Adverse Reactions of Moxifloxacin and its Safety

目的 分析莫西沙星不良反应的特点,探讨其临床用药的安全性问题。方法 选取我院肺科2015年12月—2016年12月使用莫西沙星（拜复乐）后产生不良反应的60例患者临床资料,对其进行回顾性分析,并且从药物结构、相互作用等多个方面探讨莫西沙星的用药安全性问题。结果 在60例不良反应中,有48例以注射方式给药,12例以口服方式给药。其不良反应累及系统/器官为：皮肤损害19例、中枢神经系统损伤18例、心血管系统损伤13例、横纹肌溶解症6例、其他损伤4例。结论 临床需要对莫西沙星用药安全性加以重视,对其不良反应的发生提高警惕,并定期进行监测与分析,减少莫西沙星使用中发生的安全性问题。Objective To analyze the characteristics of moxifloxacin adverse reactions and explore the safety of clinical drug use. Methods The clinical data of 60 patients with moxifloxacin from December 2015 to December 2016 were retrospectively analyzed. The drug safety of moxifloxaein was discussed from the aspects of drug structure and interaction. Results Of the 60 cases adverse reactions, 48 cases were administered by injection and 12 cases were administered orally. The adverse reactions involving the system / organ were： skin damage in 19 cases, central nervous system injury in 18 cases, cardiovascular system injury in 13 cases, rhabdomyolysis in 6 cases, and other injuries in 4 cases. Conclusion The clinical need to pay attention to the safety of moxifloxacin, to guard against the occurrence of adverse reactions, and regular monitoring and analysis to reduce the safety problems occurred during the use of moxifloxacin

Discussion on application value of pulmicort respulas combined with ambroxol and inhalation method in late neonatal pneumonia

目的探讨普米克令舒联合氨溴索雾化在治疗晚期新生儿肺炎患儿中的应用价值。方法将晚期新生儿肺炎患儿随机分为实验组和对照组,对照组给予积极抗感染和对症治疗,实验组除外对照组处理还给予普米克令舒联合氨溴索雾化吸入治疗,比较两组患儿疗效、症状体征改善情况。结果实验组疗效整体优于对照组,且在退热时间、体征变化时间和住院时间上早于对照组,差异有统计学意义(P<0.05)。结论普米克令舒联合氨溴索雾化治疗晚期新生儿肺炎效果显著,能明显提高患儿治愈率,改善患儿临床症状和体征并缩短病程。Objective To discuss the application value of pulmicort respulas combined with ambroxol with the inhalation method in late neonatal pneumonia.Methods The late neonatal pneumonia children were randomly divided into experimental group and control group, control group was given positive anti-infection and symptomatic treatment, the experimental group was given not only above but also pulmicort respulas combined with ambroxol with the inhalation method.Compared two groups of children with curative effect, the signs and symptoms improvement.Results Experimental group curative effect is better than that of control group whole, and signs of change is earlier than the control group in antifebrile time and hospital stay time, the difference is statistically significant(P<0.05).Conclusion The late neonatal pneumonia children in therapy of pulmicortrespulas combined with ambroxol with the inhalation method is remarkable, which can obviously increase the cur rate, improve the clinical signs and symptoms and shorten the course of the disease.Key word

思维盛宴聚焦WTO

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Aqueous-Processable Noncovalent Chemically Converted Graphene-Quantum Dot Composites for Flexible and Transparent Optoelectronic Films

The preparation and optoelectronic response of flexible composites via non-covalent coupling of quantum dots to chemically converted graphene is presented. The photoincluced charge transfer is confirmed by photoconductivity measurements and the photosensitivity is improved with increasing loadings of quantum dots. This opens up a new effective route to form composites for future large-area flexible and transparent optoelectronic devices