锁核酸修饰探针熔解曲线分析在Kras基因突变检测中的应用

以探针熔解曲线技术为平台，结合锁核酸（LNA）修饰探针建立熔解曲线分析（MCA）体系（MCA-LNA体系），实现一管同时检测Kras基因中7个热点突变，并通过对探针的改良达到富集突变型的效果，使其分析灵敏度得到明显提升，达0.05%～0.5%。利用MCA-LNA体系对72份临床结直肠癌标本进行KRAS突变检测，共检出24份阳性标本，与普通探针熔解曲线技术相比多检出5份突变阳性标本，经扩增阻碍突变系统（ARMS）方法验证为突变型。由上述结果可见MCA-LNA体系能显著提高检测限和阳性标本检出率，更有利于基因筛查和指导靶向治疗。福建省高校杰出青年科研人才培育计

Design and performance analysis of multi-wheeled lateral and longitudinal rocker arm series-parallel robot

The six-wheeled rocker robot and the eight-wheeled rocker robot have strong obstacle-surmounting and terrain adaptability, which are widely used in lunar and Mars exploration, military operations, and field rescue. However, for the terrain environment with low friction coefficient and more complex unstructured terrain environments such as ice and snow roads, the six-wheeled rocker robot and the eight-wheeled rocker robot are not enough, so the rocker arm robot with stronger ability to overcome obstacles and adapt to the terrain is needed. In order to solve the above technical problems, this paper innovatively designs a multi-wheeled lateral and longitudinal rocker arm series-parallel robot. Firstly, Creo3.0 is used to create a new three-dimensional model of a series-parallel robot with multi-wheeled lateral and longitudinal arms. Then, the 3D model of the robot is imported into Adams2018 to build a virtual prototype simulation model. Finally, through the construction and simulation analysis of various obstacle-surmounting terrain environments such as vertical obstacles, slopes and potholes, the adaptability, obstacle-surmounting, safety and maneuverability of the robot to different terrain environments are studied. The conclusions obtained in this paper can provide a reference for the innovative design of the obstacle-crossing mechanism of the multi-wheeled lateral and longitudinal rocker arm series-parallel robot, and the improvement of the obstacle-crossing performance, adaptability, maneuverability and safety performance on complex terrain. © Published under licence by IOP Publishing Ltd

Innovative Design and Virtual Scene Simulation Analysis of Air Carrier

In recent years, some progress has been made in the study of launching and recovering small fixed-wing aircraft by using large fixed-wing transport aircraft as air carriers, but at the same time, some problems have also been exposed. For example, the existing air carriers can only stay and operate in the air for a few hours, and the recovery efficiency and recovery success rate are low. In order to solve the above problems, this paper proposes an airship-type air carrier for launching and recovering rotor-type UAV swarms in the air. Firstly, the new concept of the air carrier is innovatively designed using Creo3.0 and Keyshot11. And research on solutions is carried out for the problems encountered in the process of innovative design of air carriers. After that, the 3D model of the air carrier created by Creo3.0 is imported into Adams2018 to establish a virtual simulation model. Finally, through the construction and simulation analysis of the aircraft carrier's release and recovery rotor UAV scene, the motion performance and use process of the air aircraft carrier mechanism are studied. The obtained conclusions can provide the basis for the innovative design of the air carrier and the design optimization of the air release and recovery process. © 2022 IEEE

Innovative Design and Simulation Analysis of Rocket and Combined Air Launch Platform

This paper uses Creo3.0 and Keyshot11 to innovatively design a new concept of rocket and combined air launch platform. Import the 3D model of the air launch platform created by Creo3.0 into Adams2018 to build a virtual simulation model. Through the construction and simulation analysis of the release, launch and recovery scenarios of the air launch platform, the motion performance and use process of the whole machine in the ground release, air launch and ground recovery scenarios are studied. The obtained conclusions can provide a basis for the optimization of the air launch platform mechanism and launch process design. And provide theoretical support for the evaluation of the rationality, adaptability and safety of the release, launch and recovery methods of the air launch platform. © 2022 IEEE

层流等离子体金属丝材喷涂工艺研究

利用层流等离子体射流，以普通工程铁丝为喷涂材料，在Q235基体表面制备金属涂层，并利用喷涂系统的参数可调性研究工艺参数对涂层质量的影响。结果表明，利用层流等离子体射流喷涂可以得到具有典型层状结构、氧化较少的致密涂层

Effects of anode temperature on working characteristics and performance of a low power arcjet thruster

An arc-heated thruster of 130–800 W input power is tested in a vacuum chamber at pressures lower than 20 Pa with argon or H2–N2 gas mixture as propellant. The time-dependent arc voltage-current curve, outside-surface temperature of the anode nozzle and the produced thrust of the firing arcjet thruster are measured in situ simultaneously, in order to analyze and evaluate the dependence of thruster working characteristics and output properties, such as specific impulse and thrust efficiency, on nozzle temperature

一种液控多阀位及多流向的可控三通阀

本发明公开了一种液控多阀位及多流向的可控三通阀，包括阀体和两个阀座，阀座与阀体通过螺纹连接，通过法兰密封垫密封，所述阀体内设有阀流通道，所述阀体内设有两个液压缸，所述液压缸包括液压杆、液压塞和液缸盖及相关密封组件，在所述液缸盖中心设有液压杆，并且在液压杆两端分别设有液压塞和阀瓣，所述阀瓣在接触阀座时通过液压杆输出的液动力作用在阀座接触面上的作用力实现闭合接触密封，在液压塞两侧对应阀瓣开启和关断的位置上设有供液压赛换向工作的换向液道a和换向液道b，其工作状态且可独立受控或共同受控；能够很好的弥补传统三通阀在功能上的不全面及使用维护上的短板，产品应用方法上更加灵活，响应上更加快速