Fabrication of Lumen Structure Based on Multi-Nozzle Biological 3D Printing System

基于多喷头生物3D打印系统和溶芯支撑法,运用超低温打印技术,以胶原为管壁材料,水凝胶F127为溶芯材料构建复合管腔结构,经过京尼平溶液交联及冻干处理后将支架浸泡在1℃的去离子水中以去除溶芯材料,从而获得胶原管腔支架结构;同时探究了以明胶/海藻酸钠为管壁结构,明胶材料为溶芯的管结构制备技术,实验证明明胶作为溶芯材料制备管结构的可行性。制备出了具有较好结构及力学性能的胶原和明胶/海藻酸钠管腔支架结构。该多喷头生物3D打印系统以溶芯工艺的方法,在构建管腔型生物结构方面具有很好的效果,为临床及再生医学提供了重要的制造工艺基础。</p

an improved particle swarm optimization based on self-adaptive escape velocity

分析了变异操作对微粒群算法（panicle swarm optimization，简称PSO）的影响，针对收敛速度慢、容易陷入局部极小等缺点，结合生物界中物种发现生存密度过大时会自动分家迁移的习性，给出了一种自适应逃逸微粒群算法，并证明了它依概率收敛到全局最优解．算法中的逃逸行为是一种简化的确定变异操作．当微粒飞行速度过小时，通过逃逸运动使微粒能够有效地进行全局和局部搜索，减弱了随机变异操作带来的不稳定性、典型复杂函数优化的仿真结果表明，该算法不仅具有更快的收敛速度，而且能更有效地进行全局搜索．China Computer Federation; IEEE Computer Societ

Fabrication of Degradable Intervertebral Fusion with Good Mechanical Properties and Biocompatibility Based on 3D Printing Technology

In this paper, the manufacture method of degradable intervertebral fusion stent with good mechanical properties and biocompatibility based on 3D printing technology is researched. Firstly, the mixing process of synthetic macromolecule and bioceramic powder is studied. And develop a high temperature stirring grinding device and realize arbitrary proportion of composite materials. Secondly, the intervertebral fusion model is processed and the print path is optimized based on discrete allocation algorithm of modeling section of cylindrical structure and print trajectory optimization algorithm. Then, the influence of printing temperature and printing layer on the bonding strength of the stent is studied, which provides a theoretical basis for the reasonable parameters setting. In addition, the composite for stent is studied, with different materials in different ratios are mixed and compressive strength and compressive modulus of each stent are tested. The ratio of composite with good mechanical strength is obtained. Finally, the intervertebral cage stent is constructed with good mechanical properties and biocompatibility

一种舌侧隐形牙齿托槽

本实用新型属于牙齿矫正技术领域，具体地说是一种舌侧隐形牙齿托槽。所述舌侧隐形牙齿托槽通过3D打印成型，包括托槽底板和托槽本体，其中托槽底板包括齿侧面和舌侧面，所述齿侧面为与舌侧牙齿曲面相适应的曲面，所述舌侧面设有托槽本体，所述托槽本体上设有用于所述弓丝穿过的沟槽。本实用新型运用三维建模技术对舌侧托槽的大小和形状进行精心的设计，以钴铬合金为材料，通过3D打印成型，其加工的曲面与牙齿表面贴合度高，大大提高了矫正器的美观及舒适度

一种具有限流功能的H桥电路

本发明涉及压电驱动领域、电极驱动领域以及恒流驱动领域，具体地说是一种具有限流功能的H桥电路，包括数字控制器连接H桥驱动器，输出H桥控制信号，H桥驱动器连接H桥，对H桥进行驱动。本发明可用于压电陶瓷驱动、电极驱动、恒流驱动，其结构简单、输出电流大且具有限流功能

一种基于库尔特原理的生物3D打印系统

本发明属于3D打印技术领域，特别涉及基于库尔特原理的生物3D打印系统，包括喷头、扰动机构、检测机构、分选机构、堆积平台及运动机构，其中喷头用于喷射液滴状或柱状颗粒混合液；扰动机构用于扰动颗粒混合液，使喷头喷出的颗粒混合液呈时间和空间上的周期分布；检测机构用于检测喷头喷出的颗粒混合液中的颗粒；分选机构用于按照检测机构检测的颗粒信息，将符合要求的液滴进行偏移，从而获取所需要的液滴；经过分选机构分选出符合要求的液滴在堆积平台上堆积成所需的形状；运动机构可使喷头与堆积平台进行相对运动，从而使颗粒可以按照空间进行设定形状的堆积。本发明可实现对细胞或其他颗粒状材料的精准控制，且打印通量大，可实现高密度打印

BMSCs-laden gelatin/sodium alginate/carboxymethyl chitosan hydrogel for 3D bioprinting

Three-dimensional (3D) bioprinting technology offers the possibility to deliver, in a defined and organized manner, scaffolding materials and living cells, and therefore holds much promise for tissue engineering and regenerative medicine. In this work, we explored the possibility of gelatin/sodium alginate/carboxymethyl chitosan (Gel/SA/CMCS) hydrogel combining with bone mesenchymal stem cells (BMSCs) for 3D bioprinting. Compared to the commonly used 3D bioprinting materials such as gelatin/sodium alginate (Gel/SA) hydrogel, the Gel/SA/CMCS hydrogel we developed shows excellent equilibrium water content, good mechanical properties, antibacterial activity, and a slow degradation rate. With this kind of material, we generated a scaffold with homogenous cell distribution. Cell viability after 3D printing showed that over 85% of the printed cells were viable at 0 and 2 days of culturing. Our work demonstrates the feasibility of mixing Gel/SA/CMCS hydrogel with stem cells for 3D bioprinting