1~30:1的效靶比范围内,CTl杀伤作用与效靶比呈正相关。当效靶比为30:1时,对照组的CTl杀伤率达(19.77±2.34)%,低于其他3组(P<0.01),而lySATE+PJAk2-dCS组较lySATE-dCS组及PJAk2-dCS组都高(P<0.05)。lySATE+PJAk2-dCS组培养上清液中Il-12及Ifn-γ的分泌水平明显高于对照组(P<0.01)。结论:SOCS1拮抗物PJAk2多肽(1001-1013)可增强dCS对胃癌细胞的抗原递呈及特异性抗肿瘤作用。Objective:To investigate the effect of pJAK2 polypeptide,an antagonist of SOCS1(suppressors of cytokine signaling 1),on antitumor effect of in vitro cultivation-induced DCs(dendritic cells).Methods:Peripheral blood was collected from the healthy volunteers,and the PBMCs(peripheral blood mononuclear cells)were isolated.DCs were induced by rhGM-CSF(recombinant human granulocyte-macrophage colony-stimulating factor)and rhIL-4(recombinant human interleukin-4).On the fifth day,DCs were divided into four groups:control group,Lysate-DCs group,pJAK2-DCs group,and Lysate + pJAK2 DCs group.On the sixth day,TNF-α(tumor necrosis factor-alpha)was added into each group.The morphological features of DCs were observed under an inverted microscope;the phenotypes were detected by FCM(flow cytometry);the killing effect of CTLs(cytotoxic T lymphocytes)on gastric cancer BGC-823 cells was evaluated by LDH(lactate dehydrogenase)cytotoxicity test;the concentrations of IL-12(interleukin-12)and IFN-γ(interferon-γ)were detected by ELISA(enzyme-linked immuno sorbent assay).Results:Mature DCs presented typically morphological and phenotypic features;the DCs in Lysate + pJAK2-DCs group had the highest expression levels of CD80,CD83,CD86 and HLA-DR(human leukocyte antigen DR).When the ratio of effectors to target cells ranged from 10:1 to 30:1,the killing activity of CTLs had a positive correlation with the ratio.When the ratio of effectors to target cells was 30:1,the killing activity of CTLs in the control group was(19.77±2.34)%,which was lowest as compared with the other groups(P < 0.01),meanwhile the killing activity of CTLs in Lysate + pJAK2-DCs group was higher than those in Lysate-DCs and pJAK2-DCs groups(P < 0.05).The levels of IL-12 and IFN-γ secretion in Lysate + pJAK2-DCs group were apparently higher than those in the control group(P < 0.01).Conclusion:An antagonist of SOCS1,pJAK2 polypeptide,can enhance the ability of antigen presentation and specific antitumor effect of DCs on gastric cancer cells.南京军区医学科技创新课题资助项目(编号:10MA068); 福建省自然科学基金面上项目(编号:2010D013); 厦门市科技计划创新项目(编号:3502z20104014