基于阵列声表面波传感器的电子鼻系统及应用初步

本文探讨电子鼻系统的建立及其气味识别能力。在建立了基于阵列声表面波传感器的电子鼻系统之后,将该电子鼻系统用于气味识别,证明它具有良好的识别气味的能力。电子鼻是一种新型分析仪器,由具备部分专一性的阵列电子化学传感器和适当的模式识别系统组成,能识别简单或复杂气味。电子鼻的应用前景是令人振奋的,诸如食品、饮料、石化、制药国家自然科学基金;厦门市科委三项科研基

非经营性国有资产的配置与监管

背景材料:1月11日,中共中央办公厅、国务院办公厅印发了《关于创新政府配置资源方式的指导意见》(简称《指导意见》),要求创新非经营性国有资产配置方式。对用于实施公共管理和提供公共服务目的的非经营性国有资产,坚持公平配置原则,积极引入竞争机制提高配置效率,提高基本公共服务的可及性、公平性

光动力学方法（PDT）治疗多形性腺瘤恶变一例报告

多形性腺瘤恶变采用PdT治疗国内尚未见报道。我科1988年治愈一例，存活至今已7年未复发。患者张xx，女，30岁，1985年右上唇颊沟长一肿物，在某地区医院手术切除三次复发。1987年7月21日我科收住院。入院检查：全身情况营养较差，消瘦、肝功gPT..

壳寡糖和聚丙烯酸的自组装行为

研究了壳寡糖和聚丙烯酸在共同溶剂水中的自组装行为.两种聚电解质之间不仅存在库仑力,而且存在相当强的氢键相互作用.在超声波作用下,能形成亚微米尺寸的球形自组装聚集体,并利用动态光散射的方法和透射电镜研究了这种自组装微球的尺寸和形态

Construction and identification of interference plasmid targeting on TNFAIP8

目的:构建并筛选出干扰效率最佳的TnfAIP8-SHrnA-P SIrEn-rETrO Q干扰质粒。方法:通过生物软件选择3个TnfAIP8基因干扰位点,构建干扰质粒并测序验证,将干扰质粒及对照质粒分别转染至A549细胞,通过rT-PCr、WESTErn blOT检测干扰效率。结果:经rT-PCr和WESTErn-blOT证实TnfAIP8-SHrnA-P SIrEn-rETrO Q干扰质粒能有效干扰并抑制细胞内TnfAIP8基因的表达,通过流式检测发现降低TnVAIP8表达可以提高细胞对A dr5SC fV诱导凋亡的敏感性。结论:成功构建和设计了对TnfAIP8基因具有显著干扰效率的干扰质粒,为进一步研究TnfAIP8基因的功能奠定了基础。Objective: To construct and screen the high efficiency interference plasmid of TFAIP8-shRNA-p SIRENRetro Q.Methods: Selected and synthesized three Target Sequence of TNFAIP8 shRNA1,TNFAIP8 shRNA2,TNFAIP8 shRNA3,and construct the TNFAIP8 interference plasmid.Transfection TNFAIP8-shRNA-p SIREN-Retro Q interference plasmid to A549 cells.Filter out the highest interference efficiency plasmid by detecting the mRNA and protein levels using RT-PCR and Western blot methods.Results: We successfully design and built three TNFAIP8-shRNA-p SIREN-Retro Q interference plasmids,and screen out the highest efficiency interference plasmid.Conclusion: Three interference plasmids targeting the TNFAIP8 gene have been constructed successfully and provide a useful tool for studying the function of TNFAIP8.国家自然科学基金项目(81272720); 福建省卫计委医学创新课题(2014-CXB-43); 厦门市科技计划项目(3502Z2083008)资

分子对接预测H5亚型禽流感病毒的广谱中和表位

H5N1禽流感病毒已经在亚洲、欧洲和非洲广泛传播,造成了巨大损失.最近我们鉴定出一株对多种来源的H5N1代表株均有良好中和活性的、识别H5亚型血凝素(hemagglutinin,HA)的广谱单克隆抗体8H5,它对寻找克服禽流感高变性的广谱治疗性抗体、疫苗和药物具有重要价值.本研究应用分子模拟技术,采用"典范结构"方法对8H5抗体Fab片段进行结构模建,并通过能量分析、SAS值分析、"拉曼强传图"检验、profile-3D分析等理论验证,获得较为合理的8H5Fab的三维空间结构.8H5Fab与3种HA蛋白晶体结构的分子对接结果表明,8H5抗体与HA蛋白的作用模式与HA宿主来源无关,但与HA结构的亚型相似性相关.综合抗原同源比对结果,推测8H5抗体识别的广谱中和表位是由HA上的Asp68,Asn72,Glu112,Lys113,Ile114,Pro118,Ser120,Tyr137,Tyr252不连续氨基酸残基组成的构象表位.这一模型将为H5亚型禽流感病毒广谱疫苗和治疗性药物的分子设计提供依据

Carbon Monoxide-Assisted Synthesis of Single-Crystalline Pd Tetrapod Nanocrystals through Hydride Formation

通讯作者地址: Zheng, NF (通讯作者),Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China 地址: 1. Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China 2. Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China 3. Xiamen Univ, Dept Phys, Xiamen 361005, Peoples R China 电子邮件地址: [email protected]; [email protected] monoxide can adsorb specifically on Pd(111) to induce the formation of unique Pd nanostructures. In the copresence of CO and H-2 single-crystalline Pd tetrapod nanocrystals have now been successfully prepared. The Pd tetrapods are enclosed by (111) surfaces and are yielded through hydride formation. Density functional theory calculations revealed that the formation of PdHx in the presence of H, reduces the binding energy of CO on Pd and thus helps to decrease the CO coverage during the synthesis, which is essential to the formation of the PdHx tetrapod nanocrystals. In addition to tetrapod nanocrystals, tetrahedral nanocrystals were also produced in the copresence of CO and H-2 when the reaction temperature was ramped to further lower the CO coverage. Upon aging in air, the as-prepared PdHx nanocrystals exhibited a shape-dependent hydrogen releasing behavior. The conversion rate of PdHx tetrapod nanocrystals into metallic Pd was faster than that of tetrahedral nanocrystals.MOST of China 2011CB932403 2009CB930703 NSFC 21131005 21021061 20925103 20973139 21133004 Fok Ying Tung Education Foundation 121011 Fundamental Research Funds for the Central Universitie

Electronic nose and its application based on surface acoustic wave sensors array

人类依靠自身的嗅觉判断日用品的质量甚至诊断疾病，受年龄等客观因素和 情绪等主观因素对同一气味评判结果的影响，需要能客观测量气味的仪器。当 前气味检测和安全检查的仪器方法也存在这样那样的问题。因此；模拟哺乳动 物的嗅觉一直是人类的梦想。本论文即致力于电子鼻识别气味的研究。 声表面波器件由于具有灵敏度高，信号易于微机处理及抗传输干扰等优点 而被我们选为人工嗅觉传感器的“平台”。本文完成了声表面波器件的选型设 计，声表面波传感器阵列振荡电路；信号调理电路和微机接口电路的设计制作， 数据采集软件的编写，以及气体产生切换恒温装置的组装。实践证明，整个电 子鼻系统的设计比较合理。在此基础上...The ability of odor identification by a new electronic nose based on 8. surface acoustic wave(SAW) sensors was first demonstrated in the present dissertation. The need of an artificial olfactory comes from the requirement of the sense of smell. For example, Those human sensory tests are inevitably affected by the inspector's state of health, mood, age etc. On the other hand, existing methods...学位：理学博士院系专业：化学化工学院化学系_分析化学学号：B1993100

Design Optimizion of Electronic Nose based on Saw Sensor Array and it's Application

本文完成了声表面波器件的选型设计，声表面波传感器阵列振荡电路，信号调理电路和微机接口电路的设计制作，数据采集软件的编写，以及气味产生切换恒温装置的组装。实践证明，整个电子鼻系统的设计比较合理。在此基础上，本文通过将电子鼻系统用于四种有机试剂，四种酒类和五种香料的识别。人工神经元网路的计算结果表明，该电子鼻系统能较好地进行上述气味的识别。本文的主要结论是：1.SAW传感器的响应机理不是传统上认为的单纯质量效应，响应机理远比选择性增重复杂的多，这种特性恰恰类似嗅觉生理上分子识别的多样性。从而赋予SAW传感器更强的选择性，使SAW传感器更适合于组成识别气味的电子鼻系统。2.基于SAW传感器阵列为核心...The ability of odor identification by an electronic nose based on 8 surface acousticwave sensors (SAWS) was demonstrated in the present paper. The SAWS-basedelectronic nose was firstly established and its frequency stability was checked. Thenby applying appropriate polymers coating on SAW devices (SAWD), the prototypeinstrument was employed to collect data from its exposing to four kinds of organi...学位：博士后院系专业：生命科学学院生物学系_植物学学号：BHBG0001

The Application of Genetic Algorithms Based on Back Propagation Neural Network in Distinguish Alcoholic Vapour

把基于反向传播神经网络的遗传算法用于酒类气体识别实验中的传感器阵列的筛选，通过评价传感器组合对反向传播神经网络识别酒类气体结果的影响，建立一种挑选传感器阵列的方法，该算法选出的变量与用统计方法得到的结果一致The genetic algorithm based on back propagation neural network was employed to select gas sensors in distinguishing alcoholic vapour experiment.After evaluating the fitness of sensor arrays, a new method of choosing gas sensors was built.The results are equivalent to that obtained by statistical method.国家自然科学基