Status on the diagnosis and treatment of BK virus infection

BK病毒（BKV）属于人类多瘤病毒中的一个亚型。BKV在普通人群中隐性感染率高达80%。近年来,随着器官移植术的广泛开展以及强效免疫抑制剂的大量使用,在免疫抑制和免疫低下的人群中,由潜伏于体内的BKV重新被激活而引起的BKV相关肾病（BKVAN）、出血性膀胱炎、输尿管狭窄等疾病越来越受到医学界的关注。目前对BKV感染缺乏明确有效的预防措施及抗病毒药物,因此早期监测器官移植术后患者体内的BKV载量、减少免疫抑制剂的使用量、及时调整免疫抑制剂治疗方案并辅助使用其他抗病毒药物对预防BKV相关疾病的发生尤为重要。文章就BKV感染相关的疾病及其临床症状、生物学特征、感染机制以及当前国内外诊断及治疗研究现状进行综述。BK virus （BKV） belongs to a subtype of human polyomavirus. Recessive infection rate of BKV in general population is about 80%. With expanded use of organ transplantation in recent years where strong immunosuppression is essential,BKV associated nephropathy（BKVAN）,hemorrhagic cystitis,ureterostenosis and other associated diseases due to the reactivation of latent BKV in immunosuppressed or immunocompromised populations are becoming more of a concern in medical community. Since the prevention measures and effective antiviral drugs for BKV are rather limited,the effective means for reducing BK associated morbidity and mortality due to BKV associated diseases are the early monitoring of viral loads,reducing the usage of immunosuppressant,adjusting immunosuppressant treatment regime and using adjuvant therapies. This review describes the clinical symptoms,biology,mechanisms and the advances in the diagnosis and treatment of BKV at home and abroad

Preparation of Monodispersed UltraSmall PtCu Alloy with Remarkable Electrocatalytic Performance

Preparation of Monodispersed UltraSmall PtCu Alloy with Remarkable Electrocatalytic Performanc

高速齿轮传动可倾瓦轴承预负荷系数影响研究

可倾瓦轴承因其稳定可靠的特点被广泛应用于现代工业，相关研究也蓬勃发展起来，但目前关于可倾瓦轴承预负荷系数的研究主要集中在低转速领域。以DyRoBeS软件为研究工具，取普遍使用的5块瓦可倾瓦轴承作为研究对象，分析在20 000 r/min、40 000 r/min、60 000 r/min的高转速工况下，预负荷系数对可倾瓦轴承工作性能的影响，为高速齿轮传动中可倾瓦的设计应用提供理论依据。预负荷系数从0.1增加至0.7的过程中，对功率损失影响不大，使最大油膜压力与刚度系数增加，最小油膜厚度与阻尼系数减小。预负荷系数的混合设置会影响各瓦块压力分布，同时使最小油膜厚度以外的轴承性能参数明显增加。所得结论对高转速可倾瓦轴承的优化设计起到积极的作用

Dividing the mind: the necessary role of the frontal lobes in separating memory from search.

Working memory plays a crucial role in the control of visual selection. Previous research has shown that attentional deployment can be biased to objects in an array matching the contents of working memory. Here, we examined the role of the frontal cortex in determining the interaction between working memory and attention. At the start of each trial, participants memorized an object cue that could contain either the target or a distracter, when the object reappeared in the subsequent search array. Relative to age-matched controls, patients suffering from damage to the frontal lobes showed a stronger effect of the memory stimulus on search. Interestingly, there was an effect of frontal damage on the mean latencies to fixate targets but the effect of memory validity on the number of first saccades to the target, and their time of initiation, was similar across the groups. The results suggest that, following the earliest deployment of attention, frontal lobe structures are involved in separating relevant target from irrelevant (object cue) information, when both are held in memory

密码子优化提高aiiaB546毕赤酵母表达活性

N-酰基高丝氨酸内酯酶是一类特异性降解N-酰基高丝氨酸内酯类信号分子（AHLs）的蛋白水解酶,通过水解AHLs生成酰基高丝氨酸,使AHLs失去活性,从而阻断病原菌的群体感应路径,使病原菌失去致病能力,其广泛存在于多种微生物中。近年来N-酰基高丝氨酸内酯酶作为一种新型抗菌策略（群体感应淬灭策略）的工具酶而成为水产养殖防治细菌性疾病研究的热点

密码子优化提高aiiaB546毕赤酵母表达活性

N-酰基高丝氨酸内酯酶是一类特异性降解N-酰基高丝氨酸内酯类信号分子（AHLs）的蛋白水解酶,通过水解AHLs生成酰基高丝氨酸,使AHLs失去活性,从而阻断病原菌的群体感应路径,使病原菌失去致病能力,其广泛存在于多种微生物中。近年来N-酰基高丝氨酸内酯酶作为一种新型抗菌策略（群体感应淬灭策略）的工具酶而成为水产养殖防治细菌性疾病研究的热点

整体式单悬臂离心压缩机用高速齿轮箱的关键技术及应用

主要介绍了整体式单悬臂离心压缩机用高速齿轮箱的特点、设计原则以及设计中的注意事项,并将这种设计方法应用于具体的产品设计,在提高设计效率和齿轮箱可靠性方面取得了良好效果

800nm布拉格反射镜型半导体可饱和吸收镜

我们在国内首先研制成功波长为800nm附近布拉格反射镜型半导体可饱和吸收镜.用布拉格反射镜型半导体可饱和吸收镜作为自启动装置,我们实现了氩离子激光器泵浦的钛宝石激光器被动连续锁模,获得了连续锁模脉冲序列,重复频率在100MHz到200MHz