不同镇痛方法对膝关节置换术后疼痛和早期康复的影响

[目的]对比不同镇痛方法对膝关节置换术后疼痛和早期康复的影响。[方法]2016年9月~2017年9月,择期行单侧全膝关节置换术(TKA)的患者75例列入本研究,依据术后镇痛方式,随机均分为3组:连续收肌管阻滞联合关节周围浸润组(CA+P组)、连续股神经阻滞联合关节周围浸润组(CF+P组)、连续硬膜外镇痛组(E组),所有患者均采用腰硬联合麻醉。记录术前、术后静息及活动状态下的疼痛视觉模拟评分(VAS)和股四头肌肌力,记录术后膝关节最大主动屈曲角度(°)和不良反应。[结果]术后24、48、72 h活动状态下,E组患者VAS评分明显高于CA+P组和CF+P组,差异有统计学意义(P<0.05)。CF+P组和E组患者术后6、12、24 h股四头肌肌力下降,差异有统计学意义(P<0.05)。CF+P组和E组术后1、2、3 d膝关节主动屈曲角度明显降低,差异有统计学意义(P<0.05)。E组加用镇痛药物用量及术后并发症的发生率明显高于其他两组,差异有统计学意义(P<0.05)。[结论]连续收肌管阻滞联合关节周围浸润可有效缓解全膝关节置换术患者疼痛,且对股四头肌肌力影响更小,不良反应发生率更低。国家自然科学基金青年项目(项目编号:81501207

New Materials of Plants in Fujian Province (Ⅰ)

在泉州湾植物调查时,发现福建省被子植物分布新记录5种(含变种),分别是:盐地碱蓬SuAEdA SAlSA、座地猪屎豆CrOTAlArIA nAnA VAr.PATulA、沙地叶下珠PHyllAnTHuS ArEnArIuS、肉叶耳草HEdyOTIS STrIgulOSA和佛欧里画眉草ErAgrOSTIS fAurIEI。标本存放于厦门大学植物标本馆(Au)。During the course of investigating the plants in Quanzhou bay,four newly recorded species and one newly recorded varieties of Angiosperm were found.They are Suaeda salsa,Crotalaria nana var.patula,Phyllanthus arenarius,Hedyotis strigulosa and Eragrostis fauriei.The voucher specimens are deposited in the Herbarium of Xiamen University(AU).海洋公益性行业专项经费项目(200705029、200905009-1

EB病毒相关性疾病病理学研究的进展

报告作者及其同事在鼻咽癌高发的广州地区所做EB 病毒相关性疾病病理学研究的进展。内容 包括: ①EB 病毒病理生物学; ②EB 病毒相关性疾病病理学; ③检测组织中的EB 病毒; ④EB 病毒血清学。 重点是EB 病毒相关性疾病的病理学以及评估各种检测EB 病毒相关性疾病患者组织和血清中EB 病毒的方 法

中国国际科学合作中的”华人现象“

将8 个国家的合作论文分成五种类型，重点考察了中国在与8 个国家的合作中所呈现的“华人现 象”。分析表明，海外华人（包括短期在外的科研人员）在现阶段正在发挥桥梁作用，在中国国际合作中表 现得非常活跃。分析了导致“华人现象”的社会基础和政策效应

Trisomy 21-induced Dysregulation of Microglial Homeostasis in Alzheimer’s Brains is Mediated by USP25

阿尔茨海默病（Alzheimer’s disease, AD）是一种最为常见的与记忆、认知能力退化相关的渐进性神经退行性疾病。唐氏综合征（Down’s syndrome, DS）是早发型阿尔茨海默病的一个重要风险因素，作为最常见的智力障碍遗传疾病，厦门大学医学院神经科学研究所王鑫教授团队揭示了治疗阿尔茨海默病和唐氏综合征新的治疗靶点，并且在小鼠模型上利用USP25小分子抑制剂成功地改善了阿尔茨海默病小鼠的认知功能，缓解了神经退行性病变的病理进程。该研究工作由王鑫教授指导完成，厦门大学医学院助理教授郑秋阳和博士生李桂林完成主要实验工作，王世华、朱琳、高月、邓青芳、张洪峰、张丽珊、吴美玲、狄安洁参与了部分研究工作。厦门大学医学院许华曦、赵颖俊和孙灏教授在研究过程中给予大力帮助和支持，清华大学董晨教授提供了Usp25基因敲除小鼠，厦门大学附属妇女儿童医院周裕林教授和郑良楷博士帮助收集了脑组织样品。Down syndrome (DS), caused by trisomy of chromosome 21, is the most significant risk factor for early-onset Alzheimer’s disease (AD); however, underlying mechanisms linking DS and AD remain unclear. Here, we show that triplication of homologous chromosome 21 genes aggravates neuroinflammation in combined murine DS-AD models. Overexpression of USP25, a deubiquitinating enzyme encoded by chromosome 21, results in microglial activation and induces synaptic and cognitive deficits, whereas genetic ablation of Usp25 reduces neuroinflammation and rescues synaptic and cognitive function in 5×FAD mice. Mechanistically, USP25 deficiency attenuates microglia-mediated proinflammatory cytokine overproduction and synapse elimination. Inhibition of USP25 reestablishes homeostatic microglial signatures and restores synaptic and cognitive function in 5×FAD mice. In summary, we demonstrate an unprecedented role for trisomy 21 and pathogenic effects associated with microgliosis as a result of the increased USP25 dosage, implicating USP25 as a therapeutic target for neuroinflammation in DS and AD.This work was supported by the National Natural Science Foundation of China (31871077, 81822014, and 81571176 to X.W.; 81701130 to Q.Z.), the National Key R&D Program of China (2016YFC1305900 to X.W.), the Natural Science Foundation of Fujian Province of China (2017J06021 to X.W.), the Fundamental Research Funds for the Chinese Central Universities (20720150061 to X.W.), and the BrightFocus Foundation (A2018214F to Yingjun Zhao). 该研究工作得到国家重点研发计划项目、国家自然科学基金、福建省自然科学基金、厦门大学校长基金的资助和支持

Comparison of the Efficacy of Two Glycyrrhizin in Treatment of Chronic Hepatitis B

目的:比较异甘草酸镁注射液与复方甘草酸苷注射液治疗慢性乙型肝炎的临床疗效和安全性。方法:62例慢性乙型肝炎患者随机分为两组,观察组32例给予异甘草酸镁注射液150 Mg加入5%~10%葡萄糖注射液250 Ml中,IVd Qd;对照组给予复方甘草酸苷注射液120 Mg加入5%~10%葡萄糖注射液250 Ml中,IVd Qd。疗程均为4周。观察两组症状、体征、肝功能等指标的变化及药品不良反应。结果:治疗后两组患者的症状、体征、肝功能指标均有明显改善,组间比较差异无统计学意义(P>0.05)。观察组与对照组有效率分别为90.63%、83.33%,差异同样无统计学意义(P>0.05)。两组均未见严重不良反应。结论:异甘草酸镁注射液治疗慢性乙型肝炎疗效确切,安全性好,与复方甘草酸苷注射液临床疗效差异不明显。bjective:To compare the clinical efficacy and security of magnesium isoglycyrrhizinate injection and compound glycyrrhizin injection in the treatment of patients with chronic hepatitis B.Methods:62 cases of chronic hepatitis B were randomly divided into the observation group and the controlled group,the 32 cases with chronic hepatitis B were treated with 150mg magnesium isoglycyrrhizinate injection and the 30 cases were treated with 120mg compound glycyrrhizin injection once daily for 4 weeks.Symptoms,signs,hepatic function tests and adverse drug reactions were observed.Results: In the two groups,their symptoms,signs,liver function indices were obviously improved and the effective rates of the observation group and the controlled group were 90.63%and 83.33%respectively.There was no significant difference between the two groups(P >0.05).There was no serious adverse reaction in them.Conclusion:Themagnesium isoglycyrrhizinate injection was obviously effective and safe for the treatment of chronic hepatitis B.The result showed that magnesium isoglycyrrhizinate injection and compound glycyrrhizin injection were not significant

基于现场总线的加速器高频控制网络设计

根据加速器高频控制系统网络化和自动化的要求,设计了一种基于Profibus-DP和Ethernet的并适用于加速器高频系统强磁场运行环境下的控制系统。系统采用S7-300PLC和S7-200PLC为核心控制设备,并以交换机为主要通信设备,构建了加速器高频系统控制网络。利用STEP7、Microwin4.0、Protool和Wincc完成PLC程序设计和上位机HMI设计。文中重点介绍了系统的网络结构、频率微调、硬件配置、软件设计。该系统设计简化了网络结构,提高了系统的可靠性和稳定性