Development of a novel fast immunoassay for HBV genotyping and study on the clinical significance of the quantitative hepatitis B core antibody level

乙型肝炎病毒（HepatitisBvirus,HBV）感染是一个严重的，世界范围内的公共卫生问题，可以导致肝炎，肝硬化（LC）和肝细胞癌（HCC），每年可以引起100万以上的人死亡。在HBV感染的临床诊断中，不同的HBV相关标志物指示了病毒产生，病毒多态性以及宿主免疫反应三个方面，从而全面了解HBV感染者的疾病状态，预测自然转归和治疗应答，监测疾病进展和治疗效果，对HBV感染者的管理和治疗起到关键的指导作用。目前在指示病毒产生的标志物方面，HBsAg，HBVDNA和HBeAg的检测手段相对成熟，商品化试剂检测性能优秀，已广泛应用于临床，然而指示病毒多态性的HBV基因型的检测受到方法学的限制难以...The hepatitis B virus (HBV) is a serious, worldwide public health problem because HBV infection can cause hepatitis, liver cirrhosis (LC) and hepatocellular carcinoma (HCC), resulting in more than one million deaths annually. In the clinical diagnostic of HBV infection, different HBV related biomarkers reflect the production of virus, virus polymorphism, and the host immune response, in order to f...学位：理学博士院系专业：生命科学学院_细胞生物学学号：2162011015395

Bilateralism, Regionalism or Multilateralism: The Choice of Trade Cooperation Strategy

第二次世界大战后的数十年内，在国际贸易合作领域起主导作用的是以GATT/WTO为代表的多边贸易框架。多数国家认识到自由贸易能够极大地推动一个国家的发展，在这样的前提下，经过八轮的多边贸易谈判，世界贸易逐渐走向自由化。然而，从80年代末到90年代初，贸易合作谈判的方式发生很大变化。多边主义的支持者如美国、日本等国家，纷纷通过建立自由贸易区，从行动上表达了对双边和区域贸易合作途径的支持。随后，在世界范围内掀起一股建立自由贸易区的热潮。对于这样一种现象，人们疑问的逻辑起点往往是，为什么会产生这样的变化？为什么这样的变化会有如此的影响？本文首先讨论引起这样变化的内在动因，总结了世界主要双边和区域贸易合...During the years after WWⅡ, multilateral system represented by GATT/WTO plays a key role in the area of trade cooperation. Realizing the benefits of free trade, more and more countries took part in multilateral cooperation to negotiate the trade-related problem, and the world trade is increasingly free. However, the method of trade negotiation changed a lot during 1980s and 1990s. The original sup...学位：经济学硕士院系专业：经济学院国际贸易系_国际贸易学学号：20021301

区域主义动因和中国的选择

区域主义和双边主义的兴起,使维持了半个世纪之久的多边主义受到强烈的冲击。为什么坚守多边主义的美国会转变对区域主义的态度?为什么如此多的国家突然产生对区域主义浓厚兴趣?本文试图解释这两个问题,归纳区域主义形成的主要因素,以及这些因素存在的内在逻辑联系,并对中国的对外贸易提出相关的政策建议

Occurrence of Typical Chloroacetamide Herbicides in Surface Waters from Jiulong River Estary and Their Abiotic Degradation

长期、大量施用的酰胺类除草剂通过沉降、地表径流等途径进入水环境，对水生生物和水生生态系统造成潜在威胁。本论文在对福建九龙江河口表层水中常用酰胺类除草剂乙草胺、丁草胺和异丙甲草胺的污染状况进行调查的基础上，研究了其在室外自然条件下天然水中的非生物降解行为，并进一步在实验室内控制条件下研究了非生物降解的影响因素，为水环境中酰胺类除草剂的持久性评价和风险评估提供技术手段和科学数据。 主要研究内容和结果如下： （1）福建九龙江口表层水中3种目标农药的残留状况 于2009年5月（丰水期）和2009年12月（枯水期）对九龙江河口表层水中三种酰胺类除草剂的污染状况进行了调查，目标物以LLE-GC-MS...Long-term, heavily used chloroacetamide herbicides put potential threats on aquatic organisms and aquatic ecosystem after entering aquatic environment via deposition, surface runoff etc.. In this dissertation, a pollution survey of three typical chloroacetamide herbicides, acetochlor, butachlor and metolachlor in Jiulong River Estaury was conducted using LLE-GC-MS. On the basis, abiotic degradatio...学位：理学硕士院系专业：海洋与环境学院环境科学与工程系_环境科学学号：2262008115153

马克思企业理论与交易成本企业理论之间的互补性

交易成本企业理论与马克思企业理论虽然各有不同,但它们的主要关系不是相互冲突,而是具有某种互补性。这种互补性集中表现在它们在企业理论这一层面上,分别从不同的角度展开了生产力与生产关系矛盾运动这一命题:马克思的企业理论是从生产力决定生产关系的角度,而交易成本企业理论则是从生产关系对生产力具有反作用的角度。显然,这两个角度相互补充。认识到两种理论之间内在的互补性,不仅对交易成本企业理论提供了一种新的理解,也为构建一种更加全面的企业理论提供了一条线索

On the Dual Nature of the Firm——Unification of the Technological Nature and the Institutional Nature

科斯在1937年发表了《企业的性质》一文，这篇文章开创了企业理论的交易成本分析范式，标志着现代企业理论研究的开始。经过科斯本人和其他一些交易成本企业理论家的努力，企业的交易成本理论已经成为现代企业理论的主流范式。虽然如此，学术界对这一理论的批评自它诞生之日起就一直没有停止过。这种批评主要集中在交易成本企业理论单纯地强调企业的制度性质，主要关注不同制度选择对组织绩效的影响，而把对企业组织技术性质的分析排除在企业理论之外，使得交易成本理论只能解释企业的部分性质，无法对企业的性质做出完整和充分的解释。在科斯之前，以亚当•斯密和马歇尔为代表的古典经济学以及新古典经济学虽然没有系统的企业理论...Coase’s article the nature of the firm which published in 1937 created the transaction cost analysis paradigm of firm theory and marks the beginning of modern firm theory research. Through the efforts from Coase and other transaction costs theorists, transaction cost theory has become the mainstream paradigm of the modern firm theory. But the criticism has always been along with it since it was bo...学位：经济学博士院系专业：经济学院经济研究所_政治经济学学号：2902008015029

多模态化与大学英语多元读写能力培养实证研究

“新伦敦小组“提出的多元读写能力概念在国内受到越来越多的重视,也极大地影响了大学英语教学的内容和方法等诸方面。文章以多模态话语理论为基础,运用实证研究的方法,对多元读写能力教学法与传统教学法在大学英语教学中的效果进行对比。结果表明:前者的效果明显优于后者,是一种符合大学英语教学特点、具有推广价值的教学方法。山东省社会科学规划研究项目“基于大学英语口语课程体系改革的英语口语立体化教材研究”(编号:11CWZJ07)的阶段性成

A Corpus-based Study of the Style in Translations of Mo Yan’s Novels:With Howard Goldblatt’s English Versions as Exemplars

本文基于语料库语言学的工具和方法，从词汇、搭配和句法层面对莫言小说葛浩文译文风格进行描写分析，并借鉴译介学、功能主义目的论和多元系统理论等视阈的研究成果用以诠释其独特文体特征的形成动因。作为翻译共性的一个重要组成部分，译本风格研究已经引起国内外学者比较广泛的兴趣。Baker率先利用语料库方法开展了文学翻译中的译本风格研究，为此项研究提供了全新的视角和范式。从此，译本风格研究逐步成为翻译研究的焦点。 受其启迪，国内翻译学界在近几年也开始涉足译本风格研究。但调查发现：基于语料库方法对译本风格进行的实证研究在国内还比较欠缺，现有研究大多停留在翻译语言特征假设的检验上，且存在方法单一、解释力相对不足...The dissertation conducts a corpus-based study of Howard Goldblatt’s translation style of Mo Yan’s novels on the lexical, collocational and syntactic levels by drawing on the theoretical achievements in such fields as Media-translatology, the Skopos Theory and the Polysystem Theory, etc. In 1993, Mona Baker introduces the corpus-based approach to translation style studies, which paved the way for ...学位：文学博士院系专业：外文学院_英语语言文学学号：1202011015401

Influence of different blood Glu cose control programs on prognosis and blood Glu cose in patients with intracerebral hemorrhage after operation together with stress hyperglycemia

目的 探讨不同血糖控制方案对脑出血术后应激性高血糖患者预后及血糖的影响。方法 采用回顾性研究方法将2015年6月~2016年5月入住我院重症医学科的52例脑出血术后应激性高血糖患者根据血糖控制方案的不同分为A组（n=25）和B组（n=27）,A组采用静脉单次推注,B组采用持续静脉泵注。比较两组的28 d生存率、格拉斯哥预后评分、血糖达标率、达标时间、血糖监测次数、低血糖发生率、血糖水平和血糖变异度指标的差异。结果 两组的28 d生存率、血糖达标率、达标时间、低血糖发生率比较,差异无统计学意义（P〉0.05）。A组的格拉斯哥预后评分显著高于B组,差异有统计学意义（P〈0.05）。A组的血糖监测次数显著少于B组,差异有统计学意义（P〈0.05）。A组的血糖最大值（Glu_（max））和血糖差值（Glu_（dif））均显著小于B组,差异有统计学意义（P〈0.05）。结论静脉单次推注胰岛素能够改善脑出血术后应激性高血糖患者的神经功能预后,可以降低入ICU后血糖最大值和血糖差异。Objective To investigate influence of different blood glucose control programs on prognosis and blood glucose in patients with intracerebral hemorrhage after operation together with stress hyperglycemia.Methods A retrospective study was conducted,and 52 patients with stress hyperglycemia after cerebral hemorrhage in our hospital from June 2015 to May 2016 were divided into group A （n=25） and group B （n=27） according to different blood glucose control programs.Group A was treated with intravenous bolus injection,and group B was treated with continuous intravenous pump.The 28 d survival rate,the Glasgow outcome score,the blood glucose compliance rate,the standard time,the fre- quency of blood glucose monitoring,the incidence rate of hypoglycemia,blood glucose levels and blood glucose variabili- ty indexes were compared between the two groups.Results There was no significant difference in 28 d survival rate,the blood glucose compliance rate,the standard time,the incidence rate of hypoglycemia between the two groups （P〉0.05）. The Glasgow outcome score in group A was significantly higher than that in group B,with significant difference （P〈 0.05）.The number of blood glucose monitoring in group A was significantly less than that in group B,with significant dif- ference （P〈0.05）.The Glu., and Glu~f in group A was significantly less than that in group B,with significant difference （P〈O.O5）.Conclusion Intravenous single bolus insulin injection can improve the prognosis of nervous function in pa- tients with intracerebral hemorrhage after operation together with stress hyperglycemia,and can reduce the maximum blood glucose and blood glucose difference after ICU.广东省东莞市医疗卫生类科技计划一般项目（2015105101220

Baseline-free damage identification of metallic sandwich panels with truss core based on vibration characteristics

A baseline-free damage identification method is proposed to identify damages in metallic sandwich panels with truss core in the article. The method is based on flexibility matrix and gapped smoothing method, with damage index defined DIm. The weight coefficient m is introduced to consider the effect of damages on both low-order modes and high-order modes. Numerical simulations and experiments are conducted to evaluate the present method. Besides, damage index DIm* is also defined by processing DIm with Teager energy operator, and comparisons between DIm and DIm* are also carried out. Results show that the proposed method is effective in detecting single damage and multiple damages of the same or different extent. The weight coefficient m plays a very important role in identification of multiple damages of different styles. When comparing with DIm*, it is found that the present index DIm is better at suppressing the singularity caused by contact nodes and detecting of multiple damages which contain small or slight damages.</p