No.7

http://purl.org/coar/resource_type/c_184

褪黑素对丙烯酰胺致睾丸毒性保护作用的机制

【目的】探讨褪黑素（MT）对丙烯酰胺（AA）诱发睾丸毒性的改善作用及机制。【方法】动物随机分为 3 组： 对照组，AA 染毒组和 AA+MT 治疗组，每组各 12 只大鼠。AA 染毒的动物连续 4 周每日灌胃 AA（15 mg/kg）。从染毒 3 周 后开始，治疗组动物先每日腹腔注射 MT 10 mg/kg（连续 1 周），30 min 后再进行 AA 染毒。对照组动物仅注射同等剂 量的生理盐水。随后分别进行线粒体膜电位、TUNEL、免疫印迹和电镜检测。【结果】研究结果表明 AA 可使睾丸组织 线粒体膜电位下降（P < 0.05），且 MT 可令其恢复（P < 0.05）。和对照组相比，MT 可下调睾丸组织中 Bax 的表达；上调 Bcl-2 的表达。TUNEL 结果进一步证实 MT 可减缓解睾丸组织中细胞凋亡现象。免疫印迹结果表明 AA 染毒组 Bcl-2/ Bax 和Bcl-xL/Bak 的比值较对照组降低（P皆< 0.05），而MT 治疗组中它们的比值升高（P皆< 0.05）。AA 染毒组中Cyt-c， Casp-3，p53 和 NF-κB 的表达水平较对照组明显升高（P 皆< 0.05），较 MT 治疗组明显下降（P 皆< 0.05）。电镜结果证实 MT 可减轻 AA 造成的睾丸曲细精管中线粒体结构受损。【结论】MT 可能通过和线粒体通路相关的抗凋亡功能，从而缓 解 AA 造成的睾丸毒性

Transportation of Wood Chips by Liquid Film Flow in Sloped Rough Terrain Pipelines(Fluids Engineering)

[Abstract] The unused biomass such as residues left on forest floor and unused portions of farm crops is considered as an important domestic and renewable energy resource. The present study addresses the forestry biomass derived from logging and thinning operations in forests. Since most of the forests in Japan locate in the mountain region, the forestry biomass has not been used continually due to the difficulty in carrying residues out of the forest. In order to promote the utilization of forestry biomass, the efficiencies for the transportation across steep slopes have to be improved. In the present study, the new method to transport wood chips by means of liquid film flow in sloped pipeline is proposed. The transportation limit of wood chips is investigated by using the test section imitating the sloped rough terrain pipeline. The wood chips are stagnated in the downstream region of hydraulic jump, which causes blockage of wood chips in the tube. To predict the flow rate of transportation limit of wood chips at a given liquid flow rate, analytical model is presented. From the comparison with the experimental results, it is found that the transportation limit in the sloped pipeline with horizontal tube can be predicted by the present analytical model.Copyright (c) 2008, 一般社団法人日本機械学会, rights: 本文データは学協会の許諾に基づきCiNiiから複製したものである, relation: isVersionOf: http://ci.nii.ac.jp/naid/110006685213