基于中医传承辅助平台挖掘《金匮要略》水气病用药规律

目的:研究《金匮要略》中治疗水气病的用药规律,为临床治疗水气病选方和用药提供参考。方法:收集并筛选《中华医典》中治疗水气病的方剂,应用中医传承辅助平台(V2.5)软件,采用频数分析、关联规则Apriori算法、改进的互信息法等数据挖掘方法对药物配伍规律进行挖掘。结果:共筛选治疗水气病处方101首,涉及107味中药,其中使用频次最高的三位药物为甘草、茯苓、桂枝;选择相关度为7、惩罚度为2,应用复杂系统熵聚类的层次聚类分析演化出3-4味药的核心组合12个,新处方6首。结论:《金匮要略》中治疗水气病以宣肺发汗,健脾利水,温阳散寒为主,反映了\"发汗利水、温阳健脾\"的祛邪与扶正兼顾之治则治法。江苏省中医药管理局江苏省中医药领军人才资助项目(SLJ0227):江苏省中医药领军人才资助项目,负责人:战丽彬;;\n江苏省教育厅江苏省大学生创新创业训练计划重点项目(201710315001Z):肠道菌群在脾虚证发病学中的意义探究,负责人:胡

End-member characteristics of sediment grain size of modern Yellow River Delta sediments and their response to channel shifts and human activities

Yellow River Delta sediments record environmental changes in the Yellow River basin at long time scales, and respond sensitively to natural and human activities such as river diversions and reservoir construction in the basin. We analyzed the grain size distribution of core YDC from onshore delta since 1976 near the river mouth were analyzed using a parametric end-member analysis model. Results show that EM1 and EM2 are composed of fine-grained clay and fine powder sand, deposited under weak hydrodynamic conditions for long distance transport in the Yellow River, while EM3 and EM4 are coarse powder sand fractions, deposited by wave and tidal action under stronger dynamic conditions. By comparing the data on channel alteration and human activities, and combining data from previous studies on sedimentation rates in the Yellow River estuary, we found that significant changes in grain size characteristics could be used as reference points for sediment age determination. The grain size parameters and end element data reflect the natural and human activities since 1976, such as the diversion of the Yellow River from Qingshuigou to the sea, the construction of the Longyangxia Reservoir, and the diversion of the Yellow River from Qingbacha to the sea. This study provide a reference for the management of the Yellow River Delta estuary and coastal engineering construction, and a scientific basis for ecological protection and high-quality development of the Yellow River basin

基于代谢组学的脾气虚证本质研究

基于代谢组学的脾气虚证本质研