迭代目标转换因子分析法测定多组分复方药物制剂的研究

采用迭代目标转换因子分析法同时测定复方冬眠灵片两组分的含量．用此法对复方冬眠灵片的两组分盐酸异丙嗪和盐酸氯丙嗪进行了测量及计算，获得满意结果．氯丙嗪平均回收率为１０１４％，ＲＳＤ为０４％（ｎ＝６）；异丙嗪平均回收率为１００４％，ＲＳＤ为１８％（ｎ＝６）．而用普通目标转换因子分析法测定，氯丙秦平均回收率为１０３１％，ＲＳＤ为４９％（ｎ＝６），异丙嗪平均回收率为９５４％，ＲＳＤ为２２％（ｎ＝６）．由此可看出迭代目标转换因子分析法较普通目标转换因子分析法具有明显的优势

A Study on the applicability on multicomponent calibration methods in chemometrics

Twelve multivariate calibration method alternatives are compared to establish the effect of spectral nonlinearity and collinearity on accuracy and precision of determined results. Simulated and real spectral data are used in this research. This study can help us to select an optimum method for determination

A Study on the applicability on multicomponent calibration methods in chemometrics

Twelve multivariate calibration method alternatives are compared to establish the effect of spectral nonlinearity and collinearity on accuracy and precision of determined results. Simulated and real spectral data are used in this research. This study can help us to select an optimum method for determination

电击信号应激免疫调节作用的中枢机制研究

目的 探讨可能参与电击信号应激免疫调节作用的中枢机制。方法 利用以电击装置为信号的情绪应激免疫调节作用动物模型，观察情绪应激后2个小时，大鼠全脑的c—fos原癌基因表达情况。结果 与对照组动物相比，以电击装置为信号刺激的情绪应激组大鼠明显表达c—fos的脑区包括额皮质、扣带皮质、杏仁体、前连合核、下丘脑背内侧核弥散部、弓状核、孤束核等。结论 这些核团可能参与了电击信号应激的免疫调节作用的中枢机制

THE EFFECT OF EMOTIONAL STRESS ON THE PRIMARY HUMORAL IMMUNITY OF RATS: INTERACTION WITH THE SYMPATHETIC NERVOUS SYSTEM

以给予经定时喂水训练大鼠空瓶刺激为情绪性心理应激源，研究了此情绪应激对大鼠特异性原发体液免疫反应的影响及其可能的作用机制。结果表明每次10分钟，共14次的情绪应激显著低大鼠抗特异性抗原OVA的抗体水平及脾脏指数，而显著增高血肾上腺素、去甲肾上腺素和皮质酮水平。研究还发现去甲肾上腺素与抗特异性抗原OVA的抗体水平呈显著负相关。该研究证实了情绪性心理应激对大鼠体液免疫功能的抑制作用，并提示交感神经系统可能参与了此免疫调节作用。The effect of exposure to emotional stress on the primary humoral immune function(antiovallum antibody level and spleen index), the endocrine response (corticosterone level, epinephrine and norepinephrine levels), the behavioral changes (exploring, grooming and attacking behavior) was studied in adult male Wistar rats. Emotional stress was induced by randomly giving empty water bottles to rats trained to drink water at two set times each day. Emotional stress were given 14 times, ten minutes per each time during experimental period. Results showed that firstly, empty water bottles induced significant attacking behavior (biting the empty water bottle and cage shed) in rats of emotional stress group, secondly emotional stress decreased the weight of the spleen and the level of specific anti-OVA IgG antibody and increased the levels of epinephrine, norepinephrine and corticosterone. A negative correlation between antibody levels and level of norepinephrine was also found. Together with the previous work in our laboratory, the results demonstrated that emotional stress suppressed the specific primary humoral immunity of rats. The sympathetic nervous system may be involved in this immunomodulation

The central mechanism of immunomodulation induced by footshock signal stress.

目的　探讨可能参与电击信号应激免疫调节作用的中枢机制。方法　利用以电击装置为信号的情绪应激免疫调节作用动物模型 ,观察情绪应激后 2个小时 ,大鼠全脑的c fos原癌基因表达情况。结果　与对照组动物相比 ,以电击装置为信号刺激的情绪应激组大鼠明显表达c fos的脑区包括额皮质、扣带皮质、杏仁体、前连合核、下丘脑背内侧核弥散部、弓状核、孤束核等。结论　这些核团可能参与了电击信号应激的免疫调节作用的中枢机

慢性情绪应激对大鼠行为、神经内分泌和免疫反应的影响:一个新的情绪应激模型

介绍一种新的情绪应激模式,即以不确定性空瓶饮水刺激作为情绪应激源,考察14 d情绪应激对大鼠行为、神经内分泌和免疫功能的影响.结果表明情绪应激诱发出明显的攻击行为,激活了HPA轴和交感神经系统,减少了特异性抗体的产生和血白细胞数目.而单纯缺水但无空瓶刺激的应激只引起探究行为、HPA轴激活和血白细胞数目降低.这些结果证明了心理行为因素对行为、内分泌和免疫功能的作用.该模型可用作拟人类的情绪应激模型(例如愤怒或焦虑),它有助于进一步研究情绪应激、行为和免疫功能间的复杂关系

慢性情绪应激对大鼠行为、神经内分泌和免疫反应的影响:一个新的情绪应激模型

介绍一种新的情绪应激模式,即以不确定性空瓶饮水刺激作为情绪应激源,考察14 d情绪应激对大鼠行为、神经内分泌和免疫功能的影响.结果表明情绪应激诱发出明显的攻击行为,激活了HPA轴和交感神经系统,减少了特异性抗体的产生和血白细胞数目.而单纯缺水但无空瓶刺激的应激只引起探究行为、HPA轴激活和血白细胞数目降低.这些结果证明了心理行为因素对行为、内分泌和免疫功能的作用.该模型可用作拟人类的情绪应激模型(例如愤怒或焦虑),它有助于进一步研究情绪应激、行为和免疫功能间的复杂关系.</p