c-Src promotes tumor cell proliferation by activating HK2

大多数肿瘤细胞即使在氧气充足的情况下依然主要靠糖酵解方式提供能量，这就是著名的Warburg效应，它是肿瘤代谢的一个重要特征。己糖激酶（hexokinase，HK）是糖酵解过程中的第一个限速酶。在哺乳动物体内，HK主要有四种亚型，即HK1、HK2、HK3和HK4，其中HK2与肿瘤的关系最为密切。目前研究表明Warburg效应的发生与原癌基因（如Ras，c-Myc，HIF-1）的过度激活和抑癌基因(如p53)的失活密切相关。c-Src是哺乳动物中最早发现的原癌基因，其蛋白是一种非受体酪氨酸蛋白激酶，c-Src蛋白通过多种信号通路调节细胞的粘着与运动、增殖与存活、血管生成及胞内运输...Most types of tumor cells mainly depend on glycolysis for energy production even in the case of sufficient oxygen, a phenomenon known as Warburg effect which has been considered as one of hallmarks of tumor metabolism. Hexokinase (HK), the first rate-limiting enzyme in glycolysis, consists of four isoforms HK1, HK2, HK3 and HK4 in mammals. It has been shown that overexpression of HK2 is closely co...学位：理学硕士院系专业：生命科学学院_生物化学与分子生物学学号：2162012115234

Applications of Electroless Deposition Ni-Cu-P Coating on the Gas Condensing Exchanger

研究硫酸铜镀液中浓度对Ni-Cu-P合金镀层的成分、组织结构及耐腐蚀性能的影响.EPMA、XRD和极化曲线镀层测试表明,以浓度为0.5g.L-1的硫酸铜作镀液镀层的耐蚀性能最优.在天然气冷凝液中考察了Ni-Cu-P、Ni-P合金镀层和铜基体的电化学耐腐蚀性能,Ni-Cu-P合金镀层的自腐蚀电位低,自腐蚀电流密度小,交流阻抗值最大.因此该镀层可作为铜质燃气冷凝换热器的耐蚀阻挡层和牺牲阳极保护镀层,防止铜管腐蚀穿孔,有效地延长铜质冷凝换热器的使用寿命.The effects of copper sulfate concentration in the plating solution on the composition,the structure and the anticorrosion properties of Ni-Cu-P deposited coating were studied by EPMA、XRD and polarization curves.The anticorrosion properties of Ni-Cu-P deposited coating was optimal as the copper sulfate concentration in the plating solution was 0.5 g·L-1.The electrochemical anticorrosion properties of Ni-Cu-P,Ni-P deposited coatings and copper plates were investigated in the gas condensate.The self-corrosion potential of Ni-Cu-P deposited coatings was low,the self-corrosion current density was small,and the electrochemical impedance was the highest.Therefore,the electroless Ni-Cu-P coatings can be used as anticorrosion cover and anodic sacrificial protective coatings of copper condensing exchanger.It could protect copper tubes from being corroded and perforated,so it could increase the effective life of copper condensing exchanger.作者联系地址：大连理工大学化工学院;北京建筑工程学院城建系;Author's Address: 1.Department of Chemical Engineering,Dalian University of Technology,Dalian,116012,Liaoning,China;2.Urban Construction Department,Beijing Institute of Civil Engineering and Architecture,Beijing,100044,Chin