The role of arsenic nano-drug in the treatment of liver cancer

目的：三氧化二砷（ATO）是临床上能够有效治疗急性早幼粒细胞性白血病的药物。然而，由于治疗剂量限制和药代动力学欠佳，影响了它在抗肿瘤治疗中的运用。亲合体（Affibody）是一类新型独特的蛋白结合配体，分子量小、亲和力强、稳定且可修饰，比普通抗体具有更多优势。目前国内外尚无将亲合体用于肝癌靶向治疗的研究。为了更加有效地将ATO药物运输到肝癌细胞并产生更高的毒性，我们前期已经合成了两种新型砷纳米药物：EGFR靶向修饰的镍砷纳米药物（Ni,As@SiO2-Affibody）、锰砷纳米药物（Mn,As@SiO2）。本文在细胞、组织、小动物等水平上研究这两种纳米药物的细胞毒性、靶向效果和抑制肝癌生长等...Background and objectives: Arsenic trioxide (ATO) is an effective clinical drug to treat acute promyelocytic leukemia. However, its application in oncotherapy is limited due to the dose-limiting toxicity and poor pharmacokinetics. Affibody is a special protein binding ligands and possesses many advantages, such as small molecular weight, strong affinity, special modification sites, and high stabil...学位：医学硕士院系专业：医学院_外科学学号：2452012115317

The Influence of Environmental Regulation on Industrial Upgrading

过去粗放式的经济发展方式使得中国环境问题不断加剧。例如北方地区的空气严重污染对人民群众的健康带来了极大的不利影响。近年来，环境污染问题日益得到政府的重视。各级政府出台了不少控制污染的政策措施，也加大了环保产业发展的扶持力度，以期通过这些途径来改善中国环境。与此同时，中国经济面临着转型升级的迫切需要。然而，环境规制对产业升级的影响，学界研究尚少。如何处理好环境规制与产业升级的关系在现阶段具有重要的现实意义，本文着眼于环境规制与产业升级的关系进行研究，以期研究结果对于解决中国现阶段环境规制与产业升级的矛盾关系提供借鉴意义。 本文以1999-2012年中国宏观层面的年度数据为样本，实证分析了环境规...In the past, the extensive mode of economic developing method cause the growing environmental problems in China. Such as air pollution in the northern areas, people's health has brought great negative impact. In recent years, government had started to focus on environmental pollution problems. All levels of government introduced a number of policy to control pollution, and started to support the d...学位：经济学硕士院系专业：经济研究所_产业经济学学号：1602013115222

The Role of the Long Non-Coding RNA AK035610 in Epileptogenesis

目的：使用海藻酸（Kainicacid，KA）诱导C57BL/6小鼠产生癫痫样发作以模拟人类颞叶癫痫的发作状态，通过基因芯片方法筛选出异常表达的长链非编码RNA（lncRNA）。选择并探讨其中一个lincRNA-AK035610及其靶基因INHBA在癫痫发病中的参与及调控机制，从而为癫痫的诊断和药物研发提供新的思路及生物学靶点。 方法：使用6-8周C57BL/6雄性小鼠，通过腹腔注射海藻酸构建癫痫发作小鼠模型，分离癫痫发作小鼠和对照小鼠的海马，提取RNA后使用长链非编码RNA基因芯片进行分析，对癫痫小鼠中发生异常表达的lncRNA，特别是位于基因之间的LincRNA进行筛选和聚类分析。通过实...Objective: In order to establish an animal model of human temporal lobe epilepsy, C57BL / 6 mice were induced into epilepticus seizures by kainic acid. To explore the dynamic changes of regulatory networks and functional pathways of lncRNA in the pathogenesis of epilepsy, and provide new evidence for the diagnosis of epilepsy and new targets for anti-epileptic drug development. Methods: C57BL / 6...学位：医学硕士院系专业：医学院_外科学学号：2452014115353

A Study of Selecting Suitable Performance Evaluation System for Chinese Enterprises

在EVA，平衡计分卡，综合计分卡等方面的文章充斥着各种刊物，大部分文章都不假思索的以知识经济的到来，智力资本的地位的重要性开始论述，之后得出企业应该实践着最新的绩效评价方法。而在实务界，平衡计分卡、综合计分卡等绩效评价方法也被广泛采用。本文从大部分文章少有思考的绩效评价方法的假设前提出发，去分析企业如何选择适合于自己的绩效评价体系，而不是以绩效评价方法的创立背景为想当然。 本文在总结企业绩效评价体系相关的基础理论和回顾国内外企业绩效评价体系的发展阶段的基础上，分析影响我国企业绩效评价体系选择的相关因素，以构建我国企业绩效评价体系选择的框架，即：从下述关于经济环境、企业层次、企业战略思维模式、...As various publications were covered with articles whose keywords were EVA, Balanced Scorecard, Comprehensive Scorecard etc., most of those articles were based on the arrival of the knowledge-based economy and the importance of intellectual capital on modern economy. And then came to conclusion that enterprises should practice the latest performance evaluation system. Meanwhile in practice, the Ba...学位：管理学硕士院系专业：管理学院会计系_会计学学号：1512005130115

The Vehicle Image Retrieval Based on Multiple Vocabularies index

车辆图像检索是智能交通系统的重要组成部分，车辆检索在停车场智能管理、高速公路自动收费、道路监控、超时停车检测等方面有着非常好的应用前景。本课题来源于高速公路服务区车辆智能检测项目，是基于特定场景下的车辆图像检索问题。 车辆图像检索主要是基于车辆检测、目标区域提取、特征提取和特征匹配的相关技术，目前关于图像检索的技术研究相对来说比较成熟。本文旨在进一步研究车辆图像特征在索引层面的融合，在有光照变化等情况的交通场景中能够进行准确的车辆图像检索。本文的主要的研究内容如下： 1.研究图像检索的流程和经典算法，分析和总结了车辆图像检索流程中的关键要素、检索流程和特征提取。研究了不同检索流程和特征提取...The vehicle image retrieval is an important part of intelligent transportation system. Vehicle retrieval has good application prospect in intelligent parking lot management, highway automatic charge, road monitoring and parking timeout detection. This paper comes from vehicle intelligent monitoring projects of highway service area, the problem bases on fixed background of vehicle image retrieval. ...学位：工程硕士院系专业：信息科学与技术学院_计算机技术学号：2302011115306

Soul Expression in the Masterpieces—— On the Literature Criticism of Li Jianwu

李健吾的文学批评一直被看作是中国印象主义批评的典范，他深受西方印象主义批评特别是法朗士、雷梅托等人的批评理论的影响，强调批评的主观印象，重视直觉感悟、主体介入和情感动力。同时，李健吾又在较大程度上自觉地将中国传统文学批评与西方印象主义批评融汇在一起，他在既有传统文学积淀的基础上，广泛地吸收传统文学批评与西方文学批评的有益因素，创造性地形成了自己独具风格的文学批评体系。在文学批评的具体实践中，李健吾的文学批评始终没有离开自由主义文化这一特定的历史背景，并由此形成了“平等、独立、公正”的批评原则，以及强调对话与创造的批评主张，乃至一种独特的“随笔式”批评文体。李健吾的文学批评对当时以左翼文学为主流...The literature criticism of Li Jianwu has long been regarded as the model of impressionism criticism in China. Influenced deeply by western impressionism criticism theories, especially those of France and Lemaitre, he emphasizes subjective impression, intuition sentiment, individual intervention and sensibility motivation. Meanwhile, he consciously to some extent combines Chinese traditional liter...学位：文学硕士院系专业：人文学院中文系_文艺学学号：X20040100

Immunohistochemical Study of Serotonin in the Digestive System of Scylla serrata

【中文摘要】 应用免疫组织化学方法对锯缘青蟹消化系统的 5- HT分泌细胞的形态和分布进行了观察 .结果表明 :5- HT阳性细胞形态多样 ,多数为卵圆形 ,少数为柱形 ,多边形或具有较长的胞突 .消化道各段均有 5- HT阳性细胞 ,中肠密度最高 ,食道次之 ,贲门胃、幽门胃和后肠较低 .5- HT阳性细胞多数位于固有膜和粘膜下层 ,少数散布于肌层 .肝胰腺也具有 5- HT阳性细胞 【英文摘要】 The morphology and distribution of serotonin(5 HT) immunoreactivity in the digestive system of Scylla serrata were investigated. 5 HT immunoreactive cells had various forms: the majority were oval, while the minority were columnar, irregular in shape, or having long processes. 5 HT immunoreactive cells were distributed throughout the digestive tract, with the highest density in the midgut, the second in the esophagus, and a low density in the stomach and hindgut. Most of the 5 HT immunoreactive c...福建省重中之重“福建省海洋生物优良种质和生物活性物质的应用基础研究”资助项