The Application of Inorganic Nanoparticles for Chemotherapy and Photothermal Therapy

随着研究人员将纳米颗粒应用于医学研究，纳米医学得到了快速的发展，它在抗癌医疗领域带来了翻天覆地的变化。纳米医学一方面使传统抗癌手段的抗癌效能得到了有效地提高，另一方面也孕育出许多全新的抗癌手段。尽管人们在抗癌纳米颗粒的制备上已经取得了许多丰硕的成果，但是在新型纳米颗粒的制备和功能化方面依然纯在着巨大的发展空间。本论文的主要工作主要集中在对新型光热纳米颗粒和多功能中空介孔纳米颗粒的制备方面，具体内容如下： 第一章：简要综述了光热纳米颗粒和多功能中空介孔纳米颗粒的研究进展。并阐述了本论文的选题依据和研究内容。 第二章：我们通过用二氧化硅对钯纳米片进行包裹，成功地提高了细胞对纳米颗粒的吞...Nanomedicines, for the medical applications of nanotechnology, are promising candidates for anticancer therapy. The nanomedicines are changing the future of therapy. New nanoparticles constantly improve the effect of the original anticancer approach and create new approach. Though many efforts have been devoted to develop new nanomaterials for caner therapy, there is still plenty of room in study ...学位：理学博士院系专业：化学化工学院_无机化学学号：2052011015371

Multifunctional ultrasmall Pd nanosheets for enhanced near-infrared photothermal therapy and chemotherapy of cancer

通讯作者地址: Zheng, NF 电子邮件地址:[email protected] (NIR) photothermal therapy has developed very quickly in recent years. However, its clinical applications are hindered by many practical problems, such as low accumulation in tumors, high laser power density and high biotoxicity in vivo. Herein, a versatile system combining chemotherapy with photothermal therapy for cancer therapy using ultrasmall Pd nanosheets (SPNS) has been developed. The SPNS can serve as pH-responsive drug carriers to efficiently deliver DOX into cancer cells and tumors. On the other hand, the coordinative loading of DOX on SPNS enhances its accumulation in tumor tissue. So we can efficiently ablate tumor using low-intensity laser radiation. Importantly, with ultrasmall size (similar to 4.4 nm), SPNS surface-functionalized with reduced glutathione (GSH) can be cleared from the body through the renal system into the urine. This cancer therapeutic nanosystem, which exhibits a significant synergistic effect and low systemic toxicity, has great potential for clinical applications.Ministry of Science and Technology of China 2011CB932403 2014CB932004 National Natural Science Foundation of China 2113100

Sub-10-nm Pd Nanosheets with Renal Clearance for Efficient Near-Infrared Photothermal Cancer Therapy

通讯作者地址: Zheng, NF (通讯作者)Efficient renal clearance is of fundamentally important property of nanoparticles for their in vivo biomedical applications. In this work, we report the successful synthesis of ultra-small Pd nanosheets (SPNS) with an average diameter of 4.4 nm and their application in photothermal cancer therapy using a near infrared laser. The ultra-small Pd nanosheets have strong optical absorption in the NIR region and high photothermal conversion efficiency (52.0%) at 808 nm. After being surface-functionalized with reduced glutathione (GSH), the SPNS-GSH was administered to mice to investigate the biodistribution, photothermal efficacy and tumor ablation in vivo. The in vivo photothermal therapy studies clearly demonstrate that surface modification with GSH allows the nanosheets to exhibit prolonged blood circulation and thus high accumulation in tumors. Upon 808 nm NIR irradiation, the tumors can be completely ablated. More importantly, with the size below the renal filtration limit (<10 nm), the GSHylated Pd nanosheets can be nicely cleared from body through the renal excretion route and into urine. Together with the high efficacy of NIR photothermal therapy, the unique renal clearance properties make the ultra-small Pd nanosheets promising for practical use in photothermal cancer therapy.MOST of China 2011CB932403 2014CB932004 NSFC of China 21131005 2092510

Silica coating improves the efficacy of Pd nanosheets for photothermal therapy of cancer cells using near infrared laser

通讯作者地址: Zheng, NF (通讯作者), Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China 地址: 1. Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China 2. Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China 电子邮件地址: [email protected] does matter! The ultrathin nature of 1.8 nm-thick Pd nanosheets prevents them entering cells effectively. A 13-times enhancement in the cells' uptake of the Pd nanosheets has now been achieved by silica coating together with surface functionalization, therefore significantly improving their NIR photothermal cell-killing efficacy.NSFC 21021061 20925103 20923004 20871100 Fok Ying Tung Education Foundation 121011 MSTC 2009CB930703 2011CB932403 NSF of Fujian Province 2009J06005 Key Scientific Project of Fujian Province 2009HZ0002-

Amphiphilic modification and asymmetric silica encapsulation of hydrophobic Au-Fe3O4 dumbbell nanoparticles

通讯作者地址: Zheng, NF (通讯作者),电子邮件地址: [email protected] facile method is developed for amphiphilic surface modification and asymmetric silica encapsulation of hydrophobic Au–Fe3O4 dumbbell nanoparticles. The obtained asymmetric Janus nanocomposites display tunable wettability, enhanced catalysis and better cell internalization as compared to those with complete silica encapsulation.MOST of China 2011CB932403 2014CB932004 NSFC of China 21131005 20925103 21333008 2102106

Hollow Mesoporous Zirconia Nanocapsules for Drug Delivery

通讯作者地址: Tang, SH (通讯作者), Xiamen Univ, Coll Chem & Chem Engn, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China 地址: 1. Xiamen Univ, Coll Chem & Chem Engn, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China 2. Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, Xiamen 361005, Peoples R China 电子邮件地址: [email protected] mesoporous zirconia nanocapsules (hm-ZrO2) with a hollow core/porous shell structure are demonstrated as effective vehicles for anti-cancer drug delivery. While the highly porous feature of the shell allows the drug, doxorubicin(DOX), to easily pass through between the inner void space and surrounding environment of the particles, the void space in the core endows the nanocapsules with high drug loading capacity. The larger the inner hollow diameter, the higher their DOX loading capacity. A loading of 102% related to the weight of hm-ZrO2 is achieved by the nanocapsules with an inner diameter of 385 nm. Due to their pH-dependent charge nature, hm-ZrO2 loaded DOX exhibit pH-dependent drug releasing kinetics. A lower pH offers a faster DOX release rate from hm-ZrO2. Such a property makes the loaded DOX easily release from the nanocapsules when up-taken by living cells. Although the flow cytometry reveals more uptake of hm-ZrO2 particles by normal cells, hm-ZrO2 loaded DOX release more drugs in cancer cells than in normal cells, leading to more cytotoxicity toward tumor cells and less cytotoxicity to healthy cells than free DOX.NSFC 20925103,20871100,20721001 Fok Ying Tung Education Foundation 121011 RFDP 200803841010 NSF of Fujian Province 2009J06005 Key Scientific Project of Fujian Province 2009HZ0002-

Etching Growth under Surface Confinement: An Effective Strategy To Prepare Mesocrystalline Pd Nanocorolla

通讯作者地址: Zheng, NF (通讯作者),Xiamen Univ, Coll Chem & Chem Engn, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China 地址: 1. Xiamen Univ, Coll Chem & Chem Engn, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China 2. Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, Xiamen 361005, Peoples R China 电子邮件地址: [email protected] etching growth strategy was developed to prepare corolla-like Pd mesocrystals consisting of unidirectionally aligned, well-spaced, and connected ultrathin (1.8-nm-thick) Pd nanosheets. The combined use of CO and Fe(3+) is critical to the successful synthesis of the branched corolla-like Pd mesocrystals. While CO functions as the surface-confining agent to allow anisotropic growth of the 1.8-nm-thick Pd nanosheets as branches, Fe(3+) etches the Pd seeds at the early stage of the reaction to induce formation of the branched structure. Inheriting the unique properties of 1.8-nm-thick Pd nanosheets, the as-prepared Pd mesocrystals display well-defined surface plasmon resonance absorption in the near-infrared region, a high electrochemically active surface area, and a significant photothermal effect when irradiated with a near-infrared laser. Owing to the presence of internal voids and increased apparent thickness, the Pd mesocrystals also exhibit several features superior to those of single-domain Pd nanosheets, making them promising for electrocatalysis and cancer photothermal therapy applications.NSFC 21131005 21021061 20925103 20871100 Fok Ying Tung Education Foundation 121011 MOST of China 2011CB932403 2009CB930703 NSF of Fujian Province 2009J06005 Key Scientific Project of Fujian Province 2009HZ0002-

Enhancing the Photothermal Stability of Plasmonic Metal Nanoplates by a Core-Shell Architecture

通讯作者地址: Zheng, NF (通讯作者),Xiamen Univ, Coll Chem & Chem Engn, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China 地址: 1. Xiamen Univ, Coll Chem & Chem Engn, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China 2. Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China 电子邮件地址: [email protected] core shell bimetal nanoplates: A facile seeded-growth strategy is developed to prepare uniform plasmonic Pd@Ag core-shell bimetallic nanoplates. The as-prepared Pd@Ag nanoplates are not only uniform in both size and shape, but also display tunable SPR properties and significantly enhanced photothermal stability as compared with 2D pure-Ag nanostructures. They can thus be readily used as stable substrates for MR surface-enhanced Raman scattering and as NIR absorbers for photothermal cancer therapy.NSFC 21021061,20925103,20923004,20871100 Fok Ying Tung Education Foundation 121011 MOST of China 2011CB932403,2009CB930703 NSF of Fujian Province 2009J06005 Key Scientific Project of Fujian Province 2009HZ0002-

Controlled Formation of Concave Tetrahedral/Trigonal Bipyramidal Palladium Nanocrystals

通讯作者地址: Zheng, NF (通讯作者), Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China 地址: 1. Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China 2. Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China 电子邮件地址: [email protected] concave Pd nanocrystals with uniform diameter were successfully prepared in the presence of formaldehyde. While the outer surfaces of the as-prepared concave Pd nanocrystals are {111}, the faces concave toward the polyhedral. center are high-surface-energy {110} faces. The degree of concavity and therefore the percentage of {110} of the nanocrystals are tunable by varying the amount of formaldehyde and the reaction temperature. Owing to the existence of active {110} facets, the electrocatalytic activity of the concave Pd nanocrystals displays dependency on their degree of concavity.NSFC20871100,20721001 MSTC 92009CB930703 RFDP 200803841010 NSF 2009J06005 Fujian Province 2009HZ0002-

Core-Shell Pd@Au Nanoplates as Theranostic Agents for In-Vivo Photoacoustic Imaging, CT Imaging, and Photothermal Therapy

通讯作者地址: Liu, GMinistry of Science and Technology of China 2011CB932403 2014CB932004 National Natural Science Foundation of China 21420102001 21131005 8142202