Intermolecular Multiple- Quantum Coherences and Their Applications on Biological Tissues

高分辨核磁共振(nuClEAr MAgnETIC rESOnAnCE,nMr)波谱是一种能够在非侵入性状态下获得生物组织分子信息的有效手段。分子间多量子相干(InTErMOlECulAr MulTIPlE-QuAnTuM COHErEnCE,IMQC)信号源于分子间的远程偶极相互作用,仅依赖于偶极相关距离内的磁场相对均匀性,因此可用于在不均匀磁场下获得高分辨的nMr谱。文中简要介绍了IMQC的发展历程及现状,并主要讨论了IMQC方法及其在活体及生物组织中的应用。虽然IMQC目前应用在老鼠身上比较常见,但最近的研究表明IMQC方法已被用于人体小脑的研究,将来IMQC方法将有可能应用于人体的其他器官以及其他的动物研究,具有广阔的发展前景。High resolution nuclear magnetic resonance(NMR) spectroscopy offers an effectively noninvasive method to obtain molecular information in biological tissues.Intermolecular multiple- quantum coherences(iMQCs) originating from distant dipolar interactions between spins just rely on the relative homogeneity of magnetic field within the dipolar correlation distance.Therefore,iMQC can acquire high- resolution NMR spectroscopy in inhomogeneous fields.In this review,the development history and current situation of iMQC were briefly introduced,and the applications of iMQC on in vivo biological tissues were mainly discussed.Although it is more common to apply iMQC in mice /rats,recent investigation indicated that iMQCs can also been used in the study of human cerebellums.In the future,iMQC may be applied to study other organs of human and other animals,indicating that it is a promising method.国家自然科学基金资助项目(项目编号:11105114

High-Resolution Absorptive NMR Spectroscopy in Inhomogeneous Magnetic Fields

高分辨核磁共振(NuclearMagneticResonance,NMR)波谱是一种能够在非侵入性状态下获得生物组织分子信息的有效手段。现已被广泛应用于物理学、化学、生物及医药等领域。传统的液体高分辨核磁共振实验对磁场的均匀度要求很高。但在很多情况下，由于样品或者环境的原因很难获得均匀的磁场。分子间多量子相干信号(intermolecularMultiple-QuantumCoherence,iMQC)源于分子间的远程偶极相互作用，仅依赖于偶极相关距离内的磁场相对均匀性，可用于在不均匀磁场下获得高分辨的NMR谱。目前获得吸收谱的iMQC高分辨方法并不多见，本论文提出了一种在不均匀场下获得吸收谱...High-resolution nuclear magnetic resonance (NMR) spectroscopy, which has been widely used in many fields such as physics, chemistry, biology and medicine, offers an effectively noninvasive method to obtain molecular information in biological tissues. In conventional liquid high-resolution NMR experiments, the highly homogeneity of magnetic field is typically required. In many cases, however, homog...学位：工程硕士院系专业：物理与机电工程学院_电子与通信工程学号：1982011115287