19 research outputs found

    遥感及部分相关学科SCI收录期刊介绍

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    以表格的形式介绍了SCIE收录的15种遥感类目期刊的英文刊名、中文刊名、出版国和最新影响因子,并将其中SCI收录的6种期刊进行了全面的揭示,包括英文刊名、汉译刊名、出版周期、原版刊号、最新影响因子、国际标准刊号、出版地、出版者、联系地址、最新期刊网址,期刊描述等全方位的期刊信息。期刊描述内容包括:期刊的创刊年以及期刊的发展,期刊刊载的主要内容,网站可免费获取的该刊目次和文摘及全文信息等

    学科化信息服务工作实践研究

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    以中科院新疆生态与地理研究所文献信息中心学科化信息服务工作为例,将学科化信息服务工作实践研究的背景、成果和成功的实践经验熔为一炉。通过对学科化信息服务工作的实践研究,探索服务理念、工作模式和服务能力的创新,并展望学科化信息服务的工作远景,推动学科化信息服务工作的深入开展

    力学微环境调控肝血窦内皮细胞表型维持与去分化

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    目的肝血窦内皮细胞(liver sinusoidal endothelial cells,LSEC)是肝内一种高度分化的非实质细胞,具有独特的表型特征,在肝脏组织稳态维持中起关键作用。基质硬度、血流剪切等力学微环境的变化是多种肝脏疾病发展过程中的重要因素,但其是否可以直接调控LSEC的表型维持或去分化尚不明确。方法体外培养小鼠原代LSEC细胞

    Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli

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    Liver sinusoidal endothelial cells (LSECs) are the gatekeeper of liver to maintain hepatic homeostasis. They are formed into the highly specialized endothelium between vascular lumen and the space of Disse and are mechanosensitive to respond varied microenvironments. Shear stress and mechanical stretch induced by blood perfusion and substrate stiffness enhancement derived from deposition of extracellular matrix (ECM) are major mechanical stimuli that surround LSECs. This review introduces how LSECs respond to the external forces in both physiological and pathological cases and what is the interplay of LSECs with other hepatic cells. Molecular mechanisms that potentiate LSECs mechanotransduction are also discussed

    试论图书馆资源、服务与读者认同[C]

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    图书馆向何处去?读者不明白,图书馆员也未必清楚。我们跟踪了几个月的“中国网站排名”,感觉情况不容乐观。赢得社会民众的广泛认同,在网络信息服务中谋得一席之地,已经成为摆在图书馆界的第一课题。如何审时度势、扬长避短,找准每个图书馆的定位、资源与服务,有针对性的开展图书馆宣传和读者认同的研究,也已经成为影响图书馆事业发展的重要环节。通过网络发展状况、网站排名、网民结构,分析我国图书馆存在的问题,找准读者需求,成为辅助公众获得成功的知识的沃土,图书馆才真真走上了可持续发展之路

    Trail Formation Alleviates Excessive Adhesion and Maintains Efficient Neutrophil Migration

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    Migrating neutrophils are found to leave behind subcellular trails in vivo, but the underlying mechanisms remain unclear. Here, an in vitro cell migration test plus an in vivo observation was applied to monitor neutrophil migration on intercellular cell adhesion molecule 1 (ICAM 1) presenting surfaces. Results indicated that migrating neutrophils left behind long lasting, chemokine containing trails. Trail formation tended to alleviate excessive cell adhesion enhanced by the trans binding antibody and maintain efficient cell migration, which was associated with differential instantaneous edge velocity between the cell front and rear. CD11a and CD11b worked differently in inducing trail formation with polarized distributions on the cell body and uropod. Trail release at the cell rear was attributed to membrane ripping, in which fi2 integrin was disrupted from the cell membrane through myosin mediated rear contraction and integrin cytoskeleton dissociation, potentiating a specialized strategy of integrin loss and cell deadhesion to maintain efficient migration. Moreover, neutrophil trails left on the substrate served as immune forerunners to recruit dendritic cells. These results provided an insight in elucidating the mechanisms of neutrophil trail formation and deciphering the roles of trail formation in efficient neutrophil migration

    Hepatic differentiation of human embryonic stem cells by coupling substrate stiffness and microtopography

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    Mechanical or physical cues are associated with the growth and differentiation of embryonic stem cells (ESCs). While the substrate stiffness or topography independently affects the differentiation of ESCs, their cooperative regulation on lineage-specific differentiation remains largely unknown. Here, four topographical configurations on stiff or soft polyacrylamide hydrogel were combined to direct hepatic differentiation of human H1 cells via a four-stage protocol, and the coupled impacts of stiffness and topography were quantified at distinct stages. Data indicated that the substrate stiffness is dominant in stemness maintenance on stiff gel and hepatic differentiation on soft gel while substrate topography assists the differentiation of hepatocyte-like cells in positive correlation with the circularity of H1 clones initially formed on the substrate. The differentiated cells exhibited liver-specific functions such as maintaining the capacities of CYP450 metabolism, glycogen synthesis, ICG engulfment, and repairing liver injury in CCl4-treated mice. These results implied that the coupling of substrate stiffness and topography, combined with the biochemical signals, is favorable to improve the efficiency and functionality of hepatic differentiation of human ESCs

    数字图书馆建设浅析——以新疆科学数字图书馆为例/Analysis on the Digital Library——Xinjiang Scientific Digital Library as Example[J]

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    数字图书馆建设改变了图书馆的馆藏资源结构,把文献信息资源与服务推送到了读者桌面上,提供一对多的24小时无障碍即时服务,从而突破了馆舍、馆藏、服务手段、传播渠道等一系列曾经困扰图书馆发展的瓶颈,改变了读者利用文献信息资源的方式和图书馆的服务理念,使得图书馆服务的深度和广度都得到了极大的延伸.本文结合新疆科学数字图书馆建设经历,对数字图书馆建设过程中应注意的问题、服务机制、宣传机制、服务项目设置等进行了回顾和总结,希望寻求快速、有效、良性的可持续发展之路

    2012年新疆ISTP论文统计分析/Statistics and Analysis on the Papers Covered by ISTP during 2012 in Xinjiang[J]

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    本文以《科技会议录索引》(Index to Scientific and Technical Proceedings,简称ISTP)为统计源,对新疆2012年被其收录的任意作者的论文从作者分布、机构分布、文献语言分布、发文情报源分布、文献类型分布、学科分布,以及主要合作国家分布七个方面进行了全面的统计分析,可供地区科研管理部门制定科技规划、引进人才、实施成果奖励等提供参考

    从SCI论文统计分析看肉苁蓉研究水平及发展/Analysis of the Research and Development of Cistanche from Statistical Results of SCI Papers[J]

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    根据SCI收录论文的统计数据,分析了随着肉苁蓉研究的发展和学科领域的不同,科研人员的研究成果在SCI收录论文上所反映发生的差异和变化,并以此为依据,对肉苁蓉领域的研究、应用和发展提出了意见
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