Characteristics of Dry and Wet Changes and Future Trends in the Tarim River Basin Based on the Standardized Precipitation Evapotranspiration Index

Global changes in drought and wetness and their future trends in arid regions have recently become a major focus of research attention. The Tarim River Basin (TRB) in Xinjiang, China, is among the most climate-sensitive regions in the world. This study uses data from the past 60 years (1962–2021) to analyze the spatial and temporal features of drought and wetness conditions in the TRB, calculating the Standardized Precipitation Evapotranspiration Index (SPEI). Trend detection for SPEI is performed using the BEAST mutation test, identification of drought events using the theory of operations, and spatial and temporal analyses of dry and wet changes using Empirical Orthogonal Function (EOF) decomposition. Additionally, the CMIP6 dataset is used to estimate future changes. The study results indicate the following: (1) From 1962 to 1998, the TRB exhibited a “warm and wet” trend that suddenly shifted from “wet-to-dry” in 1998 and subsequently transitioned to a pronounced “warm and dry” trend. (2) After the “wet-to-dry” shift, the frequency of drought events noticeably increased. The northern section of the basin witnessed more frequent drought events, albeit with lower severity, while the southern part had fewer occurrences but with higher severity. The spatial distribution of drought event frequency and severity is inconsistent. (3) The EOF decomposition results for SPEI-variable fields at 1-, 3-, and 6-month time scales show that the cumulative variance contribution rate of the first three principal spatial modal feature vectors exceeds 70%. The spatial distribution of the modes includes a consistent pattern across the entire basin, a north–south opposite pattern, and an east–west opposite pattern. (4) The future trend of drought in the TRB is expected to intensify, manifesting a spatial pattern characterized by dryness in the middle of the basin and wetness around the periphery. These research findings can provide support for decisions addressing regional drought risks

Development of Nasal Vaccines and the Associated Challenges

Viruses, bacteria, fungi, and several other pathogenic microorganisms usually infect the host via the surface cells of respiratory mucosa. Nasal vaccination could provide a strong mucosal and systemic immunity to combat these infections. The intranasal route of vaccination offers the advantage of easy accessibility over the injection administration. Therefore, nasal immunization is considered a promising strategy for disease prevention, particularly in the case of infectious diseases of the respiratory system. The development of a nasal vaccine, particularly the strategies of adjuvant and antigens design and optimization, enabling rapid induction of protective mucosal and systemic responses against the disease. In recent times, the development of efficacious nasal vaccines with an adequate safety profile has progressed rapidly, with effective handling and overcoming of the challenges encountered during the process. In this context, the present report summarizes the most recent findings regarding the strategies used for developing nasal vaccines as an efficient alternative to conventional vaccines

Nutrition knowledge, attitudes, behaviours and the influencing factors among non-parent caregivers of rural left-behind children under 7 years old in China

AbstractObjectiveTo explore and compare nutrition knowledge, attitudes and behaviours (KAB) between non-parent and parent caregivers of children under 7 years old in Chinese rural areas, and to identify the factors influencing their nutrition KAB.DesignFace-to-face interviews were carried out with 1691 non-parent caregivers and 1670 parent caregivers in the selected study areas; multivariate logistic regression models were used to identify the factors influencing nutrition KAB in caregivers.ResultsThe awareness rate of nutrition knowledge, the rate of positive attitudes and the rate of optimal behaviours in non-parent caregivers (52·2 %, 56·9 % and 37·7 %, respectively) were significantly lower than in the parent group (63·8 %, 62·1 % and 42·8 %, respectively). Multivariate logistic regression modelling showed that caregivers’ family income and care will, and children’s age and gender, were associated with caregivers’ nutrition KAB after controlling the possible confounding variables (caregivers’ age, gender, education and occupation).ConclusionsNon-parent caregivers had relatively poor nutrition KAB. Extra efforts and targeted education programmes aimed to improve rural non-parent caregivers’ nutrition KAB are wanted and need to be emphasized.</jats:sec

Encapsulating electron-deficient dyes into metal–organic capsules to achieve high reduction potentials

The host–guest system constructed by incorporating the electron-deficient dyes, anthraquinones, into electron-rich metal–organic capsules has successfully achieved efficient photocatalytic reduction of aryl chlorides via multiphoton excitation.</jats:p

The Epidemiology of Influenza and the Associated Vaccines Development in China: A Review

Influenza prevention and control has been one of the biggest challenges encountered in the public health domain. The vaccination against influenza plays a pivotal role in the prevention of influenza, particularly for the elderly and small children. According to the epidemiology of influenza in China, the nation is under a heavy burden of this disease. Therefore, as a contribution to the prevention and control of influenza in China through the provision of relevant information, the present report discusses the production and batch issuance of the influenza vaccine, analysis of the vaccination status and vaccination rate of the influenza vaccine, and the development trend of the influenza vaccine in China

Association of Inflammatory Cytokines With Non-Alcoholic Fatty Liver Disease

BackgroundInflammatory cytokines have been considered to be significant factors contributing to the development and progression of non-alcoholic fatty liver disease (NAFLD). However, the role of inflammatory cytokines in NAFLD remains inconclusive.ObjectiveThis study aimed to evaluate the association between inflammatory cytokines and NAFLD.MethodsPubMed, Web of Science, the Cochrane Library, and EMBASE databases were searched until 31 December 2021 to identify eligible studies that reported the association of inflammatory cytokine with NAFLD and its subtypes. We pooled odds ratios (ORs) and hazard risk (HRs) with 95% confidence intervals (CIs) and conducted heterogeneity tests. Sensitivity analysis and analysis for publication bias were also carried out.ResultsThe search in the databases identified 51 relevant studies that investigated the association between 19 different inflammatory cytokines and NAFLD based on 36,074 patients and 47,052 controls. The results of the meta-analysis showed significant associations for C-reactive protein (CRP), interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and intercellular adhesion molecule-1 (ICAM-1) with NAFLD (ORs of 1.41, 1.08, 1.50, 1.15 and 2.17, respectively). In contrast, we observed non-significant associations for interferon-γ (IFN-γ), insulin-like growth factor (IGF-II), interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-7 (IL-7), interleukin-8 (IL-8), interleukin-10 (IL-10), interleukin-12 (IL-12), monocyte chemoattractant protein-1(MCP-1), and transforming growth factor-β (TGF-β) with NAFLD. Our results also showed that CRP, IL-1β, and TNF-α were significantly associated with non-alcoholic steatohepatitis (NASH) and hepatic fibrosis.ConclusionsOur results indicated that increased CRP, IL‐1β, IL-6, TNF‐α, and ICAM-1 concentrations were significantly associated with increased risks of NAFLD. These inflammatory mediators may serve as biomarkers for NAFLD subjects and expect to provide new insights into the aetiology of NAFLD as well as early diagnosis and intervention.</jats:sec

Suspended cell lines for inactivated virus vaccine production

Introduction Inactivated virus vaccines are the most widely used tool to prevent disease. To meet vaccine production demands, increasing attention has been placed on identifying methods to improve vaccine production efficiency. The use of suspended cells can greatly increase vaccine production. Suspension acclimation is a traditional method to convert adherent cells to suspension strains. Furthermore, as genetic engineering technology has developed, increasing attention has focused on the development of suspension cell lines using targeted genetic engineering techniques. Areas covered This review systematically summarizes and analyzes the development and research progress of various inactivated viral vaccine production suspension cell lines and provides protocols and candidate target genes for the engineered establishment of additional suspension cell lines for vaccine production. Expert opinion The use of suspended cells can significantly improve the production efficiency of inactivated virus vaccines and other biological products. Presently, cell suspension culture is the key component to improve many vaccine production processes

Table_2_Association between inflammatory markers and non-alcoholic fatty liver disease in obese children.XLSX

BackgroundGiven the high prevalence of non-alcoholic fatty liver disease (NAFLD) in obese children, non-invasive markers of disease to date are still limited and worth exploring.ObjectiveThis study aimed to evaluate the association between inflammatory markers and NAFLD in obese children.MethodsWe performed a case-control study in Hunan Children's Hospital from September 2020 to September 2021. Study participants were children with obesity diagnosed with NAFLD by abdominal ultrasound examination. Mean platelet volume (MPV), platelet distribution width (PDW), neutrophil, lymphocyte, monocyte, and platelet counts were extracted from medical records and inflammatory cytokines were measured by enzyme-linked immunosorbent assay (ELISA). Multivariable logistic regression analysis was performed to evaluate the association between inflammatory markers and NAFLD. We also used receiver operating characteristic curve analysis to assess the discriminative ability of inflammatory cytokines for NAFLD.ResultsTwo hundred and sixty-seven obese children were enrolled, including 176 NAFLD patients and 91 simple obesity controls. Multivariable logistic model indicated that increased interleukin (IL)-1β [odds ratio (OR) = 1.15, 95% confidence interval (CI): 1.04–1.27], IL-6 (OR = 1.28, 95% CI: 1.07–1.53), and IL-17 (OR = 1.04, 95% CI: 1.02–1.07) levels were significantly associated with NAFLD. In contrast, we observed non-significant associations for IL-8, IL-12, IL-21, IL-32, tumor necrosis factor-α (TNF-α), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), mean platelet volume (MPV), and platelet distribution width (PDW) with NAFLD. The area under the curves (AUCs) of IL-1β, IL-6, and IL-17 to discriminate obese children with or without NAFLD were 0.94, 0.94, and 0.97, respectively.ConclusionsOur results indicated that IL-1β, IL-6, and IL-17 levels were significantly associated with NAFLD. These inflammatory cytokines may serve as non-invasive markers to determine the development of NAFLD and potentially identify additional avenues for therapeutic intervention.</p