いい音・悪い音 : 音を目で見ると

When young, one of the authors heard someone say \u27In fact there\u27s little difference between the refreshing waterfall sound and the traffic noise on roads.\u27 So-called good sounds include insects\u27 chirping, tinkles of the wind-bell and piano tunes. Bad ones include noises of trams or machinery. What makes the difference between a \u27good sound\u27 and a \u27bad sound\u27? This paper intended to visually compare the frequencies of various sounds using Windows Media Player. The results obtained were as follows. 1. So-called good sounds generally had sharp fluctuations in their frequency ranges as shown on attached graphs. 2. So-called bad sounds had less sharp fluctuations in their frequency ranges, hence did not show a clear sound. 3. However, the fluctuations of the waterfall sound and the fluctuations of the traffic noise of the road were not very different, which suggests for some sounds the existence of other factors such as listeners\u27 psychology; memories of the past, the milieu and connotations

基于气相色谱-质谱联用技术的痛风病人血清代谢特征分析

痛风是一组仅见于人类的异质性疾病,随着时间的推移,将导致慢性关节炎并逐渐致残。该研究将基于气相色谱-质谱联用技术（GC-MS）的代谢组学方法应用于痛风病人的血清代谢特征分析。首先利用GCMS获得痛风病人和健康人的血清代谢指纹图谱,采用多变量统计分析对所得数据进行分析。主成分分析（PCA）得分图显示,痛风病人与健康人的血清代谢谱有差异。通过偏最小二乘-判别分析（PLS-DA）对样品进行进一步分型,根据模型的变量重要性因子（VIP值）及非参数检验结果筛选差异代谢物。共筛选出43种可能与痛风相关的代谢物,并对其中22个变量进行结构鉴定,主要包括丙二醇、2,3-二羟基丁酸、2,4-二羟基丁酸、赤藓糖醇、苏糖醇、苏糖酸、阿拉伯糖醇、D-葡萄糖酸、肌醇、次黄嘌呤、尿酸、尿苷、3-羟基-3-甲基丁酸、鸟氨酸、吲哚-3-乳酸、单乙醇胺、甘油、甘油酸、月桂酸及亚油酸等代谢物。与健康人相比,痛风病人的糖代谢、核苷酸代谢、氨基酸代谢及脂类代谢均发生了明显的紊乱。这些结果将为痛风临床诊断及治疗提供重要依据