Square Wave Stripping Voltammetric Behaviors of Actinomycin D on Glod Electrode and Its Application

应用方波溶出伏安法研究了放线菌素D在KH2PO4-Na2HPO4缓冲溶液中于金电极上的电化学行为以及酸度、预富集沉积电位、预富集沉积时间、方波频率、方波幅度、电位增量等的影响,优化测定参数,建立一种直接测定放线菌素D的电分析测定方法.在0.1～10.0μmol.L-1浓度范围内,放线菌素D与其方波溶出伏安氧化峰电流呈良好的线性关系,相关系数0.9991,检测限1.0×10-8mol.L-1.The electrochemical behaviors of Actinomycin D(ACTD)at glod electrode were investigated by square wave stripping voltammeter in the KH2PO4-Na2HPO4 buffer solution(pH=5.90).The sensitive oxidation peak of ACTD was observed and the potential peak for ACTD is-0.17 V(vs.SCE).The Experimental parameters,such as pH value,amplitude,accumulation potential and time were optimized,and a direct electroanalytical method for determining ACTD was developed.The peak currents were proportional to the concentration of ACTD in the range of 0.1μmol·L-1～10.0μmol·L-1,and the linear regression coefficient equaled 0.9991.The detection limit for ACTD was 1.0×10-8mol·L-1.作者联系地址：西华师范大学化学化工学院,西华师范大学化学化工学院,西华师范大学化学化工学院 四川南充637002,四川南充637002,四川南充637002Author's Address: Institute of Chemical Engineering,China West Normal University,Nanchong 637002,Sichuan,Chin

Square Wave Stripping Voltammetric Behaviors of Rutin on Glassy Carbon Electrode and Its Application

应用方波溶出伏安法研究了芦丁在0.1mol.L-1HAc-NaAc缓冲溶液中于玻碳电极上的电化学行为.考察了溶液酸度、沉积电位、沉积时间等因素对芦丁方波溶出伏安行为的影响,优化了实验参数.结果表明,在pH3.0的HAc-NaAc缓冲溶液中,芦丁在-0.46 V产生溶出峰,峰电流与芦丁的浓度在5.0×10-8mol.L-1~1.0×10-6mol.L-1范围内呈现良好的线性关系,相关系数0.997 99,检测限1.1×10-8mol.L-1.可用于药剂中芦丁含量的测定.The electrochemical behaviors of rutin(Rt) at glassy carbon electrode were studied by square wave stripping voltammeter in the presence of 0.1mol·L-1HAc-NaAc buffer solution(pH=3.0).The sensitive oxidation peak of rutin was observed and which potential peak is 0.46V(vs.SCE).The experimental parameters,such as pH value,deposition potential and deposition time were investigated and selected.The peak currents were proportional to the concentration of rutin in range of 5.0×10-8 mol·L-1~1.0×10-6mol·L-1,and the linear regression coefficient equaled 0.99799,the detection limit was 1.1×10-8 mol·L-1.This method was applied to the determination of rutin content in tablet with satisfactory results.作者联系地址：西华师范大学化学化工学院,西华师范大学化学化工学院,西华师范大学化学化工学院,西华师范大学化学化工学院 四川南充637002,四川南充637002,四川南充637002,四川南充637002Author's Address: Institute of Chemical Engineering,China West Normal University,Nanchong 637002,Sichuan,Chin

Electrochemical Behavior and Determination of Paracetamol on Activated Glassy Carbon Electrode

应用循环伏安法,研究了对乙酰氨基酚(PCT)在活化玻碳电极上的电化学行为.在pH=4.00的HAc-NaAc缓冲溶液中,PCT的CV扫描于0.54 V左右出现一对明显的氧化-还原峰.电极反应为2电子、2质子的受吸附控制的准可逆过程.其氧化峰电流与PCT浓度在8.00×10-6~2.00×10-4mol.L-1范围内呈良好的线性关系,相关系数r=-0.99918;检出限为6.34×10-6mol.L-1.用于药物样品PCT的含量测定,结果满意.The electrochemical behavior of paracetamol(PCT) was studied at glassy carbon electrode activated by cyclic voltammetry.In HAc-NaAc buffer solution(pH=4.00),a couple of sensitive redox peaks were recorded about 0.54 V in the cyclic voltammograms.The result indicated that the process was controlled by adsorption and nearly reversible.The reaction electron and proton numbers were estimated,respectively,to be two.Excllent linearity was observed in the correlation between the oxidation peak current and the concentration of PCT in the range of 8.00×10-6～2.00×10-4 mol·L-1.The correlative coefficient was-0.999 18.The detection limit was 6.34×10-6 mol·L-1.This method can be used for the determination of PCT real samples.作者联系地址：西华师范大学化学化工学院;Author's Address: Institute of Chemical Engineering,China West Normal University,Nanchong 637002,Sichuan,Chin