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Fabrication of Lumen Structure Based on Multi-Nozzle Biological 3D Printing System
Authors
慕丽
王强
王赫然
郑雄飞
Publication date
1 January 2019
Publisher
Abstract
基于多喷头生物3D打印系统和溶芯支撑法,运用超低温打印技术,以胶原为管壁材料,水凝胶F127为溶芯材料构建复合管腔结构,经过京尼平溶液交联及冻干处理后将支架浸泡在1℃的去离子水中以去除溶芯材料,从而获得胶原管腔支架结构;同时探究了以明胶/海藻酸钠为管壁结构,明胶材料为溶芯的管结构制备技术,实验证明明胶作为溶芯材料制备管结构的可行性。制备出了具有较好结构及力学性能的胶原和明胶/海藻酸钠管腔支架结构。该多喷头生物3D打印系统以溶芯工艺的方法,在构建管腔型生物结构方面具有很好的效果,为临床及再生医学提供了重要的制造工艺基础。</p
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Shenyang Institute of Automation,Chinese Academy Of Sciences
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Last time updated on 08/01/2020